Uts2r (urotensin 2 receptor) - Rat Genome Database

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Gene: Uts2r (urotensin 2 receptor) Rattus norvegicus
Analyze
Symbol: Uts2r
Name: urotensin 2 receptor
RGD ID: 621884
Description: Enables urotensin II receptor activity. Involved in several processes, including positive regulation of vasoconstriction; regulation of blood pressure; and regulation of circadian sleep/wake cycle. Located in early endosome and recycling endosome. Used to study acute kidney failure; endomyocardial fibrosis; and hypertension. Biomarker of cardiomyopathy and myocardial infarction. Orthologous to human UTS2R (urotensin 2 receptor); INTERACTS WITH ammonium chloride; C60 fullerene; copper atom.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: G-protein coupled receptor 14; G-protein coupled sensory epithelial neuropeptide-like receptor; Gpr14; putative G protein-coupled receptor (SENR); putative G protein-coupled receptor (SENR) gene; Senr; UR-2-R; UR-II-R; urotensin II receptor; urotensin-2 receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810106,936,398 - 106,937,558 (+)NCBIGRCr8
mRatBN7.210106,438,092 - 106,439,252 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10106,438,092 - 106,439,252 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10111,540,796 - 111,541,956 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010111,003,849 - 111,005,009 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010106,358,527 - 106,359,687 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010110,364,291 - 110,365,451 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10110,364,291 - 110,365,451 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010109,951,008 - 109,952,168 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410110,394,782 - 110,395,942 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110110,409,285 - 110,410,446 (+)NCBI
Celera10104,976,678 - 104,977,838 (+)NCBICelera
Cytogenetic Map10q32.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Uts2rRatacute kidney failure  IMP 2306847 RGD 
Uts2rRatcardiomyopathy  IEP 2306796associated with Diabetes Mellitus more ...RGD 
Uts2rRatDiabetic Nephropathies  ISOUTS2R (Homo sapiens)2306805mRNA:increased expression:kidneyRGD 
Uts2rRatDiabetic Nephropathies  IEP 2306786associated with Diabetes Mellitus more ...RGD 
Uts2rRatendomyocardial fibrosis  IMP 2306833 RGD 
Uts2rRatExperimental Diabetes Mellitus  IMP 2306839 RGD 
Uts2rRathypertension  IDA 1580812 RGD 
Uts2rRatmyocardial infarction  IEP 2306846associated with Heart Failure more ...RGD 
Uts2rRatMyocardial Reperfusion Injury  IMP 2306836 RGD 
Uts2rRattype 2 diabetes mellitus  ISOUts2r (Mus musculus)2306785mRNA:increased expression:skeletal muscleRGD 
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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Uts2rRatgeneralized epilepsy  ISOUTS2R (Homo sapiens)8554872ClinVar Annotator: match by term: Epileptic encephalopathyClinVarPMID:28492532

1 to 20 of 29 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Uts2rRat1,2-dichloroethane increases expressionISOUts2r (Mus musculus)6480464ethylene dichloride results in increased expression of UTS2R mRNACTDPMID:28960355
Uts2rRat12-methyltetradecanoic acid multiple interactionsISOUTS2R (Homo sapiens)6480464aseanostatin P5 binds to and results in increased activity of UTS2R proteinCTDPMID:31378678
Uts2rRat17alpha-ethynylestradiol multiple interactionsISOUts2r (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UTS2R mRNACTDPMID:17942748
Uts2rRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOUts2r (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UTS2R mRNACTDPMID:17942748
Uts2rRataflatoxin B1 decreases expressionISOUTS2R (Homo sapiens)6480464Aflatoxin B1 results in decreased expression of UTS2R mRNACTDPMID:22100608
Uts2rRatammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of UTS2R mRNACTDPMID:16483693
Uts2rRatatrazine increases expressionISOUTS2R (Homo sapiens)6480464Atrazine results in increased expression of UTS2R mRNACTDPMID:22378314
Uts2rRatbenzo[a]pyrene multiple interactionsISOUts2r (Mus musculus)6480464Benzo(a)pyrene promotes the reaction [AHR protein binds to UTS2R promoter]CTDPMID:19654925
Uts2rRatbisphenol A decreases methylationISOUts2r (Mus musculus)6480464bisphenol A results in decreased methylation of UTS2R promoterCTDPMID:27312807
Uts2rRatC60 fullerene decreases expressionEXP 6480464fullerene C60 results in decreased expression of UTS2R mRNACTDPMID:19167457
Uts2rRatcopper atom increases expressionEXP 6480464Copper deficiency results in increased expression of UTS2R mRNACTDPMID:26033743
Uts2rRatcopper(0) increases expressionEXP 6480464Copper deficiency results in increased expression of UTS2R mRNACTDPMID:26033743
Uts2rRatdimethyl sulfoxide affects expressionISOUTS2R (Homo sapiens)6480464Dimethyl Sulfoxide affects the expression of UTS2R mRNACTDPMID:24834073
Uts2rRatdisodium selenite increases expressionISOUTS2R (Homo sapiens)6480464Sodium Selenite results in increased expression of UTS2R mRNACTDPMID:18175754
Uts2rRatlipopolysaccharide multiple interactionsISOUTS2R (Homo sapiens)6480464[S-(1 more ...CTDPMID:35811015
Uts2rRatN-nitrosodiethylamine increases expressionEXP 6480464Diethylnitrosamine results in increased expression of UTS2R mRNA and Diethylnitrosamine results in increased expression of UTS2R proteinCTDPMID:21056072
Uts2rRatparacetamol affects expressionISOUts2r (Mus musculus)6480464Acetaminophen affects the expression of UTS2R mRNACTDPMID:17562736
Uts2rRatquercitrin increases expressionISOUTS2R (Homo sapiens)6480464quercitrin results in increased expression of UTS2R mRNACTDPMID:25193878
Uts2rRatresveratrol multiple interactionsISOUTS2R (Homo sapiens)6480464[Plant Extracts co-treated with Resveratrol] results in decreased expression of UTS2R mRNACTDPMID:23557933
Uts2rRatS-(1,2-dichlorovinyl)-L-cysteine multiple interactionsISOUTS2R (Homo sapiens)6480464[S-(1 more ...CTDPMID:35811015

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Biological Process
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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Uts2rRatblood vessel diameter maintenance involved_inIEAInterPro:IPR0006701600115GO_REF:0000002InterProGO_REF:0000002
Uts2rRatG protein-coupled receptor signaling pathway involved_inIEAInterPro:IPR000276 and InterPro:IPR0006701600115GO_REF:0000002InterProGO_REF:0000002
Uts2rRatG protein-coupled receptor signaling pathway involved_inIEAUniProtKB-KW:KW-02971600115GO_REF:0000043UniProtGO_REF:0000043
Uts2rRatnegative regulation of blood pressure  IMP 2306837 RGD 
Uts2rRatnegative regulation of glomerular filtration  IMP 2306837 RGD 
Uts2rRatnegative regulation of urine volume  IMP 2306837 RGD 
Uts2rRatneuropeptide signaling pathway involved_inIBAFB:FBgn0036278 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Uts2rRatpositive regulation of angiogenesis  IMP 2306830 RGD 
Uts2rRatpositive regulation of blood pressure  IMP 2306836 RGD 
Uts2rRatpositive regulation of cell growth  IMP 2306846 RGD 
Uts2rRatpositive regulation of circadian sleep/wake cycle, REM sleep  IMP 2306844 RGD 
Uts2rRatpositive regulation of circadian sleep/wake cycle, wakefulness  IMP 2306844 RGD 
Uts2rRatpositive regulation of cytosolic calcium ion concentration  IMP 2306846 RGD 
Uts2rRatpositive regulation of fibroblast proliferation  IMP 2306833 RGD 
Uts2rRatpositive regulation of vasoconstriction  IMP 2306845 RGD 
Uts2rRatregulation of blood pressure involved_inIEAInterPro:IPR0006701600115GO_REF:0000002InterProGO_REF:0000002
Uts2rRatresponse to xenobiotic stimulus  IEP 2306814isoproterenolRGD 
Uts2rRatsignal transduction involved_inIEAUniProtKB-KW:KW-08071600115GO_REF:0000043UniProtGO_REF:0000043
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Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Uts2rRatearly endosome  IDA 2306843 RGD 
Uts2rRatmembrane located_inIEAInterPro:IPR000276 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Uts2rRatmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Uts2rRatplasma membrane is_active_inIBAFB:FBgn0036278 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Uts2rRatplasma membrane located_inIEAUniProtKB-KW:KW-10031600115GO_REF:0000043UniProtGO_REF:0000043
Uts2rRatplasma membrane located_inIEAUniProtKB-SubCell:SL-00391600115GO_REF:0000044UniProtGO_REF:0000044
Uts2rRatrecycling endosome  IDA 2306843 RGD 

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Uts2rRatG protein-coupled receptor activity enablesIEAUniProtKB-KW:KW-02971600115GO_REF:0000043UniProtGO_REF:0000043
Uts2rRatG protein-coupled receptor activity enablesIEAInterPro:IPR0002761600115GO_REF:0000002InterProGO_REF:0000002
Uts2rRaturotensin II receptor activity enablesIEAInterPro:IPR0006701600115GO_REF:0000002InterProGO_REF:0000002
Uts2rRaturotensin II receptor activity  IDA 2306843 RGD 
Uts2rRaturotensin II receptor activity enablesIBAPANTHER:PTN001201163 and Uts2r (Rattus norvegicus)1600115GO_REF:0000033GO_CentralGO_REF:0000033


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#
Reference Title
Reference Citation
1. Increased expression of urotensin II and its cognate receptor GPR14 in atherosclerotic lesions of the human aorta. Bousette N, etal., Atherosclerosis. 2004 Sep;176(1):117-23.
2. Urotensin-II receptor blockade with SB-611812 attenuates cardiac remodeling in experimental ischemic heart disease. Bousette N, etal., Peptides. 2006 Nov;27(11):2919-26. Epub 2006 Aug 17.
3. Pharmacology of the urotensin-II receptor antagonist palosuran (ACT-058362; 1-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl) -urea sulfate salt): first demonstration of a pathophysiological role of the urotensin System. Clozel M, etal., J Pharmacol Exp Ther. 2004 Oct;311(1):204-12. Epub 2004 May 14.
4. The urotensin-II receptor antagonist palosuran improves pancreatic and renal function in diabetic rats. Clozel M, etal., J Pharmacol Exp Ther. 2006 Mar;316(3):1115-21. Epub 2005 Nov 2.
5. Elevated expression of urotensin II and its receptor in diabetic cardiomyopathy. Dai HY, etal., J Diabetes Complications. 2008 Mar-Apr;22(2):137-43.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Contractile responses of aortae from WKY and SHR to vasoconstrictors. Gendron G, etal., Clin Exp Hypertens. 2004 Aug;26(6):511-23.
8. Arrestin-independent internalization and recycling of the urotensin receptor contribute to long-lasting urotensin II-mediated vasoconstriction. Giebing G, etal., Circ Res. 2005 Sep 30;97(7):707-15. Epub 2005 Sep 1.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Urotensin II modulates rapid eye movement sleep through activation of brainstem cholinergic neurons. Huitron-Resendiz S, etal., J Neurosci. 2005 Jun 8;25(23):5465-74.
11. Urotensin-II-mediated cardiomyocyte hypertrophy: effect of receptor antagonism and role of inflammatory mediators. Johns DG, etal., Naunyn Schmiedebergs Arch Pharmacol. 2004 Oct;370(4):238-50. Epub 2004 Sep 30.
12. Increased expression of urotensin II and urotensin II receptor in human diabetic nephropathy. Langham RG, etal., Am J Kidney Dis. 2004 Nov;44(5):826-31.
13. Central cardiovascular action of urotensin II in spontaneously hypertensive rats. Lin Y, etal., Hypertens Res. 2003 Oct;26(10):839-45.
14. Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors. Marchese A, etal., Genomics 1995 Sep 20;29(2):335-44.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Urotensin II and urotensin II-related peptide (URP) in cardiac ischemia-reperfusion injury. Prosser HC, etal., Peptides. 2008 May;29(5):770-7. Epub 2007 Aug 21.
18. GOA pipeline RGD automated data pipeline
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Urotensin II and renal function in the rat. Song W, etal., Kidney Int. 2006 Apr;69(8):1360-8.
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PMID:10581185   PMID:12495432   PMID:14550283   PMID:15273242   PMID:15458389   PMID:15476951   PMID:16290260   PMID:16685423   PMID:16942596   PMID:17628210   PMID:17905478   PMID:18082287  
PMID:18318439   PMID:18509066   PMID:18701623   PMID:18955095   PMID:19463745   PMID:19906507   PMID:20422157   PMID:20870804   PMID:21056072   PMID:21180151   PMID:21186587   PMID:22044114  
PMID:22245063   PMID:22563490   PMID:24878476   PMID:25175740   PMID:25803040   PMID:27208703   PMID:34866110  



Uts2r
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810106,936,398 - 106,937,558 (+)NCBIGRCr8
mRatBN7.210106,438,092 - 106,439,252 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10106,438,092 - 106,439,252 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10111,540,796 - 111,541,956 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010111,003,849 - 111,005,009 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010106,358,527 - 106,359,687 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010110,364,291 - 110,365,451 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10110,364,291 - 110,365,451 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010109,951,008 - 109,952,168 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410110,394,782 - 110,395,942 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110110,409,285 - 110,410,446 (+)NCBI
Celera10104,976,678 - 104,977,838 (+)NCBICelera
Cytogenetic Map10q32.3NCBI
UTS2R
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381782,371,765 - 82,377,458 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1782,371,765 - 82,377,458 (+)EnsemblGRCh38hg38GRCh38
GRCh371780,329,641 - 80,335,334 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361777,925,490 - 77,926,659 (+)NCBINCBI36Build 36hg18NCBI36
Build 341777,925,489 - 77,926,659NCBI
Celera1776,924,342 - 76,925,511 (+)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1775,730,768 - 75,731,937 (+)NCBIHuRef
CHM1_11780,417,675 - 80,418,844 (+)NCBICHM1_1
T2T-CHM13v2.01783,240,931 - 83,246,624 (+)NCBIT2T-CHM13v2.0
Uts2r
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911121,051,097 - 121,052,799 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11121,051,097 - 121,052,799 (+)EnsemblGRCm39 Ensembl
GRCm3811121,160,271 - 121,161,973 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11121,160,271 - 121,161,973 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711121,021,585 - 121,023,287 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611120,976,361 - 120,978,063 (+)NCBIMGSCv36mm8
Celera11132,898,462 - 132,900,164 (+)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1185.02NCBI
Uts2r
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955506756,859 - 761,891 (-)NCBIChiLan1.0ChiLan1.0
UTS2R
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21998,913,633 - 98,918,934 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan117103,817,766 - 103,823,271 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01776,783,432 - 76,788,639 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11782,592,312 - 82,593,702 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1782,592,312 - 82,593,702 (+)Ensemblpanpan1.1panPan2
UTS2R
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha9587,915 - 589,510 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.09579,205 - 580,800 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl9579,646 - 580,884 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.19573,778 - 575,373 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.09734,681 - 736,277 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.09809,533 - 811,128 (-)NCBIUU_Cfam_GSD_1.0
Uts2r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602541,802 - 546,097 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493692324,952 - 31,083 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UTS2R
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.112695,765 - 700,678 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2129,985 - 13,120 (+)NCBISscrofa10.2Sscrofa10.2susScr3
UTS2R
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11674,284,472 - 74,291,074 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1674,288,333 - 74,289,502 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607745,928,730 - 45,935,411 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

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Variants in Uts2r
1 total Variants

Predicted Target Of
Summary Value
Count of predictions:102
Count of miRNA genes:86
Interacting mature miRNAs:96
Transcripts:ENSRNOT00000054926
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


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The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1064890616107211142Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)90404397107211142Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)90404397107211142Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093223816107057807Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1090404397107211142Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1090404397107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat

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alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
7 11 21 45 30 28 19 13 19 6 78 40 39 4 32 9



Ensembl Acc Id: ENSRNOT00000054926   ⟹   ENSRNOP00000051809
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10106,438,092 - 106,439,252 (+)Ensembl
Rnor_6.0 Ensembl10110,364,291 - 110,365,451 (+)Ensembl
RefSeq Acc Id: NM_020537   ⟹   NP_065412
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810106,936,398 - 106,937,558 (+)NCBI
mRatBN7.210106,438,092 - 106,439,252 (+)NCBI
Rnor_6.010110,364,291 - 110,365,451 (+)NCBI
Rnor_5.010109,951,008 - 109,952,168 (+)NCBI
RGSC_v3.410110,394,782 - 110,395,942 (+)RGD
Celera10104,976,678 - 104,977,838 (+)RGD
Sequence:
1 to 9 of 9 rows
Protein RefSeqs NP_065412 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA80111 (Get FASTA)   NCBI Sequence Viewer  
  AAC52593 (Get FASTA)   NCBI Sequence Viewer  
  BAA25251 (Get FASTA)   NCBI Sequence Viewer  
  BAA82357 (Get FASTA)   NCBI Sequence Viewer  
  EDM06933 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000051809
  ENSRNOP00000051809.1
GenBank Protein P49684 (Get FASTA)   NCBI Sequence Viewer  
1 to 9 of 9 rows
RefSeq Acc Id: NP_065412   ⟸   NM_020537
- UniProtKB: P48041 (UniProtKB/Swiss-Prot),   P49684 (UniProtKB/Swiss-Prot),   A6HLM8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000051809   ⟸   ENSRNOT00000054926
Name Modeler Protein Id AA Range Protein Structure
AF-P49684-F1-model_v2 AlphaFold P49684 1-386 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 24 of 24 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-22366 BioCyc
Ensembl Genes ENSRNOG00000036669 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000054926 ENTREZGENE
  ENSRNOT00000054926.2 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  Urot_II_rcpt UniProtKB/Swiss-Prot
KEGG Report rno:57305 UniProtKB/Swiss-Prot
NCBI Gene 57305 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot
  UROTENSIN-2 RECEPTOR UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Uts2r PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  UROTENSIN2R UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000036669 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt A6HLM8 ENTREZGENE, UniProtKB/TrEMBL
  P48041 ENTREZGENE
  P49684 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary P48041 UniProtKB/Swiss-Prot
1 to 24 of 24 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Uts2r  urotensin 2 receptor  Senr  putative G protein-coupled receptor (SENR) gene  Symbol and Name updated 1299863 APPROVED
2002-08-07 Senr  putative G protein-coupled receptor (SENR) gene      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_homology shows 27% overall identity and 41% in the transmembrane domains to the somatostatin receptor SSTR 4 633970