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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:1332177 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UTS2R mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:1332177 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UTS2R mRNA | CTD | PMID:17942748 | aflatoxin B1 | decreases expression | ISO | RGD:1342744 | 6480464 | Aflatoxin B1 results in decreased expression of UTS2R mRNA | CTD | PMID:22100608 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of UTS2R mRNA | CTD | PMID:16483693 | benzo[a]pyrene | multiple interactions | ISO | RGD:1332177 | 6480464 | Benzo(a)pyrene promotes the reaction [AHR protein binds to UTS2R promoter] | CTD | PMID:19654925 | C60 fullerene | decreases expression | EXP | | 6480464 | fullerene C60 results in decreased expression of UTS2R mRNA | CTD | PMID:19167457 | disodium selenite | increases expression | ISO | RGD:1342744 | 6480464 | Sodium Selenite results in increased expression of UTS2R mRNA | CTD | PMID:18175754 | N-nitrosodiethylamine | increases expression | EXP | | 6480464 | Diethylnitrosamine results in increased expression of UTS2R protein; more ... | CTD | PMID:21056072 | paracetamol | affects expression | ISO | RGD:1332177 | 6480464 | Acetaminophen affects the expression of UTS2R mRNA | CTD | PMID:17562736 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Neuroactive ligand-receptor interaction |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Neuroactive ligand-receptor interaction |
References - curated| 1. |
Bousette N, etal., Atherosclerosis. 2004 Sep;176(1):117-23. |
| 2. |
Bousette N, etal., Peptides. 2006 Nov;27(11):2919-26. Epub 2006 Aug 17. |
| 3. |
Clozel M, etal., J Pharmacol Exp Ther. 2004 Oct;311(1):204-12. Epub 2004 May 14. |
| 4. |
Clozel M, etal., J Pharmacol Exp Ther. 2006 Mar;316(3):1115-21. Epub 2005 Nov 2. |
| 5. |
Dai HY, etal., J Diabetes Complications. 2008 Mar-Apr;22(2):137-43. |
| 6. |
Gendron G, etal., Clin Exp Hypertens. 2004 Aug;26(6):511-23. |
| 7. |
Giebing G, etal., Circ Res. 2005 Sep 30;97(7):707-15. Epub 2005 Sep 1. |
| 8. |
GOA data from the GO Consortium |
| 9. |
Huitron-Resendiz S, etal., J Neurosci. 2005 Jun 8;25(23):5465-74. |
| 10. |
Johns DG, etal., Naunyn Schmiedebergs Arch Pharmacol. 2004 Oct;370(4):238-50. Epub 2004 Sep 30. |
| 11. |
Langham RG, etal., Am J Kidney Dis. 2004 Nov;44(5):826-31. |
| 12. |
Lin Y, etal., Hypertens Res. 2003 Oct;26(10):839-45. |
| 13. |
Marchese A, etal., Genomics 1995 Sep 20;29(2):335-44. |
| 14. |
MGD data from the GO Consortium |
| 15. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 16. |
Prosser HC, etal., Peptides. 2008 May;29(5):770-7. Epub 2007 Aug 21. |
| 17. |
RGD automated data pipeline |
| 18. |
RGD automated import pipeline for gene-chemical interactions |
| 19. |
Song W, etal., Kidney Int. 2006 Apr;69(8):1360-8. |
| 20. |
Spinazzi R, etal., Int J Mol Med. 2006 Dec;18(6):1107-12. |
| 21. |
Tal M, etal., Biochem Biophys Res Commun 1995 Apr 17;209(2):752-9. |
| 22. |
Tian L, etal., Am J Physiol Endocrinol Metab. 2008 Nov;295(5):E1234-42. Epub 2008 Sep 16. |
| 23. |
Wang HX, etal., Regul Pept. 2009 Apr 10;154(1-3):85-90. Epub 2009 Jan 27. |
| 24. |
Zhang YG, etal., Acta Pharmacol Sin. 2007 Jan;28(1):36-43. |
References - uncurated| PubMed | 10581185 |
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| 18701623 | |
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| 21056072 | |
| 21180151 | |
| 21186587 | |
| 22044114 | |
| 22245063 | |
| 22563490 |
RGD Disease Portals| Uts2r has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Uts2r (Rattus norvegicus) |
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| UTS2R (Homo sapiens) |
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| Uts2r (Mus musculus) |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_020537 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06066473 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01067030 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AB012210 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AB029611 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473948 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U23483 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U32673 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_020537 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_065412 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_065412 | (Get FASTA) |
| GenBank Protein | AAA80111 | (Get FASTA) |
| AAC52593 | (Get FASTA) | |
| BAA25251 | (Get FASTA) | |
| BAA82357 | (Get FASTA) | |
| EDM06933 | (Get FASTA) | |
| P49684 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000036669 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000051809 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000054926 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 57305 | ENTREZGENE |
| Germonline | ENSRNOG00000036669 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 10345 | ENTREZGENE |
| InterPro | 7TM_GPCR_Rhodpsn | UniProtKB/Swiss-Prot |
| GPCR_Rhodpsn_supfam | UniProtKB/Swiss-Prot | |
| Urot_II_rcpt | UniProtKB/Swiss-Prot | |
| IPI | IPI00196404 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:57305 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Pfam | 7tm_1 | UniProtKB/Swiss-Prot |
| PRINTS | GPCRRHODOPSN | UniProtKB/Swiss-Prot |
| UROTENSIN2R | UniProtKB/Swiss-Prot | |
| PROSITE | G_PROTEIN_RECEP_F1_1 | UniProtKB/Swiss-Prot |
| G_PROTEIN_RECEP_F1_2 | UniProtKB/Swiss-Prot | |
| UniGene | Rn.44230 | ENTREZGENE |
| UniProt | UR2R_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2005-01-20 | Uts2r | urotensin 2 receptor | Senr | putative G protein-coupled receptor (SENR) gene | Symbol and Name updated | 10779 | APPROVED |
| 2002-08-07 | Senr | putative G protein-coupled receptor (SENR) gene | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_homology | shows 27% overall identity and 41% in the transmembrane domains to the somatostatin receptor SSTR 4 | 633970 |
| More on Uts2r | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 621884 |
| Created: | 2002-08-06 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.