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Gene: Cyb5r4 (cytochrome b5 reductase 4) Rattus norvegicus

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Symbol:

Cyb5r4

Name:

cytochrome b5 reductase 4

RGD ID:

621834

Description:

Enables NADPH-hemoprotein reductase activity; flavin adenine dinucleotide binding activity; and heme binding activity. Involved in NADP+ metabolic process. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human CYB5R4 (cytochrome b5 reductase 4); INTERACTS WITH 3-chloropropane-1,2-diol; bisphenol A; finasteride.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

b5&b5R; b5+b5R; cb5/cb5R; flavohemoprotein b5+b5R; flavohemoprotein b5/b5R; N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein; NADPH cytochrome B5 oxidoreductase; Ncb5or

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CYB5R4 (cytochrome b5 reductase 4)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Cyb5r4 (cytochrome b5 reductase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	LOC102015388 (cytochrome b5 reductase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LOC100977566 (cytochrome b5 reductase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CYB5R4 (cytochrome b5 reductase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	LOC101972377 (cytochrome b5 reductase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CYB5R4 (cytochrome b5 reductase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CYB5R4 (cytochrome b5 reductase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	LOC101712442 (cytochrome b5 reductase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	LOC116906836 (cytochrome b5 reductase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	CYB5R4 (cytochrome b5 reductase 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Cyb5r4 (cytochrome b5 reductase 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cyb5r4 (cytochrome b5 reductase 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG11257	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	IRC21	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	IRC21	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	cyb5r4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	cyb5r4	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	96,860,415 - 96,925,789 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	96,861,090 - 96,926,094 (+)	Ensembl				GRCr8
mRatBN7.2	8	87,975,596 - 88,048,356 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	87,981,116 - 88,045,832 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	93,650,953 - 93,719,284 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	91,850,171 - 91,918,500 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	89,687,460 - 89,752,164 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	94,693,273 - 94,757,989 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	94,693,290 - 94,757,988 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	94,201,509 - 94,266,046 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	92,278,453 - 92,343,490 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	87,566,998 - 87,631,697 (+)	NCBI		Celera
RGSC_v3.1	8	92,297,907 - 92,362,944 (+)	NCBI
Cytogenetic Map	8	q31	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

diabetes mellitus (ISO)

type 2 diabetes mellitus (ISO,ISS)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-methylcholine (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-chloropropane-1,2-diol (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

bisphenol F (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

calcitriol (ISO)

carbamazepine (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

Dibutyl phosphate (ISO)

dicrotophos (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

finasteride (EXP)

flavonoids (EXP)

folic acid (ISO)

ivermectin (ISO)

N-nitrosodiethylamine (EXP)

nickel atom (ISO)

ochratoxin A (EXP)

paracetamol (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium dodecyl sulfate (ISO)

succimer (ISO)

thimerosal (ISO)

triphenyl phosphate (ISO)

valproic acid (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell development (ISO)

glucose homeostasis (ISO)

insulin secretion (ISO)

NADP+ metabolic process (IDA)

reactive oxygen species metabolic process (IEA,ISO)

response to antibiotic (ISO)

superoxide metabolic process (IBA,IEA,ISO)

Cellular Component

cytoplasm (IBA)

endoplasmic reticulum (IBA,IEA,ISO)

perinuclear region of cytoplasm (IEA,ISO)

Molecular Function

cytochrome-b5 reductase activity, acting on NAD(P)H (IBA,IEA,ISO)

cytochrome-b5 reductase activity, acting on NADH (IEA)

flavin adenine dinucleotide binding (IDA)

heme binding (IBA,IDA,IEA)

metal ion binding (IEA)

NAD(P)H oxidase H2O2-forming activity (IEA,ISO)

NADPH-hemoprotein reductase activity (IDA)

oxidoreductase activity (IEA)

oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor (IEA,ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Variation in NCB5OR: studies of relationships to type 2 diabetes, maturity-onset diabetes of the young, and gestational diabetes mellitus.	Andersen G, etal., Diabetes. 2004 Nov;53(11):2992-7.
2.	Identification and characterization of a novel splice variant of mouse and rat cytochrome b5/cytochrome b5 reductase.	Curry BJ, etal., Genomics 2004 Mar;83(3):425-38.
3.	Heterologous expression of an endogenous rat cytochrome b(5)/cytochrome b(5) reductase fusion protein: identification of histidines 62 and 85 as the heme axial ligands.	Davis CA, etal., Arch Biochem Biophys 2002 Apr 1;400(1):63-75.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Comprehensive gene review and curation	RGD comprehensive gene curation
10.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
11.	Absence of a reductase, NCB5OR, causes insulin-deficient diabetes.	Xie J, etal., Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10750-5. Epub 2004 Jul 9.

Additional References at PubMed

PMID:10611283	PMID:15131110	PMID:16216070	PMID:17343567

Genomics

Comparative Map Data

Cyb5r4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	96,860,415 - 96,925,789 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	96,861,090 - 96,926,094 (+)	Ensembl				GRCr8
mRatBN7.2	8	87,975,596 - 88,048,356 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	87,981,116 - 88,045,832 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	93,650,953 - 93,719,284 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	91,850,171 - 91,918,500 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	89,687,460 - 89,752,164 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	94,693,273 - 94,757,989 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	94,693,290 - 94,757,988 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	94,201,509 - 94,266,046 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	92,278,453 - 92,343,490 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	87,566,998 - 87,631,697 (+)	NCBI		Celera
RGSC_v3.1	8	92,297,907 - 92,362,944 (+)	NCBI
Cytogenetic Map	8	q31	NCBI

CYB5R4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	83,859,689 - 83,967,423 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	83,859,646 - 83,967,423 (+)	Ensembl			hg38	GRCh38
GRCh37	6	84,569,408 - 84,677,142 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	84,626,089 - 84,726,865 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	6	84,626,123 - 84,726,674	NCBI
Celera	6	85,002,725 - 85,103,498 (+)	NCBI		Celera
Cytogenetic Map	6	q14.2	NCBI
HuRef	6	81,798,925 - 81,899,771 (+)	NCBI		HuRef
CHM1_1	6	84,666,984 - 84,767,748 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	85,082,972 - 85,190,710 (+)	NCBI		T2T-CHM13v2.0

Cyb5r4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	86,904,082 - 86,959,827 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	86,904,067 - 86,959,827 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	9	87,022,008 - 87,077,774 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	87,022,014 - 87,077,774 (+)	Ensembl			mm10	GRCm38
MGSCv37	9	86,916,864 - 86,972,609 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	9	86,824,920 - 86,874,828 (+)	NCBI		MGSCv36	mm8
Celera	9	84,113,215 - 84,171,883 (+)	NCBI		Celera
Cytogenetic Map	9	E3.1	NCBI
cM Map	9	46.69	NCBI

LOC102015388
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955411	11,424,505 - 11,508,193 (+)	Ensembl
ChiLan1.0	NW_004955411	11,424,923 - 11,508,193 (+)	NCBI	ChiLan1.0	ChiLan1.0

LOC100977566
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	103,954,929 - 104,128,651 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	101,851,777 - 102,025,439 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	81,756,292 - 81,864,365 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	85,030,058 - 85,130,948 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	85,030,058 - 85,130,948 (+)	Ensembl			panPan2	panpan1.1

CYB5R4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	44,170,571 - 44,247,494 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	44,141,582 - 44,247,493 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	43,984,884 - 44,061,808 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	44,939,461 - 45,016,397 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	44,910,520 - 45,016,397 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	44,278,425 - 44,355,345 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	44,212,124 - 44,290,343 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	44,388,887 - 44,465,817 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

LOC101972377
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	79,366,025 - 79,452,857 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936510	7,018,038 - 7,100,128 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936510	7,018,038 - 7,104,491 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CYB5R4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	53,092,036 - 53,191,212 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	1	53,092,006 - 53,191,216 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	59,472,987 - 59,530,977 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CYB5R4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	13	8,524,358 - 8,632,837 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	13	8,524,400 - 8,632,288 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666040	184,736,774 - 184,842,102 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

LOC101712442
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624799	10,660,984 - 10,748,735 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

LOC116906836
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	8	81,055,699 - 81,107,582 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Cyb5r4
346 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	694
Count of miRNA genes:	207
Interacting mature miRNAs:	243
Transcripts:	ENSRNOT00000013908, ENSRNOT00000013975
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
12879878	Bw183	Body weight QTL 183		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	8	62848139	107848139	Rat
1300177	Cm2	Cardiac mass QTL 2	3.65		heart mass (VT:0007028)	heart weight (CMO:0000017)	8	63141536	109261840	Rat
1549909	Stresp11	Stress response QTL 11	6.83	0.0019	stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	8	82352698	127352698	Rat
1549908	Neudeg1	Neurodegradation QTL 1	5.5	0	nervous system integrity trait (VT:0010566)	logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)	8	58337123	103337123	Rat
12879879	Cm99	Cardiac mass QTL 99		0.001	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	62848139	107848139	Rat
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	49849908	118871671	Rat
9590292	Uminl3	Urine mineral level QTL 3	3.62	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	8	80768445	125768445	Rat
1331804	Cm30	Cardiac mass QTL 30	3.77443		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	8	62970527	107970527	Rat
1578769	Uae31	Urinary albumin excretion QTL 31	3.3	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	39106363	103375781	Rat
12879880	Cm100	Cardiac mass QTL 100		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	8	62848139	107848139	Rat
12879881	Cm101	Cardiac mass QTL 101		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	8	62848139	107848139	Rat
12879882	Am8	Aortic mass QTL 8		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	8	62848139	107848139	Rat
12879883	Kidm65	Kidney mass QTL 65		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	62848139	107848139	Rat
70161	Bp62	Blood pressure QTL 62	2.9	0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	51589699	99045312	Rat
71120	Niddm21	Non-insulin dependent diabetes mellitus QTL 21	3.73		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	8	66992095	111992095	Rat
1358912	Bw51	Body weight QTL 51	2.95		body mass (VT:0001259)	body weight (CMO:0000012)	8	60248093	105248093	Rat
1578765	Klgr1	Kidney lesion grade QTL 1	3.3	0.0001	kidney morphology trait (VT:0002135)	organ lesion measurement (CMO:0000677)	8	39106363	103375781	Rat
634332	Pia18	Pristane induced arthritis QTL 18	4		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	84192326	132782436	Rat
1300171	Bp184	Blood pressure QTL 184	3.66		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	8	79394435	132782436	Rat
1578755	Pur5	Proteinuria QTL 5	3.3	0.0001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	8	39106258	103375958	Rat
631210	Bw3	Body weight QTL3	5.9		mesenteric fat pad mass (VT:0010427)	mesenteric fat pad weight to body weight ratio (CMO:0000654)	8	61019838	121662124	Rat
2293697	Bmd39	Bone mineral density QTL 39			femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	8	62848139	107848139	Rat
8662823	Vetf5	Vascular elastic tissue fragility QTL 5	1.9		artery integrity trait (VT:0010639)	patent ductus arteriosus score (CMO:0002566)	8	63404444	108404444	Rat
1358896	Bp262	Blood pressure QTL 262	2.89		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	35464071	107982864	Rat
1331837	Bw23	Body weight QTL 23	4.19	0.00007	body mass (VT:0001259)	body weight (CMO:0000012)	8	55428416	107963099	Rat
1331838	Niddm61	Non-insulin dependent diabetes mellitus QTL 61	3.53	0.0004	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	8	62963099	107963099	Rat
8694446	Bw170	Body weight QTL 170	12.07	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	8	80768445	125768445	Rat
631650	Stl6	Serum triglyceride level QTL 6	4	0.0019	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	70041301	121080908	Rat
1331769	Rf39	Renal function QTL 39	3.871		urine output (VT:0003620)	timed urine volume (CMO:0000260)	8	50763951	107970527	Rat
1581557	Eae16	Experimental allergic encephalomyelitis QTL 16	3.8		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	8	68690349	119799881	Rat
10450865	Bw175	Body weight QTL 175	4.1		total fat pad mass (VT:0015008)	adipose tissue molecular composition measurement (CMO:0000484)	8	84192326	129192326	Rat
1358907	Cm40	Cardiac mass QTL 40	1.89		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	35464071	107982864	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	55428333	127966348	Rat
2316950	Scl66	Serum cholesterol level QTL 66	4.1		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	39106363	114525825	Rat
2300181	Bmd55	Bone mineral density QTL 55	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	85348065	130348065	Rat
724540	Uae8	Urinary albumin excretion QTL 8	5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	8	39106258	103375958	Rat
10402857	Bp380	Blood pressure QTL 380		0.95	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	62848139	107848139	Rat
1358892	Kidm26	Kidney mass QTL 26	3.69		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	35464071	107982864	Rat
2301402	Bp316	Blood pressure QTL 316		0.005	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	62848139	107848139	Rat
631664	Hcar3	Hepatocarcinoma resistance QTL 3	2.9	0.0005	liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	8	62982864	107982864	Rat
8694200	Abfw4	Abdominal fat weight QTL 4	9.07	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	8	80768445	125768445	Rat
8694392	Bw161	Body weight QTL 161	8.06	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	8	80768445	125768445	Rat
61437	Cia6	Collagen induced arthritis QTL 6			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	91340911	131690273	Rat

Markers in Region

AI232043

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	88,045,549 - 88,045,721 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	94,757,705 - 94,757,876	NCBI	Rnor6.0
Rnor_5.0	8	94,265,762 - 94,265,933	UniSTS	Rnor5.0
RGSC_v3.4	8	92,343,206 - 92,343,377	UniSTS	RGSC3.4
Celera	8	87,631,413 - 87,631,584	UniSTS
RH 3.4 Map	8	1020.0	UniSTS
Cytogenetic Map	8	q31	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_133427	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006243472	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017595428	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039080740	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063264810	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063264811	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC117045	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF307840	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY321370	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY321371	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC080240	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000013908 ⟹ ENSRNOP00000013909

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	96,861,099 - 96,926,094 (+)	Ensembl
mRatBN7.2 Ensembl	8	87,981,116 - 88,045,832 (+)	Ensembl
Rnor_6.0 Ensembl	8	94,693,290 - 94,757,988 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000111365 ⟹ ENSRNOP00000093571

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	96,861,101 - 96,926,094 (+)	Ensembl
mRatBN7.2 Ensembl	8	87,981,116 - 88,045,832 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000119185 ⟹ ENSRNOP00000085891

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	96,861,090 - 96,925,787 (+)	Ensembl
mRatBN7.2 Ensembl	8	87,981,116 - 88,045,832 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000119351 ⟹ ENSRNOP00000091593

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	96,861,099 - 96,926,094 (+)	Ensembl
mRatBN7.2 Ensembl	8	87,981,157 - 88,045,820 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000162833 ⟹ ENSRNOP00000111146

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	96,865,603 - 96,926,094 (+)	Ensembl

RefSeq Acc Id:

NM_133427 ⟹ NP_596918

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	96,861,089 - 96,925,789 (+)	NCBI
mRatBN7.2	8	87,981,128 - 88,045,834 (+)	NCBI
Rnor_6.0	8	94,693,290 - 94,757,989 (+)	NCBI
Rnor_5.0	8	94,201,509 - 94,266,046 (+)	NCBI
RGSC_v3.4	8	92,278,453 - 92,343,490 (+)	RGD
Celera	8	87,566,998 - 87,631,697 (+)	NCBI

Sequence:

show sequence

TGGCGACCCCGGAAGTGGGTCGGGGGCTTGGCCTCGGCCAGGCCAAGGAGCCGGCACAGATAGT
GGTGGCCGCTGGAGTCCGGCCAACCGAGCCTGTCCGGTGGCGGAGGCCGGATGCGGCCCGAGCC
GGGGGCCCAGGATGCTGAACGTCCCTTCCCAGGCTTTCCCGGCCCCCGGCTCCCAGCAGCGCGT
TGCCTCCCAGGGGCGTAGCAAGGTACCTTTAAAACAAGGCAGGAGTCTTATGGATTGGATCCGA
TTGACCAAAAGTGGAAAGGACTTCACGGGATTGAAGGGCGGGTTAATTGAAGTAACAGAAGAAG
AACTTAAGAAGCACAACAAGAAAGACGACTGTTGGATATGCATAAGAGGGTTTGTTTACAATGT
CAGCCCATATATGGAGTATCATCCTGGTGGGGAGGATGAGCTTATGAGAGCCGCAGGAGCAGAT
GGAACGGATCTTTTTAATGAGGTGCATCGTTGGGTCAATTATGAATCCATGCTGAAAGAGTGCC
TGGTTGGCAGGATGGCTGTGAAGCCCGCTGTTCCGAAAGACTGTCATGAAGGAAAGAGAGTCTT
AAATGGCATGCTTCCCAAGAGCCAAGTGACAGACACACTGCCCAGGGAAGGCCCCAGTTCTCCA
AGCTATGATTGGTTCCAAACAGAGTCTTCAGTGACCATTGTTATATACACCAAGCAGAAGAATA
TCAATTTAGACTCAGTAATCGTTGACCTCCAGGATGACTCCTTGAGAGCAGAAGCAGTCATCAA
GGATCATTCTTATCTTATACATATTGGGTTAAGCCATGAAGTTCAAGAAAATTTTTCTGTACGG
GTTATTGAGAATGTTGGAAAAATAGAGATTGTCCTACAAAAGAAAGAAACTGTTTCTTGGAAAT
GTCTTGGTGATCCCCTGGAGAAACATGATTCTTTTATTCCAAAGAAAGATACAGGCTTGTACTA
TAGACAGTGCCAGTTAATTTCCAAGGAAGACGTTACTCATGACACAAGGCTCTTCTGTCTGATG
CTGCCTCCCAGTACTCACCTTCAGGTGCCAGTTGGGCAACATGTTTACCTCAAGCTCAGTGTCA
CAGGTGCAGAAATAGTAAAGCCATATACACCCGTGTCTGAGTCCTTACTCTCAGATTTTAAAGA
ACCAGTTCTTTCCCCAAATAAGTACATCTACTTTTTGATCAAAATCTATCCTGCTGGACTCTTC
ACGCCAGAACTTGATCGTCTTCAGATTGGAGATTTTGTTTCTGTAAGTGGTCCTGAGGGCAATT
TTAAAGTTTCCAAACTCCAGGAAGTGGAAGATCTCTTTTTATTGGCAGCCGGAACAGGCTTCAC
ACCAATGGTTACTGTACTGAATCACGCTTTAACTCACATGTCCAGTCTCAGGAAGGTGAAGTTA
ATGTTCTTCAATAAAACAGAGGATGACATAATTTGGAGATGCCAGCTAGAGAAATTGGCATTAA
AAGATAAAAGATTTCATGTTGAATATGTTCTCTCGGCACCTTCCCCAGAATGGAATGGCAAACA
GGGACACGTGTCACGAGCTCTTCTCTCTGAATTTTTGCAACGAAGTTTAGAAAATTCTAAAGTC
TTCCTTTGCATCTGTGGACCAACCCCATTTACAGATGAGGGGATAAGGTTGCTGCATGATCTTA
ACTTTTCCGATGATGAGATTCATGGTTTTACAGCATAATAAAAAGATGCCATTGTCTTTTATTC
CACTAGTTTATACTTGTGATTGCCTAGGGTTTTTTAAAAGAATTTTTGTATGTACGAAAGGTTA
ATCAGAATCCAGGCTTCCGTTTCTGCAATGAAGTCATGTGTCTTCAGTACAGGTAACTTCTTGG
TTTAATGTTTGTACCGTGACTTACTTTTCTGCTGATGCCTGACCTGAAACTTCAGTCATGACAG
CAGGTGCATACAAGAGCCTTTGTTATGAGCTGCAAGTTTCCTTACCACTGAAATTGTATCACTG
TTCTGCAGTAAACACTTGTATTTTATGACATGATAAACTAAGCAATCATTTTGGTCACTTTTTA
TGCTGCAAGATATCTTCTGAGCAATACAGATTAAGTTTTACACTGCACTGTTCACTCAGGAATC
GATGGTGTATATCCTTATTAGTCTTAACACACAGAATGCTGTAACTATTTGTGGTCAGGTTTTG
TGGGTGTCCATGGCATTGTTACAGATAGAATAAAACTATACTTCATACTTTTTAAAAAAAAAAA
AAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006243472 ⟹ XP_006243534

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	96,861,073 - 96,925,789 (+)	NCBI
mRatBN7.2	8	87,981,109 - 88,048,356 (+)	NCBI
Rnor_6.0	8	94,693,273 - 94,757,989 (+)	NCBI
Rnor_5.0	8	94,201,509 - 94,266,046 (+)	NCBI

Sequence:

show sequence

ACCACGCTCCTGACCCCTGGCGACCCCGGAAGTGGGTCGGGGGCTTGGCCTCGGCCAGGCCAAG
GAGCCGGCACAGATAGTGGTGGCCGCTGGAGTCCGGCCAACCGAGCCTGTCCGGTGGCGGAGGC
CGGATGCGGCCCGAGCCGGGGGCCCAGGATGCTGAACGTCCCTTCCCAGGCTTTCCCGGCCCCC
GGCTCCCAGCAGCGCGTTGCCTCCCAGGGGCGTAGCAAGGTACCTTTAAAACAAGGCAGGAGTC
TTATGGATTGGATCCGATTGACCAAAAGTGGAAAGGACTTCACGGGATTGAAGGGCGGGTTAAT
TGAAGTAACAGAAGAAGAACTTAAGAAGCACAACAAGAAAGACGACTGTTGGATATGCATAAGA
GGGTTTGTTTACAATGTCAGCCCATATATGGAGTATCATCCTGGTGGGGAGGATGAGCTTATGA
GAGCCGCAGGAGCAGATGGAACGGATCTTTTTAATGAGGTGCATCGTTGGGTCAATTATGAATC
CATGCTGAAAGAGTGCCTGGTTGGCAGGATGGCTGTGAAGCCCGCTGTTCCGAAAGGCATGCTT
CCCAAGAGCCAAGTGACAGACACACTGCCCAGGGAAGGCCCCAGTTCTCCAAGCTATGATTGGT
TCCAAACAGAGTCTTCAGTGACCATTGTTATATACACCAAGCAGAAGAATATCAATTTAGACTC
AGTAATCGTTGACCTCCAGGATGACTCCTTGAGAGCAGAAGCAGTCATCAAGGATCATTCTTAT
CTTATACATATTGGGTTAAGCCATGAAGTTCAAGAAAATTTTTCTGTACGGGTTATTGAGAATG
TTGGAAAAATAGAGATTGTCCTACAAAAGAAAGAAACTGTTTCTTGGAAATGTCTTGGTGATCC
CCTGGAGAAACATGATTCTTTTATTCCAAAGAAAGATACAGGCTTGTACTATAGACAGTGCCAG
TTAATTTCCAAGGAAGACGTTACTCATGACACAAGGCTCTTCTGTCTGATGCTGCCTCCCAGTA
CTCACCTTCAGGTGCCAGTTGGGCAACATGTTTACCTCAAGCTCAGTGTCACAGGTGCAGAAAT
AGTAAAGCCATATACACCCGTGTCTGAGTCCTTACTCTCAGATTTTAAAGAACCAGTTCTTTCC
CCAAATAAGTACATCTACTTTTTGATCAAAATCTATCCTGCTGGACTCTTCACGCCAGAACTTG
ATCGTCTTCAGATTGGAGATTTTGTTTCTGTAAGTGGTCCTGAGGGCAATTTTAAAGTTTCCAA
ACTCCAGGAAGTGGAAGATCTCTTTTTATTGGCAGCCGGAACAGGCTTCACACCAATGGTTACT
GTACTGAATCACGCTTTAACTCACATGTCCAGTCTCAGGAAGGTGAAGTTAATGTTCTTCAATA
AAACAGAGGATGACATAATTTGGAGATGCCAGCTAGAGAAATTGGCATTAAAAGATAAAAGATT
TCATGTTGAATATGTTCTCTCGGCACCTTCCCCAGAATGGAATGGCAAACAGGGACACGTGTCA
CGAGCTCTTCTCTCTGAATTTTTGCAACGAAGTTTAGAAAATTCTAAAGTCTTCCTTTGCATCT
GTGGACCAACCCCATTTACAGATGAGGGGATAAGGTTGCTGCATGATCTTAACTTTTCCGATGA
TGAGATTCATGGTTTTACAGCATAATAAAAAGATGCCATTGTCTTTTATTCCACTAGTTTATAC
TTGTGATTGCCTAGGGTTTTTTAAAAGAATTTTTGTATGTACGAAAGGTTAATCAGAATCCAGG
CTTCCGTTTCTGCAATGAAGTCATGTGTCTTCAGTACAGGTAACTTCTTGGTTTAATGTTTGTA
CCGTGACTTACTTTTCTGCTGATGCCTGACCTGAAACTTCAGTCATGACAGCAGGTGCATACAA
GAGCCTTTGTTATGAGCTGCAAGTTTCCTTACCACTGAAATTGTATCACTGTTCTGCAGTAAAC
ACTTGTATTTTATGACATGATAAACTAAGCAATCATTTTGGTCACTTTTTATGCTGCAAGATAT
CTTCTGAGCAATACAGATTAAGTTTTACACTGCACTGTTCACTCAGGAATCGATGGTGTATATC
CTTATTAGTCTTAACACACAGAATGCTGTAACTATTTGTGGTCAGGTTTTGTGGGTGTCCATGG
CATTGTTACAGATAGAATAAAACTATACTTCATACTTTTTA

hide sequence

RefSeq Acc Id:

XM_017595428 ⟹ XP_017450917

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	96,861,073 - 96,925,789 (+)	NCBI
mRatBN7.2	8	87,981,156 - 88,048,356 (+)	NCBI
Rnor_6.0	8	94,693,319 - 94,757,989 (+)	NCBI

Sequence:

show sequence

GGCCTCGGCCAGGCCAAGGAGCCGGCACAGATAGTGGTGGCCGCTGGAGTCCGGCCAACCGAGC
CTGTCCGGTGGCGGAGGCCGGATGCGGCCCGAGCCGGGGGCCCAGGATGCTGAACGTCCCTTCC
CAGGCTTTCCCGGCCCCCGGCTCCCAGCAGCGCGTTGCCTCCCAGGGGCGTAGCAAGGTACCTT
TAAAACAAGGCAGGAGTCTTATGGATTGGATCCGATTGACCAAAAGTGGAAAGGACTTCACGGG
ATTGAAGGGCGGGTTAATTGAAGTAACAGAAGAAGAACTTAAGAAGCACAACAAGAAAGACGAC
TGTTGGATATGCATAAGAGGGTTTGTTTACAATGTCAGCCCATATATGGAGTATCATCCTGGTG
GGGAGGATGAGCTTATGAGAGCCGCAGGAGCAGATGGAACGGATCTTTTTAATGAGGTGCATCG
TTGGGTCAATTATGAATCCATGCTGAAAGAGTGCCTGGTTGGCAGGATGGCTGTGAAGCCCGCT
GTTCCGAAAGACTGTCATGAAGGAAAGAGAGTCTTAAATGGCATGCTTCCCAAGAGCCAAGTGA
CAGACACACTGCCCAGGGAAGGCCCCAGTTCTCCAAGCTATGATTGGTTCCAAACAGAGTCTTC
AGTGACCATTGTTATATACACCAAGCAGAAGAATATCAATTTAGACTCAGTAATCGTTGACCTC
CAGGATGACTCCTTGAGAGCAGAAGCAGTCATCAAGGATCATTCTTATCTTATACATATTGGGT
TAAGCCATGAAGTTCAAGAAAATTTTTCTGTACGGGTTATTGAGAATGTTGGAAAAATAGAGAT
TGTCCTACAAAAGAAAGAAACTGTTTCTTGGAAATGTCTTGGTGATCCCCTGGAGAAACATGAT
TCTTTTATTCCAAAGAAAGATACAGGCTTGTACTATAGACAGTGCCAGTTAATTTCCAAGGAAG
ACGTTACTCATGACACAAGGCTCTTCTGTCTGATGCTGCCTCCCAGTACTCACCTTCAGGTGCC
AGTTGGGCAACATGTTTACCTCAAGCTCAGTGTCACAGGAGATTTTGTTTCTGTAAGTGGTCCT
GAGGGCAATTTTAAAGTTTCCAAACTCCAGGAAGTGGAAGATCTCTTTTTATTGGCAGCCGGAA
CAGGCTTCACACCAATGGTTACTGTACTGAATCACGCTTTAACTCACATGTCCAGTCTCAGGAA
GGTGAAGTTAATGTTCTTCAATAAAACAGAGGATGACATAATTTGGAGATGCCAGCTAGAGAAA
TTGGCATTAAAAGATAAAAGATTTCATGTTGAATATGTTCTCTCGGCACCTTCCCCAGAATGGA
ATGGCAAACAGGGACACGTGTCACGAGCTCTTCTCTCTGAATTTTTGCAACGAAGTTTAGAAAA
TTCTAAAGTCTTCCTTTGCATCTGTGGACCAACCCCATTTACAGATGAGGGGATAAGGTTGCTG
CATGATCTTAACTTTTCCGATGATGAGATTCATGGTTTTACAGCATAATAAAAAGATGCCATTG
TCTTTTATTCCACTAGTTTATACTTGTGATTGCCTAGGGTTTTTTAAAAGAATTTTTGTATGTA
CGAAAGGTTAATCAGAATCCAGGCTTCCGTTTCTGCAATGAAGTCATGTGTCTTCAGTACAGGT
AACTTCTTGGTTTAATGTTTGTACCGTGACTTACTTTTCTGCTGATGCCTGACCTGAAACTTCA
GTCATGACAGCAGGTGCATACAAGAGCCTTTGTTATGAGCTGCAAGTTTCCTTACCACTGAAAT
TGTATCACTGTTCTGCAGTAAACACTTGTATTTTATGACATGATAAACTAAGCAATCATTTTGG
TCACTTTTTATGCTGCAAGATATCTTCTGAGCAATACAGATTAAGTTTTACACTGCACTGTTCA
CTCAGGAATCGATGGTGTATATCCTTATTAGTCTTAACACACAGAATGCTGTAACTATTTGTGG
TCAGGTTTTGTGGGTGTCCATGGCATTGTTACAGATAGAATAAAACTATACTTCATACTTTTTA

hide sequence

RefSeq Acc Id:

XM_039080740 ⟹ XP_038936668

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	96,860,415 - 96,925,789 (+)	NCBI
mRatBN7.2	8	87,981,451 - 88,045,306 (+)	NCBI

RefSeq Acc Id:

XM_063264810 ⟹ XP_063120880

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	96,861,072 - 96,925,789 (+)	NCBI

RefSeq Acc Id:

XM_063264811 ⟹ XP_063120881

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	96,875,562 - 96,925,789 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_596918	(Get FASTA)	NCBI Sequence Viewer
	XP_006243534	(Get FASTA)	NCBI Sequence Viewer
	XP_017450917	(Get FASTA)	NCBI Sequence Viewer
	XP_038936668	(Get FASTA)	NCBI Sequence Viewer
	XP_063120880	(Get FASTA)	NCBI Sequence Viewer
	XP_063120881	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAG45053	(Get FASTA)	NCBI Sequence Viewer
	AAH80240	(Get FASTA)	NCBI Sequence Viewer
	AAQ83902	(Get FASTA)	NCBI Sequence Viewer
	AAQ83903	(Get FASTA)	NCBI Sequence Viewer
	EDL77606	(Get FASTA)	NCBI Sequence Viewer
	EDL77607	(Get FASTA)	NCBI Sequence Viewer
	EDL77608	(Get FASTA)	NCBI Sequence Viewer
	EDL77609	(Get FASTA)	NCBI Sequence Viewer
	EDL77610	(Get FASTA)	NCBI Sequence Viewer
	EDL77611	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000013909
	ENSRNOP00000085891
	ENSRNOP00000093571
	ENSRNOP00000111146
GenBank Protein	Q68EJ0	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_596918 ⟸ NM_133427

- UniProtKB:

Q9EPZ4 (UniProtKB/Swiss-Prot), Q6VXY3 (UniProtKB/Swiss-Prot), Q6VXY2 (UniProtKB/Swiss-Prot), Q68EJ0 (UniProtKB/Swiss-Prot), A0A0G2JSK2 (UniProtKB/TrEMBL), A6I1W7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLNVPSQAFPAPGSQQRVASQGRSKVPLKQGRSLMDWIRLTKSGKDFTGLKGGLIEVTEEELKK
HNKKDDCWICIRGFVYNVSPYMEYHPGGEDELMRAAGADGTDLFNEVHRWVNYESMLKECLVGR
MAVKPAVPKDCHEGKRVLNGMLPKSQVTDTLPREGPSSPSYDWFQTESSVTIVIYTKQKNINLD
SVIVDLQDDSLRAEAVIKDHSYLIHIGLSHEVQENFSVRVIENVGKIEIVLQKKETVSWKCLGD
PLEKHDSFIPKKDTGLYYRQCQLISKEDVTHDTRLFCLMLPPSTHLQVPVGQHVYLKLSVTGAE
IVKPYTPVSESLLSDFKEPVLSPNKYIYFLIKIYPAGLFTPELDRLQIGDFVSVSGPEGNFKVS
KLQEVEDLFLLAAGTGFTPMVTVLNHALTHMSSLRKVKLMFFNKTEDDIIWRCQLEKLALKDKR
FHVEYVLSAPSPEWNGKQGHVSRALLSEFLQRSLENSKVFLCICGPTPFTDEGIRLLHDLNFSD
DEIHGFTA

hide sequence

RefSeq Acc Id:	XP_006243534 ⟸ XM_006243472
- Peptide Label:	isoform X1
- UniProtKB:	Q9EPZ4 (UniProtKB/Swiss-Prot), Q6VXY3 (UniProtKB/Swiss-Prot), Q6VXY2 (UniProtKB/Swiss-Prot), Q68EJ0 (UniProtKB/Swiss-Prot), A0A8I6A4B1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLNVPSQAFPAPGSQQRVASQGRSKVPLKQGRSLMDWIRLTKSGKDFTGLKGGLIEVTEEELKK HNKKDDCWICIRGFVYNVSPYMEYHPGGEDELMRAAGADGTDLFNEVHRWVNYESMLKECLVGR MAVKPAVPKGMLPKSQVTDTLPREGPSSPSYDWFQTESSVTIVIYTKQKNINLDSVIVDLQDDS LRAEAVIKDHSYLIHIGLSHEVQENFSVRVIENVGKIEIVLQKKETVSWKCLGDPLEKHDSFIP KKDTGLYYRQCQLISKEDVTHDTRLFCLMLPPSTHLQVPVGQHVYLKLSVTGAEIVKPYTPVSE SLLSDFKEPVLSPNKYIYFLIKIYPAGLFTPELDRLQIGDFVSVSGPEGNFKVSKLQEVEDLFL LAAGTGFTPMVTVLNHALTHMSSLRKVKLMFFNKTEDDIIWRCQLEKLALKDKRFHVEYVLSAP SPEWNGKQGHVSRALLSEFLQRSLENSKVFLCICGPTPFTDEGIRLLHDLNFSDDEIHGFTA hide sequence

RefSeq Acc Id:	XP_017450917 ⟸ XM_017595428
- Peptide Label:	isoform X3
- UniProtKB:	Q9EPZ4 (UniProtKB/Swiss-Prot), Q6VXY3 (UniProtKB/Swiss-Prot), Q6VXY2 (UniProtKB/Swiss-Prot), Q68EJ0 (UniProtKB/Swiss-Prot), A0A8I6GKQ4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLNVPSQAFPAPGSQQRVASQGRSKVPLKQGRSLMDWIRLTKSGKDFTGLKGGLIEVTEEELKK HNKKDDCWICIRGFVYNVSPYMEYHPGGEDELMRAAGADGTDLFNEVHRWVNYESMLKECLVGR MAVKPAVPKDCHEGKRVLNGMLPKSQVTDTLPREGPSSPSYDWFQTESSVTIVIYTKQKNINLD SVIVDLQDDSLRAEAVIKDHSYLIHIGLSHEVQENFSVRVIENVGKIEIVLQKKETVSWKCLGD PLEKHDSFIPKKDTGLYYRQCQLISKEDVTHDTRLFCLMLPPSTHLQVPVGQHVYLKLSVTGDF VSVSGPEGNFKVSKLQEVEDLFLLAAGTGFTPMVTVLNHALTHMSSLRKVKLMFFNKTEDDIIW RCQLEKLALKDKRFHVEYVLSAPSPEWNGKQGHVSRALLSEFLQRSLENSKVFLCICGPTPFTD EGIRLLHDLNFSDDEIHGFTA hide sequence

Ensembl Acc Id:

ENSRNOP00000013909 ⟸ ENSRNOT00000013908

RefSeq Acc Id:	XP_038936668 ⟸ XM_039080740
- Peptide Label:	isoform X2
- UniProtKB:	A6I1W6 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000091593 ⟸ ENSRNOT00000119351

Ensembl Acc Id:

ENSRNOP00000085891 ⟸ ENSRNOT00000119185

Ensembl Acc Id:

ENSRNOP00000093571 ⟸ ENSRNOT00000111365

RefSeq Acc Id:	XP_063120880 ⟸ XM_063264810
- Peptide Label:	isoform X4
- UniProtKB:	Q9EPZ4 (UniProtKB/Swiss-Prot), Q6VXY3 (UniProtKB/Swiss-Prot), Q6VXY2 (UniProtKB/Swiss-Prot), Q68EJ0 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_063120881 ⟸ XM_063264811
- Peptide Label:	isoform X5
- UniProtKB:	A6I1W8 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000111146 ⟸ ENSRNOT00000162833

Protein Domains

CS Cytochrome b5 heme-binding FAD-binding FR-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q68EJ0-F1-model_v2	AlphaFold	Q68EJ0	1-520	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696164

Promoter ID:

EPDNEW_R6689

Type:

initiation region

Name:

Cyb5r4_1

Description:

cytochrome b5 reductase 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	94,693,281 - 94,693,341	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621834	AgrOrtholog
BioCyc Gene	G2FUF-29633	BioCyc
Ensembl Genes	ENSRNOG00000010024	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000013908	ENTREZGENE
	ENSRNOT00000111365	ENTREZGENE
	ENSRNOT00000119185	ENTREZGENE
	ENSRNOT00000162833	ENTREZGENE
Gene3D-CATH	2.60.40.790	UniProtKB/Swiss-Prot
	3.10.120.10	UniProtKB/Swiss-Prot
	3.40.50.80	UniProtKB/Swiss-Prot
	Translation factors	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7099950	IMAGE-MGC_LOAD
InterPro	Cbr1-like_FAD-bd_dom	UniProtKB/Swiss-Prot
	CS_dom	UniProtKB/Swiss-Prot
	Cyt_B5-like_heme/steroid-bd	UniProtKB/Swiss-Prot
	Cyt_B5-like_heme/steroid_sf	UniProtKB/Swiss-Prot
	Cyt_B5_heme-BS	UniProtKB/Swiss-Prot
	Cytochrome_b5/Flavoprotein_Rdt	UniProtKB/Swiss-Prot
	FAD-bd_FR_type	UniProtKB/Swiss-Prot
	FNR_nucleotide-bd	UniProtKB/Swiss-Prot
	HSP20-like_chaperone	UniProtKB/Swiss-Prot
	OxRdtase_FAD/NAD-bd	UniProtKB/Swiss-Prot
	p23_NCB5OR	UniProtKB/Swiss-Prot
	Riboflavin_synthase-like_b-brl	UniProtKB/Swiss-Prot
KEGG Report	rno:171015	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:91492	IMAGE-MGC_LOAD
NCBI Gene	171015	ENTREZGENE
PANTHER	CYTOCHROME B5 REDUCTASE 4	UniProtKB/Swiss-Prot
	CYTOCHROME B5 REDUCTASE 4 FAMILY MEMBER	UniProtKB/Swiss-Prot
Pfam	Cyt-b5	UniProtKB/Swiss-Prot
	FAD_binding_6	UniProtKB/Swiss-Prot
	NAD_binding_1	UniProtKB/Swiss-Prot
	PF04969	UniProtKB/Swiss-Prot
PhenoGen	Cyb5r4	PhenoGen
PRINTS	CYTB5RDTASE	UniProtKB/Swiss-Prot
	CYTOCHROMEB5	UniProtKB/Swiss-Prot
PROSITE	CYTOCHROME_B5_1	UniProtKB/Swiss-Prot
	CYTOCHROME_B5_2	UniProtKB/Swiss-Prot
	FAD_FR	UniProtKB/Swiss-Prot
	PS51203	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000010024	RatGTEx
SMART	Cyt-b5	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF49764	UniProtKB/Swiss-Prot
	SSF52343	UniProtKB/Swiss-Prot
	SSF55856	UniProtKB/Swiss-Prot
	SSF63380	UniProtKB/Swiss-Prot
UniProt	A0A0G2JSK2	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6A4B1	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6ABY9_RAT	UniProtKB/TrEMBL
	A0A8I6GKQ4	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0M3W9_RAT	UniProtKB/TrEMBL
	A6I1W6	ENTREZGENE, UniProtKB/TrEMBL
	A6I1W7	ENTREZGENE, UniProtKB/TrEMBL
	A6I1W8	ENTREZGENE, UniProtKB/TrEMBL
	A6I1W9_RAT	UniProtKB/TrEMBL
	A6I1X0_RAT	UniProtKB/TrEMBL
	A6I1X1_RAT	UniProtKB/TrEMBL
	NB5R4_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q6VXY2	ENTREZGENE
	Q6VXY3	ENTREZGENE
	Q9EPZ4	ENTREZGENE
UniProt Secondary	Q6VXY2	UniProtKB/Swiss-Prot
	Q6VXY3	UniProtKB/Swiss-Prot
	Q9EPZ4	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-03-30	Cyb5r4	cytochrome b5 reductase 4	Ncb5or	NADPH cytochrome B5 oxidoreductase	Symbol and Name updated	1299863	APPROVED
2004-02-10	Ncb5or	NADPH cytochrome B5 oxidoreductase	b5&b5R	flavohemoprotein b5+b5R	Symbol and Name updated to reflect Human and Mouse nomenclature	625702	APPROVED
2002-08-07	b5&b5R	flavohemoprotein b5+b5R			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_domains	contains heme and FAD domains at the amino and carboxy termini, respectively	632262
gene_protein	493 amino acids	632262

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - MGI