Gene:	Cyb5r4 ( Rattus norvegicus ) cytochrome b5 reductase 4
Description:	NADPH cytochrome B5 oxidoreductase; a cytosolic fusion hemoflavoprotein
Synonyms:	b5&b5R; Ncb5or; NADPH cytochrome B5 oxidoreductase; flavohemoprotein b5+b5R;  (details...)
ArrayIDs:	5682286; 6630309; 6580526; 6405245; rc_AI232043_at; 1370827_at; 6028970; 6581422; A_44_P496438; 6487053; 6061900; 5639087; A_43_P13191; A_44_P179704; 6197937; GE13573; 6611405; 6338032; 6544446; 6309914; 6655937; 6068238; 5950203; 6240050; 5897014; 5963711; 6166322; 6003553;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: CYB5R4     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Cyb5r4     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Cyb5r4 genome assembly 3.1 8 92297907 - 92362944     Rat Celera Assembly 8 87567020 - 87631697     RGSC genome assembly v3.4 8 92278453 - 92343490     Cytogenetic 8 q31 Mus musculus Cyb5r4 Mouse genome assembly build 36.1 9 86921809 - 86971717     Cytogenetic 9 9 E3.1 Homo sapiens CYB5R4 human genome assembly 6 84626123 - 84726674     Human genome assembly build 36.2 6 84626089 - 84726865     Cytogenetic 6 6pter-q22.33   View comparative maps:      NCBI MapViewer
Genome
View:
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Annotation
Molecular Function	Gene Ontology protein binding,  NADPH-hemoprotein reductase activity,  NAD(P)H oxidase activity ...  (details...)
Biological Process	Gene Ontology oxidation reduction,  generation of precursor metabolites and energy,  glucose homeostasis ...  (details...)
Cellular Component	Gene Ontology perinuclear region of cytoplasm,  endoplasmic reticulum (details...)
Protein	Note Reference 493 amino acids 632262
Domain	Note Reference contains heme and FAD domains at the amino and carboxy termini, respectively 632262
External Links
Databases	DATABASE ID SOURCE PROSITE: FAD_FR IPI PROSITE: CS IPI PROSITE: CYTOCHROME_B5_1 IPI PROSITE: CYTOCHROME_B5_2 IPI UNIPARC: UPI000150AF0B IPI UNIPARC: UPI000150AF0A IPI UNIPARC: UPI0001B7A970 IPI UNIPARC: UPI0001B7A96F IPI UNIPARC: UPI0001B7A971 IPI KEGG Report: rno:171015 ENTREZGENE HomoloGene Group ID: 69207 ENTREZGENE Germonline: 621834 Pfam: Cyt-b5 IPI Pfam: FAD_binding_6 IPI Pfam: NAD_binding_1 IPI Pfam: CS IPI InterPro: Cyt_B5. IPI InterPro: CS. IPI InterPro: CS_domain. IPI InterPro: Riboflavin_synthase-like_b-brl. IPI InterPro: Cyt_B5_heme-BS. IPI InterPro: OxRdtase_FAD/NAD_bd. IPI InterPro: OxRdtase_FAD-bd. IPI InterPro: NADH-Cyt_B5_reductase. IPI InterPro: HSP20-like_chaperone. IPI InterPro: Fd_Rdtase_FAD-bd. IPI IPI: IPI00948290 IPI IPI: IPI00949562 IPI IPI: IPI00563048 IPI IPI: IPI00189672 IPI IPI: IPI00390401 IPI Ensembl Protein: ENSRNOP00000060739 IPI Ensembl Protein: ENSRNOP00000039062 IPI Ensembl Protein: ENSRNOP00000013909 IPI Ensembl Protein: ENSRNOP00000013975 IPI Gene3D-CATH: Cyt_B5 IPI IMAGE_CLONE: IMAGE:7099950 IMAGE-MGC_LOAD Entrez Gene: Cyb5r4 ENTREZGENE MGC_CLONE: MGC:91492 IMAGE-MGC_LOAD UniProt: NB5R4_RAT IPI UniProt: NB5R4_RAT IPI Ensembl Genes: ENSRNOG00000010024 IPI Superfamily-SCOP: Riboflavin_synthase_like_b-brl IPI Superfamily-SCOP: HSP20_chap IPI Superfamily-SCOP: Cyt_B5 IPI PRINTS: CYTOCHROMEB5. IPI PRINTS: CYTB5RDTASE. IPI
Sequences	Nucleotide: AF307840 Get FASTA Search GEO Profiles Nucleotide: AY321371 Get FASTA Search GEO Profiles Nucleotide: NM_133427 Get FASTA Search GEO Profiles Nucleotide: AY321370 Get FASTA Search GEO Profiles Nucleotide: CH473954 Get FASTA Search GEO Profiles Nucleotide: BC080240 Get FASTA Search GEO Profiles (View all 6 Nucleotide Accessions) Protein: AAG45053 Get FASTA Protein: Q68EJ0 Get FASTA Protein: AAQ83903 Get FASTA Protein: EDL77607 Get FASTA Protein: AAQ83902 Get FASTA Protein: NP_596918 Get FASTA Protein: AAH80240 Get FASTA Protein: EDL77606 Get FASTA Protein: EDL77611 Get FASTA Protein: EDL77610 Get FASTA Protein: EDL77609 Get FASTA Protein: EDL77608 Get FASTA (View all 12 Protein Accessions)
Clusters	UniGene: 3334
References
Curated References	5 references in RGD related to Cyb5r4
Other References	4 other references at PubMed related to Cyb5r4
Database Information
RGD ID	621834
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 30-MAR-06: Cyb5r4 cytochrome b5 reductase 4 Ncb5or NADPH cytochrome B5 oxidoreductase APPROVED Symbol and Name updated 1299863 10-FEB-04: Ncb5or NADPH cytochrome B5 oxidoreductase b5&b5R flavohemoprotein b5+b5R APPROVED Symbol and Name updated to reflect Human and Mouse nomenclature 625702 07-AUG-02: b5&b5R flavohemoprotein b5+b5R PROVISIONAL Symbol and Name status set to provisional 70820