Cxcl3 (C-X-C motif chemokine ligand 3) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Cxcl3 (C-X-C motif chemokine ligand 3) Rattus norvegicus
Analyze
Symbol: Cxcl3
Name: C-X-C motif chemokine ligand 3
RGD ID: 621812
Description: Enables chemokine activity. Involved in cellular response to lipopolysaccharide; neutrophil chemotaxis; and positive regulation of cytosolic calcium ion concentration. Located in extracellular space. Biomarker of Coronavirus infectious disease and bacterial pneumonia. Orthologous to human CXCL1 (C-X-C motif chemokine ligand 1); CXCL2 (C-X-C motif chemokine ligand 2); and CXCL3 (C-X-C motif chemokine ligand 3); PARTICIPATES IN interleukin-23 signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C-X-C motif chemokine 3; chemokine (C-X-C motif) ligand 3; Cinc-2; Cinc2; cytokine-induced neutrophil chemoattractant 2; cytokine-induced neutrophil chemoattractant-2; gene model 1960, (NCBI); Gm1960; macrophage inflammatory protein 2-alpha/beta; MIP2-alpha/beta
RGD Orthologs
Human
Mouse
Bonobo
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81417,571,900 - 17,573,624 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1417,571,900 - 17,573,624 (-)EnsemblGRCr8
mRatBN7.21417,287,727 - 17,289,451 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1417,270,146 - 17,289,511 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1417,288,069 - 17,289,789 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01418,606,992 - 18,608,712 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01417,299,296 - 17,301,016 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01418,820,168 - 18,839,659 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1418,820,168 - 18,839,595 (-)Ensemblrn6Rnor6.0
Rnor_5.01418,729,345 - 18,748,734 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41418,767,306 - 18,787,340 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1416,646,603 - 16,666,030 (-)NCBICelera
RGSC_v3.11418,767,305 - 18,787,340 (-)NCBI
Cytogenetic Map14p22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-anisomycin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoic acid  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-nicotine  (ISO)
1,1,1-trichloroethane  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2''-galloylhyperin  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrobenzenesulfonic acid  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-nitrofluorene  (EXP)
2-tert-butylhydroquinone  (ISO)
22-Hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
3-Nitrofluoranthene  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-Hydroxybenzophenone  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nitroquinoline N-oxide  (ISO)
5-fluorouracil  (ISO)
5-Isoxazoleacetic acid, 4,5-dihydro-3-(4-hydroxyphenyl)-, methyl ester  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
7,12-dimethyltetraphene  (ISO)
9-cis-retinoic acid  (ISO)
A-967079  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (EXP,ISO)
adenine  (ISO)
aflatoxin B1  (ISO)
Aflatoxin G1  (ISO)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
alpha-amanitin  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
aluminium sulfate (anhydrous)  (ISO)
AM-251  (ISO)
amitrole  (EXP)
amlexanox  (ISO)
ammonium chloride  (EXP)
amphibole asbestos  (EXP)
amphotericin B  (ISO)
andrographolide  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
apocynin  (ISO)
aripiprazole  (ISO)
arsane  (ISO)
arsenic acid  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
asperentin  (ISO)
astemizole  (EXP)
astressin 2B  (ISO)
atrazine  (ISO)
atropine  (ISO)
Azoxymethane  (ISO)
Bardoxolone methyl  (ISO)
benzalkonium chloride  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beryllium sulfate  (ISO)
beta-D-glucosamine  (EXP)
beta-naphthoflavone  (ISO)
bexarotene  (EXP)
bifenthrin  (ISO)
biphenyl-2-ol  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
bortezomib  (ISO)
Botulinum toxin type A  (ISO)
Brevianamide A  (ISO)
budesonide  (EXP)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
C.I. Natural Red 20  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
capecitabine  (ISO)
carbon nanotube  (EXP,ISO)
carmustine  (ISO)
carrageenan  (ISO)
carvacrol  (ISO)
ceruletide  (ISO)
cetirizine  (ISO)
chenodeoxycholic acid  (ISO)
chlorogenic acid  (ISO)
chloropicrin  (ISO)
chloroprene  (EXP,ISO)
chlorotoluron  (ISO)
choline  (ISO)
chondroitin sulfate  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clozapine  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
cobalt(2+) sulfate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
corosolic acid  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
curcumin  (ISO)
cyanuric chloride  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (EXP)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dicloxacillin  (ISO)
Didecyldimethylammonium  (ISO)
diethyl malate  (ISO)
diethyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diisopropyl fluorophosphate  (ISO)
dimercaprol  (ISO)
dinitrogen  (ISO)
dioxygen  (EXP,ISO)
diquat  (ISO)
domperidone  (ISO)
doramapimod  (ISO)
doxorubicin  (ISO)
edaravone  (EXP)
elemental selenium  (ISO)
enniatin  (ISO)
epoxiconazole  (ISO)
equol  (ISO)
Erionite  (ISO)
ethanol  (ISO)
eugenol  (ISO)
ferric oxide  (ISO)
flavonoids  (EXP)
flucloxacillin  (ISO)
fluoranthene  (ISO)
fluticasone  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
gadolinium trichloride  (ISO)
gemcitabine  (ISO)
glucose  (ISO)
glutathione  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
gossypol  (ISO)
graphene oxide  (ISO)
halothane  (ISO)
heparan sulfate  (ISO)
hesperidin  (ISO)
hispidulin  (ISO)
hydrogen peroxide  (ISO)
hydroxychloroquine  (ISO)
imiquimod  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
isoflurane  (ISO)
isotretinoin  (ISO)
itraconazole  (ISO)
ketamine  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
leukotriene B4  (ISO)
leukotriene C4  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
maslinic acid  (ISO)
mesalamine  (ISO)
methamphetamine  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
metoclopramide  (ISO)
Microcystin la  (EXP)
microcystin-LR  (ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (ISO)
muramyl dipeptide  (ISO)
mycophenolic acid  (ISO)
mycotoxin  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (ISO)
naphthalene  (ISO)
neocuproine  (ISO)
neoechinulin A  (ISO)
nevirapine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
nonivamide  (ISO)
o-anisidine  (ISO)
obeticholic acid  (ISO)
okadaic acid  (ISO)
oleanolic acid  (ISO)
oroxylin A  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
parthenolide  (ISO)
PD 0325901  (ISO)
pentanal  (ISO)
pentane-2,3-dione  (EXP)
perfluorobutyric acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phalloidin  (ISO)
phenylarsine oxide  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
Phytolaccoside E  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
poly(I:C)  (ISO)
polymyxin B2  (ISO)
potassium bromate  (ISO)
potassium chromate  (ISO)
prednisolone  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
Primycin  (ISO)
progesterone  (ISO)
propanal  (ISO)
propofol  (ISO)
propylparaben  (ISO)
Pyridostigmine bromide  (ISO)
quercetin  (ISO)
resolvin D1  (ISO)
resolvin D2  (ISO)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
ritonavir  (ISO)
rofecoxib  (ISO)
rosmarinic acid  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
salvianolic acid B  (ISO)
SB 203580  (ISO)
SB-239063  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
Shikonin  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
sodium dodecyl sulfate  (ISO)
Soman  (ISO)
sterigmatocystin  (ISO)
styrene  (ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
sulfapyridine  (ISO)
sulfasalazine  (ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
tauro-beta-muricholic acid  (ISO)
taurocholic acid  (ISO)
tebufenpyrad  (ISO)
telmisartan  (EXP)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thioacetamide  (ISO)
thiram  (ISO)
Tiron  (ISO)
titanium dioxide  (EXP,ISO)
TMC-120A  (ISO)
toluene 2,4-diisocyanate  (ISO)
tremolite asbestos  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vanadyl sulfate  (ISO)
vancomycin  (ISO)
vitamin D  (ISO)
XL147  (ISO)
zaragozic acid A  (ISO)
zileuton  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc nitrate  (ISO)
zinc oxide  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Impaired interleukin-8 chemokine secretion by staphylococcus aureus-activated epithelium and T-cell chemotaxis in cystic fibrosis. Al Alam D, etal., Am J Respir Cell Mol Biol. 2010 Jun;42(6):644-50. Epub 2009 Jul 13.
2. Role of cytokine-induced neutrophil chemoattractant-2 (CINC-2) alpha in a rat model of chronic bronchopulmonary infections with Pseudomonas aeruginosa. Amano H, etal., Cytokine. 2000 Nov;12(11):1662-8.
3. Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease. Brito VGB, etal., Front Pharmacol. 2020 Nov 11;11:579926. doi: 10.3389/fphar.2020.579926. eCollection 2020.
4. Titanium dioxide nanoparticles induce emphysema-like lung injury in mice. Chen HW, etal., FASEB J. 2006 Nov;20(13):2393-5. Epub 2006 Oct 5.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Characterization of the inflammatory response during acute and post-acute phases after severe burn. Gauglitz GG, etal., Shock. 2008 Nov;30(5):503-7.
7. Rat coronaviruses infect rat alveolar type I epithelial cells and induce expression of CXC chemokines. Miura TA, etal., Virology. 2007 Dec 20;369(2):288-98. Epub 2007 Sep 5.
8. Immunolocalization of CXC chemokine and recruitment of polymorphonuclear leukocytes in the rat molar periodontal tissue after topical application of lipopolysaccharide. Miyauchi M, etal., Histochem Cell Biol. 2004 Apr;121(4):291-7. Epub 2004 Mar 24.
9. Identification of cytokine-induced neutrophil chemoattractants (CINC), rat GRO/CINC-2 alpha and CINC-2 beta, produced by granulation tissue in culture: purification, complete amino acid sequences and characterization. Nakagawa H, etal., Biochem J 1994 Jul 15;301 ( Pt 2):545-50.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Gene structure, cDNA cloning, and expression of the rat cytokine-induced neutrophil chemoattractant-2 (CINC-2) gene. Shibata F, etal., Cytokine 1998 Mar;10(3):169-74.
14. Differential changes in the concentrations of cytokine-induced neutrophil chemoattractant (CINC)-1 and CINC-2 in exudate during rat lipopolysaccharide-induced inflammation. Shibata F, etal., Cytokine. 1996 Mar;8(3):222-6.
15. Identification of a common receptor for three types of rat cytokine-induced neutrophil chemoattractants (CINCs). Shibata F, etal., Cytokine. 2000 Sep;12(9):1368-73.
16. The expression of three types of CINCs by lipopolysaccharide-stimulated rat macrophages is inhibited similarly by anti-inflammatory steroids. Shibata F, etal., Inflamm Res. 2000 Feb;49(2):80-5.
Additional References at PubMed
PMID:8471066   PMID:8607872   PMID:12829448   PMID:12949249   PMID:14764687   PMID:16055671   PMID:18323732   PMID:19497959   PMID:20226088   PMID:20602290   PMID:27967265   PMID:31616413  
PMID:37194082  


Genomics

Comparative Map Data
Cxcl3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81417,571,900 - 17,573,624 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1417,571,900 - 17,573,624 (-)EnsemblGRCr8
mRatBN7.21417,287,727 - 17,289,451 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1417,270,146 - 17,289,511 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1417,288,069 - 17,289,789 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01418,606,992 - 18,608,712 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01417,299,296 - 17,301,016 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01418,820,168 - 18,839,659 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1418,820,168 - 18,839,595 (-)Ensemblrn6Rnor6.0
Rnor_5.01418,729,345 - 18,748,734 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41418,767,306 - 18,787,340 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1416,646,603 - 16,666,030 (-)NCBICelera
RGSC_v3.11418,767,305 - 18,787,340 (-)NCBI
Cytogenetic Map14p22NCBI
CXCL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38473,869,393 - 73,871,308 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl473,869,392 - 73,871,308 (+)Ensemblhg38GRCh38
GRCh37474,735,110 - 74,737,025 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36474,953,973 - 74,955,817 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34475,100,143 - 75,101,988NCBI
Celera472,095,237 - 72,097,087 (+)NCBICelera
Cytogenetic Map4q13.3NCBI
HuRef470,546,248 - 70,548,158 (+)NCBIHuRef
CHM1_1474,771,032 - 74,772,942 (+)NCBICHM1_1
T2T-CHM13v2.0477,213,030 - 77,214,945 (+)NCBIT2T-CHM13v2.0
Cxcl3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39590,933,960 - 90,935,952 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl590,933,962 - 90,937,459 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38590,786,101 - 90,788,093 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl590,786,103 - 90,789,600 (+)Ensemblmm10GRCm38
MGSCv37591,215,129 - 91,217,116 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36591,861,303 - 91,863,290 (+)NCBIMGSCv36mm8
Celera588,937,720 - 88,939,708 (+)NCBICelera
Cytogenetic Map5E1NCBI
cM Map544.78NCBI
LOC100976904
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2356,193,010 - 56,195,078 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1456,382,200 - 56,384,184 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0450,325,248 - 50,327,165 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1456,157,626 - 56,159,522 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl456,153,899 - 56,159,474 (-)EnsemblpanPan2panpan1.1

Variants

.
Variants in Cxcl3
39 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:43
Interacting mature miRNAs:50
Transcripts:ENSRNOT00000034090
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14395787821572472Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14395787818558812Rat
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14140068101Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14140068101Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14939329839411170Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141133490630674469Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141133471628389666Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14395787831121464Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14117877928Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14862139853621398Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14395787824886169Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141415516Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14131893212Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14862139853621398Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141513759431238250Rat

Markers in Region
D14Rat77  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81417,567,968 - 17,568,235 (+)Marker Load Pipeline
Rnor_6.01418,833,818 - 18,834,102NCBIRnor6.0
Rnor_5.01418,742,995 - 18,743,279UniSTSRnor5.0
RGSC_v3.41418,781,071 - 18,782,022UniSTSRGSC3.4
Celera1416,660,252 - 16,660,493UniSTS
RH 3.4 Map14216.4RGD
RH 3.4 Map14216.4UniSTS
RH 2.0 Map14215.5RGD
SHRSP x BN Map146.92RGD
Cytogenetic Map14p22UniSTS
AI045017  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21417,270,396 - 17,270,567 (+)MAPPERmRatBN7.2
Rnor_6.01418,820,419 - 18,820,589NCBIRnor6.0
Rnor_5.01418,729,596 - 18,729,766UniSTSRnor5.0
RGSC_v3.41418,767,557 - 18,767,727UniSTSRGSC3.4
Celera1416,646,854 - 16,647,024UniSTS
RH 3.4 Map14213.6UniSTS
Cytogenetic Map14p22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 8 35 114 70 71 40 49 40 6 199 104 3 102 32 72 31 13 13

Sequence


Ensembl Acc Id: ENSRNOT00000034090   ⟹   ENSRNOP00000038520
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1417,270,146 - 17,289,380 (-)Ensembl
Rnor_6.0 Ensembl1418,820,168 - 18,839,420 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000078746   ⟹   ENSRNOP00000070985
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1417,571,900 - 17,573,624 (-)Ensembl
mRatBN7.2 Ensembl1417,287,726 - 17,289,511 (-)Ensembl
Rnor_6.0 Ensembl1418,837,821 - 18,839,595 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098120   ⟹   ENSRNOP00000077076
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1417,288,291 - 17,289,380 (-)Ensembl
RefSeq Acc Id: NM_001394590   ⟹   NP_001381519
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81417,571,900 - 17,573,624 (-)NCBI
mRatBN7.21417,287,727 - 17,289,451 (-)NCBI
Ensembl Acc Id: ENSRNOP00000038520   ⟸   ENSRNOT00000034090
Ensembl Acc Id: ENSRNOP00000070985   ⟸   ENSRNOT00000078746
Ensembl Acc Id: ENSRNOP00000077076   ⟸   ENSRNOT00000098120
RefSeq Acc Id: NP_001381519   ⟸   NM_001394590
- Peptide Label: precursor
- UniProtKB: Q5CZ55 (UniProtKB/Swiss-Prot),   Q10747 (UniProtKB/Swiss-Prot),   Q10746 (UniProtKB/Swiss-Prot),   Q9EP62 (UniProtKB/Swiss-Prot),   A6KKE0 (UniProtKB/TrEMBL),   A6KKD9 (UniProtKB/TrEMBL)
Protein Domains
Chemokine interleukin-8-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q10746-F1-model_v2 AlphaFold Q10746 1-101 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699227
Promoter ID:EPDNEW_R9751
Type:single initiation site
Name:Cxcl3_1
Description:chemokine (C-X-C motif) ligand 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01418,839,486 - 18,839,546EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621812 AgrOrtholog
BioCyc Gene G2FUF-16209 BioCyc
Ensembl Genes ENSRNOG00000028043 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000034090.4 UniProtKB/Swiss-Prot
  ENSRNOT00000078746 ENTREZGENE
  ENSRNOT00000098120.1 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.50.40 UniProtKB/Swiss-Prot
InterPro Chemokine_b/g/d UniProtKB/Swiss-Prot
  Chemokine_CXC UniProtKB/Swiss-Prot
  Chemokine_CXC_CS UniProtKB/Swiss-Prot
  Chemokine_IL8-like_dom UniProtKB/Swiss-Prot
  CXC_Chemokine_domain UniProtKB/Swiss-Prot
  Interleukin_8-like_sf UniProtKB/Swiss-Prot
NCBI Gene 171551 ENTREZGENE
PANTHER C-X-C MOTIF CHEMOKINE 3 UniProtKB/Swiss-Prot
  SMALL INDUCIBLE CYTOKINE A UniProtKB/Swiss-Prot
Pfam IL8 UniProtKB/Swiss-Prot
PhenoGen Cxcl3 PhenoGen
PRINTS INTERLEUKIN8 UniProtKB/Swiss-Prot
  SMALLCYTKCXC UniProtKB/Swiss-Prot
PROSITE SMALL_CYTOKINES_CXC UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000028043 RatGTEx
SMART SCY UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54117 UniProtKB/Swiss-Prot
UniProt A0A8L2R3J1_RAT UniProtKB/TrEMBL
  A6KKD9 ENTREZGENE, UniProtKB/TrEMBL
  A6KKE0 ENTREZGENE, UniProtKB/TrEMBL
  CXCL3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q10747 ENTREZGENE
  Q5CZ55 ENTREZGENE
  Q9EP62 ENTREZGENE
UniProt Secondary Q10747 UniProtKB/Swiss-Prot
  Q5CZ55 UniProtKB/Swiss-Prot
  Q9EP62 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-12-12 Cxcl3  C-X-C motif chemokine ligand 3  Cxcl3  chemokine (C-X-C motif) ligand 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-25 Cxcl3  chemokine (C-X-C motif) ligand 3  Gm1960  gene model 1960, (NCBI)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Gm1960  gene model 1960, (NCBI)  Cinc2  cytokine-induced neutrophil chemoattractant-2  Symbol and Name updated 1299863 APPROVED
2002-08-07 Cinc2  cytokine-induced neutrophil chemoattractant-2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_product member of the CXC chemokine family 632410
gene_transcript has two splicing isoforms, CINC-2 alpha and CINC-2 beta 632410