Cxcl3 (C-X-C motif chemokine ligand 3) - Rat Genome Database

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Gene: Cxcl3 (C-X-C motif chemokine ligand 3) Rattus norvegicus
Analyze
Symbol: Cxcl3
Name: C-X-C motif chemokine ligand 3
RGD ID: 621812
Description: Enables chemokine activity. Involved in cellular response to lipopolysaccharide; neutrophil chemotaxis; and positive regulation of cytosolic calcium ion concentration. Located in extracellular space. Biomarker of Coronavirus infectious disease and bacterial pneumonia. Orthologous to human CXCL1 (C-X-C motif chemokine ligand 1); CXCL2 (C-X-C motif chemokine ligand 2); and CXCL3 (C-X-C motif chemokine ligand 3); PARTICIPATES IN interleukin-23 signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C-X-C motif chemokine 3; chemokine (C-X-C motif) ligand 3; Cinc-2; Cinc2; cytokine-induced neutrophil chemoattractant 2; cytokine-induced neutrophil chemoattractant-2; gene model 1960, (NCBI); Gm1960; macrophage inflammatory protein 2-alpha/beta; MIP2-alpha/beta
RGD Orthologs
Human
Mouse
Bonobo
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81417,571,900 - 17,573,624 (-)NCBIGRCr8
mRatBN7.21417,287,727 - 17,289,451 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1417,270,146 - 17,289,511 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1417,288,069 - 17,289,789 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01418,606,992 - 18,608,712 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01417,299,296 - 17,301,016 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01418,820,168 - 18,839,659 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1418,820,168 - 18,839,595 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01418,729,345 - 18,748,734 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41418,767,306 - 18,787,340 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11418,767,305 - 18,787,340 (-)NCBI
Celera1416,646,603 - 16,666,030 (-)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 13 of 13 rows

  
Object Symbol
Species
Term
Qualifier
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Reference
Notes
Source
Original Reference(s)
Cxcl3RatAlveolar Bone Loss treatmentIEP 329956421associated with hypertension and periodontal diseaseRGD 
Cxcl3Ratasthma severityISOCXCL1 (Homo sapiens)9068941 RGDPMID:20371397 and REF_RGD_ID:5134983
Cxcl3Ratbacterial pneumonia  IEP 5135234 RGD 
Cxcl3RatBurns  IEP 5135231protein:increased expression:serumRGD 
Cxcl3Ratcommon cold  ISOCXCL1 (Homo sapiens)9068941associated with Pulmonary Disease more ...RGDPMID:20395558 and REF_RGD_ID:4145446
Cxcl3RatCoronavirus infectious disease  IEP 5135236 RGD 
Cxcl3RatCOVID-19  ISOCXCL1 (Homo sapiens)9068941mRNA:increased expression:bronchoalveolar lavage (human)RGDPMID:32407669 and REF_RGD_ID:30296672
Cxcl3Ratcystic fibrosis  ISOCXCL1 (Homo sapiens)5135456 RGD 
Cxcl3Rathyperhomocysteinemia  ISOCXCL1 (Homo sapiens)9068941protein:increased expression:plasmaRGDPMID:11950713 and REF_RGD_ID:5135249
Cxcl3RatInflammation  IEP 5135240 RGD 
Cxcl3RatNasal Polyps  ISOCXCL1 (Homo sapiens)9068941associated with Sinusitis and mRNA:increased expression:respiratory system mucosaRGDPMID:19178793 and REF_RGD_ID:5134986
Cxcl3Ratpulmonary emphysema  ISOCxcl3 (Mus musculus)5135245mRNA:increased expression:lungRGD 
Cxcl3Ratsevere acute respiratory syndrome  ISOCxcl3 (Mus musculus)9068941mRNA:altered expression:lung (mouse)RGDPMID:32364527 and REF_RGD_ID:27226699
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1 to 13 of 13 rows
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Original Reference(s)
Cxcl3Ratallergic disease  ISOCXCL1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21625544
Cxcl3Ratautoimmune hepatitis  ISOCXCL1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21227906
Cxcl3RatBronchial Hyperreactivity  ISOCXCL1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12388339
Cxcl3RatChemical and Drug Induced Liver Injury  ISOCXCL1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16118408
Cxcl3Ratchronic obstructive pulmonary disease  ISOCXCL1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23099361
Cxcl3RatExperimental Liver Cirrhosis  ISOCXCL1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25380136
Cxcl3RatHemorrhagic Shock  ISOCXCL1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21192278
Cxcl3Ratjuvenile rheumatoid arthritis  ISOCXCL1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19565504
Cxcl3RatLiver Neoplasms  ISOCXCL1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:33010264
Cxcl3Ratpneumonia  ISOCXCL1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21625544
Cxcl3RatReperfusion Injury  ISOCXCL1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16526316
Cxcl3Ratrespiratory allergy  ISOCXCL1 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:23056391
Cxcl3RatWounds and Injuries  ISOCXCL1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21192278
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1 to 20 of 553 rows

  
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Original Reference(s)
Cxcl3Rat(-)-anisomycin multiple interactionsISOCXCL1 (Homo sapiens)6480464[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [Anisomycin results in increased expression of CXCL1 mRNA]CTDPMID:22003189
Cxcl3Rat(-)-anisomycin increases expressionISOCXCL1 (Homo sapiens)6480464Anisomycin results in increased expression of CXCL1 mRNACTDPMID:22003189
Cxcl3Rat(-)-epigallocatechin 3-gallate multiple interactionsISOCXCL1 (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CXCL1 mRNACTDPMID:22079256
Cxcl3Rat(4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoic acid multiple interactionsISOCxcl3 (Mus musculus)648046417-hydroxy-4 more ...CTDPMID:21724996
Cxcl3Rat(R,R,R)-alpha-tocopherol multiple interactionsISOCxcl3 (Mus musculus)6480464[alpha-Tocopherol co-treated with SB 239063] inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of CXCL1 mRNA]]CTDPMID:29284473
Cxcl3Rat(S)-nicotine decreases secretionISOCxcl3 (Mus musculus)6480464Nicotine results in decreased secretion of CXCL1 proteinCTDPMID:22093924
Cxcl3Rat(S)-nicotine increases expressionISOCxcl3 (Mus musculus)6480464Nicotine results in increased expression of CXCL1 proteinCTDPMID:16254210
Cxcl3Rat(S)-nicotine decreases expressionISOCxcl3 (Mus musculus)6480464Nicotine results in decreased expression of CXCL1 mRNACTDPMID:22093924
Cxcl3Rat1,1,1-trichloroethane decreases expressionISOCxcl3 (Mus musculus)64804641 more ...CTDPMID:25270620
Cxcl3Rat1,3-benzothiazole-2-thiol increases expressionISOCXCL1 (Homo sapiens)6480464captax results in increased expression of CXCL1 mRNACTDPMID:20713136
Cxcl3Rat1,4-phenylenediamine increases expressionISOCXCL1 (Homo sapiens)64804644-phenylenediamine results in increased expression of CXCL1 mRNACTDPMID:20713136
Cxcl3Rat1-chloro-2,4-dinitrobenzene increases expressionISOCXCL1 (Homo sapiens)6480464Dinitrochlorobenzene results in increased expression of CXCL1 mRNACTDPMID:20146380 and PMID:20713136
Cxcl3Rat1-chloro-2,4-dinitrobenzene multiple interactionsISOCxcl3 (Mus musculus)6480464NFE2L2 protein inhibits the reaction [Dinitrochlorobenzene results in increased expression of CXCL1 mRNA]CTDPMID:28219650
Cxcl3Rat1-chloro-2,4-dinitrobenzene increases expressionISOCxcl3 (Mus musculus)6480464Dinitrochlorobenzene results in increased expression of CXCL1 mRNACTDPMID:19647056 more ...
Cxcl3Rat1-fluoro-2,4-dinitrobenzene increases expressionISOCxcl3 (Mus musculus)6480464Dinitrofluorobenzene results in increased expression of CXCL1 mRNACTDPMID:15719370
Cxcl3Rat1-naphthyl isothiocyanate increases expressionISOCxcl3 (Mus musculus)64804641-Naphthylisothiocyanate results in increased expression of CXCL1 mRNA and 1-Naphthylisothiocyanate results in increased expression of CXCL1 proteinCTDPMID:21070799 more ...
Cxcl3Rat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of CXCL3 mRNACTDPMID:30723492
Cxcl3Rat1-naphthyl isothiocyanate multiple interactionsISOCxcl3 (Mus musculus)6480464[3-(5-(4-(cyclopentyloxy)-2-hydroxybenzoyl)-2-((3-hydroxy-1 more ...CTDPMID:21356363 more ...
Cxcl3Rat1-nitropyrene increases expressionISOCXCL1 (Homo sapiens)64804641-nitropyrene results in increased expression of CXCL1 mRNACTDPMID:19041380 more ...
Cxcl3Rat17alpha-ethynylestradiol multiple interactionsISOCxcl3 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CXCL1 mRNACTDPMID:17942748

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Biological Process
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Object Symbol
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Original Reference(s)
Cxcl3Ratantimicrobial humoral immune response mediated by antimicrobial peptide involved_inISOCXCL1 (Homo sapiens) and UniProtKB:P09341-PRO_00000050491624291 PMID:12949249RGDPMID:12949249
Cxcl3Ratcellular response to lipopolysaccharide  IEP 5135239 RGD 
Cxcl3Ratchemotaxis involved_inIEAInterPro:IPR0338991600115GO_REF:0000002InterProGO_REF:0000002
Cxcl3Ratchemotaxis involved_inIEAUniProtKB-KW:KW-01451600115GO_REF:0000043UniProtGO_REF:0000043
Cxcl3Ratdefense response involved_inIEAInterPro:IPR0338991600115GO_REF:0000002InterProGO_REF:0000002
Cxcl3Ratimmune response involved_inIEAInterPro:IPR001089 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Cxcl3Ratinflammatory response involved_inIEAUniProtKB-KW:KW-03951600115GO_REF:0000043UniProtGO_REF:0000043
Cxcl3Ratneutrophil chemotaxis  NAS 632410 RGD 
Cxcl3Ratneutrophil chemotaxis  IDA 5135014 RGD 
Cxcl3Ratneutrophil chemotaxis involved_inISOCxcl3 (Mus musculus)1624291 PMID:14764687RGDPMID:14764687
Cxcl3Ratneutrophil chemotaxis involved_inIEAUniProtKB:Q6W5C0 and ensembl:ENSMUSP000000313261600115GO_REF:0000107EnsemblGO_REF:0000107
Cxcl3Ratneutrophil chemotaxis involved_inIDA 632411PMID:8043001UniProt 
Cxcl3Ratpositive regulation of cytosolic calcium ion concentration  IDA 5135014 RGD 
Cxcl3Ratresponse to lipid involved_inIEAARBA:ARBA000280731600115GO_REF:0000117UniProtGO_REF:0000117
Cxcl3Ratresponse to lipopolysaccharide  IEP 5135238 RGD 
Cxcl3Ratsignal transduction involved_inIEAGO:00051251600115GO_REF:0000108GOCGO_REF:0000108
1 to 16 of 16 rows

Cellular Component

  
Object Symbol
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Original Reference(s)
Cxcl3Ratextracellular region located_inIEAUniProtKB-SubCell:SL-02431600115GO_REF:0000044UniProtGO_REF:0000044
Cxcl3Ratextracellular region located_inIEAUniProtKB-KW:KW-09641600115GO_REF:0000043UniProtGO_REF:0000043
Cxcl3Ratextracellular region located_inIEAInterPro:IPR001089 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Cxcl3Ratextracellular space  IDA 5135231 RGD 
Cxcl3Ratextracellular space located_inIEAUniProtKB-KW:KW-02021600115GO_REF:0000043UniProtGO_REF:0000043
Cxcl3Ratextracellular space located_inIEAUniRule:UR0000832511600115GO_REF:0000104UniProtGO_REF:0000104
Cxcl3Ratextracellular space located_inISSUniProtKB:P198761600115GO_REF:0000024UniProtGO_REF:0000024

Molecular Function

  

Imported Annotations - PID (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cxcl3Ratinterleukin-23 signaling pathway  ISOCXCL1 (Homo sapiens)9068941 PIDPID:200154

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#
Reference Title
Reference Citation
1. Impaired interleukin-8 chemokine secretion by staphylococcus aureus-activated epithelium and T-cell chemotaxis in cystic fibrosis. Al Alam D, etal., Am J Respir Cell Mol Biol. 2010 Jun;42(6):644-50. Epub 2009 Jul 13.
2. Role of cytokine-induced neutrophil chemoattractant-2 (CINC-2) alpha in a rat model of chronic bronchopulmonary infections with Pseudomonas aeruginosa. Amano H, etal., Cytokine. 2000 Nov;12(11):1662-8.
3. Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease. Brito VGB, etal., Front Pharmacol. 2020 Nov 11;11:579926. doi: 10.3389/fphar.2020.579926. eCollection 2020.
4. Titanium dioxide nanoparticles induce emphysema-like lung injury in mice. Chen HW, etal., FASEB J. 2006 Nov;20(13):2393-5. Epub 2006 Oct 5.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Characterization of the inflammatory response during acute and post-acute phases after severe burn. Gauglitz GG, etal., Shock. 2008 Nov;30(5):503-7.
7. Rat coronaviruses infect rat alveolar type I epithelial cells and induce expression of CXC chemokines. Miura TA, etal., Virology. 2007 Dec 20;369(2):288-98. Epub 2007 Sep 5.
8. Immunolocalization of CXC chemokine and recruitment of polymorphonuclear leukocytes in the rat molar periodontal tissue after topical application of lipopolysaccharide. Miyauchi M, etal., Histochem Cell Biol. 2004 Apr;121(4):291-7. Epub 2004 Mar 24.
9. Identification of cytokine-induced neutrophil chemoattractants (CINC), rat GRO/CINC-2 alpha and CINC-2 beta, produced by granulation tissue in culture: purification, complete amino acid sequences and characterization. Nakagawa H, etal., Biochem J 1994 Jul 15;301 ( Pt 2):545-50.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Gene structure, cDNA cloning, and expression of the rat cytokine-induced neutrophil chemoattractant-2 (CINC-2) gene. Shibata F, etal., Cytokine 1998 Mar;10(3):169-74.
14. Differential changes in the concentrations of cytokine-induced neutrophil chemoattractant (CINC)-1 and CINC-2 in exudate during rat lipopolysaccharide-induced inflammation. Shibata F, etal., Cytokine. 1996 Mar;8(3):222-6.
15. Identification of a common receptor for three types of rat cytokine-induced neutrophil chemoattractants (CINCs). Shibata F, etal., Cytokine. 2000 Sep;12(9):1368-73.
16. The expression of three types of CINCs by lipopolysaccharide-stimulated rat macrophages is inhibited similarly by anti-inflammatory steroids. Shibata F, etal., Inflamm Res. 2000 Feb;49(2):80-5.
1 to 16 of 16 rows
PMID:8471066   PMID:8607872   PMID:12829448   PMID:12949249   PMID:14764687   PMID:16055671   PMID:18323732   PMID:19497959   PMID:20226088   PMID:20602290   PMID:27967265   PMID:31616413  
PMID:37194082  



Cxcl3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81417,571,900 - 17,573,624 (-)NCBIGRCr8
mRatBN7.21417,287,727 - 17,289,451 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1417,270,146 - 17,289,511 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1417,288,069 - 17,289,789 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01418,606,992 - 18,608,712 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01417,299,296 - 17,301,016 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01418,820,168 - 18,839,659 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1418,820,168 - 18,839,595 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01418,729,345 - 18,748,734 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41418,767,306 - 18,787,340 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11418,767,305 - 18,787,340 (-)NCBI
Celera1416,646,603 - 16,666,030 (-)NCBICelera
Cytogenetic Map14p22NCBI
CXCL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38473,869,393 - 73,871,308 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl473,869,393 - 73,871,308 (+)EnsemblGRCh38hg38GRCh38
GRCh37474,735,110 - 74,737,025 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36474,953,973 - 74,955,817 (+)NCBINCBI36Build 36hg18NCBI36
Build 34475,100,143 - 75,101,988NCBI
Celera472,095,237 - 72,097,087 (+)NCBICelera
Cytogenetic Map4q13.3NCBI
HuRef470,546,248 - 70,548,158 (+)NCBIHuRef
CHM1_1474,771,032 - 74,772,942 (+)NCBICHM1_1
T2T-CHM13v2.0477,213,030 - 77,214,945 (+)NCBIT2T-CHM13v2.0
Cxcl3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39590,933,960 - 90,935,952 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl590,933,962 - 90,937,459 (+)EnsemblGRCm39 Ensembl
GRCm38590,786,101 - 90,788,093 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl590,786,103 - 90,789,600 (+)EnsemblGRCm38mm10GRCm38
MGSCv37591,215,129 - 91,217,116 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36591,861,303 - 91,863,290 (+)NCBIMGSCv36mm8
Celera588,937,720 - 88,939,708 (+)NCBICelera
Cytogenetic Map5E1NCBI
cM Map544.78NCBI
LOC100976904
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2356,193,010 - 56,195,078 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1456,382,200 - 56,384,184 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0450,325,248 - 50,327,165 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1456,157,626 - 56,159,522 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl456,153,899 - 56,159,474 (-)Ensemblpanpan1.1panPan2

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Variants in Cxcl3
27 total Variants

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:43
Interacting mature miRNAs:50
Transcripts:ENSRNOT00000034090
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 16 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14381307418274691Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141103081230320092Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062228035204Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat

1 to 10 of 16 rows
D14Rat77  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81417,567,968 - 17,568,235 (+)Marker Load Pipeline
Rnor_6.01418,833,818 - 18,834,102NCBIRnor6.0
Rnor_5.01418,742,995 - 18,743,279UniSTSRnor5.0
RGSC_v3.41418,781,071 - 18,782,022UniSTSRGSC3.4
Celera1416,660,252 - 16,660,493UniSTS
RH 3.4 Map14216.4RGD
RH 3.4 Map14216.4UniSTS
RH 2.0 Map14215.5RGD
SHRSP x BN Map146.92RGD
Cytogenetic Map14p22UniSTS
AI045017  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21417,270,396 - 17,270,567 (+)MAPPERmRatBN7.2
Rnor_6.01418,820,419 - 18,820,589NCBIRnor6.0
Rnor_5.01418,729,596 - 18,729,766UniSTSRnor5.0
RGSC_v3.41418,767,557 - 18,767,727UniSTSRGSC3.4
Celera1416,646,854 - 16,647,024UniSTS
RH 3.4 Map14213.6UniSTS
Cytogenetic Map14p22UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
8 8 23 81 70 71 40 23 40 6 142 64 63 22 41 31



Ensembl Acc Id: ENSRNOT00000034090   ⟹   ENSRNOP00000038520
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1417,270,146 - 17,289,380 (-)Ensembl
Rnor_6.0 Ensembl1418,820,168 - 18,839,420 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000078746   ⟹   ENSRNOP00000070985
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1417,287,726 - 17,289,511 (-)Ensembl
Rnor_6.0 Ensembl1418,837,821 - 18,839,595 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098120   ⟹   ENSRNOP00000077076
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1417,288,291 - 17,289,380 (-)Ensembl
RefSeq Acc Id: NM_001394590   ⟹   NP_001381519
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81417,571,900 - 17,573,624 (-)NCBI
mRatBN7.21417,287,727 - 17,289,451 (-)NCBI
1 to 12 of 12 rows
Protein RefSeqs NP_001381519 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAB12279 (Get FASTA)   NCBI Sequence Viewer  
  BAB12280 (Get FASTA)   NCBI Sequence Viewer  
  BAB12336 (Get FASTA)   NCBI Sequence Viewer  
  EDL88570 (Get FASTA)   NCBI Sequence Viewer  
  EDL88571 (Get FASTA)   NCBI Sequence Viewer  
  EDL88572 (Get FASTA)   NCBI Sequence Viewer  
  EDL88573 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000038520.2
  ENSRNOP00000070985
  ENSRNOP00000077076.1
GenBank Protein Q10746 (Get FASTA)   NCBI Sequence Viewer  
1 to 12 of 12 rows
Ensembl Acc Id: ENSRNOP00000038520   ⟸   ENSRNOT00000034090
Ensembl Acc Id: ENSRNOP00000070985   ⟸   ENSRNOT00000078746
Ensembl Acc Id: ENSRNOP00000077076   ⟸   ENSRNOT00000098120
RefSeq Acc Id: NP_001381519   ⟸   NM_001394590
- Peptide Label: precursor
- UniProtKB: Q5CZ55 (UniProtKB/Swiss-Prot),   Q10747 (UniProtKB/Swiss-Prot),   Q10746 (UniProtKB/Swiss-Prot),   Q9EP62 (UniProtKB/Swiss-Prot),   A6KKE0 (UniProtKB/TrEMBL),   A6KKD9 (UniProtKB/TrEMBL)
Chemokine interleukin-8-like

Name Modeler Protein Id AA Range Protein Structure
AF-Q10746-F1-model_v2 AlphaFold Q10746 1-101 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13699227
Promoter ID:EPDNEW_R9751
Type:single initiation site
Name:Cxcl3_1
Description:chemokine (C-X-C motif) ligand 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01418,839,486 - 18,839,546EPDNEW


1 to 33 of 33 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-16209 BioCyc
Ensembl Genes ENSRNOG00000028043 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000034090.4 UniProtKB/Swiss-Prot
  ENSRNOT00000078746 ENTREZGENE
  ENSRNOT00000098120.1 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.50.40 UniProtKB/Swiss-Prot
InterPro Chemokine_b/g/d UniProtKB/Swiss-Prot
  Chemokine_CXC UniProtKB/Swiss-Prot
  Chemokine_CXC_CS UniProtKB/Swiss-Prot
  Chemokine_IL8-like_dom UniProtKB/Swiss-Prot
  CXC_Chemokine_domain UniProtKB/Swiss-Prot
  Interleukin_8-like_sf UniProtKB/Swiss-Prot
NCBI Gene 171551 ENTREZGENE
PANTHER C-X-C MOTIF CHEMOKINE 3 UniProtKB/Swiss-Prot
  SMALL INDUCIBLE CYTOKINE A UniProtKB/Swiss-Prot
Pfam IL8 UniProtKB/Swiss-Prot
PhenoGen Cxcl3 PhenoGen
PRINTS INTERLEUKIN8 UniProtKB/Swiss-Prot
  SMALLCYTKCXC UniProtKB/Swiss-Prot
PROSITE SMALL_CYTOKINES_CXC UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000028043 RatGTEx
SMART SCY UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54117 UniProtKB/Swiss-Prot
UniProt A0A8L2R3J1_RAT UniProtKB/TrEMBL
  A6KKD9 ENTREZGENE, UniProtKB/TrEMBL
  A6KKE0 ENTREZGENE, UniProtKB/TrEMBL
  CXCL3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q10747 ENTREZGENE
  Q5CZ55 ENTREZGENE
  Q9EP62 ENTREZGENE
UniProt Secondary Q10747 UniProtKB/Swiss-Prot
  Q5CZ55 UniProtKB/Swiss-Prot
  Q9EP62 UniProtKB/Swiss-Prot
1 to 33 of 33 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-12-12 Cxcl3  C-X-C motif chemokine ligand 3  Cxcl3  chemokine (C-X-C motif) ligand 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-25 Cxcl3  chemokine (C-X-C motif) ligand 3  Gm1960  gene model 1960, (NCBI)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Gm1960  gene model 1960, (NCBI)  Cinc2  cytokine-induced neutrophil chemoattractant-2  Symbol and Name updated 1299863 APPROVED
2002-08-07 Cinc2  cytokine-induced neutrophil chemoattractant-2      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_product member of the CXC chemokine family 632410
gene_transcript has two splicing isoforms, CINC-2 alpha and CINC-2 beta 632410