Itga2 (integrin subunit alpha 2) - Rat Genome Database

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Gene: Itga2 (integrin subunit alpha 2) Rattus norvegicus
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Symbol: Itga2
Name: integrin subunit alpha 2
RGD ID: 621632
Description: Enables collagen binding activity; integrin binding activity; and laminin binding activity. Involved in several processes, including positive regulation of biosynthetic process; positive regulation of cell migration; and positive regulation of cellular component organization. Located in several cellular components, including axon terminus; focal adhesion; and perinuclear region of cytoplasm. Is active in presynapse. Biomarker of placental insufficiency. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); blood platelet disease (multiple); diabetes mellitus (multiple); retinal vascular disease (multiple); and von Willebrand's disease (multiple). Orthologous to human ITGA2 (integrin subunit alpha 2); PARTICIPATES IN integrin mediated signaling pathway; syndecan signaling pathway; arrhythmogenic right ventricular cardiomyopathy pathway; INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CD49B; GPIa; HPA-5; integrin alpha 2; integrin alpha-2; integrin, alpha 2; platelet glycoprotein Ia
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8248,253,412 - 48,354,509 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl248,253,412 - 48,354,509 (-)EnsemblGRCr8
mRatBN7.2246,520,345 - 46,621,487 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl246,523,948 - 46,621,481 (-)EnsemblmRatBN7.2
Rnor_6.0246,996,904 - 47,097,011 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl247,000,323 - 47,096,961 (-)Ensemblrn6Rnor6.0
Rnor_5.0271,536,102 - 71,636,203 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4246,967,681 - 47,080,909 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera242,276,508 - 42,376,910 (-)NCBICelera
Cytogenetic Map2q14NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+)-schisandrin B  (EXP)
(D-Ala(2)-mephe(4)-gly-ol(5))enkephalin  (ISO)
(R)-adrenaline  (ISO)
1,2-dichloroethane  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,6-dimethoxyphenol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
8-Br-cAMP  (ISO)
acetylsalicylic acid  (ISO)
ADP  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-amanitin  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (EXP,ISO)
atrazine  (EXP)
belinostat  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbamazepine  (ISO)
carnosic acid  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
clopidogrel  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
Didecyldimethylammonium  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enalapril  (ISO)
Enterolactone  (ISO)
ethanol  (EXP)
fenfluramine  (ISO)
Fulvic acid  (ISO)
furfural  (ISO)
genistein  (ISO)
geranylgeraniol  (EXP,ISO)
glyphosate  (ISO)
histamine  (EXP)
hydrogen peroxide  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
irinotecan  (ISO)
ivermectin  (ISO)
leflunomide  (ISO)
medroxyprogesterone acetate  (ISO)
methylisothiazolinone  (ISO)
mevalonic acid  (EXP,ISO)
mifepristone  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
morusin  (ISO)
Muraglitazar  (EXP)
N-acetyl-L-cysteine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nevirapine  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paclitaxel  (EXP)
paracetamol  (ISO)
paricalcitol  (ISO)
PD 0325901  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP,ISO)
progesterone  (EXP,ISO)
prostaglandin E2  (EXP,ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
Rutecarpine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
serotonin  (EXP,ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sotorasib  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
titanium dioxide  (ISO)
trametinib  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell adhesion  (IEA)
cell adhesion mediated by integrin  (IEA,ISO)
cell-cell adhesion  (IBA)
cell-matrix adhesion  (IEA,ISO)
cell-substrate adhesion  (IEA,ISO)
cellular response to estradiol stimulus  (IEP)
cellular response to mechanical stimulus  (IEP)
collagen-activated signaling pathway  (IEA,ISO)
detection of mechanical stimulus involved in sensory perception of pain  (IMP)
female pregnancy  (IEP)
focal adhesion assembly  (IMP)
hepatocyte differentiation  (IEP)
hypotonic response  (IMP)
integrin-mediated signaling pathway  (IBA,IEA,ISO)
mammary gland development  (IEP)
mesodermal cell differentiation  (IEA,ISO)
positive regulation of alkaline phosphatase activity  (IMP)
positive regulation of cell adhesion  (IMP)
positive regulation of cell projection organization  (IMP)
positive regulation of collagen biosynthetic process  (IMP)
positive regulation of DNA binding  (IMP)
positive regulation of epithelial cell migration  (IMP)
positive regulation of leukocyte migration  (IMP)
positive regulation of phagocytosis, engulfment  (IMP)
positive regulation of positive chemotaxis  (IMP)
positive regulation of smooth muscle cell migration  (IMP)
positive regulation of smooth muscle cell proliferation  (IMP)
positive regulation of smooth muscle contraction  (IMP)
positive regulation of translation  (IMP)
positive regulation of transmission of nerve impulse  (IMP)
response to amine  (IEP)
response to hypoxia  (IEP)
response to L-ascorbic acid  (IEP)
response to muscle activity  (IEP)
response to parathyroid hormone  (IEP)
response to xenobiotic stimulus  (IEP)
skin morphogenesis  (IMP)
substrate-dependent cell migration  (IEA,ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Interaction of transient receptor potential vanilloid 4, integrin, and SRC tyrosine kinase in mechanical hyperalgesia. Alessandri-Haber N, etal., J Neurosci. 2008 Jan 30;28(5):1046-57.
2. Genetic polymorphisms of platelet glycoprotein Ia and the risk for premature myocardial infarction: effects on the release of sCD40L during the acute phase of premature myocardial infarction. Antoniades C, etal., J Am Coll Cardiol. 2006 May 16;47(10):1959-66. Epub 2006 Apr 27.
3. Platelet glycoprotein Ia gene dimorphism alpha2-807 in malignant arrhythmia in coronary artery disease. Anvari A, etal., Thromb Res. 2000 May 15;98(4):281-6.
4. No association between the ITGA2 807T allele and retinopathy in french patients with type 2 diabetes. Arsene S, etal., Thromb Res. 2011 Sep;128(3):293-5. doi: 10.1016/j.thromres.2011.05.009. Epub 2011 Jun 1.
5. Association analysis of genetic variations of eNOS and alpha2beta1 integrin genes with type 2 diabetic retinopathy. Azmy R, etal., Appl Clin Genet. 2012 Jul 24;5:55-65. doi: 10.2147/TACG.S31979. Print 2012.
6. Idiopathic sudden sensorineural hearing loss: classic cardiovascular and new genetic risk factors. Ballesteros F, etal., Audiol Neurootol. 2012;17(6):400-8. doi: 10.1159/000341989. Epub 2012 Aug 30.
7. Differential integrin expression by cardiac fibroblasts from hypertensive and exercise-trained rat hearts. Burgess ML, etal., Cardiovasc Pathol. 2002 Mar-Apr;11(2):78-87.
8. Iron deficiency anaemia in young women. Carlsson LE, etal., Eur J Haematol. 2002 Jun;68(6):341-4.
9. Infiltrating cells and IFNgamma production in the injected eye after uniocular anterior chamber inoculation of HSV-1. Cathcart HM, etal., Invest Ophthalmol Vis Sci. 2009 May;50(5):2269-75. doi: 10.1167/iovs.08-2874.
10. Syndecan-2 overexpression regulates adhesion and migration through cooperation with integrin alpha2. Choi S, etal., Biochem Biophys Res Commun. 2009 Jun 26;384(2):231-5. Epub 2009 Apr 24.
11. The integrin alpha2beta1 agonist, aggretin, promotes proliferation and migration of VSMC through NF-kB translocation and PDGF production. Chung CH, etal., Br J Pharmacol. 2009 Mar;156(5):846-56. Epub 2009 Feb 23.
12. Collagen platelet receptor polymorphisms integrin alpha2beta1 C807T and GPVI Q317L and risk of ischemic stroke. Cole VJ, etal., J Thromb Haemost. 2003 May;1(5):963-70.
13. Glanzmann's thrombasthenia: modulation of clinical phenotype by alpha2C807T gene polymorphism. D'Andrea G and Margaglione M, Haematologica. 2003 Dec;88(12):1378-82.
14. The platelet glycoprotein Ia/IIa gene polymorphism C807T/G873A: a novel risk factor for retinal vein occlusion. Dodson PM, etal., Eye (Lond). 2003 Aug;17(6):772-7.
15. Improved metabolic control decreases platelet activation markers in patients with type-2 diabetes. Eibl N, etal., Eur J Clin Invest. 2004 Mar;34(3):205-9.
16. Distribution of alpha and beta integrin subunits in the adult rat hippocampus after pilocarpine-induced neuronal cell loss, axonal reorganization and reactive astrogliosis. Fasen K, etal., Acta Neuropathol. 2003 Oct;106(4):319-22. Epub 2003 Jul 8.
17. Crucial role of fibroblast integrins alpha2 and beta1 in maintaining the structural and mechanical properties of the skin. Fujimura T, etal., J Dermatol Sci. 2007 Jan;45(1):45-53. Epub 2006 Nov 21.
18. Ascorbic acid alters collagen integrins in bone culture. Ganta DR, etal., Endocrinology. 1997 Sep;138(9):3606-12.
19. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
20. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
21. Placental gene expression in a rat 'model' of placental insufficiency. Goyal R, etal., Placenta. 2010 Jul;31(7):568-75. Epub 2010 Jun 8.
22. Plasmacytoid precursor dendritic cells from NOD mice exhibit impaired function: are they a component of diabetes pathogenesis? Huang Y, etal., Diabetes. 2008 Sep;57(9):2360-70. Epub 2008 Jun 20.
23. Collagen phagocytosis and apoptosis are induced by high level alkaline phosphatase expression in rat fibroblasts. Hui MZ, etal., J Cell Physiol. 1997 Sep;172(3):323-33.
24. Modulation of alpha2beta1 integrin changes during mammary gland development by beta-oestradiol. Iype T, etal., Biochim Biophys Acta. 2001 Jan 15;1499(3):232-41.
25. Progesterone modulates integrin {alpha}2 (ITGA2) and {alpha}11 (ITGA11) in the pregnant cervix. Ji H, etal., Reprod Sci. 2011 Feb;18(2):156-63. doi: 10.1177/1933719110382305. Epub 2010 Oct 19.
26. Distribution of integrin subunits in human diabetic kidneys. Jin DK, etal., J Am Soc Nephrol. 1996 Dec;7(12):2636-45.
27. Parathyroid hormone (1-34) regulates integrin expression in vivo in rat osteoblasts. Kaiser E, etal., J Cell Biochem 2001;83(4):617-30.
28. Decreased expression of alpha2 integrin in fibroblasts isolated from cyclosporin A- induced gingival overgrowth in rats. Kataoka M, etal., J Periodontal Res 2003 Oct;38(5):533-7.
29. Integrin alpha2beta1 affects mechano-transduction in slowly and rapidly adapting cutaneous mechanoreceptors in rat hairy skin. Khalsa PS, etal., Neuroscience. 2004;129(2):447-59.
30. The expression of mesenchymal, neural and haematopoietic stem cell markers in adult hepatocytes proliferating in vitro. Koenig S, etal., J Hepatol. 2006 Jun;44(6):1115-24. Epub 2005 Nov 7.
31. Enhanced laminin carbonylation by monocytes in diabetes mellitus. Kostidou E, etal., Clin Biochem. 2007 Jun;40(9-10):671-9. Epub 2007 Mar 28.
32. An association of candidate gene haplotypes and bleeding severity in von Willebrand disease (VWD) type 1 pedigrees. Kunicki TJ, etal., Blood. 2004 Oct 15;104(8):2359-67. Epub 2004 Jun 29.
33. An association of candidate gene haplotypes and bleeding severity in von Willebrand disease type 2A, 2B, and 2M pedigrees. Kunicki TJ, etal., J Thromb Haemost. 2006 Jan;4(1):137-47.
34. Polymorphisms of PAI-1 and platelet GP Ia may associate with impairment of renal function and thrombocytopenia in Puumala hantavirus infection. Laine O, etal., Thromb Res. 2012 May;129(5):611-5. doi: 10.1016/j.thromres.2011.11.007. Epub 2011 Nov 30.
35. Predominance of NK1.1+TCR alpha beta+ or DX5+TCR alpha beta+ T cells in mice conditioned with fractionated lymphoid irradiation protects against graft-versus-host disease: "natural suppressor" cells. Lan F, etal., J Immunol. 2001 Aug 15;167(4):2087-96.
36. EDN1 Lys198Asn is associated with diabetic retinopathy in type 2 diabetes. Li H, etal., Mol Vis. 2008 Sep 15;14:1698-704.
37. [The effect of mechanical stimulation on the expression of alpha 2, beta 1, beta 3 integrins and the proliferation, synthetic function in rat osteoblasts] Li L, etal., Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2003 Jun;20(2):187-92.
38. Prevention of embryo loss in non-obese diabetic mice using adoptive ITGA2(+)ISG20(+) natural killer-cell transfer. Lin Y, etal., Reproduction. 2009 Jun;137(6):943-55. Epub 2009 Mar 25.
39. Polymorphism in Integrin ITGA2 is Associated with Ischemic Stroke and Altered Serum Cholesterol in Chinese Individuals. Lu JX, etal., Balkan Med J. 2014 Mar;31(1):55-9. doi: 10.5152/balkanmedj.2013.7993. Epub 2014 Mar 1.
40. Integrin alpha2beta1 regulates neutrophil recruitment and inflammatory activity in experimental colitis in mice. Lundberg S, etal., Inflamm Bowel Dis. 2006 Mar;12(3):172-7.
41. The 807T allele in alpha2 integrin is protective against atherosclerotic arterial wall thickening and the occurrence of plaque in patients with type 2 diabetes. Maeno T, etal., Diabetes. 2002 May;51(5):1523-8.
42. Role of MT1-MMP in the osteogenic differentiation. Manduca P, etal., Bone. 2009 Feb;44(2):251-65. Epub 2008 Nov 5.
43. A mandibular propulsive appliance modulates collagen-binding integrins distribution in the young rat condylar cartilage. Marques MR, etal., Biorheology. 2006;43(3-4):293-302.
44. Glomerular epithelial and mesangial cells differentially modulate the binding specificities of VLA-1 and VLA-2. Mendrick DL, etal., Lab Invest. 1995 Mar;72(3):367-75.
45. Time course of changes in serum glucose, insulin, lipids and tissue lipase activities in macrosomic offspring of rats with streptozotocin-induced diabetes. Merzouk H, etal., Clin Sci (Lond). 2000 Jan;98(1):21-30.
46. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
47. Type I collagen-induced osteoblastic differentiation of bone-marrow cells mediated by collagen-alpha2beta1 integrin interaction. Mizuno M, etal., J Cell Physiol. 2000 Aug;184(2):207-13.
48. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
49. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
50. Phenotypic heterogeneity influences the behavior of rat aortic smooth muscle cells in collagen lattice. Orlandi A, etal., Exp Cell Res. 2005 Dec 10;311(2):317-27. Epub 2005 Nov 2.
51. Association of the gene polymorphisms of platelet glycoprotein Ia and IIb/IIIa with myocardial infarction and extent of coronary artery disease in the Korean population. Park S, etal., Yonsei Med J. 2004 Jun 30;45(3):428-34.
52. Platelet membrane glycoprotein polymorphisms do not influence the clinical expressivity of von Willebrand disease type 1. Pereira J, etal., Thromb Haemost. 2003 Dec;90(6):1135-40.
53. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
54. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
55. Polymorphism of the glycoprotein Ia and IIIa in the group of women in childbirth does not correlate with an increased risk of developing thrombosis. Podciechowski L, etal., Neuro Endocrinol Lett. 2005 Dec;26(6):789-94.
56. Association of the platelet glycoprotein Ia C807T/G873A gene polymorphism and thrombosis in Behcet patients. Polat G, etal., Haematologia (Budap). 2002;32(2):121-8.
57. The role of alpha1beta1 integrin in wound contraction. A quantitative analysis of liver myofibroblasts in vivo and in primary culture. Racine-Samson L, etal., J Biol Chem. 1997 Dec 5;272(49):30911-7.
58. Diabetes duration may modify the association between genetic variation in the glycoprotein Ia subunit of the platelet collagen receptor and risk of severe diabetic retinopathy: a working hypothesis. Reiner AP, etal., Thromb Haemost. 2003 Jan;89(1):142-8.
59. GOA pipeline RGD automated data pipeline
60. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
61. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
62. Differential effects of CD18, CD29, and CD49 integrin subunit inhibition on neutrophil migration in pulmonary inflammation. Ridger VC, etal., J Immunol. 2001 Mar 1;166(5):3484-90.
63. Differentiation of mesenchymal stem cells towards a nucleus pulposus-like phenotype in vitro: implications for cell-based transplantation therapy. Risbud MV, etal., Spine. 2004 Dec 1;29(23):2627-32.
64. Hypoxia activates MAPK activity in rat nucleus pulposus cells: regulation of integrin expression and cell survival. Risbud MV, etal., Spine. 2005 Nov 15;30(22):2503-9.
65. Vascular risk factors in sudden hearing loss. Rudack C, etal., Thromb Haemost. 2006 Mar;95(3):454-61.
66. Polyamines are important for attachment of IEC-6 cells to extracellular matrix. Santos MF, etal., Am J Physiol. 1997 Jul;273(1 Pt 1):G175-83.
67. Association of the platelet glycoprotein Ia C807T gene polymorphism with nonfatal myocardial infarction in younger patients. Santoso S, etal., Blood. 1999 Apr 15;93(8):2449-53.
68. Induction of cellular processes containing collagenase and retinoid by integrin-binding to interstitial collagen in hepatic stellate cell culture. Sato M, etal., Cell Biol Int. 1998;22(2):115-25.
69. Distinct structural forms of type I collagen modulate cell cycle regulatory proteins in mesangial cells. Schocklmann HO, etal., Kidney Int. 2000 Sep;58(3):1108-20.
70. Inherited platelet glycoprotein polymorphisms and a risk for coronary heart disease in young central Europeans. Sperr WR, etal., Thromb Res. 1998 May 1;90(3):117-23.
71. The integrins. Takada Y, etal., Genome Biol. 2007;8(5):215.
72. Differential susceptibility of osteosarcoma cells and primary osteoblasts to cell detachment caused by snake venom metalloproteinase protein. Tang CH, etal., Toxicon. 2004 Jan;43(1):11-20.
73. Alpha 2 beta 1 integrin is required for the collagen and FGF-1 induced cell dispersion in a rat bladder carcinoma cell line. Valles AM, etal., Cell Adhes Commun. 1996 Sep;4(3):187-99.
74. Smooth muscle actin determines mechanical force-induced p38 activation. Wang J, etal., J Biol Chem. 2005 Feb 25;280(8):7273-84. Epub 2004 Dec 9.
75. Improvement of fertility with adoptive CD25+ natural killer cell transfer in subfertile non-obese diabetic mice. Wang W, etal., Reprod Biomed Online. 2009 Jan;18(1):95-103.
76. The thrombospondin receptor CD47 (IAP) modulates and associates with alpha2 beta1 integrin in vascular smooth muscle cells. Wang XQ and Frazier WA, Mol Biol Cell. 1998 Apr;9(4):865-74.
77. Role of thrombophilic gene polymorphisms in branch retinal vein occlusion. Weger M, etal., Ophthalmology. 2005 Nov;112(11):1910-5. Epub 2005 Sep 12.
78. Integrin alpha(2)beta(1) (VLA-2) is a principal receptor used by neutrophils for locomotion in extravascular tissue. Werr J, etal., Blood. 2000 Mar 1;95(5):1804-9.
79. Complex patterns of expression suggest extensive roles for the alpha 2 beta 1 integrin in murine development. Wu JE and Santoro SA, Dev Dyn 1994 Apr;199(4):292-314.
80. Identification of a heparin binding site and the biological activities of the laminin alpha1 chain carboxy-terminal globular domain. Yoshida I, etal., J Cell Physiol. 1999 Apr;179(1):18-28.
81. Correlation between the polymorphism of glycoprotein Ia gene and acute coronary syndrome. Zhao Y, etal., Chin Med Sci J. 2004 Mar;19(1):13-8.
Additional References at PubMed
PMID:11518510   PMID:11767049   PMID:14707119   PMID:15811857   PMID:16973387   PMID:18098323   PMID:19581412   PMID:19648922   PMID:19933311   PMID:20563599   PMID:20818394   PMID:21126803  
PMID:21310825   PMID:21423176   PMID:23023225   PMID:23154389   PMID:23382103   PMID:23658023   PMID:24823363   PMID:25336636   PMID:27169768   PMID:27827993   PMID:29023021   PMID:31964805  


Genomics

Comparative Map Data
Itga2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8248,253,412 - 48,354,509 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl248,253,412 - 48,354,509 (-)EnsemblGRCr8
mRatBN7.2246,520,345 - 46,621,487 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl246,523,948 - 46,621,481 (-)EnsemblmRatBN7.2
Rnor_6.0246,996,904 - 47,097,011 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl247,000,323 - 47,096,961 (-)Ensemblrn6Rnor6.0
Rnor_5.0271,536,102 - 71,636,203 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4246,967,681 - 47,080,909 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera242,276,508 - 42,376,910 (-)NCBICelera
Cytogenetic Map2q14NCBI
ITGA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38552,989,352 - 53,094,779 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl552,989,320 - 53,094,779 (+)Ensemblhg38GRCh38
GRCh37552,285,182 - 52,390,609 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36552,320,913 - 52,426,366 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34552,321,013 - 52,423,947NCBI
Celera549,238,739 - 49,344,187 (+)NCBICelera
Cytogenetic Map5q11.2NCBI
HuRef549,257,212 - 49,362,658 (+)NCBIHuRef
CHM1_1552,287,738 - 52,393,158 (+)NCBICHM1_1
T2T-CHM13v2.0553,817,115 - 53,922,565 (+)NCBIT2T-CHM13v2.0
Itga2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913114,969,617 - 115,068,588 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13114,969,617 - 115,068,636 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3813114,833,081 - 114,932,100 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13114,833,081 - 114,932,100 (-)Ensemblmm10GRCm38
MGSCv3713115,626,120 - 115,722,249 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3613115,956,790 - 116,052,919 (-)NCBIMGSCv36mm8
Celera13119,179,611 - 119,279,864 (-)NCBICelera
Cytogenetic Map13D2.2NCBI
cM Map1364.61NCBI
Itga2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544614,309,349 - 14,422,170 (-)Ensembl
ChiLan1.0NW_00495544614,309,516 - 14,421,991 (-)NCBIChiLan1.0ChiLan1.0
ITGA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2460,843,032 - 60,952,088 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1558,996,794 - 59,105,394 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0560,935,452 - 61,040,726 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1562,554,387 - 62,659,641 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl562,555,370 - 62,659,720 (-)EnsemblpanPan2panpan1.1
ITGA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1462,170,137 - 62,268,962 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl462,170,452 - 62,268,983 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha461,941,741 - 62,043,869 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0462,664,801 - 62,766,959 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl462,668,472 - 62,766,954 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1462,440,055 - 62,542,152 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0462,564,620 - 62,666,770 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0463,091,317 - 63,193,515 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Itga2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213205,383,765 - 205,481,351 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648014,320,692 - 14,417,786 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648014,320,292 - 14,417,828 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITGA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1632,336,292 - 32,437,103 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11632,336,240 - 32,440,311 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21634,164,830 - 34,262,490 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ITGA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1449,280,289 - 49,382,101 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl449,317,648 - 49,380,051 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660821,745,561 - 1,848,173 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itga2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247596,281,561 - 6,376,712 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247596,281,698 - 6,376,702 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Itga2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13181,794,006 - 181,881,118 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Itga2
575 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:127
Count of miRNA genes:112
Interacting mature miRNAs:119
Transcripts:ENSRNOT00000015940
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21332504158325041Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22411781369117813Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23675034481750344Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
9590080Insglur4Insulin/glucose ratio QTL 428.70.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)2615276751152767Rat
1300160Hrtrt3Heart rate QTL 33.62heart pumping trait (VT:2000009)absolute change in heart rate (CMO:0000534)23561408353462005Rat
1579916Bp270Blood pressure QTL 2700.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21605188361051883Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22203804467038044Rat
731166Mamtr2Mammary tumor resistance QTL 20.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2962358154623581Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)240306867124537199Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
9685065Swd6Spike wave discharge measurement QTL 65.80.01brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge rate (CMO:0001739)24095742350526673Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22888999173889991Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)241801363104744824Rat
1331764Bp205Blood pressure QTL 2053.476arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21436870759368707Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)24490435585286097Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)244537979112567334Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)27605533104774005Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266683465677Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)2573632550736325Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)238426449111295694Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21822713763227137Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23686864381868643Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)24490435589904355Rat
1582246Cm60Cardiac mass QTL 605.8heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)23326999678269996Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266673652666Rat

Markers in Region
Itga2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2881,370,500 - 81,371,432 (+)MAPPERmRatBN7.2
mRatBN7.25151,753,551 - 151,753,981 (+)MAPPERmRatBN7.2
Rnor_6.05157,965,849 - 157,966,278NCBIRnor6.0
Rnor_6.0887,860,151 - 87,861,082NCBIRnor6.0
Rnor_5.05161,705,374 - 161,705,803UniSTSRnor5.0
Rnor_5.0887,397,241 - 87,398,172UniSTSRnor5.0
RGSC_v3.45158,300,223 - 158,300,652UniSTSRGSC3.4
RGSC_v3.4885,503,428 - 85,504,359UniSTSRGSC3.4
Celera5150,133,234 - 150,133,663UniSTS
Cytogenetic Map8q31UniSTS
Cytogenetic Map2q14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 66 144 87 86 55 92 55 6 345 191 11 123 75 91 31 12 12

Sequence


Ensembl Acc Id: ENSRNOT00000077401   ⟹   ENSRNOP00000072929
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl248,253,412 - 48,354,509 (-)Ensembl
mRatBN7.2 Ensembl246,523,948 - 46,621,481 (-)Ensembl
Rnor_6.0 Ensembl247,000,323 - 47,096,961 (-)Ensembl
RefSeq Acc Id: NM_001427291   ⟹   NP_001414220
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8248,253,412 - 48,354,509 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001414220 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAB62267 (Get FASTA)   NCBI Sequence Viewer  
  EDM10390 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000072929
  ENSRNOP00000072929.1
Ensembl Acc Id: ENSRNOP00000072929   ⟸   ENSRNOT00000077401
RefSeq Acc Id: NP_001414220   ⟸   NM_001427291
- Peptide Label: precursor
- UniProtKB: A0A0G2K470 (UniProtKB/TrEMBL),   A6I5T2 (UniProtKB/TrEMBL)
Protein Domains
VWFA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K470-F1-model_v2 AlphaFold A0A0G2K470 1-1178 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691158
Promoter ID:EPDNEW_R1673
Type:multiple initiation site
Name:Itga2_1
Description:integrin subunit alpha 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0247,096,969 - 47,097,029EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621632 AgrOrtholog
BioCyc Gene G2FUF-54326 BioCyc
Ensembl Genes ENSRNOG00000058111 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000077401 ENTREZGENE
  ENSRNOT00000077401.3 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.130 UniProtKB/TrEMBL
  3.40.50.410 UniProtKB/TrEMBL
  Bicelle-embedded integrin alpha(iib) transmembrane segment UniProtKB/TrEMBL
  Integrin domains. Chain A, domain 2 UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 3 UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 4 UniProtKB/TrEMBL
InterPro FG-GAP UniProtKB/TrEMBL
  Int_alpha_beta-p UniProtKB/TrEMBL
  Integrin_alpha UniProtKB/TrEMBL
  Integrin_alpha_C_CS UniProtKB/TrEMBL
  Integrin_alpha_Ig-like_2 UniProtKB/TrEMBL
  Integrin_alpha_Ig-like_3 UniProtKB/TrEMBL
  Integrin_alpha_N UniProtKB/TrEMBL
  Integrin_dom UniProtKB/TrEMBL
  VWF_A UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/TrEMBL
NCBI Gene 170921 ENTREZGENE
PANTHER INTEGRIN ALPHA UniProtKB/TrEMBL
  INTEGRIN ALPHA-2 UniProtKB/TrEMBL
Pfam FG-GAP UniProtKB/TrEMBL
  Integrin_A_Ig_2 UniProtKB/TrEMBL
  Integrin_A_Ig_3 UniProtKB/TrEMBL
  Integrin_alpha UniProtKB/TrEMBL
  VWA UniProtKB/TrEMBL
PharmGKB ITGA2 RGD
PhenoGen Itga2 PhenoGen
PRINTS INTEGRINA UniProtKB/TrEMBL
  VWFADOMAIN UniProtKB/TrEMBL
PROSITE FG_GAP UniProtKB/TrEMBL
  INTEGRIN_ALPHA UniProtKB/TrEMBL
  VWFA UniProtKB/TrEMBL
RatGTEx ENSRNOG00000058111 RatGTEx
SMART Int_alpha UniProtKB/TrEMBL
  VWA UniProtKB/TrEMBL
Superfamily-SCOP SSF53300 UniProtKB/TrEMBL
  SSF69179 UniProtKB/TrEMBL
  SSF69318 UniProtKB/TrEMBL
UniProt A0A0G2K470 ENTREZGENE, UniProtKB/TrEMBL
  A6I5T2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-02-07 Itga2  integrin subunit alpha 2  Itga2  integrin alpha 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-02 Itga2  integrin alpha 2  Itga2  integrin, alpha 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Itga2  integrin, alpha 2    integrin alpha 2  Name updated 1299863 APPROVED
2002-08-07 Itga2  integrin alpha 2      Symbol and Name status set to provisional 70820 PROVISIONAL