Ndrg4 (NDRG family member 4) - Rat Genome Database

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Gene: Ndrg4 (NDRG family member 4) Rattus norvegicus
Analyze
Symbol: Ndrg4
Name: NDRG family member 4
RGD ID: 621593
Description: Involved in positive regulation of ERK1 and ERK2 cascade and positive regulation of neuron projection development. Located in endoplasmic reticulum membrane. Orthologous to human NDRG4 (NDRG family member 4); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AF045564; Bdm1; brain development-related molecule 1; development-related protein; N-myc downstream regulated 4; N-myc downstream regulated gene 4; Ndr4; smap8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8199,357,470 - 9,393,465 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl199,357,470 - 9,392,972 (-)EnsemblGRCr8
mRatBN7.2199,351,408 - 9,387,398 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl199,351,404 - 9,386,914 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx199,319,881 - 9,355,408 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01910,086,712 - 10,122,239 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0199,373,028 - 9,408,555 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0199,766,439 - 9,802,396 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl199,766,439 - 9,801,942 (-)Ensemblrn6Rnor6.0
Rnor_5.0199,751,517 - 9,787,463 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4199,808,017 - 9,818,974 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera199,246,398 - 9,281,901 (-)NCBICelera
RGSC_v3.1199,812,842 - 9,823,800 (-)NCBI
Cytogenetic Map19p13NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
Allylamine  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
diethyl phthalate  (EXP)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
diquat  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
folic acid  (ISO)
glycine betaine  (EXP)
indometacin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
nickel atom  (ISO)
Nutlin-3  (ISO)
okadaic acid  (ISO)
paracetamol  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
progesterone  (EXP)
propanal  (ISO)
raloxifene  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sotorasib  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
taurine  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
trametinib  (ISO)
troglitazone  (ISO)
uranium atom  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
WIN 55212-2  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. NDRG4 is downregulated in glioblastoma and inhibits cell proliferation. Ding W, etal., OMICS. 2012 May;16(5):263-7. doi: 10.1089/omi.2011.0146. Epub 2012 Apr 10.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Ndrg4 enhances NGF-induced ERK activation uncoupled with Elk-1 activation. Hongo S, etal., J Cell Biochem. 2006 May 1;98(1):185-93.
4. Downregulation of N-Myc downstream-regulated gene 4 influences patient survival in gliomas. Li S, etal., Brain Tumor Pathol. 2013 Jan;30(1):8-14. doi: 10.1007/s10014-012-0092-2. Epub 2012 Mar 8.
5. Molecular characterization of NDRG4/Bdm1 protein isoforms that are differentially regulated during rat brain development. Nakada N, etal., Brain Res Dev Brain Res 2002 Apr 30;135(1-2):45-53.
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. A novel homocysteine-responsive gene, smap8, modulates mitogenesis in rat vascular smooth muscle cells. Nishimoto S, etal., Eur J Biochem 2003 Jun;270(11):2521-31.
8. Inhibition of neurite outgrowth by reduced level of NDRG4 protein in antisense transfected PC12 cells. Ohki T, etal., Brain Res Dev Brain Res 2002 Apr 30;135(1-2):55-63.
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. NDRG4 protein-deficient mice exhibit spatial learning deficits and vulnerabilities to cerebral ischemia. Yamamoto H, etal., J Biol Chem. 2011 Jul 22;286(29):26158-65. doi: 10.1074/jbc.M111.256446. Epub 2011 Jun 2.
13. Molecular cloning and characterization of a novel developmentally regulated gene, Bdm1, showing predominant expression in postnatal rat brain. Yamauchi Y, etal., Brain Res Mol Brain Res 1999 May 7;68(1-2):149-58.
Additional References at PubMed
PMID:14693380   PMID:17465030   PMID:17998568   PMID:19193716   PMID:19535783   PMID:24048452   PMID:26780215   PMID:28131823   PMID:30593880   PMID:32048632  


Genomics

Comparative Map Data
Ndrg4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8199,357,470 - 9,393,465 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl199,357,470 - 9,392,972 (-)EnsemblGRCr8
mRatBN7.2199,351,408 - 9,387,398 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl199,351,404 - 9,386,914 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx199,319,881 - 9,355,408 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01910,086,712 - 10,122,239 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0199,373,028 - 9,408,555 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0199,766,439 - 9,802,396 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl199,766,439 - 9,801,942 (-)Ensemblrn6Rnor6.0
Rnor_5.0199,751,517 - 9,787,463 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4199,808,017 - 9,818,974 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera199,246,398 - 9,281,901 (-)NCBICelera
RGSC_v3.1199,812,842 - 9,823,800 (-)NCBI
Cytogenetic Map19p13NCBI
NDRG4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381658,463,715 - 58,515,387 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1658,462,846 - 58,513,628 (+)Ensemblhg38GRCh38
GRCh371658,497,619 - 58,547,523 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361657,055,118 - 57,105,024 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341657,079,160 - 57,105,023NCBI
Celera1642,996,552 - 43,046,481 (+)NCBICelera
Cytogenetic Map16q21NCBI
HuRef1644,366,336 - 44,415,505 (+)NCBIHuRef
CHM1_11659,904,745 - 59,954,713 (+)NCBICHM1_1
T2T-CHM13v2.01664,258,952 - 64,310,470 (+)NCBIT2T-CHM13v2.0
Ndrg4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39896,403,602 - 96,441,584 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl896,403,608 - 96,441,747 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38895,676,974 - 95,714,956 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl895,676,980 - 95,715,119 (+)Ensemblmm10GRCm38
MGSCv37898,226,963 - 98,238,856 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36898,592,192 - 98,604,085 (+)NCBIMGSCv36mm8
Celera8100,013,817 - 100,025,880 (+)NCBICelera
Cytogenetic Map8D1NCBI
cM Map847.12NCBI
Ndrg4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543315,914,823 - 15,933,659 (+)Ensembl
ChiLan1.0NW_00495543315,914,884 - 15,933,000 (+)NCBIChiLan1.0ChiLan1.0
NDRG4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21867,924,082 - 67,974,779 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11673,847,649 - 73,898,326 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01638,729,616 - 38,780,173 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11657,857,414 - 57,907,557 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1657,857,414 - 57,907,557 (+)EnsemblpanPan2panpan1.1
NDRG4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1258,144,113 - 58,160,885 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl258,144,105 - 58,183,470 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha254,774,500 - 54,814,175 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0258,682,946 - 58,722,669 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl258,682,172 - 58,722,648 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1255,512,573 - 55,552,254 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0256,519,817 - 56,560,052 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0257,414,873 - 57,454,588 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ndrg4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934949,292,489 - 49,334,543 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647510,255,197 - 10,296,620 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647510,254,511 - 10,296,593 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NDRG4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl620,223,667 - 20,265,576 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1620,222,876 - 20,265,581 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2618,283,793 - 18,326,496 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NDRG4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1544,402,021 - 44,452,829 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl544,402,453 - 44,455,245 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604731,718,955 - 31,769,835 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ndrg4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474627,763,055 - 27,802,729 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474627,763,055 - 27,803,622 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ndrg4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1172,498,788 - 2,534,593 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ndrg4
139 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:654
Count of miRNA genes:197
Interacting mature miRNAs:231
Transcripts:ENSRNOT00000017413, ENSRNOT00000017494, ENSRNOT00000051414
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131969901Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19799775052997750Rat
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124694445Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19799775052997750Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19799775052997750Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19799775052997750Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)19574806450748064Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127361636Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 83 59 6 347 183 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001271091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_031967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006255123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF045564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF524894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH013091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY217029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY217030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY217031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY217032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY217033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY255791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB585874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB713901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM054107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000017413   ⟹   ENSRNOP00000017413
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl199,357,470 - 9,368,496 (-)Ensembl
mRatBN7.2 Ensembl199,351,404 - 9,362,435 (-)Ensembl
Rnor_6.0 Ensembl199,766,439 - 9,777,465 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000017494   ⟹   ENSRNOP00000017494
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl199,357,470 - 9,392,972 (-)Ensembl
mRatBN7.2 Ensembl199,351,408 - 9,386,914 (-)Ensembl
Rnor_6.0 Ensembl199,766,439 - 9,801,942 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000051414   ⟹   ENSRNOP00000044520
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl199,357,470 - 9,392,972 (-)Ensembl
mRatBN7.2 Ensembl199,351,408 - 9,386,914 (-)Ensembl
Rnor_6.0 Ensembl199,766,439 - 9,801,942 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110322   ⟹   ENSRNOP00000091492
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl199,357,470 - 9,392,972 (-)Ensembl
mRatBN7.2 Ensembl199,351,408 - 9,369,546 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115384   ⟹   ENSRNOP00000079935
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl199,357,470 - 9,392,972 (-)Ensembl
mRatBN7.2 Ensembl199,351,408 - 9,386,914 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116737   ⟹   ENSRNOP00000084746
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl199,357,470 - 9,371,484 (-)Ensembl
mRatBN7.2 Ensembl199,351,414 - 9,362,394 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117717   ⟹   ENSRNOP00000082556
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl199,357,470 - 9,367,548 (-)Ensembl
mRatBN7.2 Ensembl199,351,545 - 9,362,403 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119566   ⟹   ENSRNOP00000085740
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl199,357,470 - 9,367,476 (-)Ensembl
mRatBN7.2 Ensembl199,351,430 - 9,369,546 (-)Ensembl
RefSeq Acc Id: NM_001271091   ⟹   NP_001258020
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8199,357,470 - 9,392,972 (-)NCBI
mRatBN7.2199,351,408 - 9,386,914 (-)NCBI
Rnor_6.0199,766,439 - 9,801,942 (-)NCBI
Rnor_5.0199,751,517 - 9,787,463 (-)NCBI
Celera199,246,398 - 9,281,901 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001271092   ⟹   NP_001258021
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8199,357,470 - 9,392,972 (-)NCBI
mRatBN7.2199,351,408 - 9,386,914 (-)NCBI
Rnor_6.0199,766,439 - 9,801,942 (-)NCBI
Rnor_5.0199,751,517 - 9,787,463 (-)NCBI
Celera199,246,398 - 9,281,901 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001271093   ⟹   NP_001258022
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8199,357,470 - 9,380,294 (-)NCBI
mRatBN7.2199,351,408 - 9,374,234 (-)NCBI
Rnor_6.0199,766,439 - 9,789,263 (-)NCBI
Rnor_5.0199,751,517 - 9,787,463 (-)NCBI
Celera199,246,398 - 9,269,222 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001271094   ⟹   NP_001258023
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8199,357,470 - 9,380,294 (-)NCBI
mRatBN7.2199,351,408 - 9,374,234 (-)NCBI
Rnor_6.0199,766,439 - 9,789,263 (-)NCBI
Rnor_5.0199,751,517 - 9,787,463 (-)NCBI
Celera199,246,398 - 9,269,222 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001271095   ⟹   NP_001258024
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8199,357,470 - 9,368,496 (-)NCBI
mRatBN7.2199,351,408 - 9,362,435 (-)NCBI
Rnor_6.0199,766,439 - 9,777,465 (-)NCBI
Rnor_5.0199,751,517 - 9,787,463 (-)NCBI
Celera199,246,398 - 9,257,424 (-)NCBI
Sequence:
RefSeq Acc Id: NM_031967   ⟹   NP_114173
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8199,357,470 - 9,368,496 (-)NCBI
mRatBN7.2199,351,408 - 9,362,435 (-)NCBI
Rnor_6.0199,766,439 - 9,777,465 (-)NCBI
Rnor_5.0199,751,517 - 9,787,463 (-)NCBI
RGSC_v3.4199,808,017 - 9,818,974 (-)RGD
Celera199,246,398 - 9,257,424 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006255123   ⟹   XP_006255185
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8199,357,470 - 9,393,465 (-)NCBI
mRatBN7.2199,351,408 - 9,387,398 (-)NCBI
Rnor_6.0199,766,439 - 9,802,396 (-)NCBI
Rnor_5.0199,751,517 - 9,787,463 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063278270   ⟹   XP_063134340
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8199,357,470 - 9,393,296 (-)NCBI
RefSeq Acc Id: XM_063278271   ⟹   XP_063134341
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8199,357,470 - 9,368,529 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001258020 (Get FASTA)   NCBI Sequence Viewer  
  NP_001258021 (Get FASTA)   NCBI Sequence Viewer  
  NP_001258022 (Get FASTA)   NCBI Sequence Viewer  
  NP_001258023 (Get FASTA)   NCBI Sequence Viewer  
  NP_001258024 (Get FASTA)   NCBI Sequence Viewer  
  NP_114173 (Get FASTA)   NCBI Sequence Viewer  
  XP_006255185 (Get FASTA)   NCBI Sequence Viewer  
  XP_063134340 (Get FASTA)   NCBI Sequence Viewer  
  XP_063134341 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD02415 (Get FASTA)   NCBI Sequence Viewer  
  AAO65543 (Get FASTA)   NCBI Sequence Viewer  
  AAO65544 (Get FASTA)   NCBI Sequence Viewer  
  AAO65545 (Get FASTA)   NCBI Sequence Viewer  
  AAO65546 (Get FASTA)   NCBI Sequence Viewer  
  AAO65547 (Get FASTA)   NCBI Sequence Viewer  
  AAP46191 (Get FASTA)   NCBI Sequence Viewer  
  AAP46192 (Get FASTA)   NCBI Sequence Viewer  
  AAQ17047 (Get FASTA)   NCBI Sequence Viewer  
  AAQ17219 (Get FASTA)   NCBI Sequence Viewer  
  EDL87272 (Get FASTA)   NCBI Sequence Viewer  
  EDL87273 (Get FASTA)   NCBI Sequence Viewer  
  EDL87274 (Get FASTA)   NCBI Sequence Viewer  
  EDL87275 (Get FASTA)   NCBI Sequence Viewer  
  EDL87276 (Get FASTA)   NCBI Sequence Viewer  
  EDL87277 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000017413
  ENSRNOP00000017494
  ENSRNOP00000044520
  ENSRNOP00000084746
GenBank Protein Q9Z2L9 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_114173   ⟸   NM_031967
- Peptide Label: isoform 5
- UniProtKB: Q9Z2L9 (UniProtKB/Swiss-Prot),   Q7TST8 (UniProtKB/Swiss-Prot),   Q78ZK9 (UniProtKB/Swiss-Prot),   Q6XQ65 (UniProtKB/Swiss-Prot),   Q6XQ64 (UniProtKB/Swiss-Prot),   Q6XQ63 (UniProtKB/Swiss-Prot),   Q6XQ62 (UniProtKB/Swiss-Prot),   A6JXZ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258021   ⟸   NM_001271092
- Peptide Label: isoform 2 precursor
- UniProtKB: D3Z831 (UniProtKB/TrEMBL),   A6JXZ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258020   ⟸   NM_001271091
- Peptide Label: isoform 1 precursor
- UniProtKB: D3ZUT8 (UniProtKB/TrEMBL),   A0A8I6G5X2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258023   ⟸   NM_001271094
- Peptide Label: isoform 4
- UniProtKB: A0A8I6G5X2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258022   ⟸   NM_001271093
- Peptide Label: isoform 3
- UniProtKB: A0A8I6G5X2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258024   ⟸   NM_001271095
- Peptide Label: isoform 6
- UniProtKB: Q9Z2L9 (UniProtKB/Swiss-Prot),   Q7TST8 (UniProtKB/Swiss-Prot),   Q78ZK9 (UniProtKB/Swiss-Prot),   Q6XQ65 (UniProtKB/Swiss-Prot),   Q6XQ64 (UniProtKB/Swiss-Prot),   Q6XQ63 (UniProtKB/Swiss-Prot),   Q6XQ62 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006255185   ⟸   XM_006255123
- Peptide Label: isoform X2
- UniProtKB: A0A8I6G5X2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000044520   ⟸   ENSRNOT00000051414
Ensembl Acc Id: ENSRNOP00000017494   ⟸   ENSRNOT00000017494
Ensembl Acc Id: ENSRNOP00000017413   ⟸   ENSRNOT00000017413
Ensembl Acc Id: ENSRNOP00000082556   ⟸   ENSRNOT00000117717
Ensembl Acc Id: ENSRNOP00000079935   ⟸   ENSRNOT00000115384
Ensembl Acc Id: ENSRNOP00000091492   ⟸   ENSRNOT00000110322
Ensembl Acc Id: ENSRNOP00000084746   ⟸   ENSRNOT00000116737
Ensembl Acc Id: ENSRNOP00000085740   ⟸   ENSRNOT00000119566
RefSeq Acc Id: XP_063134340   ⟸   XM_063278270
- Peptide Label: isoform X1
- UniProtKB: A6JXZ4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063134341   ⟸   XM_063278271
- Peptide Label: isoform X3
- UniProtKB: Q9Z2L9 (UniProtKB/Swiss-Prot),   Q7TST8 (UniProtKB/Swiss-Prot),   Q78ZK9 (UniProtKB/Swiss-Prot),   Q6XQ65 (UniProtKB/Swiss-Prot),   Q6XQ64 (UniProtKB/Swiss-Prot),   Q6XQ63 (UniProtKB/Swiss-Prot),   Q6XQ62 (UniProtKB/Swiss-Prot),   G3V7P8 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z2L9-F1-model_v2 AlphaFold Q9Z2L9 1-352 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700924
Promoter ID:EPDNEW_R11448
Type:single initiation site
Name:Ndrg4_1
Description:NDRG family member 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0199,777,436 - 9,777,496EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621593 AgrOrtholog
BioCyc Gene G2FUF-6544 BioCyc
Ensembl Genes ENSRNOG00000012482 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000017413 ENTREZGENE
  ENSRNOT00000017494 ENTREZGENE
  ENSRNOT00000051414 ENTREZGENE
  ENSRNOT00000116737 ENTREZGENE
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot
InterPro AB_hydrolase UniProtKB/Swiss-Prot
  NDRG UniProtKB/Swiss-Prot
NCBI Gene 64457 ENTREZGENE
PANTHER PTHR11034 UniProtKB/Swiss-Prot
Pfam Ndr UniProtKB/Swiss-Prot
PhenoGen Ndrg4 PhenoGen
RatGTEx ENSRNOG00000012482 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot
UniProt A0A8I5ZTQ9_RAT UniProtKB/TrEMBL
  A0A8I5ZYL3_RAT UniProtKB/TrEMBL
  A0A8I6A4R1_RAT UniProtKB/TrEMBL
  A0A8I6ARW2_RAT UniProtKB/TrEMBL
  A0A8I6G5X2 ENTREZGENE, UniProtKB/TrEMBL
  A6JXZ4 ENTREZGENE, UniProtKB/TrEMBL
  A6JXZ5 ENTREZGENE, UniProtKB/TrEMBL
  A6JXZ6_RAT UniProtKB/TrEMBL
  A6JXZ7_RAT UniProtKB/TrEMBL
  A6JXZ8_RAT UniProtKB/TrEMBL
  A6JXZ9_RAT UniProtKB/TrEMBL
  D3Z831 ENTREZGENE, UniProtKB/TrEMBL
  D3ZUT8 ENTREZGENE, UniProtKB/TrEMBL
  G3V7P8 ENTREZGENE, UniProtKB/TrEMBL
  NDRG4_RAT UniProtKB/Swiss-Prot
  Q6XQ62 ENTREZGENE
  Q6XQ63 ENTREZGENE
  Q6XQ64 ENTREZGENE
  Q6XQ65 ENTREZGENE
  Q78ZK9 ENTREZGENE
  Q7TST8 ENTREZGENE
  Q9Z2L9 ENTREZGENE
UniProt Secondary Q6XQ62 UniProtKB/Swiss-Prot
  Q6XQ63 UniProtKB/Swiss-Prot
  Q6XQ64 UniProtKB/Swiss-Prot
  Q6XQ65 UniProtKB/Swiss-Prot
  Q78ZK9 UniProtKB/Swiss-Prot
  Q7TST8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-01-22 Ndrg4  NDRG family member 4  Ndrg4  N-myc downstream regulated gene 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Ndrg4  N-myc downstream regulated gene 4  Ndr4  N-myc downstream regulated 4  Symbol and Name updated 1299863 APPROVED
2004-04-22 Ndr4  N-myc downstream regulated 4  AF045564  development-related protein  Symbol and Name updated to reflect Human and Mouse nomenclature 625702 APPROVED
2002-08-07 AF045564  development-related protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localizes mainly in the mitochondria and endoplasmic reticulum 1304242
gene_expression expressed widely in the olfactory bulb, cerebral cortex, hippocampus, cerebellum, thalamus, and medulla oblongata 1304220
gene_process plays a role in neurite outgrowth 1304243