RGD Reference Report - Ndrg4 enhances NGF-induced ERK activation uncoupled with Elk-1 activation. - Rat Genome Database

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Ndrg4 enhances NGF-induced ERK activation uncoupled with Elk-1 activation.

Authors: Hongo, S  Watanabe, T  Takahashi, K  Miyazaki, A 
Citation: Hongo S, etal., J Cell Biochem. 2006 May 1;98(1):185-93.
RGD ID: 10047195
Pubmed: PMID:16408304   (View Abstract at PubMed)
DOI: DOI:10.1002/jcb.20763   (Journal Full-text)

Ndrg4 is expressed predominantly in the early postnatal rat brain and may be related to neural cell differentiation. PC12 cell lines stably expressing increased levels of Ndrg4 protein display enhanced NGF-induced phosphorylation of MEK and ERK. In contrast, the Ndrg4-C2-overexpressed PC12 cell lines showed attenuated NGF-promoted phosphorylation of Elk-1, which is a nuclear target of ERK. A reporter assay also indicated that Ndrg4-C2 suppresses Elk-1-mediated transcriptional activation and SRE reporter expression. The suppressive effect of Ndrg4-C2 on NGF-induced activation of Elk-1 was abolished by colchicine but not by cytochalasin D, suggesting that microtubules are involved in the reduced activation of Elk-1 by Ndrg4. Ndrg4 may play a role in supporting the activation of ERK and its target proteins needed for neuronal differentiation and in reducing the activation of Elk-1 implicated in cell growth.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
positive regulation of ERK1 and ERK2 cascade involved_inIDA 10047195PMID:16408304BHF-UCL 

Objects Annotated

Genes (Rattus norvegicus)
Ndrg4  (NDRG family member 4)


Additional Information