Sub1 (SUB1 regulator of transcription) - Rat Genome Database

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Gene: Sub1 (SUB1 regulator of transcription) Rattus norvegicus
Analyze
Symbol: Sub1
Name: SUB1 regulator of transcription
RGD ID: 621582
Description: Predicted to enable several functions, including DNA binding activity; identical protein binding activity; and transcription coactivator activity. Predicted to be involved in RNA polymerase II promoter clearance; protein homooligomerization; and regulation of nucleobase-containing compound metabolic process. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Orthologous to human SUB1 (SUB1 regulator of transcription); PARTICIPATES IN RNA polymerase III transcription pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: activated RNA polymerase II transcriptional coactivator p15; Loc192269; MGC109653; p14; PC4; positive cofactor 4; pR-ET2 encoded oncodevelopmental protein; RNA polymerase II transcriptional coactivator; Rpo2tc1; SUB1 homolog; SUB1 homolog (S. cerevisiae); SUB1 homolog, transcriptional regulator
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8262,735,379 - 62,747,545 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl262,732,736 - 62,747,679 (-)EnsemblGRCr8
mRatBN7.2261,005,646 - 61,020,486 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl243,299,239 - 43,299,924 (+)EnsemblmRatBN7.2
mRatBN7.2 Ensembl261,005,666 - 61,020,436 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx268,138,134 - 68,150,187 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0266,259,692 - 66,271,744 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0261,261,040 - 61,273,093 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0262,019,902 - 62,034,704 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl262,022,567 - 62,034,628 (-)Ensemblrn6Rnor6.0
Rnor_5.0282,656,079 - 82,670,881 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4261,418,076 - 61,430,139 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera257,672,589 - 57,684,652 (+)NCBICelera
RGSC_v3.1261,346,310 - 61,356,225 (-)NCBI
Cytogenetic Map2q16NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dimethoxyphenol  (ISO)
2-methylcholine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
7,12-dimethyltetraphene  (ISO)
actinomycin D  (ISO)
aflatoxin M1  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bufotalin  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
clobetasol  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dicrotophos  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
erianin  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenthion  (ISO)
fipronil  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
furfural  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
lamivudine  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
mitomycin C  (ISO)
nicotine  (ISO)
Nutlin-3  (ISO)
paclitaxel  (ISO)
PhIP  (EXP)
quercetin  (ISO)
rotenone  (EXP,ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
titanium dioxide  (ISO)
Tributyltin oxide  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transcription reinitiation by RNA polymerase III. Dieci G, etal., Biochim Biophys Acta. 2013 Mar-Apr;1829(3-4):331-41. doi: 10.1016/j.bbagrm.2012.10.009. Epub 2012 Nov 3.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Regulation of pol III transcription by nutrient and stress signaling pathways. Moir RD and Willis IM, Biochim Biophys Acta. 2013 Mar-Apr;1829(3-4):361-75. doi: 10.1016/j.bbagrm.2012.11.001. Epub 2012 Nov 16.
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
8. Proteomics profiling of nuclear proteins for kidney fibroblasts suggests hypoxia, meiosis, and cancer may meet in the nucleus. Shakib K, etal., Proteomics. 2005 Jul;5(11):2819-38.
9. Molecular cloning and characterization of a cDNA clone for a protein specifically expressed in embryo as well as in a chemically induced pancreatic B cell tumor of rat. Soma G, etal., Biochem Biophys Res Commun 1984 Oct 15;124(1):164-71.
Additional References at PubMed
PMID:8062391   PMID:12477932   PMID:15489334   PMID:16415882   PMID:17130840   PMID:18836447   PMID:20458337   PMID:22206666   PMID:22658674   PMID:22681889   PMID:23376485   PMID:23390484  
PMID:25416956   PMID:28369605  


Genomics

Comparative Map Data
Sub1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8262,735,379 - 62,747,545 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl262,732,736 - 62,747,679 (-)EnsemblGRCr8
mRatBN7.2261,005,646 - 61,020,486 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl243,299,239 - 43,299,924 (+)EnsemblmRatBN7.2
mRatBN7.2 Ensembl261,005,666 - 61,020,436 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx268,138,134 - 68,150,187 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0266,259,692 - 66,271,744 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0261,261,040 - 61,273,093 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0262,019,902 - 62,034,704 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl262,022,567 - 62,034,628 (-)Ensemblrn6Rnor6.0
Rnor_5.0282,656,079 - 82,670,881 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4261,418,076 - 61,430,139 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera257,672,589 - 57,684,652 (+)NCBICelera
RGSC_v3.1261,346,310 - 61,356,225 (-)NCBI
Cytogenetic Map2q16NCBI
SUB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38532,585,557 - 32,604,079 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl532,531,633 - 32,604,507 (+)Ensemblhg38GRCh38
GRCh37532,585,663 - 32,604,185 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36532,621,434 - 32,637,820 (+)NCBIBuild 36Build 36hg18NCBI36
Celera532,467,253 - 32,485,840 (+)NCBICelera
Cytogenetic Map5p13.3NCBI
HuRef532,553,427 - 32,572,031 (+)NCBIHuRef
CHM1_1532,587,724 - 32,606,294 (+)NCBICHM1_1
T2T-CHM13v2.0532,699,227 - 32,717,759 (+)NCBIT2T-CHM13v2.0
Sub1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391511,981,422 - 11,996,091 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1511,981,425 - 11,997,069 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381511,981,336 - 11,996,038 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1511,981,339 - 11,996,983 (-)Ensemblmm10GRCm38
MGSCv371511,911,094 - 11,925,762 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361511,926,064 - 11,940,732 (-)NCBIMGSCv36mm8
Celera1511,766,100 - 11,780,766 (-)NCBICelera
Cytogenetic Map15A1NCBI
cM Map155.9NCBI
Sub1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542618,380,117 - 18,394,627 (+)Ensembl
ChiLan1.0NW_00495542618,380,680 - 18,394,627 (+)NCBIChiLan1.0ChiLan1.0
SUB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2477,698,383 - 77,770,692 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1575,852,014 - 75,924,250 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0577,728,309 - 77,800,534 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1583,112,131 - 83,130,755 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl583,112,131 - 83,130,755 (-)EnsemblpanPan2panpan1.1
SUB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1474,931,105 - 74,951,707 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl474,933,620 - 74,951,573 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha474,569,825 - 74,588,278 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0475,452,940 - 75,471,575 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl475,450,912 - 75,471,527 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1475,190,470 - 75,208,907 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0475,319,042 - 75,337,517 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0475,849,695 - 75,868,156 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Sub1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213223,122,805 - 223,137,782 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365188,233,338 - 8,249,549 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365188,236,026 - 8,249,007 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SUB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1618,758,962 - 18,779,419 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11618,758,886 - 18,779,421 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SUB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1431,860,744 - 31,879,851 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl431,860,830 - 31,877,070 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607122,118,817 - 22,135,778 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sub1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475922,009,266 - 22,037,394 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475922,010,097 - 22,027,807 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Sub1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13169,084,112 - 169,098,956 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Sub1
96 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:246
Count of miRNA genes:190
Interacting mature miRNAs:206
Transcripts:ENSRNOT00000074446
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578777Stresp15Stress response QTL 1520.05blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)261556902106556902Rat
6480225Gdil1Gastrointestinal dilation QTL 1enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)25838820177302351Rat
631500Bp99Blood pressure QTL 992.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)261051883104684275Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22411781369117813Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23675034481750344Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
5684996Bmd85Bone mineral density QTL 854.70.024tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)261051541105724065Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22203804467038044Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)240306867124537199Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22888999173889991Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)241801363104744824Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)24490435585286097Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)244537979112567334Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
5684990Bmd82Bone mineral density QTL 822.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)261051541105724065Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)27605533104774005Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266683465677Rat
1359034Bp274Blood pressure QTL 274arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)25126685996266859Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)260861391105861391Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)238426449111295694Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21822713763227137Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23686864381868643Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)24490435589904355Rat
1582246Cm60Cardiac mass QTL 605.8heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)23326999678269996Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)261051541143746880Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266673652666Rat

Markers in Region
RH128729  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2q16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000074446   ⟹   ENSRNOP00000067467
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl243,299,239 - 43,299,924 (+)Ensembl
Rnor_6.0 Ensembl262,022,567 - 62,034,628 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109925   ⟹   ENSRNOP00000077928
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl261,005,666 - 61,019,879 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113169   ⟹   ENSRNOP00000092370
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl262,732,736 - 62,747,679 (-)Ensembl
mRatBN7.2 Ensembl261,005,666 - 61,020,436 (-)Ensembl
RefSeq Acc Id: NM_001009618   ⟹   NP_001009618
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8262,735,379 - 62,747,442 (-)NCBI
mRatBN7.2261,008,309 - 61,020,372 (-)NCBI
Rnor_6.0262,022,565 - 62,034,628 (-)NCBI
Rnor_5.0282,656,079 - 82,670,881 (+)NCBI
RGSC_v3.4261,418,076 - 61,430,139 (-)RGD
Celera257,672,589 - 57,684,652 (+)RGD
Sequence:
RefSeq Acc Id: XM_006232043   ⟹   XP_006232105
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8262,735,379 - 62,747,545 (-)NCBI
mRatBN7.2261,005,646 - 61,020,486 (-)NCBI
Rnor_6.0262,019,902 - 62,034,704 (-)NCBI
Rnor_5.0282,656,079 - 82,670,881 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039101675   ⟹   XP_038957603
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8262,735,379 - 62,747,232 (-)NCBI
mRatBN7.2261,005,646 - 61,020,048 (-)NCBI
RefSeq Acc Id: XM_039101676   ⟹   XP_038957604
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8262,735,379 - 62,746,906 (-)NCBI
mRatBN7.2261,005,646 - 61,019,677 (-)NCBI
RefSeq Acc Id: XM_039101677   ⟹   XP_038957605
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8262,735,379 - 62,747,077 (-)NCBI
mRatBN7.2261,005,646 - 61,019,749 (-)NCBI
RefSeq Acc Id: XM_063281272   ⟹   XP_063137342
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8262,735,379 - 62,747,387 (-)NCBI
RefSeq Acc Id: NP_001009618   ⟸   NM_001009618
- UniProtKB: Q5M805 (UniProtKB/Swiss-Prot),   Q63396 (UniProtKB/Swiss-Prot),   A6KJQ6 (UniProtKB/TrEMBL),   A0A8I5ZJM1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232105   ⟸   XM_006232043
- Peptide Label: isoform X1
- UniProtKB: Q5M805 (UniProtKB/Swiss-Prot),   Q63396 (UniProtKB/Swiss-Prot),   A6KJQ6 (UniProtKB/TrEMBL),   A0A8I5ZJM1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000067467   ⟸   ENSRNOT00000074446
RefSeq Acc Id: XP_038957603   ⟸   XM_039101675
- Peptide Label: isoform X1
- UniProtKB: Q63396 (UniProtKB/Swiss-Prot),   Q5M805 (UniProtKB/Swiss-Prot),   A6KJQ6 (UniProtKB/TrEMBL),   A0A8I5ZJM1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957605   ⟸   XM_039101677
- Peptide Label: isoform X1
- UniProtKB: Q63396 (UniProtKB/Swiss-Prot),   Q5M805 (UniProtKB/Swiss-Prot),   A6KJQ6 (UniProtKB/TrEMBL),   A0A8I5ZJM1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957604   ⟸   XM_039101676
- Peptide Label: isoform X1
- UniProtKB: Q63396 (UniProtKB/Swiss-Prot),   Q5M805 (UniProtKB/Swiss-Prot),   A6KJQ6 (UniProtKB/TrEMBL),   A0A8I5ZJM1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000092370   ⟸   ENSRNOT00000113169
Ensembl Acc Id: ENSRNOP00000077928   ⟸   ENSRNOT00000109925
RefSeq Acc Id: XP_063137342   ⟸   XM_063281272
- Peptide Label: isoform X1
- UniProtKB: Q63396 (UniProtKB/Swiss-Prot),   Q5M805 (UniProtKB/Swiss-Prot),   A0A8I5ZJM1 (UniProtKB/TrEMBL),   A6KJQ6 (UniProtKB/TrEMBL)
Protein Domains
Transcriptional coactivator p15 (PC4) C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63396-F1-model_v2 AlphaFold Q63396 1-127 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691193
Promoter ID:EPDNEW_R1717
Type:multiple initiation site
Name:Sub1_1
Description:SUB1 homolog, transcriptional regulator
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0262,034,664 - 62,034,724EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621582 AgrOrtholog
BioCyc Gene G2FUF-54052 BioCyc
Ensembl Genes ENSRNOG00000050563 Ensembl
  ENSRNOG00000067555 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000113169 ENTREZGENE
  ENSRNOT00000113169.1 UniProtKB/Swiss-Prot
Gene3D-CATH Transcriptional Coactivator Pc4, Chain A UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7368325 IMAGE-MGC_LOAD
InterPro PC4 UniProtKB/Swiss-Prot
  ssDNA-bd_transcriptional_reg UniProtKB/Swiss-Prot
  Sub1/Tcp4-like UniProtKB/Swiss-Prot
KEGG Report rno:192269 UniProtKB/Swiss-Prot
MGC_CLONE MGC:109653 IMAGE-MGC_LOAD
NCBI Gene 192269 ENTREZGENE
PANTHER PTHR13215 UniProtKB/Swiss-Prot
Pfam PC4 UniProtKB/Swiss-Prot
PhenoGen Sub1 PhenoGen
RatGTEx ENSRNOG00000050563 RatGTEx
  ENSRNOG00000067555 RatGTEx
Superfamily-SCOP SSF54447 UniProtKB/Swiss-Prot
UniProt A0A8I5ZJM1 ENTREZGENE
  A6KJQ6 ENTREZGENE, UniProtKB/TrEMBL
  Q5M805 ENTREZGENE
  Q63396 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q5M805 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-05 Sub1  SUB1 regulator of transcription  Sub1  SUB1 homolog, transcriptional regulator  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-10-01 Sub1  SUB1 homolog, transcriptional regulator  Sub1  SUB1 homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Sub1  SUB1 homolog (S. cerevisiae)  Rpo2tc1  RNA polymerase II transcriptional coactivator  Symbol and Name updated 1299863 APPROVED
2005-01-20 Rpo2tc1  RNA polymerase II transcriptional coactivator  Loc192269  pR-ET2 encoded oncodevelopmental protein  Symbol and Name updated 1299863 APPROVED
2002-08-07 Loc192269  pR-ET2 encoded oncodevelopmental protein      Symbol and Name status set to provisional 70820 PROVISIONAL