Rnase3 (ribonuclease A family member 3) - Rat Genome Database

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Gene: Rnase3 (ribonuclease A family member 3) Rattus norvegicus
Analyze
Symbol: Rnase3 (Ensembl: Rnase17)
Name: ribonuclease A family member 3 (Ensembl:ribonuclease 17)
RGD ID: 621580
Description: Predicted to enable RNA nuclease activity and lipopolysaccharide binding activity. Predicted to be involved in chemotaxis; defense response to Gram-positive bacterium; and defense response to symbiont. Predicted to be located in cytoplasm. Predicted to be active in extracellular space. Orthologous to human RNASE3 (ribonuclease A family member 3); INTERACTS WITH ammonium chloride; bisphenol A; decabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: EAR; EAR-11; Ear11; ECP; eosinophil cationic protein; eosinophil secondary granule ribonuclease 11; eosinophil-associated ribonuclease; eosinophil-associated, ribonuclease A family, member 11; Loc192264; R1; R7; ribonuclease 1; ribonuclease 3; ribonuclease 7; ribonuclease, RNase A family, 3; RNase 3
RGD Orthologs
Human
Mouse
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81526,985,399 - 26,986,269 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1526,985,271 - 26,986,400 (-)EnsemblGRCr8
mRatBN7.21524,511,894 - 24,512,764 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,511,891 - 24,512,790 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1527,283,046 - 27,283,916 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01528,238,210 - 28,239,080 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01526,491,605 - 26,492,475 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1525,683,731 - 25,684,601 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive1525,593,798 - 25,594,668 (-)NCBILyon_Normotensive
Lyon_Hypertensive1525,696,884 - 25,697,754 (-)NCBILyon_Hypertensive
F344_StmMcwi1526,298,174 - 26,299,044 (-)NCBIF344_StmMcwi
Rnor_6.01528,216,744 - 28,217,614 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1528,216,744 - 28,217,614 (-)Ensemblrn6Rnor6.0
Rnor_5.01532,053,025 - 32,053,895 (-)NCBIRnor_5.0Rnor_5.0rn5
Cytogenetic Map15p14NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
extracellular space  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. Identification of cDNA encoding rat eosinophil cationic protein/eosinophil-associated ribonuclease. Nittoh T, etal., Biochim Biophys Acta 1997 Mar 20;1351(1-2):42-6.
6. A novel prognostic signature for idiopathic pulmonary fibrosis based on five-immune-related genes. Qiu L, etal., Ann Transl Med. 2021 Oct;9(20):1570. doi: 10.21037/atm-21-4545.
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10594173   PMID:12860195   PMID:18178677   PMID:20619905   PMID:22677423   PMID:23376485   PMID:23992292  


Genomics

Comparative Map Data
Rnase3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81526,985,399 - 26,986,269 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1526,985,271 - 26,986,400 (-)EnsemblGRCr8
mRatBN7.21524,511,894 - 24,512,764 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,511,891 - 24,512,790 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1527,283,046 - 27,283,916 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01528,238,210 - 28,239,080 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01526,491,605 - 26,492,475 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1525,683,731 - 25,684,601 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive1525,593,798 - 25,594,668 (-)NCBILyon_Normotensive
Lyon_Hypertensive1525,696,884 - 25,697,754 (-)NCBILyon_Hypertensive
F344_StmMcwi1526,298,174 - 26,299,044 (-)NCBIF344_StmMcwi
Rnor_6.01528,216,744 - 28,217,614 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1528,216,744 - 28,217,614 (-)Ensemblrn6Rnor6.0
Rnor_5.01532,053,025 - 32,053,895 (-)NCBIRnor_5.0Rnor_5.0rn5
Cytogenetic Map15p14NCBI
RNASE3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381420,891,385 - 20,892,348 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1420,891,385 - 20,892,348 (+)Ensemblhg38GRCh38
GRCh371421,359,544 - 21,360,507 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361420,429,402 - 20,430,347 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341420,429,401 - 20,430,347NCBI
Celera141,220,428 - 1,221,373 (+)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef141,480,722 - 1,481,667 (+)NCBIHuRef
CHM1_11421,361,699 - 21,362,644 (+)NCBICHM1_1
T2T-CHM13v2.01415,088,805 - 15,089,768 (+)NCBIT2T-CHM13v2.0
Ear1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391444,056,222 - 44,057,096 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1444,056,222 - 44,112,974 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381443,818,765 - 43,819,639 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1443,818,765 - 43,875,517 (-)Ensemblmm10GRCm38
MGSCv371444,396,430 - 44,397,304 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361442,698,632 - 42,699,506 (-)NCBIMGSCv36mm8
Cytogenetic Map14C1NCBI
cM Map1422.51NCBI
LOC102163838
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1778,179,285 - 78,180,221 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1

Variants

.
Variants in Rnase3
11 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15139411584Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152272835342072050Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15132342855Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151691152132439851Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat

Markers in Region
RH133047  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera1524,766,542 - 24,766,758UniSTS
Celera1524,864,784 - 24,865,001UniSTS
Cytogenetic Map15p14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
2 3 9 16 41 52 32 18 32 72 36 8 10 1 36 20

Sequence


Ensembl Acc Id: ENSRNOT00000040857   ⟹   ENSRNOP00000044390
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1528,216,744 - 28,217,614 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000048941   ⟹   ENSRNOP00000050225
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1526,985,271 - 26,986,400 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119723   ⟹   ENSRNOP00000084145
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1524,511,891 - 24,512,790 (-)Ensembl
RefSeq Acc Id: NM_138902   ⟹   NP_620257
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81526,985,399 - 26,986,269 (-)NCBI
mRatBN7.21524,511,894 - 24,512,764 (-)NCBI
Dahl_SR_JrHsd1525,683,731 - 25,684,601 (-)NCBI
Lyon_Normotensive1525,593,798 - 25,594,668 (-)NCBI
Lyon_Hypertensive1525,696,884 - 25,697,754 (-)NCBI
F344_StmMcwi1526,298,174 - 26,299,044 (-)NCBI
Rnor_6.01528,216,744 - 28,217,614 (-)NCBI
Rnor_5.01532,053,025 - 32,053,895 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_620257 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD51665 (Get FASTA)   NCBI Sequence Viewer  
  BAA13648 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000050225
  ENSRNOP00000076490.1
  ENSRNOP00000084145.1
GenBank Protein P70709 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_620257   ⟸   NM_138902
- Peptide Label: precursor
- UniProtKB: P70709 (UniProtKB/Swiss-Prot),   W0UVG3 (UniProtKB/TrEMBL),   Q9R130 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000044390   ⟸   ENSRNOT00000040857
Ensembl Acc Id: ENSRNOP00000084145   ⟸   ENSRNOT00000119723
Ensembl Acc Id: ENSRNOP00000050225   ⟸   ENSRNOT00000048941
Protein Domains
Ribonuclease A-domain

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70709-F1-model_v2 AlphaFold P70709 1-155 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621580 AgrOrtholog
BioCyc Gene G2FUF-14008 BioCyc
Ensembl Genes ENSRNOG00000031445 Ensembl
  ENSRNOG00000063957 Ensembl, ENTREZGENE
  ENSRNOG00000064658 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00000068464 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000048941 ENTREZGENE
  ENSRNOT00000105605.1 UniProtKB/Swiss-Prot
  ENSRNOT00000119723.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.130.10 UniProtKB/Swiss-Prot
InterPro RNaseA UniProtKB/Swiss-Prot
  RNaseA-like_dom_sf UniProtKB/Swiss-Prot
  RNaseA_AS UniProtKB/Swiss-Prot
  RNaseA_domain UniProtKB/Swiss-Prot
KEGG Report rno:192264 UniProtKB/Swiss-Prot
NCBI Gene 192264 ENTREZGENE
PANTHER EOSINOPHIL CATIONIC PROTEIN UniProtKB/Swiss-Prot
  PTHR11437 UniProtKB/Swiss-Prot
Pfam RnaseA UniProtKB/Swiss-Prot
PhenoGen Rnase3 PhenoGen
PRINTS RIBONUCLEASE UniProtKB/Swiss-Prot
PROSITE RNASE_PANCREATIC UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000031445 RatGTEx
  ENSRNOG00000063957 RatGTEx
  ENSRNOG00000064658 RatGTEx
  ENSRNOG00000068464 RatGTEx
SMART RNAse_Pc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54076 UniProtKB/Swiss-Prot
UniProt ECP_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9R130 ENTREZGENE, UniProtKB/TrEMBL
  W0UVG3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-27 Rnase3  ribonuclease A family member 3  Rnase3  ribonuclease, RNase A family, 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-07-23 Rnase3  ribonuclease, RNase A family, 3  Ear11  eosinophil-associated, ribonuclease A family, member 11  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Ear11  eosinophil-associated, ribonuclease A family, member 11  Loc192264  eosinophil cationic protein  Symbol and Name updated 1299863 APPROVED
2002-08-07 Loc192264  eosinophil cationic protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein has an isoelectric point of 9.85 633277