Npffr1 (neuropeptide FF receptor 1) - Rat Genome Database

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Gene: Npffr1 (neuropeptide FF receptor 1) Rattus norvegicus
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Symbol: Npffr1
Name: neuropeptide FF receptor 1
RGD ID: 621570
Description: Enables neuropeptide receptor activity. Involved in neuropeptide signaling pathway. Predicted to be located in membrane. Predicted to be active in cilium and plasma membrane. Orthologous to human NPFFR1 (neuropeptide FF receptor 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: G protein-coupled receptor 147; G-protein coupled receptor 147; Gpr147; NPFF1; OT7T022; RFamide-related peptide receptor; RFamide-related peptide receptor OT7T022
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82030,082,604 - 30,116,752 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2030,082,604 - 30,114,998 (+)EnsemblGRCr8
mRatBN7.22029,539,795 - 29,573,951 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2029,539,795 - 29,571,196 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2030,555,746 - 30,587,142 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02029,942,024 - 29,973,412 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02030,684,511 - 30,715,898 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02031,214,950 - 31,248,710 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2031,234,493 - 31,245,955 (+)Ensemblrn6Rnor6.0
Rnor_5.02032,997,426 - 33,030,516 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42028,983,735 - 28,995,194 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2030,966,998 - 30,998,217 (+)NCBICelera
RGSC_v3.12028,997,534 - 29,008,994 (+)NCBI
Cytogenetic Map20q11NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
9+0 non-motile cilium  (IEA,ISO)
cilium  (IEA,ISO)
membrane  (IEA)
plasma membrane  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Identification and characterization of two G protein-coupled receptors for neuropeptide FF. Bonini JA, etal., J Biol Chem 2000 Dec 15;275(50):39324-31.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals. Hinuma S, etal., Nat Cell Biol 2000 Oct;2(10):703-8.
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14696013   PMID:20136694   PMID:22691952   PMID:24088662   PMID:24412804   PMID:25144921   PMID:28154160  


Genomics

Comparative Map Data
Npffr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82030,082,604 - 30,116,752 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2030,082,604 - 30,114,998 (+)EnsemblGRCr8
mRatBN7.22029,539,795 - 29,573,951 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2029,539,795 - 29,571,196 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2030,555,746 - 30,587,142 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02029,942,024 - 29,973,412 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02030,684,511 - 30,715,898 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02031,214,950 - 31,248,710 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2031,234,493 - 31,245,955 (+)Ensemblrn6Rnor6.0
Rnor_5.02032,997,426 - 33,030,516 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42028,983,735 - 28,995,194 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2030,966,998 - 30,998,217 (+)NCBICelera
RGSC_v3.12028,997,534 - 29,008,994 (+)NCBI
Cytogenetic Map20q11NCBI
NPFFR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381070,247,329 - 70,284,004 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1070,247,329 - 70,284,004 (-)Ensemblhg38GRCh38
GRCh371072,007,085 - 72,043,760 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361071,684,719 - 71,707,727 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341071,684,718 - 71,696,154NCBI
Celera1065,294,771 - 65,323,520 (-)NCBICelera
Cytogenetic Map10q22.1NCBI
HuRef1066,007,982 - 66,036,738 (-)NCBIHuRef
CHM1_11072,296,529 - 72,325,723 (-)NCBICHM1_1
T2T-CHM13v2.01071,116,278 - 71,152,972 (-)NCBIT2T-CHM13v2.0
Npffr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391061,430,600 - 61,465,243 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1061,431,271 - 61,464,344 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381061,595,295 - 61,629,464 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1061,595,492 - 61,628,565 (+)Ensemblmm10GRCm38
MGSCv371061,058,232 - 61,089,133 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361060,991,514 - 61,021,742 (+)NCBIMGSCv36mm8
Celera1062,696,844 - 62,727,819 (+)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1032.24NCBI
Npffr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543720,976,867 - 21,001,194 (+)Ensembl
ChiLan1.0NW_00495543720,976,867 - 21,001,194 (+)NCBIChiLan1.0ChiLan1.0
NPFFR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2882,401,334 - 82,438,138 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11082,406,655 - 82,443,459 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01066,721,483 - 66,758,287 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11069,257,022 - 69,291,838 (-)NCBIPanPan1.1PanPan1.1panPan2
NPFFR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1421,191,403 - 21,223,715 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl421,197,733 - 21,203,099 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha421,323,904 - 21,351,213 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0421,466,975 - 21,492,765 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl421,473,411 - 21,493,131 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1421,364,430 - 21,390,200 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0421,569,576 - 21,595,343 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0421,920,758 - 21,946,551 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Npffr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721359,834,368 - 59,851,935 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365218,329,153 - 8,342,246 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365218,327,093 - 8,342,390 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPFFR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1473,182,892 - 73,205,829 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11473,183,585 - 73,195,804 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21479,103,900 - 79,116,127 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NPFFR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1961,030,574 - 61,052,052 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl961,041,567 - 61,051,960 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604821,770,185 - 21,792,342 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Npffr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247544,396,759 - 4,406,078 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247544,390,049 - 4,410,208 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Npffr1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11827,420,667 - 27,451,376 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Npffr1
134 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:78
Count of miRNA genes:67
Interacting mature miRNAs:73
Transcripts:ENSRNOT00000000675
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202668936256021148Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)202074558556021148Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202668936256021148Rat
1598870Bp289Blood pressure QTL 2892.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)20821635953216359Rat
1598858Cm61Cardiac mass QTL 613.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)20821635953216359Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202679235356021148Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)201224324249189476Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202668936256021148Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202668936256021148Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
3 5 46 123 30 25 13 16 13 2 137 81 2 115 38 73 12 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000000675   ⟹   ENSRNOP00000000675
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2030,082,604 - 30,114,998 (+)Ensembl
mRatBN7.2 Ensembl2029,539,795 - 29,571,196 (+)Ensembl
Rnor_6.0 Ensembl2031,234,493 - 31,245,955 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115618   ⟹   ENSRNOP00000096765
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2030,102,318 - 30,114,998 (+)Ensembl
mRatBN7.2 Ensembl2029,559,513 - 29,571,196 (+)Ensembl
RefSeq Acc Id: NM_022291   ⟹   NP_071627
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82030,082,604 - 30,113,997 (+)NCBI
mRatBN7.22029,539,795 - 29,571,196 (+)NCBI
Rnor_6.02031,214,950 - 31,245,955 (+)NCBI
Rnor_5.02032,997,426 - 33,030,516 (+)NCBI
RGSC_v3.42028,983,735 - 28,995,194 (+)RGD
Celera2030,966,998 - 30,998,217 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006256485   ⟹   XP_006256547
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82030,102,424 - 30,116,752 (+)NCBI
mRatBN7.22029,559,528 - 29,573,951 (+)NCBI
Rnor_6.02031,234,328 - 31,248,710 (+)NCBI
Rnor_5.02032,997,426 - 33,030,516 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063279491   ⟹   XP_063135561
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82030,111,121 - 30,116,752 (+)NCBI
RefSeq Acc Id: NP_071627   ⟸   NM_022291
- UniProtKB: Q9EP86 (UniProtKB/Swiss-Prot),   F1LN94 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256547   ⟸   XM_006256485
- Peptide Label: isoform X1
- UniProtKB: Q9EP86 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000000675   ⟸   ENSRNOT00000000675
Ensembl Acc Id: ENSRNOP00000096765   ⟸   ENSRNOT00000115618
RefSeq Acc Id: XP_063135561   ⟸   XM_063279491
- Peptide Label: isoform X2
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9EP86-F1-model_v2 AlphaFold Q9EP86 1-432 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621570 AgrOrtholog
BioCyc Gene G2FUF-3718 BioCyc
Ensembl Genes ENSRNOG00000000559 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000000675 ENTREZGENE
  ENSRNOT00000115618 ENTREZGENE
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  NPFF_rcpt UniProtKB/Swiss-Prot
  NPFF_rcpt_1 UniProtKB/Swiss-Prot
NCBI Gene 64107 ENTREZGENE
PANTHER NEUROPEPTIDE FF RECEPTOR 1 UniProtKB/Swiss-Prot
  NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Npffr1 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  NPFFRECEPTOR UniProtKB/Swiss-Prot
  NPFFRECEPTR1 UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000000559 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt A0A8I6ARK6_RAT UniProtKB/TrEMBL
  A6K402_RAT UniProtKB/TrEMBL
  F1LN94 ENTREZGENE, UniProtKB/TrEMBL
  NPFF1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Npffr1  neuropeptide FF receptor 1  Gpr147  G protein-coupled receptor 147  Symbol and Name updated 1299863 APPROVED
2005-01-20 Gpr147  G protein-coupled receptor 147  OT7T022  RFamide-related peptide receptor  Symbol and Name updated 1299863 APPROVED
2002-08-07 OT7T022  RFamide-related peptide receptor      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in particular regions of the hypothalamus 61730
gene_expression expressed in dorsal horn of the spinal cord, the lateral hypothalamus, the spinal trigeminal nuclei, and the thalamic nuclei supports 633416