Lim2 (lens intrinsic membrane protein 2) - Rat Genome Database

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Gene: Lim2 (lens intrinsic membrane protein 2) Rattus norvegicus
Analyze
Symbol: Lim2
Name: lens intrinsic membrane protein 2
RGD ID: 621482
Description: Predicted to be a structural constituent of eye lens. Predicted to act upstream of or within lens development in camera-type eye. Located in vesicle. Human ortholog(s) of this gene implicated in cataract and cataract 19 multiple types. Orthologous to human LIM2 (lens intrinsic membrane protein 2); INTERACTS WITH acrylamide; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: lens fiber membrane intrinsic protein; lens intrinsic membrane protein 2 (19 kDa); lens intrinsic membrane protein 2, 19kDa; MP17; MP18; Mp19; MP20
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81102,974,188 - 102,980,358 (+)NCBIGRCr8
mRatBN7.2193,837,597 - 93,843,769 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl193,837,597 - 93,843,769 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx199,222,952 - 99,229,118 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01107,695,622 - 107,701,792 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01100,988,204 - 100,994,372 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0198,495,082 - 98,501,248 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl198,495,082 - 98,501,249 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0199,571,887 - 99,578,053 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4193,805,817 - 93,811,981 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1193,883,926 - 93,890,087 (+)NCBI
Celera188,114,711 - 88,120,877 (+)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Lim2Ratcataract onsetISOLIM2 (Homo sapiens)1600309DNA:missense mutation:cds: p.F105V (human)RGD 
Lim2RatCOVID-19  ISOLIM2 (Homo sapiens)9068941mRNA:decreased expression:peripheral blood mononuclear cell (human)RGDPMID:32228226 and REF_RGD_ID:28912744
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Lim2Ratcataract  ISOLIM2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25741868 more ...
Lim2Ratcataract 19 multiple types  ISOLIM2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11917274 more ...
Lim2Ratgenetic disease  ISOLIM2 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:21386927 more ...
Lim2Ratmultiple acyl-CoA dehydrogenase deficiency  ISOLIM2 (Homo sapiens)8554872ClinVar Annotator: match by term: Multiple acyl-CoA dehydrogenase deficiencyClinVarPMID:16510302 more ...
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Lim2Ratadult respiratory distress syndrome  ISOLIM2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25070658
Lim2Ratcataract  ISOLIM2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11917274
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Lim2Ratcataract  ISSLim2 (Mus musculus)13592920OMIM:601371MouseDO 
Lim2Ratcataract 19 multiple types  ISSLim2 (Mus musculus)13592920OMIM:615277MouseDO 
Object Symbol
Species
Term
Qualifier
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Reference
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Original Reference(s)
Lim2Ratcataract 19 multiple types  ISOLIM2 (Homo sapiens)7240710 OMIM 

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Lim2Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOLIM2 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of LIM2 mRNACTDPMID:20106945 and PMID:21632981
Lim2Ratacrylamide decreases expressionEXP 6480464Acrylamide results in decreased expression of LIM2 mRNACTDPMID:28959563
Lim2Ratammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of LIM2 mRNACTDPMID:16483693
Lim2Ratbenzo[a]pyrene increases expressionISOLIM2 (Homo sapiens)6480464Benzo(a)pyrene results in increased expression of LIM2 mRNACTDPMID:20106945 more ...
Lim2Ratbenzo[a]pyrene affects methylationISOLIM2 (Homo sapiens)6480464Benzo(a)pyrene affects the methylation of LIM2 promoterCTDPMID:27901495
Lim2Ratbenzo[a]pyrene decreases methylationISOLIM2 (Homo sapiens)6480464Benzo(a)pyrene results in decreased methylation of LIM2 3' UTRCTDPMID:27901495
Lim2Ratbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of LIM2 mRNACTDPMID:25181051
Lim2RatC60 fullerene decreases expressionEXP 6480464fullerene C60 results in decreased expression of LIM2 mRNACTDPMID:19167457
Lim2Ratclothianidin increases expressionISOLIM2 (Homo sapiens)6480464clothianidin results in increased expression of LIM2 mRNACTDPMID:31626844
Lim2RatDibutyl phosphate affects expressionISOLIM2 (Homo sapiens)6480464di-n-butylphosphoric acid affects the expression of LIM2 mRNACTDPMID:37042841
Lim2Ratdorsomorphin multiple interactionsISOLIM2 (Homo sapiens)6480464[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ...CTDPMID:27188386
Lim2Ratentinostat decreases expressionISOLIM2 (Homo sapiens)6480464entinostat results in decreased expression of LIM2 mRNACTDPMID:26272509
Lim2Ratentinostat multiple interactionsISOLIM2 (Homo sapiens)6480464[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LIM2 mRNACTDPMID:27188386
Lim2Ratglycidol increases expressionEXP 6480464glycidol results in increased expression of LIM2 mRNACTDPMID:24915197
Lim2Ratglycidol decreases expressionEXP 6480464glycidol results in decreased expression of LIM2 mRNACTDPMID:24395379
Lim2Ratmercury dibromide multiple interactionsISOLIM2 (Homo sapiens)6480464[NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LIM2 mRNACTDPMID:27188386
Lim2Ratmethylmercury chloride decreases expressionISOLIM2 (Homo sapiens)6480464methylmercuric chloride results in decreased expression of LIM2 mRNACTDPMID:28001369
Lim2Ratpanobinostat multiple interactionsISOLIM2 (Homo sapiens)6480464[NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LIM2 mRNACTDPMID:27188386
Lim2Ratphenylmercury acetate decreases expressionISOLIM2 (Homo sapiens)6480464Phenylmercuric Acetate results in decreased expression of LIM2 mRNACTDPMID:26272509
Lim2Ratphenylmercury acetate multiple interactionsISOLIM2 (Homo sapiens)6480464[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LIM2 mRNACTDPMID:27188386

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Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
Lim2Ratbiological_process  ND 159840703/2007: no relevant rat dataRGD 
Lim2Ratcamera-type eye development acts_upstream_of_or_withinISOLim2 (Mus musculus)1624291MGI:1862040 PMID:9238094RGDPMID:9238094
Lim2Ratcamera-type eye development acts_upstream_of_or_withinIEAUniProtKB:P56563 and ensembl:ENSMUSP000000047321600115GO_REF:0000107EnsemblGO_REF:0000107
Lim2Ratlens development in camera-type eye acts_upstream_of_or_withinISOLim2 (Mus musculus)1624291MGI:1862040 PMID:6510713 more ...RGDPMID:6510713 more ...
Lim2Ratlens development in camera-type eye acts_upstream_of_or_withinIEAUniProtKB:P56563 and ensembl:ENSMUSP000000047321600115GO_REF:0000107EnsemblGO_REF:0000107

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Lim2Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Lim2Ratmembrane located_inIEAInterPro:IPR003935 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Lim2Ratmembrane located_inIEAUniProtKB-SubCell:SL-01621600115GO_REF:0000044UniProtGO_REF:0000044
Lim2Ratplasma membrane is_active_inIBAMGI:1098726 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Lim2Ratvesicle  IDA 1566560 RGD 

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Lim2Ratstructural constituent of eye lens enablesIEAUniProtKB-KW:KW-02731600115GO_REF:0000043UniProtGO_REF:0000043
Lim2Ratstructural constituent of eye lens enablesIEAInterPro:IPR0039351600115GO_REF:0000002InterProGO_REF:0000002


1 to 11 of 11 rows
#
Reference Title
Reference Citation
1. The human lens fiber-cell intrinsic membrane protein MP19 gene: isolation and sequence analysis. Church RL and Wang JH, Curr Eye Res 1993 Dec;12(12):1057-65.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. MP20, the second most abundant lens membrane protein and member of the tetraspanin superfamily, joins the list of ligands of galectin-3. Gonen T, etal., BMC Cell Biol. 2001;2:17. Epub 2001 Aug 14.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. A missense mutation in the LIM2 gene is associated with autosomal recessive presenile cataract in an inbred Iraqi Jewish family. Pras E, etal., Am J Hum Genet. 2002 May;70(5):1363-7. Epub 2002 Mar 26.
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
1 to 11 of 11 rows
PMID:2584203   PMID:6510713   PMID:6877261   PMID:7088001   PMID:7679355   PMID:8812411   PMID:9238094  



Lim2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81102,974,188 - 102,980,358 (+)NCBIGRCr8
mRatBN7.2193,837,597 - 93,843,769 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl193,837,597 - 93,843,769 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx199,222,952 - 99,229,118 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01107,695,622 - 107,701,792 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01100,988,204 - 100,994,372 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0198,495,082 - 98,501,248 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl198,495,082 - 98,501,249 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0199,571,887 - 99,578,053 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4193,805,817 - 93,811,981 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1193,883,926 - 93,890,087 (+)NCBI
Celera188,114,711 - 88,120,877 (+)NCBICelera
Cytogenetic Map1q22NCBI
LIM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381951,379,909 - 51,387,974 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1951,379,909 - 51,387,974 (-)EnsemblGRCh38hg38GRCh38
GRCh371951,883,163 - 51,891,228 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361956,574,976 - 56,583,009 (-)NCBINCBI36Build 36hg18NCBI36
Build 341956,574,975 - 56,583,009NCBI
Celera1948,934,200 - 48,942,254 (-)NCBICelera
Cytogenetic Map19q13.41NCBI
HuRef1948,215,130 - 48,223,189 (-)NCBIHuRef
CHM1_11951,885,115 - 51,893,162 (-)NCBICHM1_1
T2T-CHM13v2.01954,468,540 - 54,476,605 (-)NCBIT2T-CHM13v2.0
Lim2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39743,079,523 - 43,085,420 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl743,079,512 - 43,085,420 (+)EnsemblGRCm39 Ensembl
GRCm38743,430,099 - 43,435,996 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl743,430,088 - 43,435,996 (+)EnsemblGRCm38mm10GRCm38
MGSCv37750,685,471 - 50,691,361 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36743,298,021 - 43,303,911 (+)NCBIMGSCv36mm8
Celera738,896,762 - 38,902,653 (+)NCBICelera
Cytogenetic Map7B3NCBI
cM Map728.25NCBI
Lim2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555581,019,244 - 1,024,375 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555581,019,709 - 1,024,375 (+)NCBIChiLan1.0ChiLan1.0
LIM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22057,417,235 - 57,425,354 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11959,338,718 - 59,346,839 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01948,315,028 - 48,323,144 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11957,200,260 - 57,208,358 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1957,200,260 - 57,208,354 (-)Ensemblpanpan1.1panPan2
LIM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11105,593,457 - 105,599,788 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1105,593,224 - 105,599,650 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1105,166,165 - 105,172,438 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01106,103,001 - 106,109,279 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1106,102,710 - 106,109,141 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11105,774,650 - 105,780,923 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01105,415,503 - 105,421,782 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01106,211,043 - 106,217,316 (+)NCBIUU_Cfam_GSD_1.0
Lim2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934923,074,318 - 23,076,287 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493737846,650 - 48,619 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LIM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl658,481,686 - 58,489,279 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1658,482,690 - 58,489,711 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2651,700,855 - 51,707,646 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LIM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1644,298,667 - 44,306,302 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl644,298,958 - 44,306,117 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607324,347,860 - 24,355,988 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lim2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248323,493,670 - 3,497,459 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248323,493,670 - 3,497,459 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Lim2
27 total Variants

Predicted Target Of
Summary Value
Count of predictions:58
Count of miRNA genes:52
Interacting mature miRNAs:56
Transcripts:ENSRNOT00000023858
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 40 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat

1 to 10 of 40 rows
BG373005  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2193,841,346 - 93,841,570 (-)MAPPERmRatBN7.2
Rnor_6.0198,497,276 - 98,497,499NCBIRnor6.0
Rnor_5.0199,574,081 - 99,574,304UniSTSRnor5.0
RGSC_v3.4193,809,566 - 93,809,789UniSTSRGSC3.4
Celera188,118,460 - 88,118,683UniSTS
Cytogenetic Map1q22UniSTS
RH127383  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2193,836,890 - 93,837,093 (-)MAPPERmRatBN7.2
Rnor_6.0198,501,753 - 98,501,955NCBIRnor6.0
Rnor_5.0199,578,558 - 99,578,760UniSTSRnor5.0
RGSC_v3.4193,805,110 - 93,805,312UniSTSRGSC3.4
Celera188,114,004 - 88,114,206UniSTS
Cytogenetic Map1q22UniSTS
GDB:373986  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2193,838,340 - 93,838,493 (-)MAPPERmRatBN7.2
Rnor_6.0198,500,353 - 98,500,505NCBIRnor6.0
Rnor_5.0199,577,158 - 99,577,310UniSTSRnor5.0
RGSC_v3.4193,806,560 - 93,806,712UniSTSRGSC3.4
Celera188,115,454 - 88,115,606UniSTS
Cytogenetic Map1q22UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
8 1 43 83 23 29 3 21 3 2 107 74 73 21 49 26



Ensembl Acc Id: ENSRNOT00000023858   ⟹   ENSRNOP00000023858
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl193,837,597 - 93,843,769 (+)Ensembl
Rnor_6.0 Ensembl198,495,082 - 98,501,249 (-)Ensembl
RefSeq Acc Id: NM_053771   ⟹   NP_446223
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81102,974,188 - 102,980,358 (+)NCBI
mRatBN7.2193,837,597 - 93,843,769 (+)NCBI
Rnor_6.0198,495,082 - 98,501,248 (-)NCBI
Rnor_5.0199,571,887 - 99,578,053 (-)NCBI
RGSC_v3.4193,805,817 - 93,811,981 (+)RGD
Celera188,114,711 - 88,120,877 (+)RGD
Sequence:
Protein RefSeqs NP_446223 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41631 (Get FASTA)   NCBI Sequence Viewer  
  AAB02792 (Get FASTA)   NCBI Sequence Viewer  
  AAB25334 (Get FASTA)   NCBI Sequence Viewer  
  EDM07559 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000023858
  ENSRNOP00000023858.1
GenBank Protein P54825 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446223   ⟸   NM_053771
- UniProtKB: P54825 (UniProtKB/Swiss-Prot),   A6JAH5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023858   ⟸   ENSRNOT00000023858

Name Modeler Protein Id AA Range Protein Structure
AF-P54825-F1-model_v2 AlphaFold P54825 1-173 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 22 of 22 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-59852 BioCyc
Ensembl Genes ENSRNOG00000017681 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023858 ENTREZGENE
  ENSRNOT00000023858.3 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.140.150 UniProtKB/Swiss-Prot
InterPro LMIP UniProtKB/Swiss-Prot
  PMP-22/EMP/MP20 UniProtKB/Swiss-Prot
  PMP22/EMP/MP20/Claudin UniProtKB/Swiss-Prot
  PMP22_EMP_MP20 UniProtKB/Swiss-Prot
KEGG Report rno:114903 UniProtKB/Swiss-Prot
NCBI Gene 114903 ENTREZGENE
PANTHER EPITHELIAL MEMBRANE PROTEIN-RELATED UniProtKB/Swiss-Prot
  LENS FIBER MEMBRANE INTRINSIC PROTEIN UniProtKB/Swiss-Prot
Pfam PMP22_Claudin UniProtKB/Swiss-Prot
PhenoGen Lim2 PhenoGen
PRINTS EPMEMFAMILY UniProtKB/Swiss-Prot
  LENSMEMPROT UniProtKB/Swiss-Prot
PROSITE PMP22_1 UniProtKB/Swiss-Prot
  PMP22_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017681 RatGTEx
UniProt A6JAH5 ENTREZGENE, UniProtKB/TrEMBL
  LMIP_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 22 of 22 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Lim2  lens intrinsic membrane protein 2    lens intrinsic membrane protein 2, 19kDa  Name updated 1299863 APPROVED
2004-09-10 Lim2  lens intrinsic membrane protein 2, 19kDa    lens intrinsic membrane protein 2 (19 kDa)  Name updated 1299863 APPROVED
2002-08-07 Lim2  lens intrinsic membrane protein 2 (19 kDa)      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_cellular_localization localized to plasma membrane 727321
gene_physical_interaction interacts with galectin-3 possibly through a lectin site 727321
gene_product member of the tetraspanin superfamily 727321