Lim2 (lens intrinsic membrane protein 2) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Lim2 (lens intrinsic membrane protein 2) Rattus norvegicus
Analyze
Symbol: Lim2
Name: lens intrinsic membrane protein 2
RGD ID: 621482
Description: Predicted to be a structural constituent of eye lens. Predicted to act upstream of or within lens development in camera-type eye. Located in vesicle. Human ortholog(s) of this gene implicated in cataract and cataract 19 multiple types. Orthologous to human LIM2 (lens intrinsic membrane protein 2); INTERACTS WITH acrylamide; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: lens fiber membrane intrinsic protein; lens intrinsic membrane protein 2 (19 kDa); lens intrinsic membrane protein 2, 19kDa; MP17; MP18; Mp19; MP20
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81102,974,188 - 102,980,358 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1102,974,188 - 102,980,358 (+)EnsemblGRCr8
mRatBN7.2193,837,597 - 93,843,769 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl193,837,597 - 93,843,769 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx199,222,952 - 99,229,118 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01107,695,622 - 107,701,792 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01100,988,204 - 100,994,372 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0198,495,082 - 98,501,248 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl198,495,082 - 98,501,249 (-)Ensemblrn6Rnor6.0
Rnor_5.0199,571,887 - 99,578,053 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4193,805,817 - 93,811,981 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera188,114,711 - 88,120,877 (+)NCBICelera
RGSC_v3.1193,883,926 - 93,890,087 (+)NCBI
Cytogenetic Map1q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)
plasma membrane  (IBA)
vesicle  (IDA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The human lens fiber-cell intrinsic membrane protein MP19 gene: isolation and sequence analysis. Church RL and Wang JH, Curr Eye Res 1993 Dec;12(12):1057-65.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. MP20, the second most abundant lens membrane protein and member of the tetraspanin superfamily, joins the list of ligands of galectin-3. Gonen T, etal., BMC Cell Biol. 2001;2:17. Epub 2001 Aug 14.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. A missense mutation in the LIM2 gene is associated with autosomal recessive presenile cataract in an inbred Iraqi Jewish family. Pras E, etal., Am J Hum Genet. 2002 May;70(5):1363-7. Epub 2002 Mar 26.
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:2584203   PMID:6510713   PMID:6877261   PMID:7088001   PMID:7679355   PMID:8812411   PMID:9238094  


Genomics

Comparative Map Data
Lim2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81102,974,188 - 102,980,358 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1102,974,188 - 102,980,358 (+)EnsemblGRCr8
mRatBN7.2193,837,597 - 93,843,769 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl193,837,597 - 93,843,769 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx199,222,952 - 99,229,118 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01107,695,622 - 107,701,792 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01100,988,204 - 100,994,372 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0198,495,082 - 98,501,248 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl198,495,082 - 98,501,249 (-)Ensemblrn6Rnor6.0
Rnor_5.0199,571,887 - 99,578,053 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4193,805,817 - 93,811,981 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera188,114,711 - 88,120,877 (+)NCBICelera
RGSC_v3.1193,883,926 - 93,890,087 (+)NCBI
Cytogenetic Map1q22NCBI
LIM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381951,379,909 - 51,387,974 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1951,379,909 - 51,388,264 (-)Ensemblhg38GRCh38
GRCh371951,883,163 - 51,891,228 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361956,574,976 - 56,583,009 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341956,574,975 - 56,583,009NCBI
Celera1948,934,200 - 48,942,254 (-)NCBICelera
Cytogenetic Map19q13.41NCBI
HuRef1948,215,130 - 48,223,189 (-)NCBIHuRef
CHM1_11951,885,115 - 51,893,162 (-)NCBICHM1_1
T2T-CHM13v2.01954,468,540 - 54,476,605 (-)NCBIT2T-CHM13v2.0
Lim2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39743,079,523 - 43,085,420 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl743,079,512 - 43,085,420 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38743,430,099 - 43,435,996 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl743,430,088 - 43,435,996 (+)Ensemblmm10GRCm38
MGSCv37750,685,471 - 50,691,361 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36743,298,021 - 43,303,911 (+)NCBIMGSCv36mm8
Celera738,896,762 - 38,902,653 (+)NCBICelera
Cytogenetic Map7B3NCBI
cM Map728.25NCBI
Lim2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555581,019,244 - 1,024,375 (+)Ensembl
ChiLan1.0NW_0049555581,019,709 - 1,024,375 (+)NCBIChiLan1.0ChiLan1.0
LIM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22057,417,235 - 57,425,354 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11959,338,718 - 59,346,839 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01948,315,028 - 48,323,144 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11957,200,260 - 57,208,358 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1957,200,260 - 57,208,354 (-)EnsemblpanPan2panpan1.1
LIM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11105,593,457 - 105,599,788 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1105,593,224 - 105,599,650 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1105,166,165 - 105,172,438 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01106,103,001 - 106,109,279 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1106,102,710 - 106,109,141 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11105,774,650 - 105,780,923 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01105,415,503 - 105,421,782 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01106,211,043 - 106,217,316 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Lim2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934923,074,318 - 23,076,287 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493737846,650 - 48,619 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LIM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl658,481,686 - 58,489,279 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1658,482,690 - 58,489,711 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2651,700,855 - 51,707,646 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LIM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1644,298,667 - 44,306,302 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl644,298,958 - 44,306,117 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607324,347,860 - 24,355,988 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lim2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248323,493,670 - 3,497,459 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248323,493,670 - 3,497,459 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Lim2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12156,042,126 - 156,048,914 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Lim2
62 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:58
Count of miRNA genes:52
Interacting mature miRNAs:56
Transcripts:ENSRNOT00000023858
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)197582336142582336Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat

Markers in Region
BG373005  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2193,841,346 - 93,841,570 (-)MAPPERmRatBN7.2
Rnor_6.0198,497,276 - 98,497,499NCBIRnor6.0
Rnor_5.0199,574,081 - 99,574,304UniSTSRnor5.0
RGSC_v3.4193,809,566 - 93,809,789UniSTSRGSC3.4
Celera188,118,460 - 88,118,683UniSTS
Cytogenetic Map1q22UniSTS
RH127383  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2193,836,890 - 93,837,093 (-)MAPPERmRatBN7.2
Rnor_6.0198,501,753 - 98,501,955NCBIRnor6.0
Rnor_5.0199,578,558 - 99,578,760UniSTSRnor5.0
RGSC_v3.4193,805,110 - 93,805,312UniSTSRGSC3.4
Celera188,114,004 - 88,114,206UniSTS
Cytogenetic Map1q22UniSTS
GDB:373986  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2193,838,340 - 93,838,493 (-)MAPPERmRatBN7.2
Rnor_6.0198,500,353 - 98,500,505NCBIRnor6.0
Rnor_5.0199,577,158 - 99,577,310UniSTSRnor5.0
RGSC_v3.4193,806,560 - 93,806,712UniSTSRGSC3.4
Celera188,115,454 - 88,115,606UniSTS
Cytogenetic Map1q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
11 2 55 84 23 29 3 60 3 2 173 127 3 73 31 53 26

Sequence


Ensembl Acc Id: ENSRNOT00000023858   ⟹   ENSRNOP00000023858
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1102,974,188 - 102,980,358 (+)Ensembl
mRatBN7.2 Ensembl193,837,597 - 93,843,769 (+)Ensembl
Rnor_6.0 Ensembl198,495,082 - 98,501,249 (-)Ensembl
RefSeq Acc Id: NM_053771   ⟹   NP_446223
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81102,974,188 - 102,980,358 (+)NCBI
mRatBN7.2193,837,597 - 93,843,769 (+)NCBI
Rnor_6.0198,495,082 - 98,501,248 (-)NCBI
Rnor_5.0199,571,887 - 99,578,053 (-)NCBI
RGSC_v3.4193,805,817 - 93,811,981 (+)RGD
Celera188,114,711 - 88,120,877 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_446223 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41631 (Get FASTA)   NCBI Sequence Viewer  
  AAB02792 (Get FASTA)   NCBI Sequence Viewer  
  AAB25334 (Get FASTA)   NCBI Sequence Viewer  
  EDM07559 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000023858
  ENSRNOP00000023858.1
GenBank Protein P54825 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446223   ⟸   NM_053771
- UniProtKB: P54825 (UniProtKB/Swiss-Prot),   A6JAH5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023858   ⟸   ENSRNOT00000023858

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P54825-F1-model_v2 AlphaFold P54825 1-173 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621482 AgrOrtholog
BioCyc Gene G2FUF-59852 BioCyc
Ensembl Genes ENSRNOG00000017681 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023858 ENTREZGENE
  ENSRNOT00000023858.3 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.140.150 UniProtKB/Swiss-Prot
InterPro LMIP UniProtKB/Swiss-Prot
  PMP-22/EMP/MP20 UniProtKB/Swiss-Prot
  PMP22/EMP/MP20/Claudin UniProtKB/Swiss-Prot
  PMP22_EMP_MP20 UniProtKB/Swiss-Prot
KEGG Report rno:114903 UniProtKB/Swiss-Prot
NCBI Gene 114903 ENTREZGENE
PANTHER EPITHELIAL MEMBRANE PROTEIN-RELATED UniProtKB/Swiss-Prot
  LENS FIBER MEMBRANE INTRINSIC PROTEIN UniProtKB/Swiss-Prot
Pfam PMP22_Claudin UniProtKB/Swiss-Prot
PhenoGen Lim2 PhenoGen
PRINTS EPMEMFAMILY UniProtKB/Swiss-Prot
  LENSMEMPROT UniProtKB/Swiss-Prot
PROSITE PMP22_1 UniProtKB/Swiss-Prot
  PMP22_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017681 RatGTEx
UniProt A6JAH5 ENTREZGENE, UniProtKB/TrEMBL
  LMIP_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Lim2  lens intrinsic membrane protein 2    lens intrinsic membrane protein 2, 19kDa  Name updated 1299863 APPROVED
2004-09-10 Lim2  lens intrinsic membrane protein 2, 19kDa    lens intrinsic membrane protein 2 (19 kDa)  Name updated 1299863 APPROVED
2002-08-07 Lim2  lens intrinsic membrane protein 2 (19 kDa)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to plasma membrane 727321
gene_physical_interaction interacts with galectin-3 possibly through a lectin site 727321
gene_product member of the tetraspanin superfamily 727321