Kcnh2 (potassium voltage-gated channel subfamily H member 2) - Rat Genome Database

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Gene: Kcnh2 (potassium voltage-gated channel subfamily H member 2) Rattus norvegicus
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Symbol: Kcnh2
Name: potassium voltage-gated channel subfamily H member 2
RGD ID: 621414
Description: Enables inward rectifier potassium channel activity and scaffold protein binding activity. Involved in potassium ion transport; regulation of membrane potential; and spinal cord development. Predicted to be located in cell surface and perinuclear region of cytoplasm. Predicted to be part of inward rectifier potassium channel complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in long QT syndrome; long QT syndrome 2; and short QT syndrome. Orthologous to human KCNH2 (potassium voltage-gated channel subfamily H member 2); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: eag-related protein 1; ERG-1; ERG1; ether-a-go-go-related gene potassium channel 1; ether-a-go-go-related protein 1; potassium channel, voltage gated eag related subfamily H, member 2; potassium voltage-gated channel, subfamily H (eag-related), member 2; r-ERG; RERG; voltage-gated inwardly rectifying potassium channel KCNH2; voltage-gated potassium channel subunit Kv11.1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8411,719,357 - 11,751,424 (+)NCBIGRCr8
mRatBN7.2410,826,834 - 10,859,009 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl410,826,928 - 10,859,008 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx415,973,605 - 16,005,332 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0411,793,792 - 11,825,521 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0410,145,580 - 10,177,308 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.047,355,066 - 7,387,282 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl47,355,574 - 7,387,253 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.047,366,726 - 7,398,606 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.446,192,644 - 6,224,285 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.146,192,643 - 6,224,284 (+)NCBI
Celera46,444,570 - 6,473,521 (+)NCBICelera
Cytogenetic Map4q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
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Original Reference(s)
Kcnh2Ratlong QT syndrome  ISOKCNH2 (Homo sapiens)1580502 RGD 
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Kcnh2RatAlstrom syndrome  ISOKCNH2 (Homo sapiens)8554872ClinVar Annotator: match by term: Alstrom's syndromeClinVarPMID:25741868 more ...
Kcnh2Ratarrhythmogenic right ventricular cardiomyopathy  ISOKCNH2 (Homo sapiens)8554872ClinVar Annotator: match by term: Cardiomyopathy and ARVCClinVarPMID:15176425 more ...
Kcnh2Ratatrial fibrillation  ISOKCNH2 (Homo sapiens)8554872ClinVar Annotator: match by term: Atrial fibrillationClinVarPMID:10807545 more ...
Kcnh2RatAutoimmune Lymphoproliferative Syndrome, Type V  ISOKCNH2 (Homo sapiens)8554872ClinVar Annotator: match by term: IMMUNE DYSREGULATION WITH AUTOIMMUNITY more ...ClinVarPMID:15176425 more ...
Kcnh2RatBrugada syndrome  ISOKCNH2 (Homo sapiens)8554872ClinVar Annotator: match by term: Sudden Unexplained Nocturnal Death Syndrome (SUNDS)ClinVarPMID:11997281 more ...
Kcnh2RatBrugada syndrome 1  ISOKCNH2 (Homo sapiens)8554872ClinVar Annotator: match by term: Right bundle branch block more ...ClinVarPMID:19716085 more ...
Kcnh2RatBrugada syndrome 1  ISOKCNH2 (Homo sapiens)8554872ClinVar Annotator: match by term: Right bundle branch block more ...ClinVarPMID:19716085 more ...
Kcnh2RatCardiac Arrhythmias  ISOKCNH2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:30369311 more ...
Kcnh2RatCardiac Arrhythmias  ISOKCNH2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10086971 more ...
Kcnh2RatCardiac Arrhythmias  ISOKCNH2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10187793 more ...
Kcnh2RatCardiac Arrhythmias  ISOKCNH2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:32843460 more ...
Kcnh2RatCardiac Arrhythmias  ISOKCNH2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10187793 more ...
Kcnh2RatCardiac Arrhythmias  ISOKCNH2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:30369311 more ...
Kcnh2RatCardiac Arrhythmias  ISOKCNH2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10187793 more ...
Kcnh2RatCardiac Arrhythmias  ISOKCNH2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10187793 more ...
Kcnh2RatCardiac Conduction Defect  ISOKCNH2 (Homo sapiens)8554872ClinVar Annotator: match by term: cardiac conduction defectClinVarPMID:17088455 more ...
Kcnh2Ratcatecholaminergic polymorphic ventricular tachycardia 1  ISOKCNH2 (Homo sapiens)8554872ClinVar Annotator: match by term: Catecholaminergic polymorphic ventricular tachycardia 1ClinVar 
Kcnh2Ratdilated cardiomyopathy  ISOKCNH2 (Homo sapiens)8554872ClinVar Annotator: match by term: Primary dilated cardiomyopathyClinVarPMID:15176425 more ...
Kcnh2Ratfamilial hypertrophic cardiomyopathy  ISOKCNH2 (Homo sapiens)8554872ClinVar Annotator: match by term: Primary familial hypertrophic cardiomyopathyClinVarPMID:11222472 more ...
Kcnh2Ratgenetic disease  ISOKCNH2 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:19716085 more ...
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Kcnh2Ratatrial fibrillation  ISOKCNH2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29892015 and PMID:30061737
Kcnh2RatCardiac Arrhythmias  ISOKCNH2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:14678746 more ...
Kcnh2RatColonic Neoplasms  ISOKCNH2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16086867
Kcnh2Ratdisease of cellular proliferation  ISOKCNH2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24830940
Kcnh2Ratlong QT syndrome  ISOKCNH2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:7889573 more ...
Kcnh2Ratlong QT syndrome 2  ISOKCNH2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Kcnh2Ratmuscular atrophy  ISOKCNH2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16723379
Kcnh2RatNeoplastic Cell Transformation  ISOKCNH2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24830940
Kcnh2RatShort QT Syndrome 1  ISOKCNH2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18724381 and PMID:29574456
Kcnh2RatTorsades de Pointes  ISOKCNH2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15043509 more ...
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Kcnh2Ratshort QT syndrome  ISSKcnh2 (Mus musculus)13592920OMIM:609620 more ...MouseDO 
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Kcnh2Ratlong QT syndrome 2  ISOKCNH2 (Homo sapiens)7240710 OMIM 
Kcnh2RatShort QT Syndrome 1  ISOKCNH2 (Homo sapiens)7240710 OMIM 

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Kcnh2Rat(+)-butaclamol decreases activityISOKCNH2 (Homo sapiens)6480464Butaclamol results in decreased activity of KCNH2 proteinCTDPMID:28551711
Kcnh2Rat(-)-lobeline decreases activityISOKCNH2 (Homo sapiens)6480464Lobeline results in decreased activity of KCNH2 proteinCTDPMID:28551711
Kcnh2Rat(R,R,R)-alpha-tocopherol multiple interactionsISOKCNH2 (Homo sapiens)6480464alpha-Tocopherol inhibits the reaction [Glucose results in decreased activity of KCNH2 protein]CTDPMID:12531891
Kcnh2Rat(S)-duloxetine hydrochloride decreases activityISOKCNH2 (Homo sapiens)6480464Duloxetine Hydrochloride results in decreased activity of KCNH2 proteinCTDPMID:28551711
Kcnh2Rat(S)-naringenin multiple interactionsISOKCNH2 (Homo sapiens)6480464Amiodarone promotes the reaction [naringenin results in decreased activity of KCNH2 protein] more ...CTDPMID:18057881
Kcnh2Rat(S)-naringenin decreases activityISOKCNH2 (Homo sapiens)6480464naringenin results in decreased activity of KCNH2 proteinCTDPMID:18057881
Kcnh2Rat(S)-nicotine increases expressionISOKcnh2 (Mus musculus)6480464Nicotine results in increased expression of KCNH2 mRNACTDPMID:17997037
Kcnh2Rat(Z)-chlorprothixene decreases activityISOKCNH2 (Homo sapiens)6480464Chlorprothixene results in decreased activity of KCNH2 proteinCTDPMID:28551711
Kcnh2Rat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane multiple interactionsISOKCNH2 (Homo sapiens)6480464[o and p'-DDT results in decreased activity of KCNH2 protein] which results in decreased import of ThalliumCTDPMID:21362439
Kcnh2Rat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane decreases activityISOKCNH2 (Homo sapiens)6480464o and p'-DDT results in decreased activity of KCNH2 proteinCTDPMID:21362439
Kcnh2Rat1,3-bis(2-ethylhexyl)-5-methyl-1,3-diazinan-5-amine decreases activityISOKCNH2 (Homo sapiens)6480464Hexetidine results in decreased activity of KCNH2 proteinCTDPMID:28551711
Kcnh2Rat1,3-diphenylguanidine multiple interactionsISOKCNH2 (Homo sapiens)6480464[diphenylguanidine results in decreased activity of KCNH2 protein] which results in decreased import of ThalliumCTDPMID:21362439
Kcnh2Rat1,3-diphenylguanidine decreases activityISOKCNH2 (Homo sapiens)6480464diphenylguanidine results in decreased activity of KCNH2 proteinCTDPMID:21362439
Kcnh2Rat1-(4-chlorophenyl)-4-(dimethylamino)-2,3-dimethyl-2-butanol decreases activityISOKCNH2 (Homo sapiens)6480464clobutinol results in decreased activity of KCNH2 proteinCTDPMID:19034038 and PMID:28551711
Kcnh2Rat1-[10-[3-[4-(2-hydroxyethyl)-1-piperidinyl]propyl]-2-phenothiazinyl]ethanone decreases activityISOKCNH2 (Homo sapiens)6480464piperacetazine results in decreased activity of KCNH2 proteinCTDPMID:28551711
Kcnh2Rat1-[2-[(4-chlorophenyl)-phenylmethoxy]ethyl]piperidine decreases activityISOKCNH2 (Homo sapiens)6480464cloperastine results in decreased activity of KCNH2 proteinCTDPMID:28551711
Kcnh2Rat1-phenyl-1-cyclopentanecarboxylic acid 2-[2-(diethylamino)ethoxy]ethyl ester decreases activityISOKCNH2 (Homo sapiens)6480464carbetapentane results in decreased activity of KCNH2 proteinCTDPMID:19034038
Kcnh2Rat10H-phenothiazine decreases activityISOKCNH2 (Homo sapiens)6480464phenothiazine results in decreased activity of KCNH2 proteinCTDPMID:28551711
Kcnh2Rat17alpha-ethynylestradiol affects expressionISOKcnh2 (Mus musculus)6480464Ethinyl Estradiol affects the expression of KCNH2 mRNACTDPMID:17555576
Kcnh2Rat17alpha-ethynylestradiol multiple interactionsISOKcnh2 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of KCNH2 mRNACTDPMID:17942748

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Biological Process
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Kcnh2Ratcardiac muscle contraction involved_inISOKCNH2 (Homo sapiens)1624291 PMID:21536673RGDPMID:21536673
Kcnh2Ratcellular response to xenobiotic stimulus involved_inISOKCNH2 (Homo sapiens)1624291 PMID:7604285RGDPMID:7604285
Kcnh2Ratmembrane depolarization during action potential involved_inISOKCNH2 (Homo sapiens)1624291 PMID:7604285RGDPMID:7604285
Kcnh2Ratmembrane repolarization involved_inISOKCNH2 (Homo sapiens)1624291 PMID:14525949RGDPMID:14525949
Kcnh2Ratmembrane repolarization during action potential involved_inISOKCNH2 (Homo sapiens)1624291 PMID:11953308 more ...RGDPMID:11953308 more ...
Kcnh2Ratmembrane repolarization during cardiac muscle cell action potential involved_inISOKCNH2 (Homo sapiens)1624291 PMID:21536673RGDPMID:21536673
Kcnh2Ratmembrane repolarization during cardiac muscle cell action potential involved_inIBAPANTHER:PTN002566349 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Kcnh2Ratmembrane repolarization during ventricular cardiac muscle cell action potential involved_inISOKCNH2 (Homo sapiens)1624291 PMID:21536673RGDPMID:21536673
Kcnh2Ratmonoatomic ion transmembrane transport involved_inIEAUniProtKB-KW:KW-0407 and UniProtKB-KW:KW-08511600115GO_REF:0000043UniProtGO_REF:0000043
Kcnh2Ratmonoatomic ion transport involved_inIEAInterPro:IPR0058211600115GO_REF:0000002InterProGO_REF:0000002
Kcnh2Ratmonoatomic ion transport involved_inIEAUniProtKB-KW:KW-04061600115GO_REF:0000043UniProtGO_REF:0000043
Kcnh2Ratnegative regulation of potassium ion export across plasma membrane involved_inISOKCNH2 (Homo sapiens)1624291 PMID:7604285 and PMID:8587608RGDPMID:7604285 and PMID:8587608
Kcnh2Ratnegative regulation of potassium ion transmembrane transport involved_inISOKCNH2 (Homo sapiens)1624291 PMID:7604285 and PMID:8587608RGDPMID:7604285 and PMID:8587608
Kcnh2Ratpositive regulation of DNA-templated transcription involved_inISOKCNH2 (Homo sapiens)1624291 PMID:31146003RGDPMID:31146003
Kcnh2Ratpositive regulation of potassium ion transmembrane transport involved_inISOKCNH2 (Homo sapiens)1624291 PMID:7736582RGDPMID:7736582
Kcnh2Ratpotassium ion export across plasma membrane involved_inISOKCNH2 (Homo sapiens)1624291UniProtKB:Q6ZRF8 more ...RGDPMID:25281747 and PMID:7604285
Kcnh2Ratpotassium ion homeostasis involved_inISOKCNH2 (Homo sapiens)1624291 PMID:7604285 and PMID:8587608RGDPMID:7604285 and PMID:8587608
Kcnh2Ratpotassium ion import across plasma membrane involved_inISOKCNH2 (Homo sapiens)1624291 PMID:7604285RGDPMID:7604285
Kcnh2Ratpotassium ion transmembrane transport involved_inISOKCNH2 (Homo sapiens)1624291 PMID:11953308 more ...RGDPMID:11953308 more ...
Kcnh2Ratpotassium ion transmembrane transport acts_upstream_of_or_withinISOKcnh2 (Mus musculus)1624291 PMID:9351446 and PMID:9351462RGDPMID:9351446 and PMID:9351462
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Cellular Component
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Molecular Function
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Kcnh2Ratdelayed rectifier potassium channel activity enablesISOKCNH2 (Homo sapiens)1624291UniProtKB:Q6ZRF8 more ...RGDPMID:25281747 and PMID:7736582
Kcnh2Ratidentical protein binding enablesISOKCNH2 (Homo sapiens)1624291UniProtKB:Q12809 more ...RGDPMID:24931372 and PMID:8995352
Kcnh2Ratinward rectifier potassium channel activity  IDA 1580505 RGD 
Kcnh2Ratinward rectifier potassium channel activity enablesIBAMGI:1341722 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Kcnh2Ratinward rectifier potassium channel activity enablesISOKcnh2 (Mus musculus)1624291 PMID:9351462RGDPMID:9351462
Kcnh2Ratinward rectifier potassium channel activity enablesISOKCNH2 (Homo sapiens)1624291 PMID:14525949 more ...RGDPMID:14525949 more ...
Kcnh2Ratinward rectifier potassium channel activity enablesISOKCNH2 (Canis lupus familiaris)1624291 PMID:11417212RGDPMID:11417212
Kcnh2Ratinward rectifier potassium channel activity NOT|enablesISOKCNH2 (Homo sapiens) more ...1624291 PMID:18559421RGDPMID:18559421
Kcnh2Ratinward rectifier potassium channel activity enablesISOKCNH2 (Homo sapiens) and UniProtKB:Q12809-11624291 PMID:10790218 more ...RGDPMID:10790218 more ...
Kcnh2Ratinward rectifier potassium channel activity NOT|enablesISOKCNH2 (Homo sapiens) and UniProtKB:Q12809-51624291 PMID:9765245RGDPMID:9765245
Kcnh2Ratinward rectifier potassium channel activity enablesISOKCNH2 (Homo sapiens) more ...1624291 PMID:18559421RGDPMID:18559421
Kcnh2Ratinward rectifier potassium channel activity enablesIDA 2314395PMID:11212207UniProt 
Kcnh2Ratinward rectifier potassium channel activity enablesIDA 729087PMID:9664620UniProt 
Kcnh2Ratmonoatomic ion channel activity  IDA 625508 RGD 
Kcnh2Ratmonoatomic ion channel activity enablesIEAInterPro:IPR0058211600115GO_REF:0000002InterProGO_REF:0000002
Kcnh2Ratpotassium channel activity  IDA 625508 RGD 
Kcnh2Ratpotassium channel activity enablesIEAUniProtKB-KW:KW-06311600115GO_REF:0000043UniProtGO_REF:0000043
Kcnh2Ratprotein binding enablesISOKCNH2 (Homo sapiens) and UniProtKB:Q12809-11624291UniProtKB:P15382 more ...RGDPMID:26363003 and PMID:9230439
Kcnh2Ratprotein binding enablesIPIUniProtKB:P516388553349PMID:22879586BHF-UCL 
Kcnh2Ratprotein binding enablesISOKCNH2 (Homo sapiens)1624291UniProtKB:P27824 more ...RGDPMID:11953308 more ...
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Imported Annotations - SMPDB

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Kcnh2Ratacebutolol pharmacodynamics pathway  ISOKCNH2 (Homo sapiens)10402751 SMPDBSMP:00296
Kcnh2Ratadrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway   ISOKCNH2 (Homo sapiens)10402751 SMPDBSMP:00296
Kcnh2Ratamiodarone pharmacodynamics pathway  ISOKCNH2 (Homo sapiens)10402751 SMPDBSMP:00665
Kcnh2Ratamlodipine pharmacodynamics pathway  ISOKCNH2 (Homo sapiens)10402751 SMPDBSMP:00376
Kcnh2Ratatenolol pharmacodynamics pathway  ISOKCNH2 (Homo sapiens)10402751 SMPDBSMP:00298
Kcnh2Ratbetaxolol pharmacodynamics pathway  ISOKCNH2 (Homo sapiens)10402751 SMPDBSMP:00299
Kcnh2Ratbisoprolol pharmacodynamics pathway  ISOKCNH2 (Homo sapiens)10402751 SMPDBSMP:00300
Kcnh2Ratbupranolol drug pathway  ISOKCNH2 (Homo sapiens)10402751 SMPDBSMP:00670
Kcnh2Ratbupranolol pharmacodynamics pathway  ISOKCNH2 (Homo sapiens)10402751 SMPDBSMP:00670
Kcnh2Ratcarvedilol pharmacodynamics pathway  ISOKCNH2 (Homo sapiens)10402751 SMPDBSMP:00367
Kcnh2Ratdiltiazem pharmacodynamics pathway  ISOKCNH2 (Homo sapiens)10402751 SMPDBSMP:00359
Kcnh2Ratdisopyramide pharmacodynamics pathway  ISOKCNH2 (Homo sapiens)10402751 SMPDBSMP:00325
Kcnh2Ratdobutamine pharmacodynamics pathway  ISOKCNH2 (Homo sapiens)10402751 SMPDBSMP:00662
Kcnh2Ratesmolol pharmacodynamics pathway  ISOKCNH2 (Homo sapiens)10402751 SMPDBSMP:00301
Kcnh2Ratflecainde pharmacodynamics pathway  ISOKCNH2 (Homo sapiens)10402751 SMPDBSMP:00331
Kcnh2Ratfosphenytoin pharmacodynamics pathway  ISOKCNH2 (Homo sapiens)10402751 SMPDBSMP:00326
Kcnh2Ratibutilide pharmacodynamics pathway  ISOKCNH2 (Homo sapiens)10402751 SMPDBSMP:00332
Kcnh2Ratisoprenaline pharmacodynamics pathway  ISOKCNH2 (Homo sapiens)10402751 SMPDBSMP:00663
Kcnh2Ratisradipine pharmacodynamics pathway  ISOKCNH2 (Homo sapiens)10402751 SMPDBSMP:00378
Kcnh2Ratlevobunolol pharmacodynamics pathway  ISOKCNH2 (Homo sapiens)10402751 SMPDBSMP:00666
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Reference Title
Reference Citation
1. RERG is a molecular correlate of the inward-rectifying K current in clonal rat pituitary cells. Bauer CK, etal., Receptors Channels 1998;6(1):19-29.
2. Regulation of an ERG K+ current by Src tyrosine kinase. Cayabyab FS and Schlichter LC, J Biol Chem 2002 Apr 19;277(16):13673-81.
3. Expression of the IKr components KCNH2 (rERG) and KCNE2 (rMiRP1) during late rat heart development. Chun KR, etal., Exp Mol Med. 2004 Aug 31;36(4):367-71.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Cell surface expression of human ether-a-go-go-related gene (hERG) channels is regulated by caveolin-3 protein via the ubiquitin ligase Nedd4-2. Guo J, etal., J Biol Chem. 2012 Sep 28;287(40):33132-41. Epub 2012 Aug 9.
7. Fast erg K+ currents in rat embryonic serotonergic neurones. Hirdes W, etal., J Physiol. 2005 Apr 1;564(Pt 1):33-49. Epub 2005 Jan 27.
8. Short QT syndrome and atrial fibrillation caused by mutation in KCNH2. Hong K, etal., J Cardiovasc Electrophysiol. 2005 Apr;16(4):394-6.
9. The regulation of the cardiac potassium channel (HERG) by caveolin-1. Lin J, etal., Biochem Cell Biol. 2008 Oct;86(5):405-15. doi: 10.1139/o08-118.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Molecular and functional characterization of ERG, KCNQ, and KCNE subtypes in rat stomach smooth muscle. Ohya S, etal., Am J Physiol Gastrointest Liver Physiol 2002 Feb;282(2):G277-87.
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Identification of two nervous system-specific members of the erg potassium channel gene family. Shi W, etal., J Neurosci 1997 Dec 15;17(24):9423-32.
19. Compendium of cardiac channel mutations in 541 consecutive unrelated patients referred for long QT syndrome genetic testing. Tester DJ, etal., Heart Rhythm. 2005 May;2(5):507-17.
20. Erg1, erg2 and erg3 K channel subunits are able to form heteromultimers. Wimmers S, etal., Pflugers Arch. 2001 Jan;441(4):450-5.
1 to 20 of 21 rows
PMID:7604285   PMID:7736582   PMID:7889573   PMID:8587608   PMID:8995352   PMID:9351446   PMID:9351462   PMID:10718922   PMID:10843886   PMID:11953308   PMID:14525949   PMID:14668215  
PMID:14670813   PMID:16339175   PMID:17322986   PMID:19913309   PMID:19921238   PMID:20605793   PMID:21063088   PMID:21463633   PMID:21536673   PMID:23589291   PMID:24931372   PMID:25281747  
PMID:27071825   PMID:28280240   PMID:29507111   PMID:29949809   PMID:30544220   PMID:32388931   PMID:32559772   PMID:33263944   PMID:33426760   PMID:35841324   PMID:38063256  



Kcnh2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8411,719,357 - 11,751,424 (+)NCBIGRCr8
mRatBN7.2410,826,834 - 10,859,009 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl410,826,928 - 10,859,008 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx415,973,605 - 16,005,332 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0411,793,792 - 11,825,521 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0410,145,580 - 10,177,308 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.047,355,066 - 7,387,282 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl47,355,574 - 7,387,253 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.047,366,726 - 7,398,606 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.446,192,644 - 6,224,285 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.146,192,643 - 6,224,284 (+)NCBI
Celera46,444,570 - 6,473,521 (+)NCBICelera
Cytogenetic Map4q11NCBI
KCNH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387150,944,961 - 150,978,321 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7150,944,961 - 150,978,321 (-)EnsemblGRCh38hg38GRCh38
GRCh377150,642,049 - 150,675,409 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367150,272,982 - 150,305,947 (-)NCBINCBI36Build 36hg18NCBI36
Build 347150,079,696 - 150,090,563NCBI
Celera7145,199,077 - 145,232,050 (-)NCBICelera
Cytogenetic Map7q36.1NCBI
HuRef7144,454,320 - 144,487,268 (-)NCBIHuRef
CHM1_17150,650,401 - 150,683,838 (-)NCBICHM1_1
T2T-CHM13v2.07152,117,824 - 152,151,201 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27149,971,333 - 150,004,698 (-)NCBI
Kcnh2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39524,524,583 - 24,556,671 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl524,524,587 - 24,556,602 (-)EnsemblGRCm39 Ensembl
GRCm38524,319,589 - 24,351,684 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl524,319,589 - 24,351,604 (-)EnsemblGRCm38mm10GRCm38
MGSCv37523,825,407 - 23,857,422 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36523,829,654 - 23,861,669 (-)NCBIMGSCv36mm8
Celera521,266,318 - 21,295,272 (-)NCBICelera
Cytogenetic Map5A3NCBI
cM Map510.94NCBI
Kcnh2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554915,391,384 - 5,422,241 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554915,391,444 - 5,422,241 (-)NCBIChiLan1.0ChiLan1.0
KCNH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26187,362,612 - 187,395,976 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1739,372,876 - 39,406,239 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07142,528,979 - 142,562,074 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17154,680,927 - 154,713,525 (-)NCBIpanpan1.1PanPan1.1panPan2
KCNH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11615,009,031 - 15,041,786 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1615,009,031 - 15,041,504 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1615,617,297 - 15,650,061 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01616,724,206 - 16,757,289 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1616,724,490 - 16,757,289 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11615,103,715 - 15,136,482 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01615,685,081 - 15,717,872 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01615,735,820 - 15,768,605 (-)NCBIUU_Cfam_GSD_1.0
Kcnh2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244051186,491,041 - 6,523,203 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365276,379,669 - 6,412,390 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365276,380,222 - 6,412,390 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl186,243,524 - 6,279,111 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1186,242,826 - 6,279,154 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2186,719,117 - 6,725,624 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNH2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121119,123,601 - 119,156,985 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21119,124,007 - 119,156,794 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607215,095,069 - 15,128,476 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnh2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248005,632,726 - 5,663,771 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248005,633,060 - 5,663,700 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Kcnh2
90 total Variants

Predicted Target Of
Summary Value
Count of predictions:308
Count of miRNA genes:165
Interacting mature miRNAs:193
Transcripts:ENSRNOT00000013800
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 29 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4131934116Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4127716890Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4131934116Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4133250345Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4133250345Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat

1 to 10 of 29 rows



alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 86 85 54 25 54 6 213 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000013800   ⟹   ENSRNOP00000013800
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl410,826,928 - 10,859,008 (+)Ensembl
Rnor_6.0 Ensembl47,355,574 - 7,387,253 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000084826   ⟹   ENSRNOP00000073593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl410,849,037 - 10,859,008 (+)Ensembl
Rnor_6.0 Ensembl47,377,563 - 7,387,240 (+)Ensembl
RefSeq Acc Id: NM_053949   ⟹   NP_446401
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8411,719,782 - 11,751,422 (+)NCBI
mRatBN7.2410,827,369 - 10,859,009 (+)NCBI
Rnor_6.047,355,601 - 7,387,241 (+)NCBI
Rnor_5.047,366,726 - 7,398,606 (+)NCBI
RGSC_v3.446,192,644 - 6,224,285 (+)RGD
Celera46,444,570 - 6,473,521 (+)RGD
Sequence:
RefSeq Acc Id: XM_006235867   ⟹   XP_006235929
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8411,719,362 - 11,751,424 (+)NCBI
mRatBN7.2410,826,834 - 10,859,008 (+)NCBI
Rnor_6.047,355,066 - 7,387,282 (+)NCBI
Rnor_5.047,366,726 - 7,398,606 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008762630   ⟹   XP_008760852
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8411,741,410 - 11,751,424 (+)NCBI
mRatBN7.2410,848,982 - 10,859,008 (+)NCBI
Rnor_6.047,377,219 - 7,387,282 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039106950   ⟹   XP_038962878
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8411,736,628 - 11,751,424 (+)NCBI
mRatBN7.2410,845,184 - 10,859,008 (+)NCBI
RefSeq Acc Id: XM_039106951   ⟹   XP_038962879
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8411,719,357 - 11,746,027 (+)NCBI
mRatBN7.2410,826,834 - 10,853,613 (+)NCBI
RefSeq Acc Id: NP_446401   ⟸   NM_053949
- UniProtKB: O08720 (UniProtKB/Swiss-Prot),   O08962 (UniProtKB/Swiss-Prot),   F1LN86 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235929   ⟸   XM_006235867
- Peptide Label: isoform X1
- UniProtKB: A6K569 (UniProtKB/TrEMBL),   F1LN86 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760852   ⟸   XM_008762630
- Peptide Label: isoform X3
- UniProtKB: Q6DKY7 (UniProtKB/TrEMBL),   A6K570 (UniProtKB/TrEMBL),   A0A0G2K5X4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073593   ⟸   ENSRNOT00000084826
Ensembl Acc Id: ENSRNOP00000013800   ⟸   ENSRNOT00000013800
Cyclic nucleotide-binding   PAC   PAS

Name Modeler Protein Id AA Range Protein Structure
AF-O08962-F1-model_v2 AlphaFold O08962 1-1163 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 40 of 49 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-46033 BioCyc
Ensembl Genes ENSRNOG00000009872 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000013800 ENTREZGENE
  ENSRNOT00000084826 ENTREZGENE
  ENSRNOT00000171126 ENTREZGENE
Gene3D-CATH 1.10.1200.260 UniProtKB/Swiss-Prot
  1.10.287.70 UniProtKB/Swiss-Prot
  2.60.120.10 UniProtKB/Swiss-Prot
  PAS domain UniProtKB/Swiss-Prot
InterPro cNMP-bd-like UniProtKB/Swiss-Prot
  cNMP-bd_dom UniProtKB/Swiss-Prot
  Ion_trans_dom UniProtKB/Swiss-Prot
  K_chnl_volt-dep_EAG/ELK/ERG UniProtKB/Swiss-Prot
  K_chnl_volt-dep_ERG UniProtKB/Swiss-Prot
  KCNH_channel UniProtKB/Swiss-Prot
  PAC UniProtKB/Swiss-Prot
  PAS UniProtKB/Swiss-Prot
  PAS-assoc_C UniProtKB/Swiss-Prot
  PAS-like_dom_sf UniProtKB/Swiss-Prot
  RmlC-like_jellyroll UniProtKB/Swiss-Prot
KEGG Report rno:117018 UniProtKB/Swiss-Prot
NCBI Gene 117018 ENTREZGENE
PANTHER POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 2 UniProtKB/Swiss-Prot
  VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL UniProtKB/Swiss-Prot
Pfam cNMP_binding UniProtKB/Swiss-Prot
  Ion_trans UniProtKB/Swiss-Prot
  PAS_9 UniProtKB/Swiss-Prot
PharmGKB KCNH2 RGD
PhenoGen Kcnh2 PhenoGen
PRINTS EAGCHANLFMLY UniProtKB/Swiss-Prot
  ERGCHANNEL UniProtKB/Swiss-Prot
PROSITE CNMP_BINDING_3 UniProtKB/Swiss-Prot
  PAC UniProtKB/Swiss-Prot
  PAS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009872 RatGTEx
SMART cNMP UniProtKB/Swiss-Prot
  PAC UniProtKB/Swiss-Prot
Superfamily-SCOP SSF51206 UniProtKB/Swiss-Prot
  SSF55785 UniProtKB/Swiss-Prot
  Voltage-gated potassium channels UniProtKB/Swiss-Prot
1 to 40 of 49 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcnh2  potassium voltage-gated channel subfamily H member 2  Kcnh2  potassium channel, voltage gated eag related subfamily H, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnh2  potassium channel, voltage gated eag related subfamily H, member 2  Kcnh2  potassium voltage-gated channel, subfamily H (eag-related), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Kcnh2  potassium voltage-gated channel, subfamily H (eag-related), member 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Kcnh2  potassium voltage-gated channel, subfamily H (eag-related), member 2      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_expression expressed in stomach fundus and antrum, brain, adrenal gland, thymus, retina, and skeletal muscle 625508
gene_function creates a voltage-dependent inward-rectifying K current 729087
gene_homology has 96% amino acid identify to HERG 729087
gene_process currents generated may counteract in the increase of muscle tone resulting in the regulation of the rhythms in stomach smooth muscle contraction 625508
gene_process responsible for the potassium current deactivation by depolarization 625508
gene_product 165-205 kDa protein 625508