Pls3 (plastin 3) - Rat Genome Database

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Pathways
Gene: Pls3 (plastin 3) Rattus norvegicus
Analyze
Symbol: Pls3
Name: plastin 3
RGD ID: 621409
Description: Predicted to enable actin filament binding activity. Predicted to be a structural constituent of presynaptic actin cytoskeleton. Involved in inner ear auditory receptor cell differentiation. Located in stereocilium. Human ortholog(s) of this gene implicated in congenital diaphragmatic hernia. Orthologous to human PLS3 (plastin 3); PARTICIPATES IN auditory mechanotransduction pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: plastin 3 (T-isoform); plastin-3; T-plastin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X116,401,247 - 116,495,898 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX116,401,293 - 116,495,893 (+)EnsemblGRCr8
mRatBN7.2X111,589,193 - 111,683,908 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX111,589,254 - 111,683,891 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX113,692,615 - 113,779,538 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X117,183,401 - 117,270,327 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X114,734,740 - 114,821,667 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X119,030,311 - 119,124,268 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX119,030,419 - 119,124,250 (+)Ensemblrn6Rnor6.0
Rnor_5.0X119,173,230 - 119,266,240 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X29,868,937 - 29,965,118 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX110,881,127 - 110,971,056 (+)NCBICelera
RGSC_v3.1X29,923,513 - 29,982,843 (-)NCBI
Cytogenetic MapXq34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-azacytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
beauvericin  (ISO)
benzbromarone  (EXP)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
bucladesine  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
coumarin  (ISO)
D-glucose  (ISO)
DDT  (EXP)
deoxynivalenol  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
enniatin  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fonofos  (ISO)
fulvestrant  (ISO)
furfural  (ISO)
gallic acid  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glucose  (ISO)
haloperidol  (ISO)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-ethionine  (EXP)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
malathion  (ISO)
manganese(II) chloride  (EXP)
medroxyprogesterone acetate  (ISO)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (EXP)
N-nitrosomorpholine  (EXP)
nefazodone  (EXP)
nickel sulfate  (ISO)
omeprazole  (EXP)
oxaliplatin  (EXP)
paracetamol  (ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
terbufos  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
tunicamycin  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transient expression of the t-isoform of plastins/fimbrin in the stereocilia of developing auditory hair cells. Daudet N and Lebart MC, Cell Motil Cytoskeleton 2002 Dec;53(4):326-36.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Review series: The cell biology of hearing. Schwander M, etal., J Cell Biol. 2010 Jul 12;190(1):9-20. doi: 10.1083/jcb.201001138.
Additional References at PubMed
PMID:7655078   PMID:12477932   PMID:23263861   PMID:24088043  


Genomics

Comparative Map Data
Pls3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X116,401,247 - 116,495,898 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX116,401,293 - 116,495,893 (+)EnsemblGRCr8
mRatBN7.2X111,589,193 - 111,683,908 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX111,589,254 - 111,683,891 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX113,692,615 - 113,779,538 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X117,183,401 - 117,270,327 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X114,734,740 - 114,821,667 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X119,030,311 - 119,124,268 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX119,030,419 - 119,124,250 (+)Ensemblrn6Rnor6.0
Rnor_5.0X119,173,230 - 119,266,240 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X29,868,937 - 29,965,118 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX110,881,127 - 110,971,056 (+)NCBICelera
RGSC_v3.1X29,923,513 - 29,982,843 (-)NCBI
Cytogenetic MapXq34NCBI
PLS3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X115,561,174 - 115,650,861 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX115,560,928 - 115,650,861 (+)Ensemblhg38GRCh38
GRCh37X114,795,501 - 114,885,181 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X114,701,765 - 114,791,246 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34X114,618,488 - 114,707,970NCBI
CeleraX115,230,242 - 115,320,243 (+)NCBICelera
Cytogenetic MapXq23NCBI
HuRefX104,379,340 - 104,468,198 (+)NCBIHuRef
CHM1_1X114,706,001 - 114,796,082 (+)NCBICHM1_1
T2T-CHM13v2.0X113,969,539 - 114,059,207 (+)NCBIT2T-CHM13v2.0
Pls3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X74,829,259 - 74,918,788 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX74,829,260 - 74,918,788 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38X75,785,653 - 75,875,182 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX75,785,654 - 75,875,182 (-)Ensemblmm10GRCm38
MGSCv37X73,030,993 - 73,120,509 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X72,038,383 - 72,127,258 (-)NCBIMGSCv36mm8
CeleraX67,188,917 - 67,297,722 (-)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX38.3NCBI
Pls3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955490122,328 - 221,388 (-)Ensembl
ChiLan1.0NW_004955490125,913 - 221,152 (-)NCBIChiLan1.0ChiLan1.0
PLS3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X115,004,895 - 115,098,747 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X115,012,733 - 115,102,356 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X104,656,110 - 104,745,702 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X115,160,032 - 115,250,144 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX115,160,032 - 115,250,144 (+)EnsemblpanPan2panpan1.1
PLS3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X88,308,817 - 88,399,682 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX88,308,888 - 88,398,810 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_TashaX74,429,089 - 74,519,776 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X90,023,698 - 90,114,659 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX90,022,719 - 90,117,154 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X87,466,392 - 87,557,283 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X89,141,351 - 89,232,259 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X88,976,701 - 89,067,622 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pls3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X87,322,781 - 87,411,736 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936499246,042 - 335,440 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936499246,042 - 335,440 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLS3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX94,885,118 - 94,971,659 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X94,885,098 - 94,971,664 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X109,452,808 - 109,539,961 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PLS3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366606528,495,210 - 28,582,236 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pls3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624940120,073 - 216,622 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624940120,073 - 216,522 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Pls3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1X101,314,037 - 101,402,273 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pls3
327 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:549
Count of miRNA genes:277
Interacting mature miRNAs:347
Transcripts:ENSRNOT00000060168
Prediction methods:Microtar, Miranda, Pita, Pita,Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X97528096142528096Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX105359969157758123Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X80434318125434318Rat
738029Stresp2Stress response QTL 23.40.0004stress-related behavior trait (VT:0010451)defensive burying - approachX92979612117740458Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X105468858125434318Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX45182909117740458Rat
2302047Pia34Pristane induced arthritis QTL 345.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1996916163141916163Rat

Markers in Region
RH139054  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X111,628,349 - 111,628,511 (+)MAPPERmRatBN7.2
Rnor_6.0X119,069,784 - 119,069,945NCBIRnor6.0
Rnor_5.0X119,211,762 - 119,211,923UniSTSRnor5.0
RGSC_v3.4X29,924,408 - 29,924,569UniSTSRGSC3.4
CeleraX110,920,170 - 110,920,331UniSTS
Cytogenetic MapXq14UniSTS
RH133212  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8X116,432,511 - 116,432,720 (+)Marker Load Pipeline
mRatBN7.2X111,620,504 - 111,620,713 (+)MAPPERmRatBN7.2
Rnor_6.0X119,061,936 - 119,062,144NCBIRnor6.0
Rnor_5.0X119,203,914 - 119,204,122UniSTSRnor5.0
RGSC_v3.4X29,932,209 - 29,932,417UniSTSRGSC3.4
CeleraX110,912,330 - 110,912,538UniSTS
Cytogenetic MapXq14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 63 59 6 327 163 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000060168   ⟹   ENSRNOP00000056912
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX116,401,293 - 116,495,893 (+)Ensembl
mRatBN7.2 EnsemblX111,589,254 - 111,683,891 (+)Ensembl
Rnor_6.0 EnsemblX119,030,419 - 119,124,250 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000139298   ⟹   ENSRNOP00000100088
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX116,401,903 - 116,495,893 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000158329   ⟹   ENSRNOP00000107822
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX116,401,318 - 116,495,893 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000162443   ⟹   ENSRNOP00000109117
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX116,401,299 - 116,495,893 (+)Ensembl
RefSeq Acc Id: NM_031084   ⟹   NP_112346
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X116,401,309 - 116,495,898 (+)NCBI
mRatBN7.2X111,589,301 - 111,683,897 (+)NCBI
Rnor_6.0X119,030,419 - 119,124,257 (+)NCBI
Rnor_5.0X119,173,230 - 119,266,240 (+)NCBI
RGSC_v3.4X29,868,937 - 29,965,118 (-)RGD
CeleraX110,881,127 - 110,971,056 (+)RGD
Sequence:
RefSeq Acc Id: XM_006257434   ⟹   XP_006257496
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X116,401,247 - 116,495,898 (+)NCBI
mRatBN7.2X111,589,193 - 111,683,908 (+)NCBI
Rnor_6.0X119,030,311 - 119,124,268 (+)NCBI
Rnor_5.0X119,173,230 - 119,266,240 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006257438   ⟹   XP_006257500
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X116,435,471 - 116,495,898 (+)NCBI
mRatBN7.2X111,623,522 - 111,683,908 (+)NCBI
Rnor_6.0X119,064,289 - 119,124,268 (+)NCBI
Rnor_5.0X119,173,230 - 119,266,240 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017602163   ⟹   XP_017457652
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X116,435,465 - 116,495,898 (+)NCBI
mRatBN7.2X111,623,470 - 111,683,908 (+)NCBI
Rnor_6.0X119,064,288 - 119,124,268 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017602164   ⟹   XP_017457653
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X116,435,678 - 116,495,898 (+)NCBI
mRatBN7.2X111,623,675 - 111,683,908 (+)NCBI
Rnor_6.0X119,065,041 - 119,124,268 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063280325   ⟹   XP_063136395
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X116,410,687 - 116,495,898 (+)NCBI
RefSeq Acc Id: XM_063280326   ⟹   XP_063136396
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X116,401,821 - 116,495,898 (+)NCBI
RefSeq Acc Id: XM_063280327   ⟹   XP_063136397
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X116,435,678 - 116,495,898 (+)NCBI
RefSeq Acc Id: NP_112346   ⟸   NM_031084
- UniProtKB: Q63598 (UniProtKB/Swiss-Prot),   A6KGB3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257496   ⟸   XM_006257434
- Peptide Label: isoform X1
- UniProtKB: Q63598 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006257500   ⟸   XM_006257438
- Peptide Label: isoform X3
- UniProtKB: Q63598 (UniProtKB/Swiss-Prot),   A6KGB3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457652   ⟸   XM_017602163
- Peptide Label: isoform X1
- UniProtKB: Q63598 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017457653   ⟸   XM_017602164
- Peptide Label: isoform X1
- UniProtKB: Q63598 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000056912   ⟸   ENSRNOT00000060168
RefSeq Acc Id: XP_063136396   ⟸   XM_063280326
- Peptide Label: isoform X2
- UniProtKB: Q63598 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063136395   ⟸   XM_063280325
- Peptide Label: isoform X1
- UniProtKB: Q63598 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063136397   ⟸   XM_063280327
- Peptide Label: isoform X3
- UniProtKB: Q63598 (UniProtKB/Swiss-Prot),   A6KGB3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000100088   ⟸   ENSRNOT00000139298
Ensembl Acc Id: ENSRNOP00000109117   ⟸   ENSRNOT00000162443
Ensembl Acc Id: ENSRNOP00000107822   ⟸   ENSRNOT00000158329
Protein Domains
Calponin-homology (CH)   EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63598-F1-model_v2 AlphaFold Q63598 1-630 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701972
Promoter ID:EPDNEW_R12496
Type:multiple initiation site
Name:Pls3_1
Description:plastin 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X119,030,430 - 119,030,490EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621409 AgrOrtholog
BioCyc Gene G2FUF-1433 BioCyc
Ensembl Genes ENSRNOG00000027520 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000060168 ENTREZGENE
  ENSRNOT00000139298 ENTREZGENE
  ENSRNOT00000158329 ENTREZGENE
Gene3D-CATH 1.10.418.10 UniProtKB/Swiss-Prot
  EF-hand UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7311086 IMAGE-MGC_LOAD
InterPro Actinin_actin-bd_CS UniProtKB/Swiss-Prot
  CH-domain UniProtKB/Swiss-Prot
  CH_dom_sf UniProtKB/Swiss-Prot
  EF-hand-dom_pair UniProtKB/Swiss-Prot
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot
  EF_hand_dom UniProtKB/Swiss-Prot
  Fimbrin/Plastin UniProtKB/Swiss-Prot
MGC_CLONE MGC:109253 IMAGE-MGC_LOAD
NCBI Gene 81748 ENTREZGENE
PANTHER PTHR19961 UniProtKB/Swiss-Prot
  PTHR19961:SF32 UniProtKB/Swiss-Prot
Pfam EF-hand_7 UniProtKB/Swiss-Prot
  PF00307 UniProtKB/Swiss-Prot
PhenoGen Pls3 PhenoGen
PROSITE ACTININ_1 UniProtKB/Swiss-Prot
  ACTININ_2 UniProtKB/Swiss-Prot
  EF_HAND_1 UniProtKB/Swiss-Prot
  EF_HAND_2 UniProtKB/Swiss-Prot
  PS50021 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000027520 RatGTEx
SMART EFh UniProtKB/Swiss-Prot
  SM00033 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot
  SSF47576 UniProtKB/Swiss-Prot
UniProt A0ABK0L6X7_RAT UniProtKB/TrEMBL
  A0ABK0LV03_RAT UniProtKB/TrEMBL
  A0ABK0LV27_RAT UniProtKB/TrEMBL
  A6KGB3 ENTREZGENE, UniProtKB/TrEMBL
  F1LPK7_RAT UniProtKB/TrEMBL
  PLST_RAT UniProtKB/Swiss-Prot
  Q562B2_RAT UniProtKB/TrEMBL
  Q63598 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Pls3  plastin 3  Pls3  plastin 3 (T-isoform)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Pls3  plastin 3 (T-isoform)      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Pls3  plastin 3 (T-isoform)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in stereocilia in the developing cochlea 731234
gene_product member of the plastins/fimbrin family of actin bundling proteins 731234