Skil (SKI-like proto-oncogene) - Rat Genome Database

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Gene: Skil (SKI-like proto-oncogene) Rattus norvegicus
Analyze
Symbol: Skil
Name: SKI-like proto-oncogene
RGD ID: 621399
Description: Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; SMAD binding activity; and identical protein binding activity. Involved in positive regulation of axonogenesis; response to cytokine; and spermatogenesis. Located in acrosomal vesicle. Biomarker of ureteral obstruction. Orthologous to human SKIL (SKI like proto-oncogene); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: SKI-like; SKI-like oncogene; ski/sno related; Skir; Sno
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Skil_v1 ; Skil_v2
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82114,175,534 - 114,203,663 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2114,175,534 - 114,201,974 (-)EnsemblGRCr8
mRatBN7.22112,247,047 - 112,275,176 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2112,247,051 - 112,275,080 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2118,894,757 - 118,922,782 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02117,007,313 - 117,035,338 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02111,716,994 - 111,745,054 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02115,862,932 - 115,891,304 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2115,866,701 - 115,891,097 (-)Ensemblrn6Rnor6.0
Rnor_5.02135,558,909 - 135,587,255 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42116,669,375 - 116,691,472 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2107,434,508 - 107,462,883 (-)NCBICelera
RGSC_v3.12116,636,239 - 116,636,434 (-)NCBI
Cytogenetic Map2q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-butoxyethanol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nonylphenol  (ISO)
4-octylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acetaldehyde  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
DDE  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
ferric oxide  (ISO)
fluoranthene  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glyphosate  (EXP)
lead diacetate  (ISO)
leflunomide  (ISO)
menadione  (ISO)
Nonylphenol  (ISO)
okadaic acid  (ISO)
orphenadrine  (EXP)
p-toluidine  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
resorcinol  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
trovafloxacin  (ISO)
valproic acid  (EXP,ISO)
vincristine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. A SnoN-Ccd1 pathway promotes axonal morphogenesis in the mammalian brain. Ikeuchi Y, etal., J Neurosci. 2009 Apr 1;29(13):4312-21.
3. Regulated production of SnoN2 is a feature of testicular differentiation. Itman C, etal., Microsc Res Tech. 2009 Jun 12.
4. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica Lu M, etal., Zhongguo Zhong Yao Za Zhi. 2009 Jan;34(1):84-8.
5. Adenoviral delivery of dominant-negative transforming growth factor beta type II receptor up-regulates transcriptional repressor SKI-like oncogene, decreases matrix metalloproteinase 2 in hepatic stellate cell and prevents liver fibrosis in rats. Marquez-Aguirre A, etal., J Gene Med. 2009 Mar;11(3):207-19.
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Defective T-cell activation is associated with augmented transforming growth factor Beta sensitivity in mice with mutations in the Sno gene. Pearson-White S and McDuffie M, Mol Cell Biol 2003 Aug;23(15):5446-59.
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. Information Derived from GenBank Report RGD, Sept. 2003
Additional References at PubMed
PMID:8514802   PMID:10531062   PMID:10811619   PMID:12764135   PMID:14712482   PMID:15657445   PMID:15677329   PMID:15967445   PMID:16109768   PMID:16675394   PMID:16966324   PMID:17202138  
PMID:17215516   PMID:17469184   PMID:17510063   PMID:17725545   PMID:18212064   PMID:18334480   PMID:19383336   PMID:19538364   PMID:20386537   PMID:22813962   PMID:23610558   PMID:28350874  
PMID:28447757   PMID:28765970   PMID:29402324   PMID:30847937   PMID:31028803   PMID:37389959  


Genomics

Comparative Map Data
Skil
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82114,175,534 - 114,203,663 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2114,175,534 - 114,201,974 (-)EnsemblGRCr8
mRatBN7.22112,247,047 - 112,275,176 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2112,247,051 - 112,275,080 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2118,894,757 - 118,922,782 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02117,007,313 - 117,035,338 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02111,716,994 - 111,745,054 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02115,862,932 - 115,891,304 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2115,866,701 - 115,891,097 (-)Ensemblrn6Rnor6.0
Rnor_5.02135,558,909 - 135,587,255 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42116,669,375 - 116,691,472 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2107,434,508 - 107,462,883 (-)NCBICelera
RGSC_v3.12116,636,239 - 116,636,434 (-)NCBI
Cytogenetic Map2q24NCBI
SKIL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383170,357,715 - 170,396,849 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3170,357,287 - 170,396,835 (+)Ensemblhg38GRCh38
GRCh373170,075,503 - 170,114,637 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363171,558,208 - 171,593,230 (+)NCBIBuild 36Build 36hg18NCBI36
Build 343171,558,217 - 171,593,238NCBI
Celera3168,475,164 - 168,510,628 (+)NCBICelera
Cytogenetic Map3q26.2NCBI
HuRef3167,445,102 - 167,484,187 (+)NCBIHuRef
CHM1_13170,038,968 - 170,078,127 (+)NCBICHM1_1
T2T-CHM13v2.03173,142,245 - 173,181,517 (+)NCBIT2T-CHM13v2.0
Skil
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39331,149,259 - 31,176,741 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl331,149,207 - 31,176,726 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38331,095,058 - 31,122,923 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl331,095,058 - 31,122,577 (+)Ensemblmm10GRCm38
MGSCv37330,993,983 - 31,021,499 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36331,285,939 - 31,313,455 (+)NCBIMGSCv36mm8
Celera331,009,172 - 31,036,688 (+)NCBICelera
Cytogenetic Map3A3NCBI
cM Map315.12NCBI
Skil
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955420530,528 - 554,551 (+)Ensembl
ChiLan1.0NW_004955420530,531 - 554,308 (+)NCBIChiLan1.0ChiLan1.0
SKIL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22168,252,584 - 168,291,912 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13168,257,410 - 168,296,636 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03167,372,104 - 167,411,287 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13175,562,001 - 175,600,181 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3175,562,007 - 175,600,181 (+)EnsemblpanPan2panpan1.1
SKIL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13434,871,770 - 34,898,681 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3434,871,574 - 34,894,854 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3443,882,840 - 43,910,662 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03434,952,312 - 34,980,146 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3434,952,451 - 34,980,135 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13434,895,746 - 34,923,551 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03434,865,482 - 34,893,269 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03435,129,073 - 35,156,913 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Skil
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602101,488,423 - 101,512,747 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365932,109,223 - 2,132,882 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365932,109,414 - 2,132,871 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SKIL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13109,029,952 - 109,059,173 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113109,029,831 - 109,059,176 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213117,925,964 - 117,940,416 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SKIL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11519,022,167 - 19,059,117 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1519,022,017 - 19,057,004 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606327,802,064 - 27,838,970 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Skil
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473048,377,499 - 48,404,141 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473048,376,625 - 48,404,059 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Skil
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13125,338,860 - 125,367,206 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Skil
48 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:123
Count of miRNA genes:102
Interacting mature miRNAs:107
Transcripts:ENSRNOT00000013191
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)2105628029150628029Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)282947902127947902Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)284056790132859658Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)282214549127214549Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)240306867124537199Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
7488933Bp368Blood pressure QTL 3680.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2104957381149957381Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
2317886Alcrsp23Alcohol response QTL 232.40.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)295142371140142371Rat
2317058Aia13Adjuvant induced arthritis QTL 132.9joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)278269809123269809Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2114032149150226270Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2100807373145807373Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2106869825151869825Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)293602631145807373Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)261051541143746880Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000013191   ⟹   ENSRNOP00000013191
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2114,175,534 - 114,201,974 (-)Ensembl
mRatBN7.2 Ensembl2112,247,051 - 112,275,080 (-)Ensembl
Rnor_6.0 Ensembl2115,866,701 - 115,891,097 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114271   ⟹   ENSRNOP00000086486
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2114,175,534 - 114,201,297 (-)Ensembl
mRatBN7.2 Ensembl2112,247,051 - 112,272,810 (-)Ensembl
RefSeq Acc Id: NM_001398590   ⟹   NP_001385519
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82114,175,534 - 114,203,572 (-)NCBI
mRatBN7.22112,247,047 - 112,275,085 (-)NCBI
RefSeq Acc Id: NM_001398591   ⟹   NP_001385520
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82114,175,534 - 114,203,572 (-)NCBI
mRatBN7.22112,247,047 - 112,275,085 (-)NCBI
RefSeq Acc Id: XM_039103606   ⟹   XP_038959534
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82114,175,534 - 114,203,663 (-)NCBI
mRatBN7.22112,247,047 - 112,275,176 (-)NCBI
RefSeq Acc Id: XM_063281141   ⟹   XP_063137211
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82114,175,534 - 114,203,663 (-)NCBI
RefSeq Acc Id: XM_063281142   ⟹   XP_063137212
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82114,175,534 - 114,203,663 (-)NCBI
RefSeq Acc Id: XM_063281143   ⟹   XP_063137213
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82114,175,534 - 114,203,663 (-)NCBI
Ensembl Acc Id: ENSRNOP00000013191   ⟸   ENSRNOT00000013191
RefSeq Acc Id: XP_038959534   ⟸   XM_039103606
- Peptide Label: isoform X1
- UniProtKB: D3ZWL1 (UniProtKB/TrEMBL),   A0A8I6A1B8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000086486   ⟸   ENSRNOT00000114271
RefSeq Acc Id: NP_001385520   ⟸   NM_001398591
- Peptide Label: isoform 2
- UniProtKB: A0A8I6A1B8 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001385519   ⟸   NM_001398590
- Peptide Label: isoform 1
- UniProtKB: D3ZWL1 (UniProtKB/TrEMBL),   A0A8I6A1B8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137213   ⟸   XM_063281143
- Peptide Label: isoform X4
- UniProtKB: A0A8I6A1B8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137212   ⟸   XM_063281142
- Peptide Label: isoform X3
- UniProtKB: A6IHK2 (UniProtKB/TrEMBL),   A0A8I6A1B8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137211   ⟸   XM_063281141
- Peptide Label: isoform X2
- UniProtKB: A6IHK3 (UniProtKB/TrEMBL),   A0A8I6A1B8 (UniProtKB/TrEMBL)
Protein Domains
c-SKI SMAD4-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZWL1-F1-model_v2 AlphaFold D3ZWL1 1-677 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691285
Promoter ID:EPDNEW_R1797
Type:initiation region
Name:Skil_1
Description:SKI-like proto-oncogene
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02115,890,970 - 115,891,030EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621399 AgrOrtholog
BioCyc Gene G2FUF-53477 BioCyc
Ensembl Genes ENSRNOG00000009899 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000013191 ENTREZGENE
  ENSRNOT00000013191.7 UniProtKB/TrEMBL
  ENSRNOT00000114271 ENTREZGENE
  ENSRNOT00000114271.2 UniProtKB/TrEMBL
Gene3D-CATH 3.10.260.20 UniProtKB/TrEMBL
  3.10.390.10 UniProtKB/TrEMBL
InterPro c-SKI_SMAD4-bd_dom UniProtKB/TrEMBL
  DNA-bd_dom_put UniProtKB/TrEMBL
  SAND_dom-like UniProtKB/TrEMBL
  Ski_DNA-bd_sf UniProtKB/TrEMBL
  Transform_Ski UniProtKB/TrEMBL
  Tscrpt_reg_SKI_SnoN UniProtKB/TrEMBL
NCBI Gene 114208 ENTREZGENE
PANTHER PTHR10005 UniProtKB/TrEMBL
  PTHR10005:SF3 UniProtKB/TrEMBL
Pfam c-SKI_SMAD_bind UniProtKB/TrEMBL
  Ski_Sno UniProtKB/TrEMBL
PhenoGen Skil PhenoGen
RatGTEx ENSRNOG00000009899 RatGTEx
SMART c-SKI_SMAD_bind UniProtKB/TrEMBL
Superfamily-SCOP Putativ_DNA_bind UniProtKB/TrEMBL
  SAND_like UniProtKB/TrEMBL
UniProt A0A8I6A1B8 ENTREZGENE, UniProtKB/TrEMBL
  A6IHK2 ENTREZGENE, UniProtKB/TrEMBL
  A6IHK3 ENTREZGENE, UniProtKB/TrEMBL
  D3ZWL1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-07-10 Skil  SKI-like proto-oncogene  Skil  SKI-like oncogene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-19 Skil  SKI-like oncogene  Skil  SKI-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-14 Skil  SKI-like  Skir  ski/sno related  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2002-08-07 Skir  ski/sno related      Symbol and Name status set to provisional 70820 PROVISIONAL