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Gene: Arl1 (ARF like GTPase 1) Rattus norvegicus

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Symbol:

Arl1

Name:

ARF like GTPase 1 (Ensembl:ADP-ribosylation factor like GTPase 1)

RGD ID:

621326

Description:

Predicted to enable several functions, including GTP binding activity; GTPase activity; and phospholipase D activator activity. Involved in Golgi organization and Golgi vesicle transport. Located in trans-Golgi network. Orthologous to human ARL1 (ARF like GTPase 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione; ammonium chloride.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

ADP-ribosylation factor like GTPase 1; ADP-ribosylation factor-like 1; ADP-ribosylation factor-like protein 1; MGC72836

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ARL1 (ARF like GTPase 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Arl1 (ADP-ribosylation factor-like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Arl1 (ARF like GTPase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ARL1 (ARF like GTPase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ARL1 (ADP ribosylation factor like GTPase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Arl1 (ARF like GTPase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ARL1 (ADP ribosylation factor like GTPase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ARL1 (ARF like GTPase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Arl1 (ARF like GTPase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Arl1 (ARF like GTPase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	ARL1 (ARF like GTPase 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Arl1 (ADP-ribosylation factor-like 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	arl1 (ADP-ribosylation factor-like 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	ARL1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Arl1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	arl-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	arl1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	arl1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	25,007,401 - 25,018,572 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	25,006,981 - 25,019,319 (+)	Ensembl				GRCr8
mRatBN7.2	7	23,120,004 - 23,131,173 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	23,119,589 - 23,131,898 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	25,114,566 - 25,125,737 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	27,277,268 - 27,288,441 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	27,054,306 - 27,065,479 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	29,282,411 - 29,293,455 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	29,282,305 - 29,293,399 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	29,384,788 - 29,395,708 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	25,403,921 - 25,416,168 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	20,279,124 - 20,290,252 (+)	NCBI		Celera
RGSC_v3.1	7	25,424,112 - 25,437,189 (+)	NCBI
Cytogenetic Map	7	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

3H-1,2-dithiole-3-thione (EXP)

4,4'-sulfonyldiphenol (ISO)

actinomycin D (ISO)

ammonium chloride (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

Aroclor 1254 (ISO)

benzo[a]pyrene (EXP,ISO)

benzo[a]pyrene diol epoxide I (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

buspirone (EXP)

cadmium dichloride (EXP,ISO)

cannabidiol (ISO)

captan (ISO)

carbon nanotube (ISO)

chloroacetaldehyde (ISO)

cisplatin (ISO)

clobetasol (ISO)

clodronic acid (ISO)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

cyclosporin A (EXP,ISO)

deguelin (ISO)

Dibutyl phosphate (ISO)

dicrotophos (ISO)

dimethyl sulfoxide (ISO)

dioxygen (ISO)

endosulfan (EXP)

enzyme inhibitor (ISO)

Erionite (ISO)

ethanol (ISO)

fenofibrate (EXP)

finasteride (EXP)

flutamide (EXP)

folic acid (ISO)

folpet (ISO)

gentamycin (EXP)

gold atom (ISO)

gold(0) (ISO)

inulin (ISO)

ivermectin (ISO)

lead diacetate (ISO)

lead(0) (ISO)

metformin (EXP)

methidathion (ISO)

methyl methanesulfonate (ISO)

Nutlin-3 (ISO)

perfluorooctane-1-sulfonic acid (ISO)

propiconazole (ISO)

raloxifene (EXP)

resveratrol (ISO)

rotenone (EXP,ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

sulindac (EXP)

tauroursodeoxycholic acid (EXP)

thapsigargin (ISO)

tolcapone (EXP)

trichloroethene (EXP)

triphenyl phosphate (ISO)

triptonide (ISO)

tunicamycin (ISO)

ursodeoxycholic acid (EXP)

valproic acid (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

Golgi organization (IMP)

Golgi vesicle transport (IMP)

intracellular protein transport (IBA)

protein localization to Golgi apparatus (IEA,ISO,ISS)

retrograde transport, endosome to Golgi (IEA,ISO,ISS)

toxin metabolic process (IEA,ISO,ISS)

vesicle-mediated transport (IBA)

Cellular Component

cytoplasm (IBA,ISO,ISS)

cytosol (IEA)

Golgi apparatus (IBA,IEA,ISO,ISS)

Golgi membrane (IEA)

membrane (IEA)

trans-Golgi network (IDA,IEA,ISO)

Molecular Function

enzyme activator activity (IEA,ISO,ISS)

GTP binding (IBA,IEA,ISO,ISS)

GTPase activity (IEA,ISO,ISS)

metal ion binding (IEA)

nucleotide binding (IEA)

phospholipase D activator activity (IEA,ISO,ISS)

protein binding (ISO)

protein domain specific binding (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Regulation of Golgi structure and function by ARF-like protein 1 (Arl1).	Lu L, etal., J Cell Sci 2001 Dec;114(Pt 24):4543-55.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	GOA pipeline	RGD automated data pipeline
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Cloning of two novel ADP-ribosylation factor-like proteins and characterization of their differential expression in 3T3-L1 cells.	Schurmann A, etal., J Biol Chem 1994 Jun 3;269(22):15683-8.

Additional References at PubMed

PMID:8798635	PMID:9624189	PMID:10980193	PMID:12477932	PMID:14580338	PMID:14718928	PMID:15489334	PMID:17488291	PMID:19224922	PMID:23376485

Genomics

Comparative Map Data

Arl1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	25,007,401 - 25,018,572 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	25,006,981 - 25,019,319 (+)	Ensembl				GRCr8
mRatBN7.2	7	23,120,004 - 23,131,173 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	23,119,589 - 23,131,898 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	25,114,566 - 25,125,737 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	27,277,268 - 27,288,441 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	27,054,306 - 27,065,479 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	29,282,411 - 29,293,455 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	29,282,305 - 29,293,399 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	29,384,788 - 29,395,708 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	25,403,921 - 25,416,168 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	20,279,124 - 20,290,252 (+)	NCBI		Celera
RGSC_v3.1	7	25,424,112 - 25,437,189 (+)	NCBI
Cytogenetic Map	7	q13	NCBI

ARL1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	101,393,116 - 101,407,820 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	101,393,116 - 101,407,772 (-)	Ensembl			hg38	GRCh38
GRCh37	12	101,786,894 - 101,801,598 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	100,311,045 - 100,325,703 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	12	100,289,381 - 100,304,040	NCBI
Celera	12	101,452,210 - 101,466,869 (-)	NCBI		Celera
Cytogenetic Map	12	q23.2	NCBI
HuRef	12	98,846,985 - 98,861,641 (-)	NCBI		HuRef
CHM1_1	12	101,752,887 - 101,767,477 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	101,354,234 - 101,368,938 (-)	NCBI		T2T-CHM13v2.0

Arl1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	88,566,720 - 88,579,956 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	88,566,720 - 88,579,956 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	10	88,730,920 - 88,744,094 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	88,730,858 - 88,744,094 (+)	Ensembl			mm10	GRCm38
MGSCv37	10	88,194,159 - 88,205,947 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	10	88,161,194 - 88,173,881 (+)	NCBI		MGSCv36	mm8
Celera	10	90,711,447 - 90,723,221 (+)	NCBI		Celera
Cytogenetic Map	10	C1	NCBI
cM Map	10	44.19	NCBI

Arl1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955405	36,913,011 - 36,918,017 (-)	Ensembl
ChiLan1.0	NW_004955405	36,913,011 - 36,932,383 (-)	NCBI	ChiLan1.0	ChiLan1.0

ARL1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	109,464,558 - 109,480,754 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	109,460,937 - 109,477,152 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	98,981,212 - 98,994,344 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	102,381,273 - 102,394,272 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	102,381,134 - 102,394,272 (-)	Ensembl			panPan2	panpan1.1

ARL1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	15	40,390,091 - 40,401,043 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	15	40,390,890 - 40,401,060 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	15	40,758,710 - 40,769,658 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	15	41,044,924 - 41,055,878 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	15	41,041,767 - 41,055,853 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	15	40,300,430 - 40,311,369 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	15	40,409,187 - 40,420,136 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	15	40,683,467 - 40,694,418 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Arl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	19,573,506 - 19,585,419 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936492	12,583,887 - 12,595,798 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936492	12,583,878 - 12,595,824 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ARL1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	82,796,121 - 82,815,936 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	5	82,795,741 - 82,812,153 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	86,794,413 - 86,804,542 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ARL1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	96,662,260 - 96,674,662 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	96,659,769 - 96,675,486 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666037	148,327,574 - 148,343,169 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Arl1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624750	6,516,531 - 6,523,671 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624750	6,516,511 - 6,522,759 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Arl1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	167,782,332 - 167,794,504 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Arl1
53 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	344
Count of miRNA genes:	200
Interacting mature miRNAs:	247
Transcripts:	ENSRNOT00000007623
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354644	Spl4	Serum phospholipid level QTL 4	4.9		blood phospholipid amount (VT:0006084)	blood phospholipid level (CMO:0001169)	7	21541977	51639954	Rat
7411569	Bw137	Body weight QTL 137		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	23807606	68807606	Rat
9590102	Sffal5	Serum free fatty acids level QTL 5	8.62	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	7	7216097	52216097	Rat
1578652	Bmd15	Bone mineral density QTL 15	5.2		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	7	10517086	62346019	Rat
631503	Bp102	Blood pressure QTL 102	1.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	1709527	46709527	Rat
1300127	Srn1	Serum renin concentration QTL 1	3.87		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	7	24179478	86817926	Rat
2298547	Neuinf5	Neuroinflammation QTL 5	3.7		nervous system integrity trait (VT:0010566)	spinal cord Cd74 protein level (CMO:0002131)	7	10112916	60150541	Rat
10059592	Kidm45	Kidney mass QTL 45	3.95	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	7	9460877	54460877	Rat
2298550	Neuinf6	Neuroinflammation QTL 6	3.3		nervous system integrity trait (VT:0010566)	spinal cord RT1-B protein level (CMO:0002132)	7	1	29716167	Rat
1354637	Scl30	Serum cholesterol level QTL 30	3.7		blood cholesterol amount (VT:0000180)	blood total cholesterol level (CMO:0000051)	7	21541977	51639954	Rat
724560	Plsm3	Polydactyly-luxate syndrome (PLS) morphotypes QTL 3		0.0003	tibia length (VT:0004357)	tibia length (CMO:0000450)	7	1	34650782	Rat
1354639	Spl5	Serum phospholipid level QTL 5	3.9		blood LDL phospholipid amount (VT:0010505)	blood low density lipoprotein phospholipid level (CMO:0001568)	7	21541977	35707405	Rat
7411566	Bw136	Body weight QTL 136	10.4	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	1	32612984	Rat
61410	Bw19	Body weight QTL 19	6.2	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	7	1669658	46669658	Rat
1643004	Pain2	Pain QTL 2	1		mechanical nociception trait (VT:0002734)	self mutilation severity score (CMO:0002145)	7	10112916	99900612	Rat
2290372	Gluco33	Glucose level QTL 33	2.71		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	1	31777942	Rat
1300149	Cm6	Cardiac mass QTL 6	4.09		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	7	1	104117804	Rat
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	1509236	116977875	Rat
9590142	Scort5	Serum corticosterone level QTL 5	24.4	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	7	1	32612984	Rat
1582260	Bw72	Body weight QTL 72	3.2	0.0043	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	39960528	Rat
1582261	Bw69	Body weight QTL 69	3.2	0.0048	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	39960528	Rat
1582262	Bw75	Body weight QTL 75	3	0.0038	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	39960528	Rat
1300132	Bp182	Blood pressure QTL 182	3.49		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	7	21541977	86817926	Rat
1300138	Hrtrt9	Heart rate QTL 9	4.72		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	7	10498820	55498820	Rat
61369	Mcs2	Mammary carcinoma susceptibility QTL 2	3.38		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	7	20920494	37412865	Rat
738033	Anxrr6	Anxiety related response QTL 6	4.1		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	7	17460447	62460447	Rat
70207	Niddm31	Non-insulin dependent diabetes mellitus QTL 31	3.9		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	7	20057232	65057232	Rat

Markers in Region

RH127965

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	23,131,667 - 23,131,859 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	29,293,950 - 29,294,141	NCBI	Rnor6.0
Rnor_5.0	7	29,396,203 - 29,396,394	UniSTS	Rnor5.0
RGSC_v3.4	7	25,416,663 - 25,416,854	UniSTS	RGSC3.4
Celera	7	20,290,748 - 20,290,939	UniSTS
RH 3.4 Map	7	119.6	UniSTS
Cytogenetic Map	7	q13	UniSTS

BQ199867

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	23,118,213 - 23,118,370 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	29,280,621 - 29,280,777	NCBI	Rnor6.0
Rnor_5.0	7	29,382,998 - 29,383,154	UniSTS	Rnor5.0
RGSC_v3.4	7	25,402,131 - 25,402,287	UniSTS	RGSC3.4
Celera	7	20,277,334 - 20,277,490	UniSTS
RH 3.4 Map	7	121.3	UniSTS
Cytogenetic Map	7	q13	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_022385	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC061553	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473960	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ210287	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ226660	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U12402	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X76920	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000007623 ⟹ ENSRNOP00000007623

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	25,009,376 - 25,018,133 (+)	Ensembl
mRatBN7.2 Ensembl	7	23,119,589 - 23,131,086 (+)	Ensembl
Rnor_6.0 Ensembl	7	29,282,305 - 29,293,399 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000103837 ⟹ ENSRNOP00000092279

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	25,007,331 - 25,019,319 (+)	Ensembl
mRatBN7.2 Ensembl	7	23,121,638 - 23,131,898 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000174100 ⟹ ENSRNOP00000099983

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	25,006,981 - 25,019,319 (+)	Ensembl

RefSeq Acc Id:

NM_022385 ⟹ NP_071780

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	25,007,401 - 25,018,572 (+)	NCBI
mRatBN7.2	7	23,120,004 - 23,131,173 (+)	NCBI
Rnor_6.0	7	29,282,411 - 29,293,455 (+)	NCBI
Rnor_5.0	7	29,384,788 - 29,395,708 (+)	NCBI
RGSC_v3.4	7	25,403,921 - 25,416,168 (+)	RGD
Celera	7	20,279,124 - 20,290,252 (+)	RGD

Sequence:

show sequence

CAGTGGACGTGGCGGCGCCCCGGCTCAATTAGGAGTCGCTGCCGAGTCCCGGCCTGTCACTGAG
GATCGGCGAGGGCGCGGCGGCGGTCCATCATGGGTGGCTTTTTCTCAAGTATATTTTCCAGTCT
CTTTGGAACCAGGGAAATGAGGATTTTAATTTTGGGATTAGATGGTGCTGGAAAAACGACAATT
TTGTACAGATTGCAGGTTGGAGAAGTTGTTACTACCATTCCCACTATTGGATTTAATGTAGAGA
CGGTGACATACAAAAATCTCAAGTTCCAAGTTTGGGACTTAGGCGGACAGACAAGTATCAGGCC
ATACTGGAGATGTTATTATTCAAACACAGATGCAGTCATCTATGTCGTTGACAGTTGTGACCGA
GACCGAATTGGCATTTCCAAGTCAGAGTTAGTTGCCATGTTGGAGGAAGAGGAGCTGAGGAAAG
CCATTTTAGTGGTGTTTGCAAATAAACAGGACATGGAGCAGGCCATGACGCCCTCAGAAATGGC
CAATGCGCTTGGGTTACCCGCCCTGAAGGACCGGAAGTGGCAGATCTTTAAAACGTCAGCAACC
AAAGGCACCGGCCTCGACGAGGCAATGGAATGGTTAGTTGAAACACTGAAAAGCAGACAGTGAG
TCCATTCACATCAGCGCCTGTGAACCAAACGCTCCGTCACAGACTCACTGAACCAGTCAGATGT
ACTTCTCGTGACTGGTGGAAGGGACTGTGTGATTCTAGCATATACAGACCTGACTTCACTATTT
GTAATAAATATAAAAAGCAAGTATCTGGTGAGAGGGTTAGCTTGATCGAATCACCCAAATGGTT
TATGTAATGTAAAATATTTCTTCCTTGTTTTCTTGTGTTAAGGTATATATTCTATTTGTAT

hide sequence

Protein Sequences


Protein RefSeqs	NP_071780	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA20668	(Get FASTA)	NCBI Sequence Viewer
	AAH61553	(Get FASTA)	NCBI Sequence Viewer
	CAA54245	(Get FASTA)	NCBI Sequence Viewer
	EDM16995	(Get FASTA)	NCBI Sequence Viewer
	EDM16996	(Get FASTA)	NCBI Sequence Viewer
	EDM16997	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000099983
GenBank Protein	P61212	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_071780 ⟸ NM_022385
- UniProtKB:	P61212 (UniProtKB/Swiss-Prot), A6IFQ1 (UniProtKB/TrEMBL), A0A8I6GK40 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGGFFSSIFSSLFGTREMRILILGLDGAGKTTILYRLQVGEVVTTIPTIGFNVETVTYKNLKFQ VWDLGGQTSIRPYWRCYYSNTDAVIYVVDSCDRDRIGISKSELVAMLEEEELRKAILVVFANKQ DMEQAMTPSEMANALGLPALKDRKWQIFKTSATKGTGLDEAMEWLVETLKSRQ hide sequence

Ensembl Acc Id:

ENSRNOP00000007623 ⟸ ENSRNOT00000007623

Ensembl Acc Id:

ENSRNOP00000092279 ⟸ ENSRNOT00000103837

Ensembl Acc Id:

ENSRNOP00000099983 ⟸ ENSRNOT00000174100

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P61212-F1-model_v2	AlphaFold	P61212	1-181	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695131

Promoter ID:

EPDNEW_R5656

Type:

initiation region

Name:

Arl1_1

Description:

ADP-ribosylation factor like GTPase 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	29,282,355 - 29,282,415	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621326	AgrOrtholog
BioCyc Gene	G2FUF-34499	BioCyc
Ensembl Genes	ENSRNOG00000005763	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000174100	ENTREZGENE
Gene3D-CATH	3.40.50.300	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:6889396	IMAGE-MGC_LOAD
InterPro	P-loop_NTPase	UniProtKB/Swiss-Prot
	Small_GTP-bd_dom	UniProtKB/Swiss-Prot
	Small_GTPase_ARF	UniProtKB/Swiss-Prot
	Small_GTPase_ARF/SAR	UniProtKB/Swiss-Prot
KEGG Report	rno:64187	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:72836	IMAGE-MGC_LOAD
NCBI Gene	64187	ENTREZGENE
PANTHER	PTHR11711	UniProtKB/Swiss-Prot
Pfam	Arf	UniProtKB/Swiss-Prot
PhenoGen	Arl1	PhenoGen
PRINTS	SAR1GTPBP	UniProtKB/Swiss-Prot
PROSITE	ARF	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000005763	RatGTEx
SMART	ARF	UniProtKB/Swiss-Prot
	RAB	UniProtKB/Swiss-Prot
	SAR	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF52540	UniProtKB/Swiss-Prot
UniProt	A0A8I6GK40	ENTREZGENE, UniProtKB/TrEMBL
	A0A8L2UHY4_RAT	UniProtKB/TrEMBL
	A6IFQ1	ENTREZGENE, UniProtKB/TrEMBL
	A6IFQ2_RAT	UniProtKB/TrEMBL
	A6IFQ3_RAT	UniProtKB/TrEMBL
	ARL1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary	P41276	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2024-11-07	Arl1	ARF like GTPase 1	Arl1	ADP-ribosylation factor like GTPase 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2015-11-19	Arl1	ADP-ribosylation factor like GTPase 1	Arl1	ADP-ribosylation factor-like 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-02-26	Arl1	ADP-ribosylation factor-like 1			Symbol and Name status set to approved	625702	APPROVED
2002-08-07	Arl1	ADP-ribosylation factor-like 1			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_cellular_localization	localized to the Golgi trans face	724590
gene_mutations_overexpression	overexpression of mutant form T31N causes disappearance of the Golgi apparatus	724590

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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