Rhob (ras homolog family member B) - Rat Genome Database

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Gene: Rhob (ras homolog family member B) Rattus norvegicus
Analyze
Symbol: Rhob
Name: ras homolog family member B
RGD ID: 621309
Description: Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in several processes, including cellular response to hydrogen peroxide; regulation of cell migration; and regulation of modification of postsynaptic structure. Predicted to act upstream of or within intracellular protein transport. Located in cytosol and membrane. Is active in synapse. Used to study melanoma. Orthologous to human RHOB (ras homolog family member B); INTERACTS WITH (S)-(-)-perillyl alcohol; 1,2,4-trimethylbenzene; 1,2-dimethylhydrazine.
Type: protein-coding (Ensembl: lncRNA)
RefSeq Status: PROVISIONAL
Previously known as: Arhb; ras homolog gene family, member B; rho-related GTP-binding protein RhoB; rhoB gene
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8637,083,030 - 37,085,204 (-)NCBIGRCr8
mRatBN7.2631,363,752 - 31,365,926 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl631,363,548 - 31,366,108 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx631,655,817 - 31,657,991 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0631,971,666 - 31,973,840 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0631,446,281 - 31,448,455 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0633,689,127 - 33,691,301 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl633,689,127 - 33,691,301 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0643,472,691 - 43,474,865 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4632,052,333 - 32,054,507 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1632,055,314 - 32,057,457 (-)NCBI
Celera630,812,638 - 30,814,812 (-)NCBICelera
Cytogenetic Map6q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-(-)-perillyl alcohol  (EXP,ISO)
(S)-nicotine  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1,3,5-trinitro-1,3,5-triazinane  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-nitrofluorene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
5-azacytidine  (ISO)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
belinostat  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-D-glucosamine  (ISO)
bisphenol A  (EXP,ISO)
buspirone  (EXP)
butan-1-ol  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carveol  (ISO)
carvone  (ISO)
celecoxib  (ISO)
cetrorelix  (ISO)
chloropicrin  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
chrysene  (ISO)
clofibrate  (ISO)
clozapine  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
deguelin  (ISO)
desogestrel  (ISO)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
diethylstilbestrol  (EXP)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fipronil  (EXP)
fluoranthene  (ISO)
fluvastatin  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
gallic acid  (ISO)
gentamycin  (EXP)
glucose  (ISO)
hexadecanoic acid  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
irinotecan  (ISO)
iron atom  (EXP)
iron dichloride  (ISO)
iron(0)  (EXP)
isobutanol  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP)
leflunomide  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lovastatin  (ISO)
manganese(II) chloride  (ISO)
mercury dibromide  (ISO)
methamphetamine  (ISO)
methapyrilene  (EXP)
methylmercury chloride  (ISO)
methylmercury(1+)  (EXP)
methylparaben  (ISO)
methylseleninic acid  (ISO)
mevalonic acid  (ISO)
microcystin-LR  (ISO)
mifepristone  (EXP)
myrtenol  (ISO)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naphthalenes  (EXP)
nefazodone  (EXP)
nickel dichloride  (EXP)
nicotine  (ISO)
NSC 23766  (ISO)
ochratoxin A  (ISO)
oleic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-menthan-3-ol  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perillic acid  (ISO)
perillyl alcohol  (EXP,ISO)
perillyl aldehyde  (ISO)
phenethyl caffeate  (EXP)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
prothioconazole  (ISO)
rac-lactic acid  (ISO)
ranitidine  (EXP)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
terbinafine  (ISO)
testosterone  (EXP)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
tetradecane  (EXP)
tetrahydropalmatine  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
torcetrapib  (ISO)
triadimefon  (ISO)
Tributyltin oxide  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
Triptolide  (EXP)
troglitazone  (ISO)
undecane  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Post-translational modifications of p21rho proteins. Adamson P, etal., J Biol Chem. 1992 Oct 5;267(28):20033-8.
2. A Rho-related GTPase is involved in Ca(2+)-dependent neurotransmitter exocytosis. Doussau F, etal., J Biol Chem. 2000 Mar 17;275(11):7764-70. doi: 10.1074/jbc.275.11.7764.
3. Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters. Fritz G, etal., Br J Cancer. 2002 Sep 9;87(6):635-44.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Extra-nuclear activation of progesterone receptor in regulating arterial smooth muscle cell migration. Hsu SP, etal., Atherosclerosis. 2011 Jul;217(1):83-9. doi: 10.1016/j.atherosclerosis.2011.02.051. Epub 2011 Mar 10.
6. The ras-related gene rhoB is an immediate-early gene inducible by v-Fps, epidermal growth factor, and platelet-derived growth factor in rat fibroblasts. Jahner D and Hunter T, Mol Cell Biol 1991 Jul;11(7):3682-90.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Distribution of Rho family GTPases in the adult rat hippocampus and cerebellum. O'Kane EM, etal., Brain Res Mol Brain Res 2003 May 26;114(1):1-8.
10. Activation of Rho GTPases by synaptic transmission in the hippocampus. O'Kane EM, etal., J Neurochem 2003 Dec;87(5):1309-12.
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Role for RhoB and PRK in the suppression of epithelial cell transformation by farnesyltransferase inhibitors. Zeng PY, etal., Oncogene 2003 Feb 27;22(8):1124-34.
Additional References at PubMed
PMID:8816443   PMID:8939998   PMID:10508588   PMID:11353846   PMID:11564874   PMID:13679852   PMID:14597666   PMID:15093731   PMID:15226397   PMID:16236794   PMID:17623777   PMID:19056867  
PMID:19637314   PMID:20460403   PMID:20717930   PMID:21347332   PMID:21373644   PMID:21423176   PMID:22871113   PMID:26388235   PMID:27549397   PMID:31573047   PMID:38073570  


Genomics

Comparative Map Data
Rhob
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8637,083,030 - 37,085,204 (-)NCBIGRCr8
mRatBN7.2631,363,752 - 31,365,926 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl631,363,548 - 31,366,108 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx631,655,817 - 31,657,991 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0631,971,666 - 31,973,840 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0631,446,281 - 31,448,455 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0633,689,127 - 33,691,301 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl633,689,127 - 33,691,301 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0643,472,691 - 43,474,865 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4632,052,333 - 32,054,507 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1632,055,314 - 32,057,457 (-)NCBI
Celera630,812,638 - 30,814,812 (-)NCBICelera
Cytogenetic Map6q14NCBI
RHOB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38220,447,074 - 20,449,440 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl220,447,074 - 20,449,440 (+)EnsemblGRCh38hg38GRCh38
GRCh37220,646,835 - 20,649,201 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36220,510,316 - 20,512,682 (+)NCBINCBI36Build 36hg18NCBI36
Build 34220,568,462 - 20,570,828NCBI
Celera220,509,553 - 20,511,920 (+)NCBICelera
Cytogenetic Map2p24.1NCBI
HuRef220,404,158 - 20,406,525 (+)NCBIHuRef
CHM1_1220,576,236 - 20,578,603 (+)NCBICHM1_1
T2T-CHM13v2.0220,480,717 - 20,483,084 (+)NCBIT2T-CHM13v2.0
Rhob
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39128,547,661 - 8,550,009 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl128,547,661 - 8,550,009 (-)EnsemblGRCm39 Ensembl
GRCm38128,497,661 - 8,500,009 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl128,497,661 - 8,500,009 (-)EnsemblGRCm38mm10GRCm38
MGSCv37128,504,564 - 8,506,791 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36128,523,766 - 8,525,993 (-)NCBIMGSCv36mm8
Celera128,887,131 - 8,889,358 (-)NCBICelera
Cytogenetic Map12A1.1NCBI
cM Map123.88NCBI
Rhob
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554692,965,041 - 2,965,631 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554692,964,968 - 2,966,998 (+)NCBIChiLan1.0ChiLan1.0
RHOB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212106,078,948 - 106,081,350 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A106,082,920 - 106,085,315 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A20,433,576 - 20,435,986 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A20,548,853 - 20,551,243 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A20,549,254 - 20,549,844 (+)Ensemblpanpan1.1panPan2
RHOB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11715,438,744 - 15,439,793 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1715,439,143 - 15,441,136 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1715,403,411 - 15,404,475 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01715,590,936 - 15,592,006 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1715,590,936 - 15,592,006 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11715,444,980 - 15,446,038 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01715,451,597 - 15,452,660 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01715,483,858 - 15,484,931 (+)NCBIUU_Cfam_GSD_1.0
Rhob
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629259,849,358 - 59,851,760 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493649310,987,801 - 10,990,207 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RHOB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3117,773,405 - 117,777,574 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13117,773,400 - 117,777,569 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23125,747,271 - 125,747,861 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RHOB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11487,247,615 - 87,249,984 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1487,249,005 - 87,249,592 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604524,967,249 - 24,969,623 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rhob
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247383,115,946 - 3,116,536 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247383,115,840 - 3,117,719 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rhob
4 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:89
Count of miRNA genes:75
Interacting mature miRNAs:80
Transcripts:ENSRNOT00000008008
Prediction methods:Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6134235784Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6137618905Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6139036266Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6141223769Rat
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6141223769Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6141223769Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6142487980Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6142487980Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6142487980Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142838846Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6143394190Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449734434305Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)61653614071636405Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)62033877762613667Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat

Markers in Region
RH66820  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2631,365,069 - 31,365,191 (+)MAPPERmRatBN7.2
Rnor_6.0633,690,445 - 33,690,566NCBIRnor6.0
Rnor_5.0643,474,009 - 43,474,130UniSTSRnor5.0
RGSC_v3.4632,053,651 - 32,053,772UniSTSRGSC3.4
Celera630,813,956 - 30,814,077UniSTS
Cytogenetic Map6q14UniSTS
BI275072  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2631,363,713 - 31,363,894 (+)MAPPERmRatBN7.2
Rnor_6.0633,689,089 - 33,689,269NCBIRnor6.0
Rnor_5.0643,472,653 - 43,472,833UniSTSRnor5.0
RGSC_v3.4632,052,295 - 32,052,475UniSTSRGSC3.4
Celera630,812,600 - 30,812,780UniSTS
Cytogenetic Map6q14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 47 31 19 31 8 11 74 35 39 11 8
Low 10 10 10 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000008008   ⟹   ENSRNOP00000008008
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl631,363,548 - 31,366,108 (+)Ensembl
Rnor_6.0 Ensembl633,689,127 - 33,691,301 (-)Ensembl
RefSeq Acc Id: NM_022542   ⟹   NP_071987
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8637,083,030 - 37,085,204 (-)NCBI
mRatBN7.2631,363,752 - 31,365,926 (-)NCBI
Rnor_6.0633,689,127 - 33,691,301 (-)NCBI
Rnor_5.0643,472,691 - 43,474,865 (-)NCBI
RGSC_v3.4632,052,333 - 32,054,507 (-)RGD
Celera630,812,638 - 30,814,812 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_071987 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA42040 (Get FASTA)   NCBI Sequence Viewer  
  EDM03074 (Get FASTA)   NCBI Sequence Viewer  
  P62747 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_071987   ⟸   NM_022542
- UniProtKB: P62747 (UniProtKB/Swiss-Prot),   A6HAL9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000008008   ⟸   ENSRNOT00000008008

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P62747-F1-model_v2 AlphaFold P62747 1-196 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694484
Promoter ID:EPDNEW_R5008
Type:single initiation site
Name:Rhob_1
Description:ras homolog family member B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0633,691,391 - 33,691,451EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621309 AgrOrtholog
BioCyc Gene G2FUF-38180 BioCyc
Ensembl Genes ENSRNOG00000021403 Ensembl
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase_Rho UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64373 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 64373 ENTREZGENE
PANTHER PTHR24072 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHO-RELATED GTP-BINDING PROTEIN RHOB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ras UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rhob PhenoGen
PRINTS RASTRNSFRMNG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ARF UniProtKB/TrEMBL
  RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000021403 RatGTEx
SMART RAB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP P-loop containing nucleoside triphosphate hydrolases UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6HAL9 ENTREZGENE, UniProtKB/TrEMBL
  P62747 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary P01121 UniProtKB/Swiss-Prot
  Q9CUV7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-15 Rhob  ras homolog family member B  Rhob  ras homolog gene family, member B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Rhob  ras homolog gene family, member B    rhoB gene  Name updated 1299863 APPROVED
2004-09-10 Rhob  rhoB gene  Arhb    Symbol and Name updated 1299863 APPROVED
2002-08-07 Arhb  rhoB gene      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation induced by epidermal growth factor and platelet-derived growth factor 704375