Mvd (mevalonate diphosphate decarboxylase) - Rat Genome Database

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Gene: Mvd (mevalonate diphosphate decarboxylase) Rattus norvegicus
Analyze
Symbol: Mvd
Name: mevalonate diphosphate decarboxylase
RGD ID: 621292
Description: Enables diphosphomevalonate decarboxylase activity. Involved in isopentenyl diphosphate biosynthetic process, mevalonate pathway and response to xenobiotic stimulus. Located in peroxisomal matrix. Human ortholog(s) of this gene implicated in porokeratosis. Orthologous to human MVD (mevalonate diphosphate decarboxylase); PARTICIPATES IN alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: diphosphomevalonate decarboxylase; MDDase; mevalonate (diphospho) decarboxylase; mevalonate pyrophosphate decarboxylase; Mvpd
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81967,404,911 - 67,414,974 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1967,404,911 - 67,422,366 (-)EnsemblGRCr8
mRatBN7.21950,496,366 - 50,506,429 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1950,496,367 - 50,507,971 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1957,291,544 - 57,301,618 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01957,971,299 - 57,981,362 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01960,190,162 - 60,200,236 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01955,258,910 - 55,268,933 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1955,258,905 - 55,268,951 (-)Ensemblrn6Rnor6.0
Rnor_5.01965,967,921 - 65,978,403 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41952,722,306 - 52,732,312 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1949,735,851 - 49,745,874 (-)NCBICelera
RGSC_v3.11952,727,186 - 52,737,193 (-)NCBI
Cytogenetic Map19q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
(R)-lipoic acid  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrotoluene  (EXP)
2,4-diaminotoluene  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-hydroxypropanoic acid  (ISO)
22-Hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acetohydrazide  (ISO)
aflatoxin B1  (ISO)
alachlor  (EXP)
aldehydo-D-glucosamine  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
Archazolid B  (ISO)
aristolochic acid A  (ISO)
ATP  (ISO)
atrazine  (EXP)
avobenzone  (ISO)
benzo[a]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
carbon nanotube  (ISO)
carmustine  (ISO)
celecoxib  (ISO)
chloroethene  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
CU-O LINKAGE  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
DDE  (ISO)
dextran sulfate  (ISO)
Di-n-hexyl phthalate  (EXP)
Di-n-octyl phthalate  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloromethane  (ISO)
Dicyclohexyl phthalate  (EXP)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP)
diisobutyl phthalate  (EXP)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (EXP,ISO)
dimethylarsinic acid  (ISO)
dinophysistoxin 1  (ISO)
dipentyl phthalate  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
Evodiamine  (ISO)
flavonoids  (EXP)
fluoranthene  (ISO)
flusilazole  (EXP,ISO)
folic acid  (ISO)
formaldehyde  (ISO)
genistein  (ISO)
hexaconazole  (ISO)
hydrazine  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
hypochlorous acid  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
isobutanol  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP)
lead diacetate  (ISO)
leflunomide  (ISO)
lipoic acid  (ISO)
metformin  (EXP)
methamphetamine  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
nickel sulfate  (ISO)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
okadaic acid  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
phenylpropanolamine  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tebuconazole  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topiramate  (EXP)
triadimefon  (EXP,ISO)
trichloroethene  (EXP,ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (EXP,ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin K  (EXP)
zaragozic acid A  (EXP,ISO)
zidovudine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
cytosol  (IBA,IEA,ISO)
peroxisomal matrix  (IDA)
peroxisome  (IDA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
4. Adverse effects of long-term exposure to bisphenol A during adulthood leading to hyperglycaemia and hypercholesterolemia in mice. Marmugi A, etal., Toxicology. 2014 Nov 5;325:133-43. doi: 10.1016/j.tox.2014.08.006. Epub 2014 Aug 26.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Difference in subcellular distribution between 45- and 37-kDa mevalonate pyrophosphate decarboxylase in rat liver. Michihara A, etal., Biol Pharm Bull 2001 Dec;24(12):1347-50.
7. Mevalonate pyrophosphate decarboxylase in stroke-prone spontaneously hypertensive rat is reduced from the age of two weeks. Michihara A, etal., Biol Pharm Bull 2001 Dec;24(12):1417-9.
8. Comparison of subcellular distribution of mevalonate pyrophosphate decarboxylase between stroke-prone spontaneously hypertensive rat and Wistar Kyoto rat. Michihara A, etal., Biol Pharm Bull. 2002 Jun;25(6):734-7.
9. Probucol decreases mevalonate pyrophosphate decarboxylase in the rat liver. Michihara A, etal., Biol Pharm Bull. 2003 Oct;26(10):1484-6.
10. Disruptive effect of chloroquine on lysosomes in cultured rat hepatocytes. Michihara A, etal., Biol Pharm Bull. 2005 Jun;28(6):947-51.
11. Purification and characterization of two mevalonate pyrophosphate decarboxylases from rat liver: a novel molecular species of 37 kDa. Michihara A, etal., J Biochem. 1997 Sep;122(3):647-54.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
15. Studies on mevalonate kinase, phosphomevalonate kinase and pyrophosphomevalonate decarboxylase in developing rat brain. Ramachandran CK and Shah SN, J Neurochem. 1977 Apr;28(4):751-7.
16. GOA pipeline RGD automated data pipeline
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
19. Defects of cholesterol biosynthesis. Waterham HR FEBS Lett. 2006 Oct 9;580(23):5442-9. Epub 2006 Jul 20.
Additional References at PubMed
PMID:8626466   PMID:9270019   PMID:11157675   PMID:11792727   PMID:12646231   PMID:14680974   PMID:14972328   PMID:26158200  


Genomics

Comparative Map Data
Mvd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81967,404,911 - 67,414,974 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1967,404,911 - 67,422,366 (-)EnsemblGRCr8
mRatBN7.21950,496,366 - 50,506,429 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1950,496,367 - 50,507,971 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1957,291,544 - 57,301,618 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01957,971,299 - 57,981,362 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01960,190,162 - 60,200,236 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01955,258,910 - 55,268,933 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1955,258,905 - 55,268,951 (-)Ensemblrn6Rnor6.0
Rnor_5.01965,967,921 - 65,978,403 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41952,722,306 - 52,732,312 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1949,735,851 - 49,745,874 (-)NCBICelera
RGSC_v3.11952,727,186 - 52,737,193 (-)NCBI
Cytogenetic Map19q12NCBI
MVD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381688,651,940 - 88,663,091 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1688,651,934 - 88,663,161 (-)Ensemblhg38GRCh38
GRCh371688,718,348 - 88,729,499 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361687,245,849 - 87,256,996 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341687,245,848 - 87,256,996NCBI
Celera1673,788,020 - 73,799,160 (-)NCBICelera
Cytogenetic Map16q24.2NCBI
HuRef1674,412,379 - 74,423,531 (-)NCBIHuRef
CHM1_11690,129,698 - 90,140,847 (-)NCBICHM1_1
T2T-CHM13v2.01694,719,870 - 94,731,025 (-)NCBIT2T-CHM13v2.0
Mvd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398123,160,335 - 123,170,161 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8123,160,340 - 123,170,161 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm388122,433,596 - 122,443,422 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8122,433,601 - 122,443,422 (-)Ensemblmm10GRCm38
MGSCv378124,957,496 - 124,967,322 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368125,319,694 - 125,329,480 (-)NCBIMGSCv36mm8
Celera8126,662,705 - 126,672,531 (-)NCBICelera
Cytogenetic Map8E1NCBI
cM Map871.05NCBI
Mvd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555412,579,074 - 2,581,821 (-)Ensembl
ChiLan1.0NW_0049555412,578,584 - 2,581,823 (-)NCBIChiLan1.0ChiLan1.0
MVD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21898,425,011 - 98,436,132 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan116104,337,122 - 104,348,237 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01669,365,070 - 69,376,149 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11689,025,571 - 89,036,975 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1689,025,572 - 89,036,964 (-)EnsemblpanPan2panpan1.1
MVD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1564,683,146 - 64,691,576 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl564,682,276 - 64,691,073 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha564,693,894 - 64,702,261 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0564,902,561 - 64,910,915 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl564,902,588 - 64,910,915 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1564,928,745 - 64,937,076 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0564,760,442 - 64,768,801 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0565,166,481 - 65,174,835 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mvd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934925,275,679 - 25,282,419 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366411,030,595 - 1,035,954 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366411,030,465 - 1,035,967 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MVD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl61,008,100 - 1,014,303 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.161,008,100 - 1,014,303 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MVD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1574,031,470 - 74,049,066 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl574,031,316 - 74,049,011 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660471,646,023 - 1,653,431 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mvd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624746905,757 - 911,591 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624746905,919 - 911,591 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Mvd
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11742,073,235 - 42,083,429 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:280
Count of miRNA genes:174
Interacting mature miRNAs:189
Transcripts:ENSRNOT00000018145
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)194622677874246245Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
2303628Vencon9Ventilatory control QTL 90.005respiration trait (VT:0001943)minute ventilation (CMO:0000132)192318858668188586Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194438513474246245Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)196124916174246245Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
1554318Bmd5Bone mineral density QTL 512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)192318858668188586Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)194172254674246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat

Markers in Region
RH131095  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01965,967,927 - 65,968,109NCBIRnor5.0
Rnor_5.01149,620,644 - 149,620,826NCBIRnor5.0
RGSC_v3.41952,722,313 - 52,722,494UniSTSRGSC3.4
RGSC_v3.4X155,617,504 - 155,617,685UniSTSRGSC3.4
Celera1949,735,858 - 49,736,039UniSTS
Celera1133,317,703 - 133,317,884UniSTS
Cytogenetic Map19q12UniSTS
Cytogenetic MapXq37UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 356 192 11 140 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000018145   ⟹   ENSRNOP00000018145
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1967,404,911 - 67,411,660 (-)Ensembl
mRatBN7.2 Ensembl1950,496,367 - 50,503,115 (-)Ensembl
Rnor_6.0 Ensembl1955,258,905 - 55,268,951 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106812   ⟹   ENSRNOP00000080265
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1967,404,911 - 67,422,366 (-)Ensembl
mRatBN7.2 Ensembl1950,496,367 - 50,507,971 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000123973   ⟹   ENSRNOP00000101763
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1967,404,911 - 67,412,219 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000165481   ⟹   ENSRNOP00000100450
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1967,404,911 - 67,415,616 (-)Ensembl
RefSeq Acc Id: NM_031062   ⟹   NP_112324
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81967,404,911 - 67,414,974 (-)NCBI
mRatBN7.21950,496,366 - 50,506,429 (-)NCBI
Rnor_6.01955,258,910 - 55,268,933 (-)NCBI
Rnor_5.01965,967,921 - 65,978,403 (-)NCBI
RGSC_v3.41952,722,306 - 52,732,312 (-)RGD
Celera1949,735,851 - 49,745,874 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_112324 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB00192 (Get FASTA)   NCBI Sequence Viewer  
  AAB92551 (Get FASTA)   NCBI Sequence Viewer  
  AAH81784 (Get FASTA)   NCBI Sequence Viewer  
  AAK00810 (Get FASTA)   NCBI Sequence Viewer  
  EDL92747 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000080265
GenBank Protein Q62967 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_112324   ⟸   NM_031062
- UniProtKB: Q62967 (UniProtKB/Swiss-Prot),   Q642E5 (UniProtKB/Swiss-Prot),   A0A8I6G6D2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018145   ⟸   ENSRNOT00000018145
Ensembl Acc Id: ENSRNOP00000080265   ⟸   ENSRNOT00000106812
Ensembl Acc Id: ENSRNOP00000101763   ⟸   ENSRNOT00000123973
Ensembl Acc Id: ENSRNOP00000100450   ⟸   ENSRNOT00000165481
Protein Domains
Diphosphomevalonate decarboxylase-like N-terminal   Mvd1 C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62967-F1-model_v2 AlphaFold Q62967 1-401 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701206
Promoter ID:EPDNEW_R11729
Type:initiation region
Name:Mvd_1
Description:mevalonate diphosphate decarboxylase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01955,268,918 - 55,268,978EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621292 AgrOrtholog
BioCyc Gene G2FUF-5397 BioCyc
BioCyc Pathway PWY-922 [mevalonate pathway I (eukaryotes and bacteria)] BioCyc
BioCyc Pathway Image PWY-922 BioCyc
Ensembl Genes ENSRNOG00000013376 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000106812 ENTREZGENE
Gene3D-CATH 3.30.230.10 UniProtKB/Swiss-Prot
  3.30.70.890 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7135885 IMAGE-MGC_LOAD
InterPro GHMP_kinase_C_sf UniProtKB/Swiss-Prot
  Mev_decarb UniProtKB/Swiss-Prot
  Mev_diP_decarb UniProtKB/Swiss-Prot
  MVD-like_N UniProtKB/Swiss-Prot
  Mvd1_C UniProtKB/Swiss-Prot
  Ribosomal_S5_D2-typ_fold UniProtKB/Swiss-Prot
  Ribosomal_S5_D2-typ_fold_subgr UniProtKB/Swiss-Prot
KEGG Report rno:81726 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93385 IMAGE-MGC_LOAD
NCBI Gene 81726 ENTREZGENE
PANTHER DIPHOSPHOMEVALONATE DECARBOXYLASE UniProtKB/Swiss-Prot
  DIPHOSPHOMEVALONATE DECARBOXYLASE UniProtKB/Swiss-Prot
Pfam MDD_C UniProtKB/Swiss-Prot
  MVD-like_N UniProtKB/Swiss-Prot
PhenoGen Mvd PhenoGen
PIRSF Mev_P_decrbx UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013376 RatGTEx
Superfamily-SCOP SSF54211 UniProtKB/Swiss-Prot
  SSF55060 UniProtKB/Swiss-Prot
UniProt A0A8I6G6D2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q9Y6_RAT UniProtKB/TrEMBL
  A0ABK0LGL7_RAT UniProtKB/TrEMBL
  A0ABK0LLC2_RAT UniProtKB/TrEMBL
  MVD1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q642E5 ENTREZGENE
UniProt Secondary Q642E5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-10 Mvd  mevalonate diphosphate decarboxylase  Mvd  mevalonate (diphospho) decarboxylase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Mvd  mevalonate (diphospho) decarboxylase    mevalonate pyrophosphate decarboxylase  Name updated 1299863 APPROVED
2002-08-07 Mvd  mevalonate pyrophosphate decarboxylase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to cytosol and peroxisome 729305
gene_protein 45-kDa and 37-kDa in size 729305