Arf6 (ARF GTPase 6) - Rat Genome Database

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Gene: Arf6 (ARF GTPase 6) Rattus norvegicus
Analyze
Symbol: Arf6
Name: ARF GTPase 6 (Ensembl:ADP-ribosylation factor 6)
RGD ID: 621279
Description: Predicted to enable several functions, including G protein activity; guanyl ribonucleotide binding activity; and thioesterase binding activity. Involved in several processes, including maintenance of postsynaptic density structure; negative regulation of dendrite development; and regulation of presynapse assembly. Located in early endosome; recycling endosome; and ruffle. Is active in glutamatergic synapse; postsynapse; and presynapse. Orthologous to human ARF6 (ARF GTPase 6); PARTICIPATES IN E-cadherin signaling pathway; phosphatidylinositol 3-kinase class I signaling pathway; endocytosis pathway; INTERACTS WITH 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ADP-ribosylation factor 6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8693,589,777 - 93,590,925 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl693,569,234 - 93,610,536 (+)EnsemblGRCr8
mRatBN7.2687,853,742 - 87,854,890 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl687,840,142 - 87,874,114 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx688,252,904 - 88,254,050 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0688,552,333 - 88,553,479 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0687,992,090 - 87,993,236 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd695,139,287 - 95,140,433 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive694,546,481 - 94,547,627 (+)NCBILyon_Normotensive
Lyon_Hypertensive692,340,268 - 92,341,414 (+)NCBILyon_Hypertensive
F344_StmMcwi691,480,266 - 91,481,414 (+)NCBIF344_StmMcwi
Rnor_6.0691,697,109 - 91,698,257 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl691,697,109 - 91,698,255 (+)Ensemblrn6Rnor6.0
Rnor_5.06101,149,908 - 101,152,127 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4691,337,496 - 91,338,644 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera686,351,473 - 86,352,621 (+)NCBICelera
RGSC_v3.1691,340,951 - 91,342,098 (+)NCBI
Cytogenetic Map6q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-bisphospho-D-glyceric acid  (ISO)
2,3-bisphosphoglyceric acid  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-vinylcyclohexene dioxide  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
aluminium trifluoride  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
bafilomycin A1  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bortezomib  (ISO)
butan-1-ol  (ISO)
cadmium dichloride  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (EXP)
diuron  (EXP)
doxorubicin  (ISO)
ethanol  (EXP)
folic acid  (ISO)
furfural  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
inulin  (ISO)
ivermectin  (ISO)
lithium chloride  (ISO)
Maduramicin  (EXP)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
nefazodone  (EXP)
nitrates  (ISO)
okadaic acid  (ISO)
ozone  (EXP)
paracetamol  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
propranolol  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
Soman  (EXP)
superoxide  (ISO)
tamibarotene  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (TAS)
cell differentiation  (IEA)
cellular response to nerve growth factor stimulus  (IDA)
cortical actin cytoskeleton organization  (IEA,ISO)
endocytic recycling  (IDA,IEA,ISO)
establishment of epithelial cell polarity  (ISO)
hepatocyte apoptotic process  (ISO)
intracellular protein transport  (IBA)
liver development  (ISO)
maintenance of postsynaptic density structure  (IDA,IMP)
myeloid cell apoptotic process  (ISO)
negative regulation of dendrite development  (IMP)
negative regulation of protein localization to cell surface  (IEA,ISO)
nervous system development  (IEA)
positive regulation of actin filament polymerization  (IEA,ISO)
positive regulation of focal adhesion disassembly  (IEA,ISO)
positive regulation of keratinocyte migration  (IEA,ISO)
positive regulation of mitotic cytokinetic process  (IEA,ISO)
positive regulation of neuron projection development  (IEA,ISO)
positive regulation of protein localization to plasma membrane  (IEA,ISO)
positive regulation of protein secretion  (IEA,ISO)
protein localization to cell surface  (IEA,ISO)
protein localization to cleavage furrow  (IEA,ISO)
protein localization to endosome  (IBA,IEA,ISO,ISS)
protein localization to plasma membrane  (IEA,ISO)
protein transport  (IEA)
regulation of dendritic spine development  (IBA,IEA,IMP,ISO)
regulation of filopodium assembly  (IEA,ISO)
regulation of neuron projection development  (IEA,ISO)
regulation of presynapse assembly  (IDA,IMP)
regulation of Rac protein signal transduction  (IEA,ISO)
ruffle assembly  (IEA,ISO)
synaptic vesicle endocytosis  (IDA,IMP)
vesicle-mediated transport  (IBA)

Cellular Component
cell cortex  (IEA,ISO)
cleavage furrow  (IEA,ISO,ISS)
cytoplasm  (IBA,IEA,ISO)
cytosol  (IEA,ISO,ISS)
early endosome  (IDA)
early endosome membrane  (IEA)
endocytic vesicle  (IBA,IEA,ISO,ISS)
endosome  (IEA,ISO)
endosome membrane  (IEA)
exocytic vesicle  (ISO)
filopodium membrane  (IEA,ISO)
Flemming body  (IEA,ISO,ISS)
glutamatergic synapse  (IDA,IMP)
Golgi apparatus  (IEA,ISO)
membrane  (IEA,ISO)
midbody  (IEA,ISO)
plasma membrane  (IBA,IEA,ISO)
postsynapse  (IDA)
presynapse  (IDA)
recycling endosome  (IDA)
recycling endosome membrane  (IBA,IEA,ISO,ISS)
ruffle  (IBA,IDA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ARF6 and EFA6A regulate the development and maintenance of dendritic spines. Choi S, etal., J Neurosci. 2006 May 3;26(18):4811-9.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Regulation of dendritic development by the ARF exchange factor ARNO. Hernandez-Deviez DJ, etal., Nat Neurosci 2002 Jul;5(7):623-4.
4. GGA3 mediates TrkA endocytic recycling to promote sustained Akt phosphorylation and cell survival. Li X, etal., Mol Biol Cell. 2015 Dec 1;26(24):4412-26. doi: 10.1091/mbc.E15-02-0087. Epub 2015 Oct 7.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. Antigen-stimulated activation of phospholipase D1b by Rac1, ARF6, and PKCalpha in RBL-2H3 cells. Powner DJ, etal., Mol Biol Cell 2002 Apr;13(4):1252-62.
10. Interspecies relationships among ADP-ribosylation factors (ARFs): evidence of evolutionary pressure to maintain individual identities. Price SR, etal., Mol Cell Biochem 1996 Jun 7;159(1):15-23.
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Arf6 regulates the cycling and the readily releasable pool of synaptic vesicles at hippocampal synapse. Tagliatti E, etal., Elife. 2016 Jan 5;5. pii: e10116. doi: 10.7554/eLife.10116.
14. Role of ARF6 in internalization of metal-binding proteins, metallothionein and transferrin, and cadmium-metallothionein toxicity in kidney proximal tubule cells. Wolff NA, etal., Toxicol Appl Pharmacol. 2008 Jul 1;230(1):78-85. Epub 2008 Feb 20.
Additional References at PubMed
PMID:8947846   PMID:9312003   PMID:10022920   PMID:10036235   PMID:10913182   PMID:12477932   PMID:12584243   PMID:14684384   PMID:14978216   PMID:15509780   PMID:15980073   PMID:16100119  
PMID:16325184   PMID:16439353   PMID:16751103   PMID:16880525   PMID:17398095   PMID:17634366   PMID:17897316   PMID:18504258   PMID:19124467   PMID:19622751   PMID:19666113   PMID:19686593  
PMID:19845506   PMID:19946888   PMID:19948740   PMID:20080746   PMID:20458337   PMID:20682791   PMID:21276423   PMID:21423176   PMID:21499258   PMID:21825135   PMID:21951725   PMID:22344257  
PMID:22836268   PMID:23376485   PMID:23533145   PMID:23572513   PMID:23603394   PMID:24392021   PMID:24469796   PMID:24600047   PMID:24616519   PMID:25490267   PMID:25605715   PMID:26019348  
PMID:26824355   PMID:26884337   PMID:27044754   PMID:27330119   PMID:29420262   PMID:31206670   PMID:31907062  


Genomics

Comparative Map Data
Arf6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8693,589,777 - 93,590,925 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl693,569,234 - 93,610,536 (+)EnsemblGRCr8
mRatBN7.2687,853,742 - 87,854,890 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl687,840,142 - 87,874,114 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx688,252,904 - 88,254,050 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0688,552,333 - 88,553,479 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0687,992,090 - 87,993,236 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd695,139,287 - 95,140,433 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive694,546,481 - 94,547,627 (+)NCBILyon_Normotensive
Lyon_Hypertensive692,340,268 - 92,341,414 (+)NCBILyon_Hypertensive
F344_StmMcwi691,480,266 - 91,481,414 (+)NCBIF344_StmMcwi
Rnor_6.0691,697,109 - 91,698,257 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl691,697,109 - 91,698,255 (+)Ensemblrn6Rnor6.0
Rnor_5.06101,149,908 - 101,152,127 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4691,337,496 - 91,338,644 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera686,351,473 - 86,352,621 (+)NCBICelera
RGSC_v3.1691,340,951 - 91,342,098 (+)NCBI
Cytogenetic Map6q24NCBI
ARF6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381449,893,082 - 49,897,054 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1449,892,608 - 49,897,054 (+)Ensemblhg38GRCh38
GRCh371450,359,800 - 50,363,772 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361449,429,486 - 49,433,522 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341449,429,588 - 49,431,484NCBI
Celera1430,226,871 - 30,230,907 (+)NCBICelera
Cytogenetic Map14q21.3NCBI
HuRef1430,484,292 - 30,488,326 (+)NCBIHuRef
CHM1_11450,297,978 - 50,302,011 (+)NCBICHM1_1
T2T-CHM13v2.01444,098,298 - 44,102,268 (+)NCBIT2T-CHM13v2.0
Arf6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391269,418,924 - 69,422,754 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1269,418,924 - 69,420,557 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381269,372,150 - 69,375,980 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1269,372,150 - 69,373,783 (+)Ensemblmm10GRCm38
MGSCv371270,473,137 - 70,476,967 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361270,290,793 - 70,292,388 (+)NCBIMGSCv36mm8
Celera1270,470,421 - 70,474,282 (+)NCBICelera
Cytogenetic Map12C2NCBI
cM Map1228.81NCBI
Arf6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540912,817,496 - 12,818,023 (-)Ensembl
ChiLan1.0NW_00495540912,814,814 - 12,818,142 (-)NCBIChiLan1.0ChiLan1.0
ARF6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21551,028,155 - 51,033,366 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11450,244,617 - 50,249,869 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01430,482,191 - 30,486,741 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11448,788,586 - 48,792,641 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1448,789,329 - 48,789,856 (+)EnsemblpanPan2panpan1.1
ARF6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1826,445,407 - 26,449,430 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl826,445,647 - 26,525,530 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha826,199,039 - 26,203,086 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0826,622,998 - 26,627,047 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl826,623,051 - 26,703,339 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1826,278,479 - 26,282,519 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0826,351,547 - 26,355,590 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0826,669,436 - 26,673,480 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Arf6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864058,503,422 - 58,507,422 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936583181,490 - 185,471 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936583181,490 - 185,466 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARF6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1179,713,299 - 179,717,841 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11179,697,582 - 179,717,299 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21200,071,305 - 200,075,268 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ARF6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12426,948,794 - 26,952,803 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2426,949,388 - 26,950,074 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605315,277,536 - 15,281,551 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arf6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473118,882,690 - 18,883,217 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473118,880,065 - 18,883,456 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Arf6
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1783,039,956 - 83,043,369 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Arf6
1 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:395
Count of miRNA genes:208
Interacting mature miRNAs:245
Transcripts:ENSRNOT00000006355
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)671278722116278722Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)664367996109367996Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)66345744194939581Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
4889933Bss88Bone structure and strength QTL 883.8tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)65368492198684921Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)646050607116278722Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)686867923110125012Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)686867923110125012Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)684490437129490437Rat
4889848Pur25Proteinuria QTL 25140.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)66303731995934232Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
5684963Bss99Bone structure and strength QTL 993.1tibia area (VT:1000281)tibia area measurement (CMO:0001382)65368492198684921Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)678204640123204640Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
5684992Bmd83Bone mineral density QTL 824.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)65368492198684921Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)676937178121937178Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)686494122112380234Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)66345744194939581Rat

Markers in Region
AW496366  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2687,854,468 - 87,854,581 (+)MAPPERmRatBN7.2
Rnor_6.0691,697,836 - 91,697,948NCBIRnor6.0
Rnor_5.06101,151,155 - 101,151,267UniSTSRnor5.0
RGSC_v3.4691,338,223 - 91,338,335UniSTSRGSC3.4
Celera686,352,200 - 86,352,312UniSTS
Cytogenetic Map6q24UniSTS
ARF6_719  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2687,853,899 - 87,854,765 (+)MAPPERmRatBN7.2
Rnor_6.0691,697,267 - 91,698,132NCBIRnor6.0
Rnor_5.06101,150,586 - 101,151,451UniSTSRnor5.0
RGSC_v3.4691,337,654 - 91,338,519UniSTSRGSC3.4
Celera686,351,631 - 86,352,496UniSTS
Cytogenetic Map6q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000006355   ⟹   ENSRNOP00000006355
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl693,589,730 - 93,610,536 (+)Ensembl
mRatBN7.2 Ensembl687,840,142 - 87,874,114 (+)Ensembl
Rnor_6.0 Ensembl691,697,109 - 91,698,255 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097511   ⟹   ENSRNOP00000079011
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl693,569,234 - 93,593,752 (+)Ensembl
mRatBN7.2 Ensembl687,852,374 - 87,857,232 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101767   ⟹   ENSRNOP00000077772
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl693,588,698 - 93,593,096 (+)Ensembl
mRatBN7.2 Ensembl687,840,679 - 87,857,061 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115929   ⟹   ENSRNOP00000080368
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl693,577,737 - 93,592,584 (+)Ensembl
mRatBN7.2 Ensembl687,852,273 - 87,857,061 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000171436   ⟹   ENSRNOP00000099185
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl693,589,134 - 93,592,585 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000173547   ⟹   ENSRNOP00000099834
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl693,589,486 - 93,592,591 (+)Ensembl
RefSeq Acc Id: NM_024152   ⟹   NP_077066
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8693,589,777 - 93,590,925 (+)NCBI
mRatBN7.2687,853,742 - 87,854,890 (+)NCBI
Dahl_SR_JrHsd695,139,287 - 95,140,433 (+)NCBI
Lyon_Normotensive694,546,481 - 94,547,627 (+)NCBI
Lyon_Hypertensive692,340,268 - 92,341,414 (+)NCBI
F344_StmMcwi691,480,266 - 91,481,414 (+)NCBI
Rnor_6.0691,697,109 - 91,698,257 (+)NCBI
Rnor_5.06101,149,908 - 101,152,127 (+)NCBI
RGSC_v3.4691,337,496 - 91,338,644 (+)RGD
Celera686,351,473 - 86,352,621 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_077066 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40690 (Get FASTA)   NCBI Sequence Viewer  
  AAH91146 (Get FASTA)   NCBI Sequence Viewer  
  EDM03520 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000077772.1
  ENSRNOP00000079011.1
  ENSRNOP00000080368.1
  ENSRNOP00000099834
GenBank Protein P62332 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_077066   ⟸   NM_024152
- UniProtKB: Q5BKA5 (UniProtKB/Swiss-Prot),   P62332 (UniProtKB/Swiss-Prot),   A6HBW5 (UniProtKB/TrEMBL),   A0A8L2Q237 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006355   ⟸   ENSRNOT00000006355
Ensembl Acc Id: ENSRNOP00000080368   ⟸   ENSRNOT00000115929
Ensembl Acc Id: ENSRNOP00000079011   ⟸   ENSRNOT00000097511
Ensembl Acc Id: ENSRNOP00000077772   ⟸   ENSRNOT00000101767
Ensembl Acc Id: ENSRNOP00000099834   ⟸   ENSRNOT00000173547
Ensembl Acc Id: ENSRNOP00000099185   ⟸   ENSRNOT00000171436

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P62332-F1-model_v2 AlphaFold P62332 1-175 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694637
Promoter ID:EPDNEW_R5160
Type:initiation region
Name:Arf6_1
Description:ADP-ribosylation factor 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0691,697,058 - 91,697,118EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621279 AgrOrtholog
BioCyc Gene G2FUF-37246 BioCyc
Ensembl Genes ENSRNOG00000004791 Ensembl
  ENSRNOG00000070951 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000097511.1 UniProtKB/Swiss-Prot
  ENSRNOT00000101767.1 UniProtKB/Swiss-Prot
  ENSRNOT00000115929.1 UniProtKB/Swiss-Prot
  ENSRNOT00000173547 ENTREZGENE
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7309902 IMAGE-MGC_LOAD
InterPro Arf6 UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  Small_GTP-bd_dom UniProtKB/Swiss-Prot
  Small_GTPase_ARF UniProtKB/Swiss-Prot
  Small_GTPase_ARF/SAR UniProtKB/Swiss-Prot
KEGG Report rno:79121 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108680 IMAGE-MGC_LOAD
NCBI Gene 79121 ENTREZGENE
PANTHER PTHR11711 UniProtKB/Swiss-Prot
Pfam Arf UniProtKB/Swiss-Prot
PhenoGen Arf6 PhenoGen
PRINTS SAR1GTPBP UniProtKB/Swiss-Prot
PROSITE ARF UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000004791 RatGTEx
  ENSRNOG00000070951 RatGTEx
SMART ARF UniProtKB/Swiss-Prot
  RAB UniProtKB/Swiss-Prot
  SAR UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A0A8L2Q237 ENTREZGENE, UniProtKB/TrEMBL
  A6HBW5 ENTREZGENE, UniProtKB/TrEMBL
  ARF6_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5BKA5 ENTREZGENE
UniProt Secondary P26438 UniProtKB/Swiss-Prot
  Q5BKA5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-11-07 Arf6  ARF GTPase 6  Arf6  ADP-ribosylation factor 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Arf6  ADP-ribosylation factor 6      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Arf6  ADP-ribosylation factor 6      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization colocalized with phospholipase D1b to the plasma membrane, membrane ruffles, and intracellularly after antigen stimulation 727254
gene_expression expressed in both embryonic and adult hippocampus 625544
gene_process activates either Rac1 or phosphoinositide kinase pathway for regulation of dendritogenesis 625544
gene_process may be involved in regulating dendritic branching 625544
gene_product small GTPase family member 625544