Top1 (DNA topoisomerase I) - Rat Genome Database

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Gene: Top1 (DNA topoisomerase I) Rattus norvegicus
Analyze
Symbol: Top1
Name: DNA topoisomerase I
RGD ID: 621246
Description: Enables DNA topoisomerase type I (single strand cut, ATP-independent) activity and chromatin DNA binding activity. Involved in several processes, including DNA topological change; cellular response to luteinizing hormone stimulus; and response to gamma radiation. Located in dense fibrillar component and fibrillar center. Orthologous to human TOP1 (DNA topoisomerase I); PARTICIPATES IN irinotecan pharmacodynamics pathway; irinotecan pharmacokinetics pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ab2-086; DNA topoisomerase 1; topoisomerase (DNA) I
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Top1-ps1  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83169,713,195 - 169,796,330 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3169,713,130 - 169,796,327 (+)EnsemblGRCr8
mRatBN7.23149,293,469 - 149,376,618 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3149,293,403 - 149,376,623 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3153,107,309 - 153,188,513 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03161,606,688 - 161,687,898 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03159,345,818 - 159,427,549 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03156,635,688 - 156,717,686 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3156,642,464 - 156,717,686 (+)Ensemblrn6Rnor6.0
Rnor_5.03162,865,335 - 162,947,076 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43151,428,931 - 151,512,884 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3147,968,261 - 148,049,789 (+)NCBICelera
RGSC_v3.13151,334,966 - 151,418,920 (+)NCBI
Cytogenetic Map3q42NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,6-dimethoxyphenol  (ISO)
3'-deamino-3'-(3-cyanomorpholin-4-yl)doxorubicin  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
actinomycin D  (ISO)
afimoxifene  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
anthracenes  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (ISO)
betulinic acid  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
Boswellic acid  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
camptothecin  (EXP,ISO)
captafol  (ISO)
chloroacetaldehyde  (ISO)
choline  (ISO)
cidofovir anhydrous  (ISO)
ciprofloxacin  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
Cyclocurcumin  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
delphinidin  (ISO)
deoxynivalenol  (ISO)
dibenzo[a,l]pyrene  (ISO)
dioxygen  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
elemental selenium  (ISO)
ethanol  (ISO)
Evodiamine  (ISO)
fenofibrate  (EXP)
flavonoids  (EXP,ISO)
fluoranthene  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furfural  (ISO)
graphene oxide  (ISO)
hydrogen peroxide  (ISO)
hydroxyurea  (ISO)
ifosfamide  (ISO)
indirubin  (ISO)
inulin  (ISO)
irinotecan  (ISO)
L-methionine  (ISO)
lapatinib  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
luteolin  (EXP)
menadione  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
miconazole  (ISO)
moxifloxacin  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nevadensin  (ISO)
Nitidine  (ISO)
Nivalenol  (ISO)
okadaic acid  (ISO)
oleanolic acid  (ISO)
oxaliplatin  (EXP,ISO)
p-anisidine  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
palmatine  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
pirinixic acid  (ISO)
propiconazole  (EXP)
raloxifene  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
testosterone  (EXP)
tetrahydropalmatine  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP,ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
ursolic acid  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromosome  (IEA)
cytoplasm  (IEA,ISO)
dense fibrillar component  (IDA)
fibrillar center  (IDA,IEA,ISO)
nuclear chromosome  (IEA,ISO)
nucleolus  (IBA,IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO)
P-body  (IEA,ISO)
perikaryon  (IEA,ISO)
protein-DNA complex  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The giant fibrillar center: a nucleolar structure enriched in upstream binding factor (UBF) that appears in transcriptionally more active sensory ganglia neurons. Casafont I, etal., J Struct Biol. 2007 Sep;159(3):451-61. Epub 2007 May 25.
2. Purified apolipoprotein B gene regulatory factor-3 is DNA topoisomerase I. Chuang SS, etal., Eur J Biochem. 1999 Aug;263(3):773-81.
3. DNA topoisomerase I from Leydig cells is modulated by luteinizing hormone and cyclic adenosine monophosphate. Crespi MD, etal., Mol Cell Endocrinol. 1987 Oct;53(3):221-6.
4. Enzymes involved in DNA synthesis in the testes are regulated by temperature in vitro. Fujisawa M, etal., Eur Urol. 1997;31(2):237-42.
5. Role of DNA topoisomerase I in the transcription of supercoiled rRNA gene. Garg LC, etal., Proc Natl Acad Sci U S A. 1987 May;84(10):3185-8.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Variations in DNA topoisomerase I activity after gamma irradiation of mature neurons. Ivanov VA Neurosci Lett. 1988 Nov 22;94(1-2):99-103.
9. DNA topoisomerase I from rat brain neurons. Ivanov VA, etal., Biochim Biophys Acta. 1986 Mar 26;866(2-3):154-60.
10. Down modulation of topoisomerase I affects DNA repair efficiency. Mao Y and Muller MT, DNA Repair (Amst) 2003 Oct 7;2(10):1115-26.
11. DNA topoisomerase I activity in regenerating liver of hypothyroid rats. Merlo M, etal., Boll Soc Ital Biol Sper. 1998 Jan-Feb;74(1-2):9-14.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Association of DNA topoisomerase I and RNA polymerase I: a possible role for topoisomerase I in ribosomal gene transcription. Rose KM, etal., Chromosoma. 1988;96(6):411-6.
18. Comparison of biochemical properties of DNA-topoisomerase I from normal and regenerating liver. Tournier MF, etal., Eur J Biochem. 1992 Nov 15;210(1):359-64.
19. Immunohistochemical analyses of DNA topoisomerase II isoforms in developing rat cerebellum. Tsutsui K, et al., J Comp Neurol. 2001 Mar 5;431(2):228-39.
Additional References at PubMed
PMID:7842491   PMID:8567649   PMID:8631793   PMID:8631794   PMID:8943335   PMID:9049244   PMID:9094096   PMID:9611241   PMID:10497031   PMID:11016921   PMID:11756244   PMID:12878161  
PMID:14594810   PMID:14654701   PMID:16127745   PMID:16261531   PMID:16791210   PMID:17355975   PMID:22206666   PMID:22215678   PMID:22658674   PMID:22681889   PMID:22904072   PMID:23012366  


Genomics

Comparative Map Data
Top1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83169,713,195 - 169,796,330 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3169,713,130 - 169,796,327 (+)EnsemblGRCr8
mRatBN7.23149,293,469 - 149,376,618 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3149,293,403 - 149,376,623 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3153,107,309 - 153,188,513 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03161,606,688 - 161,687,898 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03159,345,818 - 159,427,549 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03156,635,688 - 156,717,686 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3156,642,464 - 156,717,686 (+)Ensemblrn6Rnor6.0
Rnor_5.03162,865,335 - 162,947,076 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43151,428,931 - 151,512,884 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3147,968,261 - 148,049,789 (+)NCBICelera
RGSC_v3.13151,334,966 - 151,418,920 (+)NCBI
Cytogenetic Map3q42NCBI
TOP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382041,028,822 - 41,124,487 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2041,028,822 - 41,124,487 (+)Ensemblhg38GRCh38
GRCh372039,657,462 - 39,753,127 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362039,090,876 - 39,186,541 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342039,090,875 - 39,186,541NCBI
Celera2036,368,028 - 36,463,696 (+)NCBICelera
Cytogenetic Map20q12NCBI
HuRef2036,395,468 - 36,491,177 (+)NCBIHuRef
CHM1_12039,561,887 - 39,657,539 (+)NCBICHM1_1
T2T-CHM13v2.02042,760,511 - 42,856,164 (+)NCBIT2T-CHM13v2.0
Top1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392160,487,901 - 160,564,684 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2160,487,808 - 160,564,684 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382160,645,897 - 160,722,764 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2160,645,888 - 160,722,764 (+)Ensemblmm10GRCm38
MGSCv372160,471,633 - 160,548,500 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362160,337,671 - 160,414,152 (+)NCBIMGSCv36mm8
Celera2166,577,915 - 166,654,823 (+)NCBICelera
Cytogenetic Map2H2NCBI
cM Map280.96NCBI
Top1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544515,834,017 - 15,922,785 (-)Ensembl
ChiLan1.0NW_00495544515,834,017 - 15,922,785 (-)NCBIChiLan1.0ChiLan1.0
TOP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22146,769,898 - 46,866,351 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12046,762,969 - 46,859,450 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02037,368,606 - 37,464,649 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12038,468,197 - 38,563,842 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2038,468,452 - 38,562,652 (+)EnsemblpanPan2panpan1.1
TOP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12429,075,267 - 29,166,733 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2429,075,492 - 29,165,864 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2428,720,984 - 28,812,380 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02429,781,234 - 29,872,485 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2429,781,498 - 29,872,296 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12429,049,969 - 29,141,401 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02429,153,861 - 29,245,250 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02429,650,217 - 29,741,420 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Top1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640178,026,161 - 178,108,033 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936561641,423 - 723,518 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936561641,451 - 723,323 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TOP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1743,710,290 - 43,799,700 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11743,710,270 - 43,799,700 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21749,135,554 - 49,193,582 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TOP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1222,655,085 - 22,751,082 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl222,651,995 - 22,751,102 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605071,467,009 - 71,562,443 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Top1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249191,668,440 - 1,756,629 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046249191,668,712 - 1,756,624 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Top1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15139,937,462 - 140,018,874 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:138
Count of miRNA genes:119
Interacting mature miRNAs:123
Transcripts:ENSRNOT00000041390
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
1300113Bp176Blood pressure QTL 1763.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3166376089177728348Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161492708189428310Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3166376089189428310Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161799493176036425Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3161799270187311134Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3166376089189428310Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3141508991177728348Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat

Markers in Region
D3Rat144  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23149,313,702 - 149,313,851 (+)MAPPERmRatBN7.2
Rnor_6.03156,656,295 - 156,656,443NCBIRnor6.0
Rnor_5.03162,885,942 - 162,886,090UniSTSRnor5.0
RGSC_v3.43151,448,967 - 151,449,116RGDRGSC3.4
RGSC_v3.43151,448,968 - 151,449,116UniSTSRGSC3.4
Celera3147,988,297 - 147,988,445UniSTS
RGSC_v3.13151,355,003 - 151,355,152RGD
SHRSP x BN Map375.5299RGD
SHRSP x BN Map375.5299UniSTS
Cytogenetic Map3q42UniSTS
D3Got129  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr83169,793,879 - 169,794,137 (+)Marker Load Pipeline
mRatBN7.23149,374,167 - 149,374,425 (+)MAPPERmRatBN7.2
Rnor_6.03156,716,449 - 156,716,706NCBIRnor6.0
Rnor_5.03162,945,839 - 162,946,096UniSTSRnor5.0
RGSC_v3.43151,511,647 - 151,511,904UniSTSRGSC3.4
RGSC_v3.43151,511,646 - 151,511,904RGDRGSC3.4
Celera3148,048,552 - 148,048,809UniSTS
RGSC_v3.13151,417,683 - 151,417,940RGD
RH 3.4 Map31368.8RGD
RH 3.4 Map31368.8UniSTS
RH 2.0 Map3923.1RGD
Cytogenetic Map3q42UniSTS
BF405031  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23149,343,945 - 149,344,113 (+)MAPPERmRatBN7.2
Rnor_6.03156,686,229 - 156,686,396NCBIRnor6.0
Rnor_5.03162,915,621 - 162,915,788UniSTSRnor5.0
RGSC_v3.43151,481,427 - 151,481,594UniSTSRGSC3.4
Celera3148,018,332 - 148,018,499UniSTS
RH 3.4 Map31367.7UniSTS
Cytogenetic Map3q42UniSTS
BE115617  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21127,423,790 - 127,423,946 (+)MAPPERmRatBN7.2
mRatBN7.23149,293,404 - 149,293,572 (+)MAPPERmRatBN7.2
Rnor_6.03156,635,435 - 156,635,602NCBIRnor6.0
Rnor_6.01134,992,286 - 134,992,441NCBIRnor6.0
Rnor_5.03162,865,082 - 162,865,249UniSTSRnor5.0
Rnor_5.01136,015,943 - 136,016,098UniSTSRnor5.0
RGSC_v3.41128,843,970 - 128,844,125UniSTSRGSC3.4
RGSC_v3.43151,428,678 - 151,428,845UniSTSRGSC3.4
Celera3147,968,008 - 147,968,175UniSTS
Celera1119,553,296 - 119,553,451UniSTS
Cytogenetic Map3q42UniSTS
Cytogenetic Map1q31UniSTS
BM389249  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23149,307,989 - 149,308,159 (+)MAPPERmRatBN7.2
Rnor_6.03156,650,589 - 156,650,758NCBIRnor6.0
Rnor_5.03162,880,236 - 162,880,405UniSTSRnor5.0
RGSC_v3.43151,443,262 - 151,443,431UniSTSRGSC3.4
Celera3147,982,592 - 147,982,761UniSTS
RH 3.4 Map31364.0UniSTS
Cytogenetic Map3q42UniSTS
UniSTS:234589  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23149,297,204 - 149,297,432 (+)MAPPERmRatBN7.2
Rnor_6.03156,639,536 - 156,639,763NCBIRnor6.0
Rnor_5.03162,869,183 - 162,869,410UniSTSRnor5.0
RGSC_v3.43151,432,478 - 151,432,705UniSTSRGSC3.4
Celera3147,971,808 - 147,972,035UniSTS
Cytogenetic Map3q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000041390   ⟹   ENSRNOP00000040134
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3156,662,114 - 156,662,958 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000085354   ⟹   ENSRNOP00000072312
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3156,642,464 - 156,662,224 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000086260   ⟹   ENSRNOP00000072794
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3149,293,403 - 149,375,591 (+)Ensembl
Rnor_6.0 Ensembl3156,662,120 - 156,717,686 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113376   ⟹   ENSRNOP00000076575
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3169,713,130 - 169,796,327 (+)Ensembl
mRatBN7.2 Ensembl3149,293,451 - 149,376,623 (+)Ensembl
RefSeq Acc Id: NM_022615   ⟹   NP_072137
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83169,713,195 - 169,796,330 (+)NCBI
mRatBN7.23149,293,469 - 149,376,618 (+)NCBI
Rnor_6.03156,635,688 - 156,717,686 (+)NCBI
Rnor_5.03162,865,335 - 162,947,076 (+)NCBI
RGSC_v3.43151,428,931 - 151,512,884 (+)RGD
Celera3147,968,261 - 148,049,789 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_072137 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD30137 (Get FASTA)   NCBI Sequence Viewer  
  AAP92589 (Get FASTA)   NCBI Sequence Viewer  
  EDL96618 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000076575
GenBank Protein Q9WUL0 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_072137   ⟸   NM_022615
- UniProtKB: Q9WUL0 (UniProtKB/Swiss-Prot),   A6JWZ1 (UniProtKB/TrEMBL),   A0A8I5Y067 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072312   ⟸   ENSRNOT00000085354
Ensembl Acc Id: ENSRNOP00000040134   ⟸   ENSRNOT00000041390
Ensembl Acc Id: ENSRNOP00000072794   ⟸   ENSRNOT00000086260
Ensembl Acc Id: ENSRNOP00000076575   ⟸   ENSRNOT00000113376
Protein Domains
DNA topoisomerase I eukaryotic-type   Topo IB-type catalytic

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WUL0-F1-model_v2 AlphaFold Q9WUL0 1-767 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692628
Promoter ID:EPDNEW_R3151
Type:single initiation site
Name:Top1_1
Description:DNA topoisomerase I
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03156,662,166 - 156,662,226EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621246 AgrOrtholog
BioCyc Gene G2FUF-46971 BioCyc
Ensembl Genes ENSRNOG00000047611 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000113376 ENTREZGENE
Gene3D-CATH 1.10.10.41 UniProtKB/Swiss-Prot
  1.10.132.10 UniProtKB/Swiss-Prot
  2.170.11.10 UniProtKB/Swiss-Prot
  Topoisomerase I, Chain A, domain 3 UniProtKB/Swiss-Prot
InterPro DNA_brk_join_enz UniProtKB/Swiss-Prot
  DNA_topo_DNA_db_N_dom1 UniProtKB/Swiss-Prot
  DNA_topo_DNA_db_N_dom2 UniProtKB/Swiss-Prot
  TopoI UniProtKB/Swiss-Prot
  TopoI_AS UniProtKB/Swiss-Prot
  TopoI_C_dom UniProtKB/Swiss-Prot
  TopoI_cat_a-hlx-sub_euk UniProtKB/Swiss-Prot
  TopoI_cat_a/b-sub_euk UniProtKB/Swiss-Prot
  TopoI_cat_euk UniProtKB/Swiss-Prot
  TopoI_DNA-bd_euk UniProtKB/Swiss-Prot
  TopoI_DNA-bd_euk_N_sf UniProtKB/Swiss-Prot
  TopoI_euk UniProtKB/Swiss-Prot
  Topoisomer_I_DNA-bd UniProtKB/Swiss-Prot
  Topoisomerase_IB UniProtKB/Swiss-Prot
KEGG Report rno:64550 UniProtKB/Swiss-Prot
NCBI Gene 64550 ENTREZGENE
PANTHER DNA TOPOISOMERASE 1 UniProtKB/Swiss-Prot
  DNA TOPOISOMERASE I UniProtKB/Swiss-Prot
Pfam Topo_C_assoc UniProtKB/Swiss-Prot
  Topoisom_I UniProtKB/Swiss-Prot
  Topoisom_I_N UniProtKB/Swiss-Prot
PharmGKB TOP1 RGD
PhenoGen Top1 PhenoGen
PRINTS EUTPISMRASEI UniProtKB/Swiss-Prot
PROSITE TOPO_IB_2 UniProtKB/Swiss-Prot
  TOPOISOMERASE_I_EUK UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000047611 RatGTEx
SMART TOPEUc UniProtKB/Swiss-Prot
Superfamily-SCOP Eukaryotic DNA topoisomerase I, dispensable insert domain UniProtKB/Swiss-Prot
  SSF56349 UniProtKB/Swiss-Prot
  SSF56741 UniProtKB/Swiss-Prot
UniProt A0A8I5Y067 ENTREZGENE, UniProtKB/TrEMBL
  A6JWZ1 ENTREZGENE, UniProtKB/TrEMBL
  Q9WUL0 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-08-16 Top1  DNA topoisomerase I  Top1  topoisomerase (DNA) I  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Top1  topoisomerase (DNA) I    DNA topoisomerase I  Name updated 1299863 APPROVED
2002-08-07 Top1  DNA topoisomerase I      Symbol and Name status set to provisional 70820 PROVISIONAL