| (+)-catechin | decreases expression | ISO | RGD:733198 | 6480464 | Catechin results in decreased expression of TOP1 mRNA; more ... | CTD | PMID:15465739 |
| 17alpha-ethynylestradiol | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TOP1 mRNA | CTD | PMID:17942748 |
| 17beta-estradiol | increases expression | ISO | RGD:733198 | 6480464 | Estradiol results in increased expression of TOP1 mRNA | CTD | PMID:16514628 |
| 17beta-estradiol | affects expression | ISO | RGD:733198 | 6480464 | Estradiol affects the expression of TOP1 mRNA | CTD | PMID:22574217 |
| 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:621246 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of TOP1 protein | CTD | PMID:16548065 |
| 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of TOP1 mRNA | CTD | PMID:21570461 |
| 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TOP1 mRNA | CTD | PMID:17942748 |
| 3'-deamino-3'-(3-cyanomorpholin-4-yl)doxorubicin | increases activity | EXP | | 6480464 | 3'-deamino-3'-(3-cyano-4-morpholinyl)doxorubicin results in increased activity of TOP1 protein | CTD | PMID:2164630 |
| 4,4'-diaminodiphenylmethane | decreases expression | EXP | | 6480464 | 4,4'-diaminodiphenylmethane results in decreased expression of TOP1 mRNA | CTD | PMID:18648102 |
| 4-hydroxynon-2-enal | decreases expression | ISO | RGD:733198 | 6480464 | 4-hydroxy-2-nonenal results in decreased expression of TOP1 mRNA | CTD | PMID:12419474 |
| 5-fluorouracil | affects response to substance | ISO | RGD:733198 | 6480464 | TOP1 protein affects the susceptibility to Fluorouracil | CTD | PMID:18509181 |
| 5-fluorouracil | decreases expression | ISO | RGD:733198 | 6480464 | Fluorouracil results in decreased expression of TOP1 mRNA | CTD | PMID:16709241 |
| actinomycin D | increases activity | EXP | | 6480464 | Dactinomycin results in increased activity of TOP1 protein | CTD | PMID:2164630 |
| afimoxifene | decreases expression | ISO | RGD:733198 | 6480464 | 4-hydroxytamoxifen results in decreased expression of TOP1 mRNA | CTD | PMID:16514628 |
| all-trans-retinoic acid | decreases expression | ISO | RGD:733198 | 6480464 | Tretinoin results in decreased expression of TOP1 mRNA | CTD | PMID:15498508 |
| ammonium chloride | increases expression | ISO | RGD:621246 | 6480464 | Ammonium Chloride results in increased expression of TOP1 protein | CTD | PMID:16483693 |
| benzo[a]pyrene | multiple interactions | EXP | | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of TOP1 mRNA | CTD | PMID:21715664 |
| betulinic acid | decreases activity | ISO | RGD:733198 | 6480464 | betulinic acid results in decreased activity of TOP1 protein | CTD | PMID:10860928 |
| camptothecin | multiple interactions | ISO | RGD:733198 | 6480464 | [Ciprofloxacin co-treated with Camptothecin] results in decreased activity of TOP1 protein; more ... | CTD | PMID:18191106 |
| camptothecin | decreases activity | ISO | RGD:621246 | 6480464 | Camptothecin results in decreased activity of TOP1 protein | CTD | PMID:20600288 |
| camptothecin | decreases activity | ISO | RGD:733198 | 6480464 | Camptothecin results in decreased activity of TOP1 protein | CTD | PMID:12097280 PMID:21227924 |
| camptothecin | decreases activity | ISO | RGD:733198 | 6480464 | Camptothecin analog results in decreased activity of TOP1 protein | CTD | PMID:21056033 |
| camptothecin | decreases activity | ISO | RGD:733198 | 6480464 | Camptothecin results in decreased activity of TOP1 protein | CTD | PMID:21227924 PMID:12097280 |
| camptothecin | decreases response to substance | ISO | RGD:733198 | 6480464 | TOP1 protein mutant form results in decreased susceptibility to Camptothecin | CTD | PMID:12097280 |
| camptothecin | decreases activity | ISO | RGD:733198 | 6480464 | Camptothecin results in decreased activity of TOP1 protein | CTD | PMID:12097280 |
| choline | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TOP1 gene | CTD | PMID:20938992 |
| ciprofloxacin | multiple interactions | ISO | RGD:733198 | 6480464 | [Ciprofloxacin co-treated with Camptothecin] results in decreased activity of TOP1 protein | CTD | PMID:18191106 |
| cisplatin | increases expression | EXP | | 6480464 | Cisplatin results in increased expression of TOP1 mRNA | CTD | PMID:21151649 |
| copper atom | multiple interactions | ISO | RGD:733198 | 6480464 | [Thiosemicarbazones binds to Copper] which results in increased expression of TOP1 protein | CTD | PMID:20931265 |
| copper(0) | multiple interactions | ISO | RGD:733198 | 6480464 | [Thiosemicarbazones binds to Copper] which results in increased expression of TOP1 protein | CTD | PMID:20931265 |
| copper(2+) sulfate | increases expression | ISO | RGD:733198 | 6480464 | Copper Sulfate results in increased expression of TOP1 mRNA | CTD | PMID:19549813 |
| delphinidin | decreases activity | ISO | RGD:733198 | 6480464 | delphinidin results in decreased activity of TOP1 protein | CTD | PMID:19182879 |
| elemental selenium | decreases expression | ISO | RGD:733198 | 6480464 | Selenium results in decreased expression of TOP1 mRNA | CTD | PMID:19244175 |
| elemental selenium | multiple interactions | ISO | RGD:733198 | 6480464 | [Selenium co-treated with Vitamin E] results in decreased expression of TOP1 mRNA | CTD | PMID:19244175 |
| fenofibrate | multiple interactions | ISO | RGD:621246 | 6480464 | [Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of TOP1 mRNA | CTD | PMID:18253720 |
| folic acid | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TOP1 gene | CTD | PMID:20938992 |
| fulvestrant | decreases expression | ISO | RGD:733198 | 6480464 | fulvestrant results in decreased expression of TOP1 mRNA | CTD | PMID:16514628 |
| hydrogen peroxide | affects expression | ISO | RGD:733198 | 6480464 | Hydrogen Peroxide affects the expression of TOP1 mRNA | CTD | PMID:20044591 |
| hydrogen peroxide | increases secretion | EXP | | 6480464 | Hydrogen Peroxide results in increased secretion of TOP1 mRNA | CTD | PMID:21179422 |
| hydroxyurea | decreases expression | EXP | | 6480464 | Hydroxyurea results in decreased expression of TOP1 mRNA | CTD | PMID:12929121 |
| L-methionine | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TOP1 gene | CTD | PMID:20938992 |
| luteolin | multiple interactions | ISO | RGD:621246 | 6480464 | Luteolin binds to and results in decreased activity of TOP1 protein | CTD | PMID:12027807 |
| menadione | affects expression | ISO | RGD:733198 | 6480464 | Vitamin K 3 affects the expression of TOP1 mRNA | CTD | PMID:20044591 |
| N-nitrosodiethylamine | multiple interactions | ISO | RGD:621246 | 6480464 | [Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of TOP1 mRNA | CTD | PMID:18253720 |
| oleanolic acid | decreases activity | ISO | RGD:733198 | 6480464 | Oleanolic Acid results in decreased activity of TOP1 protein | CTD | PMID:10860928 |
| oxaliplatin | affects response to substance | ISO | RGD:733198 | 6480464 | TOP1 protein affects the susceptibility to oxaliplatin | CTD | PMID:18509181 |
| paclitaxel | decreases expression | EXP | | 6480464 | Paclitaxel results in decreased expression of TOP1 mRNA | CTD | PMID:12929121 |
| perfluorooctane-1-sulfonic acid | increases expression | ISO | RGD:621246 | 6480464 | perfluorooctane sulfonic acid results in increased expression of TOP1 mRNA | CTD | PMID:18692542 |
| raloxifene | decreases expression | ISO | RGD:733198 | 6480464 | Raloxifene results in decreased expression of TOP1 mRNA | CTD | PMID:16514628 |
| selenium atom | decreases expression | ISO | RGD:733198 | 6480464 | Selenium results in decreased expression of TOP1 mRNA | CTD | PMID:19244175 |
| selenium atom | multiple interactions | ISO | RGD:733198 | 6480464 | [Selenium co-treated with Vitamin E] results in decreased expression of TOP1 mRNA | CTD | PMID:19244175 |
| tamibarotene | decreases expression | ISO | RGD:733198 | 6480464 | Am 80 results in decreased expression of TOP1 mRNA; more ... | CTD | PMID:15498508 |
| tamoxifen | increases expression | ISO | RGD:733198 | 6480464 | Tamoxifen results in increased expression of TOP1 mRNA | CTD | PMID:15604281 |
| tunicamycin | increases expression | EXP | | 6480464 | Tunicamycin results in increased expression of TOP1 mRNA | CTD | PMID:17127020 |
| ursolic acid | decreases activity | ISO | RGD:733198 | 6480464 | ursolic acid results in decreased activity of TOP1 protein | CTD | PMID:10860928 |
| valproic acid | decreases expression | ISO | RGD:733198 | 6480464 | Valproic Acid results in decreased expression of TOP1 mRNA | CTD | PMID:19101580 |
| valproic acid | decreases expression | EXP | | 6480464 | Valproic Acid results in decreased expression of TOP1 mRNA | CTD | PMID:20546886 |
| zinc atom | multiple interactions | ISO | RGD:733198 | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of TOP1 mRNA | CTD | PMID:18593933 |
| zinc(0) | multiple interactions | ISO | RGD:733198 | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of TOP1 mRNA | CTD | PMID:18593933 |