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Gene: Psmc1 (proteasome 26S subunit, ATPase 1) Rattus norvegicus

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Symbol:

Psmc1

Name:

proteasome 26S subunit, ATPase 1

RGD ID:

621097

Description:

Enables TBP-class protein binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm; membrane; and nucleus. Predicted to be part of proteasome regulatory particle, base subcomplex. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with poor growth, spastic tetraplegia, and hearing loss. Orthologous to human PSMC1 (proteasome 26S subunit, ATPase 1); PARTICIPATES IN ubiquitin/proteasome degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-nitrofluorene; 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

26S protease regulatory subunit 4; 26S proteasome AAA-ATPase subunit RPT2; 26S proteasome regulatory subunit 4; P26s4; peptidase (prosome, macropain) 26S subunit, ATPase 1; protease (prosome, macropain) 26S subunit, ATPase 1; proteasome (prosome, macropain) 26S subunit, ATPase, 1; proteasome 26S subunit ATPase 1; s4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PSMC1 (proteasome 26S subunit, ATPase 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Psmc1 (protease (prosome, macropain) 26S subunit, ATPase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Psmc1 (proteasome 26S subunit, ATPase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PSMC1 (proteasome 26S subunit, ATPase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PSMC1 (proteasome 26S subunit, ATPase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Psmc1 (proteasome 26S subunit, ATPase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PSMC1 (proteasome 26S subunit, ATPase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PSMC1 (proteasome 26S subunit, ATPase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Psmc1 (proteasome 26S subunit, ATPase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Psmc1 (proteasome 26S subunit, ATPase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	PSMC1 (proteasome 26S subunit, ATPase 1)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Psmc1 (protease (prosome, macropain) 26S subunit, ATPase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	psmc1b (proteasome 26S subunit, ATPase 1b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	psmc1a (proteasome 26S subunit, ATPase 1a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	psmc1a (proteasome 26S subunit, ATPase 1a)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	RPT2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	rpt-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	rpt-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Rpt2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	psmc1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	psmc1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	125,122,497 - 125,134,859 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	125,122,490 - 125,134,858 (+)	Ensembl				GRCr8
mRatBN7.2	6	119,392,833 - 119,405,233 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	119,392,855 - 119,410,123 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	119,555,520 - 119,567,890 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	119,852,325 - 119,864,695 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	119,187,189 - 119,199,560 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	124,123,283 - 124,135,644 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	124,123,228 - 124,135,658 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	133,350,578 - 133,362,939 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	124,380,976 - 124,393,338 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	116,922,860 - 116,935,222 (+)	NCBI		Celera
RGSC_v3.1	6	124,384,722 - 124,397,084 (+)	NCBI
Cytogenetic Map	6	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

neurodevelopmental disorder with poor growth, spastic tetraplegia, and hearing loss (ISO)

prostate cancer (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

17beta-hydroxy-17-methylestra-4,9,11-trien-3-one (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-bromohexadecanoic acid (ISO)

2-nitrofluorene (EXP)

3H-1,2-dithiole-3-thione (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one (EXP)

5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole (EXP)

6-propyl-2-thiouracil (EXP)

acrylamide (ISO)

aflatoxin B1 (EXP)

amiodarone (EXP)

ammonium chloride (EXP)

arsane (ISO)

arsenic atom (ISO)

benzatropine (ISO)

benzbromarone (EXP)

benzo[a]pyrene (ISO)

beta-naphthoflavone (ISO)

bis(2-ethylhexyl) phthalate (EXP,ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

butane-2,3-dione (ISO)

Butylbenzyl phthalate (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

chlorpyrifos (ISO)

clofibrate (EXP)

copper(II) chloride (ISO)

copper(II) sulfate (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (EXP,ISO)

dichlorine (EXP)

dicrotophos (ISO)

diethylstilbestrol (EXP)

doxorubicin (ISO)

elemental selenium (ISO)

elesclomol (ISO)

ethanol (ISO)

finasteride (EXP)

flavone (ISO)

flutamide (EXP)

folic acid (ISO)

FR900359 (ISO)

furfural (ISO)

hypochlorous acid (ISO)

ivermectin (ISO)

L-ethionine (EXP)

leflunomide (EXP)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methapyrilene (EXP)

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal (ISO)

N-methyl-4-phenylpyridinium (ISO)

N-nitrosodimethylamine (EXP)

naled (ISO)

nefazodone (EXP)

nitrates (ISO)

omeprazole (EXP)

ozone (EXP)

patulin (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP,ISO)

phenobarbital (EXP)

phlorizin (ISO)

piperonyl butoxide (EXP)

pirinixic acid (EXP)

Propiverine (EXP)

pyrogallol (ISO)

quinoline (ISO)

selenium atom (ISO)

sodium arsenite (ISO)

sodium chloride (ISO)

sunitinib (ISO)

thapsigargin (EXP)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

trimellitic anhydride (ISO)

triphenyl phosphate (ISO)

valdecoxib (EXP)

valproic acid (EXP,ISO)

vitamin E (ISO)

zearalenone (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

proteasomal protein catabolic process (NAS)

proteasome-mediated ubiquitin-dependent protein catabolic process (IBA)

regulation of AMPA receptor activity (IDA)

Cellular Component

cytoplasm (IEA)

cytosol (IEA,ISO)

membrane (IEA)

nucleoplasm (IEA,ISO)

nucleus (IEA)

proteasome accessory complex (IEA,ISO,ISS)

proteasome complex (IEA,ISO)

proteasome regulatory particle (IEA,ISO)

proteasome regulatory particle, base subcomplex (IBA)

synaptic vesicle (IDA,NAS)

Molecular Function

ATP binding (IEA)

ATP hydrolysis activity (IEA,TAS)

nucleotide binding (IEA)

proteasome-activating activity (IBA)

protein binding (ISO)

TBP-class protein binding (IPI)

Molecular Pathway Annotations Click to see Annotation Detail View

ubiquitin/proteasome degradation pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Structures of the rat proteasomal ATPases: determination of highly conserved structural motifs and rules for their spacing.	Makino Y, etal., Biochem Biophys Res Commun 1996 Mar 27;220(3):1049-54.
3.	Multiple mammalian proteasomal ATPases, but not proteasome itself, are associated with TATA-binding protein and a novel transcriptional activator, TIP120.	Makino Y, etal., Genes Cells. 1999 Sep;4(9):529-39.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
7.	GOA pipeline	RGD automated data pipeline
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Comprehensive gene review and curation	RGD comprehensive gene curation
11.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
12.	An abundance of free regulatory (19S) proteasome particles regulates neuronal synapses.	Sun C, etal., Science. 2023 May 26;380(6647):eadf2018. doi: 10.1126/science.adf2018. Epub 2023 May 26.

Additional References at PubMed

PMID:9688553	PMID:15489334	PMID:16857966	PMID:17323924	PMID:19946888	PMID:20498273	PMID:21630459	PMID:22658674	PMID:22871113	PMID:23382946	PMID:24625528	PMID:30053369
PMID:31904090	PMID:35352799

Genomics

Comparative Map Data

Psmc1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	125,122,497 - 125,134,859 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	125,122,490 - 125,134,858 (+)	Ensembl				GRCr8
mRatBN7.2	6	119,392,833 - 119,405,233 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	119,392,855 - 119,410,123 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	119,555,520 - 119,567,890 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	119,852,325 - 119,864,695 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	119,187,189 - 119,199,560 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	124,123,283 - 124,135,644 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	124,123,228 - 124,135,658 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	133,350,578 - 133,362,939 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	124,380,976 - 124,393,338 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	116,922,860 - 116,935,222 (+)	NCBI		Celera
RGSC_v3.1	6	124,384,722 - 124,397,084 (+)	NCBI
Cytogenetic Map	6	q32	NCBI

PSMC1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	90,256,553 - 90,275,429 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	90,256,527 - 90,275,429 (+)	Ensembl			hg38	GRCh38
GRCh37	14	90,722,897 - 90,741,773 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	89,792,647 - 89,808,719 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	14	89,792,646 - 89,808,719	NCBI
Celera	14	70,770,035 - 70,786,113 (+)	NCBI		Celera
Cytogenetic Map	14	q32.11	NCBI
HuRef	14	70,897,288 - 70,913,368 (+)	NCBI		HuRef
CHM1_1	14	90,661,102 - 90,677,177 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	14	84,478,491 - 84,499,697 (+)	NCBI		T2T-CHM13v2.0

Psmc1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	100,076,461 - 100,089,623 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	100,076,413 - 100,089,664 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	12	100,110,202 - 100,123,364 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	100,110,154 - 100,123,405 (+)	Ensembl			mm10	GRCm38
MGSCv37	12	101,348,412 - 101,361,574 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	12	100,511,252 - 100,524,414 (+)	NCBI		MGSCv36	mm8
Celera	12	101,336,798 - 101,349,996 (+)	NCBI		Celera
Cytogenetic Map	12	E	NCBI
cM Map	12	50.43	NCBI

Psmc1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955438	12,704,691 - 12,721,050 (+)	Ensembl
ChiLan1.0	NW_004955438	12,705,328 - 12,721,050 (+)	NCBI	ChiLan1.0	ChiLan1.0

PSMC1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	91,400,672 - 91,416,861 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	90,617,193 - 90,633,367 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	70,873,846 - 70,889,988 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	90,225,405 - 90,241,638 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	90,225,405 - 90,241,641 (+)	Ensembl			panPan2	panpan1.1

PSMC1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	61,272,363 - 61,285,886 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	61,272,363 - 61,285,886 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	60,851,941 - 60,865,464 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	61,544,550 - 61,558,080 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	61,544,577 - 61,558,051 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	61,225,967 - 61,239,658 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	61,274,899 - 61,288,618 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	61,603,196 - 61,616,721 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Psmc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	14,600,035 - 14,613,399 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936488	17,455,461 - 17,469,527 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936488	17,455,612 - 17,468,933 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PSMC1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	112,027,921 - 112,041,489 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	7	112,027,904 - 112,041,360 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	118,594,314 - 118,607,772 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PSMC1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	67,979,449 - 67,995,103 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666053	55,265,330 - 55,281,008 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Psmc1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624734	12,153,919 - 12,174,650 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Psmc1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	6	37,441,646 - 37,442,896 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Psmc1
34 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	214
Count of miRNA genes:	143
Interacting mature miRNAs:	162
Transcripts:	ENSRNOT00000005329
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
4145118	Mcs26	Mammary carcinoma susceptibility QTL 26		0.0001	mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	6	112483610	147156653	Rat
1331797	Bp213	Blood pressure QTL 213	3.291		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	114241077	147156653	Rat
2293088	Iddm28	Insulin dependent diabetes mellitus QTL 28	5.21		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	6	68767270	135411972	Rat
1331799	Bp211	Blood pressure QTL 211	3.66407		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	88019181	136741135	Rat
10054138	Gmadr3	Adrenal mass QTL 3	3.68	0.00045	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	6	90871046	135871046	Rat
1581563	Uae33	Urinary albumin excretion QTL 33			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	93560258	136550638	Rat
1641917	Colcr5	Colorectal carcinoma resistance QTL 5	3.18	0.0009	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	6	98944780	143944780	Rat
61414	Pia3	Pristane induced arthritis QTL 3	4.5		joint integrity trait (VT:0010548)	post-insult time to onset of experimental arthritis (CMO:0001450)	6	100704576	136029228	Rat
71111	Iddm8	Insulin dependent diabetes mellitus QTL 8	1.9	0.002	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	6	110921244	147156653	Rat
724524	Uae2	Urinary albumin excretion QTL 2	2.7	0.0005	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	79198463	144254945	Rat
1358355	Srcrt4	Stress Responsive Cort QTL 4	6.39		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	106095977	147156653	Rat
2303624	Vencon5	Ventilatory control QTL 5	4.45		respiration trait (VT:0001943)	minute ventilation (CMO:0000132)	6	93778632	138778632	Rat
61329	Eae9	Experimental allergic encephalomyelitis QTL 9	3.7		body mass (VT:0001259)	change in body weight (CMO:0002045)	6	84490437	129490437	Rat
10054123	Srcrt6	Stress Responsive Cort QTL 6	2.5	0.0043	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	90871046	135871046	Rat
724536	Uae7	Urinary albumin excretion QTL 7	3.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	6	93560258	136550638	Rat
737976	Pia24	Pristane induced arthritis QTL 24			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	6	118366855	147156653	Rat
2313399	Anxrr28	Anxiety related response QTL 28			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	6	101593607	138161926	Rat
1298087	Iddm18	Insulin dependent diabetes mellitus QTL 18		0.0001	urine glucose amount (VT:0001758)	percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)	6	122236101	147156653	Rat
1581550	Pur8	Proteinuria QTL 8			urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	6	93560258	136550638	Rat
1331725	Bp212	Blood pressure QTL 212	3.52475		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	6	99437079	125323237	Rat
12801471	Schws9	Schwannoma susceptibility QTL 9			nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	6	101593607	146593607	Rat
2293085	Iddm29	Insulin dependent diabetes mellitus QTL 29	7.66		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	6	121444670	147156653	Rat

Markers in Region

BE107583

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	119,403,531 - 119,403,747 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	124,133,944 - 124,134,159	NCBI	Rnor6.0
Rnor_5.0	6	133,361,239 - 133,361,454	UniSTS	Rnor5.0
RGSC_v3.4	6	124,391,637 - 124,391,852	UniSTS	RGSC3.4
Celera	6	116,933,521 - 116,933,736	UniSTS
RH 3.4 Map	6	856.9	UniSTS
Cytogenetic Map	6	q32	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_057123	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC063157	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473982	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D50696	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ209916	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000005329 ⟹ ENSRNOP00000005329

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	125,122,490 - 125,134,857 (+)	Ensembl
mRatBN7.2 Ensembl	6	119,392,855 - 119,405,233 (+)	Ensembl
Rnor_6.0 Ensembl	6	124,123,228 - 124,135,658 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000113995 ⟹ ENSRNOP00000095712

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	125,122,491 - 125,134,858 (+)	Ensembl
mRatBN7.2 Ensembl	6	119,393,070 - 119,410,123 (+)	Ensembl

RefSeq Acc Id:

NM_057123 ⟹ NP_476464

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	125,122,497 - 125,134,859 (+)	NCBI
mRatBN7.2	6	119,392,869 - 119,405,233 (+)	NCBI
Rnor_6.0	6	124,123,283 - 124,135,644 (+)	NCBI
Rnor_5.0	6	133,350,578 - 133,362,939 (+)	NCBI
RGSC_v3.4	6	124,380,976 - 124,393,338 (+)	RGD
Celera	6	116,922,860 - 116,935,222 (+)	RGD

Sequence:

show sequence

ACGACTGAAGGAGAGATGGGTCAAAGTCAGAGTGGTGGCCATGGTCCTGGGGGTGGCAAGAAGG
ATGACAAGGACAAGAAAAAGAAATATGAACCTCCTGTCCCAACTAGAGTGGGGAAAAAGAAGAA
GAAAACCAAGGGACCAGATGCTGCCAGCAAACTGCCACTGGTAACACCTCACACCCAGTGCCGC
CTGAAATTACTAAAGCTGGAGAGAATAAAAGACTATCTTCTCATGGAGGAAGAATTCATTAGAA
ATCAGGAACAGATGAAACCACTAGAAGAAAAGCAAGAGGAGGAAAGATCAAAGGTGGATGATCT
TAGGGGAACCCCGATGTCTGTAGGAACCTTGGAAGAGATCATCGATGATAATCACGCCATTGTG
TCCACATCGGTGGGCTCAGAACACTACGTCAGCATCCTGTCATTTGTAGACAAGGATCTGCTGG
AACCGGGCTGTTCAGTCCTGCTCAACCACAAGGTGCATGCTGTGATAGGGGTGCTCATGGATGA
CACGGATCCCCTGGTCACAGTGATGAAGGTGGAAAAGGCCCCCCAGGAAACCTATGCAGATATT
GGGGGACTGGACAACCAGATCCAGGAAATTAAGGAATCTGTGGAGCTCCCTCTTACCCACCCTG
AGTATTATGAGGAGATGGGGATAAAACCACCTAAGGGGGTCATTCTCTACGGCCCGCCAGGAAC
AGGTAAAACTCTATTGGCCAAAGCAGTAGCGAACCAGACTTCAGCGACTTTCTTGCGAGTGGTT
GGCTCAGAGCTTATTCAGAAGTACCTAGGTGACGGGCCCAAGCTGGTCCGGGAGCTCTTCCGGG
TCGCTGAGGAACACGCACCGTCCATTGTGTTCATTGATGAAATCGACGCCATTGGGACCAAAAG
ATATGATTCAAACTCTGGAGGTGAGCGGGAAATCCAGCGGACAATGTTGGAACTGTTGAACCAG
TTGGATGGATTTGATTCGAGGGGAGATGTAAAAGTTATCATGGCCACAAACCGAATAGAAACTT
TGGATCCAGCACTTATCAGACCAGGCCGCATTGACAGAAAGATCGAGTTCCCCCTGCCTGATGA
AAAGACCAAGAAGCGCATCTTCCAGATCCACACAAGCAGGATGACGCTGGCTGATGATGTAACC
TTGGATGACTTGATCATGGCAAAGGATGACCTCTCTGGGGCTGACATCAAGGCAATCTGCACAG
AGGCTGGCTTGATGGCTCTGCGGGAACGCAGGATGAAAGTGACAAACGAAGACTTCAAGAAATC
TAAGGAGAACGTTCTGTATAAAAAACAAGAAGGCACCCCTGAGGGGCTGTATCTCTAGTGACAC
AGTTGTCTTCAGGGAACTTAATGAGTTTCCCCCACCTGGGAAGATGGGAAGCTGCCCCAAGGAA
TCCATCTTCCAGTTAAGTTTTGCTAGTAGAAAGCCCGTGTCGTGGAGGACGCTGTGTGGTCTGT
CTCCAATCTGTTGTTGGTCATTGTGCCCTGCAGCTCTCCGCTCCCAATAAAGGATTGTCCTGGT
TTGCTTTCTAAAAAAACAAG

hide sequence

Protein Sequences


Protein RefSeqs	NP_476464	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH63157	(Get FASTA)	NCBI Sequence Viewer
	BAA09341	(Get FASTA)	NCBI Sequence Viewer
	EDL81712	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000005329
GenBank Protein	P62193	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_476464 ⟸ NM_057123

- UniProtKB:

P62193 (UniProtKB/Swiss-Prot), A6JEG8 (UniProtKB/TrEMBL), A0A8I6APJ8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGQSQSGGHGPGGGKKDDKDKKKKYEPPVPTRVGKKKKKTKGPDAASKLPLVTPHTQCRLKLLK
LERIKDYLLMEEEFIRNQEQMKPLEEKQEEERSKVDDLRGTPMSVGTLEEIIDDNHAIVSTSVG
SEHYVSILSFVDKDLLEPGCSVLLNHKVHAVIGVLMDDTDPLVTVMKVEKAPQETYADIGGLDN
QIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELI
QKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFD
SRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDLI
MAKDDLSGADIKAICTEAGLMALRERRMKVTNEDFKKSKENVLYKKQEGTPEGLYL

hide sequence

Ensembl Acc Id:

ENSRNOP00000005329 ⟸ ENSRNOT00000005329

Ensembl Acc Id:

ENSRNOP00000095712 ⟸ ENSRNOT00000113995

Protein Domains

AAA+ ATPase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P62193-F1-model_v2	AlphaFold	P62193	1-440	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694774

Promoter ID:

EPDNEW_R5298

Type:

initiation region

Name:

Psmc1_1

Description:

proteasome 26S subunit, ATPase 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	6	124,123,276 - 124,123,336	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621097	AgrOrtholog
BioCyc Gene	G2FUF-36501	BioCyc
Ensembl Genes	ENSRNOG00000003951	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000005329	ENTREZGENE
Gene3D-CATH	1.10.8.60	UniProtKB/Swiss-Prot
	2.40.50.140	UniProtKB/Swiss-Prot
	3.40.50.300	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:6919865	IMAGE-MGC_LOAD
InterPro	26S_Proteasome_ATPase	UniProtKB/Swiss-Prot
	AAA+_ATPase	UniProtKB/Swiss-Prot
	AAA_lid_3	UniProtKB/Swiss-Prot
	ATPase_AAA_core	UniProtKB/Swiss-Prot
	ATPase_AAA_CS	UniProtKB/Swiss-Prot
	NA-bd_OB-fold	UniProtKB/Swiss-Prot
	P-loop_NTPase	UniProtKB/Swiss-Prot
	Prot_ATP_ID_OB	UniProtKB/Swiss-Prot
KEGG Report	rno:117263	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:72724	IMAGE-MGC_LOAD
NCBI Gene	117263	ENTREZGENE
PANTHER	26S PROTEASOME REGULATORY SUBUNIT	UniProtKB/Swiss-Prot
Pfam	AAA	UniProtKB/Swiss-Prot
	AAA_lid_3	UniProtKB/Swiss-Prot
	Prot_ATP_ID_OB	UniProtKB/Swiss-Prot
PharmGKB	PSMC1	RGD
PhenoGen	Psmc1	PhenoGen
PROSITE	AAA	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000003951	RatGTEx
SMART	AAA	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF52540	UniProtKB/Swiss-Prot
UniProt	A0A8I6APJ8	ENTREZGENE, UniProtKB/TrEMBL
	A0A8L2UHV1_RAT	UniProtKB/TrEMBL
	A6JEG8	ENTREZGENE, UniProtKB/TrEMBL
	P62193	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	P49014	UniProtKB/Swiss-Prot
	Q03527	UniProtKB/Swiss-Prot
	Q96AZ3	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-08-19	Psmc1	proteasome 26S subunit, ATPase 1	Psmc1	proteasome (prosome, macropain) 26S subunit, ATPase, 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-12-15	Psmc1	proteasome (prosome, macropain) 26S subunit, ATPase, 1	Psmc1	protease (prosome, macropain) 26S subunit, ATPase 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-02-22	Psmc1	protease (prosome, macropain) 26S subunit, ATPase 1	Psmc1	peptidase (prosome, macropain) 26S subunit, ATPase 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	Psmc1	peptidase (prosome, macropain) 26S subunit, ATPase 1		protease (prosome, macropain) 26S subunit, ATPase 1	Name updated	1299863	APPROVED
2002-08-07	Psmc1	protease (prosome, macropain) 26S subunit, ATPase 1			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)