Sfrp1 Rat Gene (secreted frizzled-related protein 1)

Help | FTP Download | Citing RGD | Contact Us

Keyword

Gene:
Sfrp1 ( Rattus norvegicus )
secreted frizzled-related protein 1
Description: a secreted protein involved in binding Wnt and antagonizing Wnt signaling
ArrayIDs: rc_AI058872_at; 1392068_at; 1371861_at; 6091229; GE1253201; 1383266_at; 5900684; 1382878_at; A_44_P513059; 6566072; GE1120612; 6099096; 6389419; 6673901;  (details...)
Gene Type: protein-coding

Additional Data

Homologs
Homo sapiens: SFRP1     See the Human gene in context in:     UCSC     NCBI MapViewer

Mus musculus: Sfrp1     See the Mouse gene in context in:     UCSC     NCBI MapViewer

Comparative Map Data
Species Symbol Map Name Chr. Position
Rattus norvegicus Sfrp1 Rat Celera Assembly 16 66468819 - 66507245
RGSC genome assembly v3.4 16 73029814 - 73068470
Cytogenetic 16 q12.5
genome assembly 3.1 16 73031966 - 73066892
Mus musculus Sfrp1 Mouse genome assembly build 36.1 8 24521990 - 24560104
Cytogenetic 8 8 A2
Homo sapiens SFRP1 human genome assembly 8 41238635 - 41286137
Human genome assembly build 36.2 8 41238635 - 41286137
Cytogenetic 8 p12-p11.1

View comparative maps:      NCBI MapViewer

Genome
View:

Browsers:

Annotation
Molecular Function

Gene Ontology

Wnt-protein binding,  protein binding (details...)
Biological Process

Gene Ontology

multicellular organismal development,  prostate gland development,  cell differentiation ... (details...)
Cellular Component

Gene Ontology

extracellular region (details...)
Disease

Ontology

Carcinoma in Situ,  Leiomyoma (details...)
Transcript structure

Note Reference

region -202 to -144 contains the transcriptional activation domain 724587

Regulation

Note Reference

promoter activity is induced by phosphorylated CREB and the adaptor protein CBP 724587

External Links
Databases
DATABASE ID SOURCE
SMART: FRI IPI
SMART: C345C IPI
PROSITE: NTR IPI
PROSITE: FZ IPI
UNIPARC: UPI0000DA3E92 IPI
UNIPARC: UPI0000DA3F3A IPI
KEGG Report: rno:84402 ENTREZGENE
HomoloGene Group ID: 2266 ENTREZGENE
Germonline: 621074
Pfam: NTR IPI
Pfam: Fz IPI
KEGG Pathway: 04310 ENTREZGENE
InterPro: TIMP-like_OB-fold. IPI
InterPro: Netrin_module_non-TIMP. IPI
InterPro: Netrin_domain. IPI
InterPro: Frizzled_related. IPI
InterPro: Frizzled_dom_subgr. IPI
InterPro: Frizzled_Cys-rich. IPI
InterPro: Frizzled-like_dom. IPI
IPI: IPI00188165 IPI
IPI: IPI00765344 IPI
Ensembl Protein: ENSRNOP00000024128 IPI
Gene3D-CATH: Frizzled_Cys-rich IPI
Entrez Gene: Sfrp1 ENTREZGENE
UniProt: SFRP1_RAT IPI
Ensembl Genes: ENSRNOG00000017783 IPI
Superfamily-SCOP: TIMP_like IPI
Superfamily-SCOP: Frizzled_Cys-rich IPI
PANTHER: Fz_related IPI
Sequences
Nucleotide: XM_224987 Get FASTA Search GEO Profiles
Nucleotide: AF167308 Get FASTA Search GEO Profiles
Nucleotide: CH473970 Get FASTA Search GEO Profiles
Nucleotide: XM_001072532 Get FASTA Search GEO Profiles
(View all 4 Nucleotide Accessions)
Protein: XP_001072532 Get FASTA
Protein: XP_224987 Get FASTA
Protein: EDM09033 Get FASTA
Protein: Q9R168 Get FASTA
Protein: AAD49337 Get FASTA
(View all 5 Protein Accessions)
Clusters
UniGene: 163333

References
Curated References
7 references in RGD related to Sfrp1

Other References
5 other references at PubMed related to Sfrp1

Database Information
RGD ID 621074
History

Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference

14-DEC-04: Sfrp1 secreted frizzled-related protein 1 APPROVED Symbol and Name status set to approved 1299863

07-AUG-02: Sfrp1 secreted frizzled-related protein 1 PROVISIONAL Symbol and Name status set to provisional 70820