Lamc1 (laminin subunit gamma 1) - Rat Genome Database

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Gene: Lamc1 (laminin subunit gamma 1) Rattus norvegicus
Analyze
Symbol: Lamc1
Name: laminin subunit gamma 1
RGD ID: 621052
Description: Predicted to enable glycosphingolipid binding activity. Predicted to be an extracellular matrix structural constituent. Predicted to be involved in several processes, including hair follicle cell proliferation; hair follicle morphogenesis; and neuron differentiation. Predicted to act upstream of or within neuron projection development. Located in extracellular matrix. Part of laminin-1 complex. Orthologous to human LAMC1 (laminin subunit gamma 1); PARTICIPATES IN cell-extracellular matrix signaling pathway; Entamoebiasis pathway; prion disease pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: B2e; laminin subunit gamma-1; laminin, gamma 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81367,924,872 - 68,051,986 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1367,924,872 - 68,051,986 (-)EnsemblGRCr8
mRatBN7.21365,374,372 - 65,501,492 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1365,374,372 - 65,501,492 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1367,978,376 - 68,104,929 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01369,265,739 - 69,392,805 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01366,517,058 - 66,644,103 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01370,656,727 - 70,783,515 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1370,658,707 - 70,783,515 (-)Ensemblrn6Rnor6.0
Rnor_5.01375,617,972 - 75,749,359 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41368,241,453 - 68,369,419 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1365,279,355 - 65,406,336 (-)NCBICelera
RGSC_v3.11368,256,660 - 68,268,487 (-)NCBI
Cytogenetic Map13q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butoxyethanol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
Azoxymethane  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bromochloroacetic acid  (ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (EXP)
carbamazepine  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP,ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
genistein  (ISO)
glucose  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-serine  (EXP)
lithium chloride  (ISO)
menadione  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methotrexate  (ISO)
mitoxantrone  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nickel sulfate  (ISO)
oxaliplatin  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylephrine  (EXP)
pirinixic acid  (ISO)
piroxicam  (ISO)
poly(I:C)  (ISO)
potassium chromate  (ISO)
profenofos  (EXP)
progesterone  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (EXP)
sulindac sulfide  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP,ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
tungsten  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Synergistic activation of the rat laminin gamma1 chain promoter by the gut-enriched Kruppel-like factor (GKLF/KLF4) and Sp1. Higaki Y, etal., Nucleic Acids Res 2002 Jun 1;30(11):2270-9.
4. Laminin-6 assembles into multimolecular fibrillar complexes with perlecan and participates in mechanical-signal transduction via a dystroglycan-dependent, integrin-independent mechanism. Jones JC, etal., J Cell Sci. 2005 Jun 15;118(Pt 12):2557-66. Epub 2005 May 31.
5. bcn-1 Element-dependent activation of the laminin gamma 1 chain gene by the cooperative action of transcription factor E3 (TFE3) and Smad proteins. Kawata Y, etal., J Biol Chem 2002 Mar 29;277(13):11375-84.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. A common variant association study in ethnic Saudi Arabs reveals novel susceptibility loci for hypertriglyceridemia. Ram R, etal., Clin Genet. 2017 Mar;91(3):371-378. doi: 10.1111/cge.12859. Epub 2017 Jan 30.
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Carboxy terminal sequence and synthesis of rat kidney laminin gamma 1 chain. Vanden Heuvel GB, etal., Kidney Int 1996 Mar;49(3):752-60.
12. The effect of extended lymphadenectomy on survival in patients with gastric adenocarcinoma. Volpe CM, etal., J Am Coll Surg. 1995 Jul;181(1):56-64.
Additional References at PubMed
PMID:1292752   PMID:7670489   PMID:9264260   PMID:9299121   PMID:9396756   PMID:12051813   PMID:12529372   PMID:12743034   PMID:14557481   PMID:15159456   PMID:15561105   PMID:15895400  
PMID:16236823   PMID:16892452   PMID:18184742   PMID:18757743   PMID:19056867   PMID:19118221   PMID:19199708   PMID:20167606   PMID:20551380   PMID:21362503   PMID:22475395   PMID:22952693  
PMID:23376485   PMID:23533145   PMID:23658023   PMID:24006456   PMID:25957583   PMID:27068509   PMID:27559042   PMID:38609046  


Genomics

Comparative Map Data
Lamc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81367,924,872 - 68,051,986 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1367,924,872 - 68,051,986 (-)EnsemblGRCr8
mRatBN7.21365,374,372 - 65,501,492 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1365,374,372 - 65,501,492 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1367,978,376 - 68,104,929 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01369,265,739 - 69,392,805 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01366,517,058 - 66,644,103 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01370,656,727 - 70,783,515 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1370,658,707 - 70,783,515 (-)Ensemblrn6Rnor6.0
Rnor_5.01375,617,972 - 75,749,359 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41368,241,453 - 68,369,419 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1365,279,355 - 65,406,336 (-)NCBICelera
RGSC_v3.11368,256,660 - 68,268,487 (-)NCBI
Cytogenetic Map13q21NCBI
LAMC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381183,023,420 - 183,145,592 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1183,023,420 - 183,145,592 (+)Ensemblhg38GRCh38
GRCh371182,992,555 - 183,114,727 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361181,259,218 - 181,381,350 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341179,724,209 - 179,846,384NCBI
Celera1156,103,698 - 156,225,839 (+)NCBICelera
Cytogenetic Map1q25.3NCBI
HuRef1154,228,644 - 154,350,771 (+)NCBIHuRef
CHM1_11184,415,719 - 184,537,861 (+)NCBICHM1_1
T2T-CHM13v2.01182,382,573 - 182,504,736 (+)NCBIT2T-CHM13v2.0
Lamc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391153,094,668 - 153,208,532 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1153,094,668 - 153,208,532 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381153,218,922 - 153,332,786 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,218,922 - 153,332,786 (-)Ensemblmm10GRCm38
MGSCv371155,066,052 - 155,179,916 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361154,981,140 - 155,095,004 (-)NCBIMGSCv36mm8
Celera1155,640,123 - 155,755,639 (-)NCBICelera
Cytogenetic Map1G3NCBI
cM Map165.3NCBI
Lamc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540621,863,836 - 21,992,199 (+)Ensembl
ChiLan1.0NW_00495540621,863,836 - 21,990,161 (+)NCBIChiLan1.0ChiLan1.0
LAMC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2166,584,163 - 66,706,520 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1166,267,661 - 66,390,046 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01158,541,635 - 158,663,836 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11162,700,704 - 162,822,534 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1162,700,704 - 162,822,534 (+)EnsemblpanPan2panpan1.1
LAMC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1716,406,421 - 16,528,372 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl716,404,495 - 16,526,000 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha715,992,748 - 16,114,168 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0716,136,951 - 16,259,344 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl716,136,951 - 16,257,388 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1716,047,760 - 16,168,747 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0716,156,304 - 16,277,740 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0716,286,773 - 16,408,562 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Lamc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934488,826,740 - 88,936,435 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364816,673,488 - 6,783,191 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364816,675,620 - 6,783,184 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LAMC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9124,283,224 - 124,405,964 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.19124,283,668 - 124,405,967 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29136,545,710 - 136,668,768 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LAMC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12546,233,409 - 46,354,060 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2546,231,780 - 46,353,557 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605547,451,170 - 47,571,755 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lamc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462481410,570,356 - 10,701,977 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462481410,572,026 - 10,701,805 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Lamc1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11032,695,130 - 32,816,269 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Lamc1
910 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:970
Count of miRNA genes:324
Interacting mature miRNAs:409
Transcripts:ENSRNOT00000003605
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134874981487285480Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132485392569853925Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133996821183286298Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133708798382087983Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134098358585983585Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)136242459288113509Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132624480871244808Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133379409678794096Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133483494779834947Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133981472684814726Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133996821184968211Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132624480871244808Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)133828629883286298Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat

Markers in Region
D13Rat28  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21365,450,686 - 65,450,871 (+)MAPPERmRatBN7.2
Rnor_6.01370,733,323 - 70,733,507NCBIRnor6.0
Rnor_5.01375,698,791 - 75,698,975UniSTSRnor5.0
RGSC_v3.41368,317,763 - 68,317,947UniSTSRGSC3.4
RGSC_v3.41368,317,762 - 68,318,125RGDRGSC3.4
Celera1365,355,565 - 65,355,749UniSTS
RGSC_v3.11368,331,842 - 68,332,205RGD
RH 3.4 Map13303.7UniSTS
RH 3.4 Map13303.7RGD
RH 2.0 Map13405.4RGD
SHRSP x BN Map1323.7598RGD
Cytogenetic Map13q21UniSTS
RH128406  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21365,374,488 - 65,374,680 (+)MAPPERmRatBN7.2
Rnor_6.01370,656,844 - 70,657,035NCBIRnor6.0
Rnor_5.01375,622,312 - 75,622,503UniSTSRnor5.0
RGSC_v3.41368,241,570 - 68,241,761UniSTSRGSC3.4
Celera1365,279,472 - 65,279,663UniSTS
Cytogenetic Map13q21UniSTS
RH143373  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21365,443,166 - 65,443,297 (+)MAPPERmRatBN7.2
Rnor_6.01370,725,806 - 70,725,936NCBIRnor6.0
Rnor_5.01375,691,274 - 75,691,404UniSTSRnor5.0
RGSC_v3.41368,310,246 - 68,310,376UniSTSRGSC3.4
Celera1365,348,048 - 65,348,178UniSTS
RH 3.4 Map13341.1UniSTS
Cytogenetic Map13q21UniSTS
RH138458  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21365,502,149 - 65,502,319 (+)MAPPERmRatBN7.2
Rnor_6.01370,784,173 - 70,784,342NCBIRnor6.0
Rnor_5.01375,749,826 - 75,749,995UniSTSRnor5.0
RGSC_v3.41368,370,077 - 68,370,246UniSTSRGSC3.4
Celera1365,406,994 - 65,407,163UniSTS
Cytogenetic Map13q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000003605   ⟹   ENSRNOP00000003605
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1367,924,872 - 68,051,986 (-)Ensembl
mRatBN7.2 Ensembl1365,374,372 - 65,501,492 (-)Ensembl
Rnor_6.0 Ensembl1370,658,707 - 70,783,515 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092288
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1370,658,994 - 70,659,757 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092521   ⟹   ENSRNOP00000075899
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1370,661,386 - 70,667,658 (-)Ensembl
RefSeq Acc Id: NM_053966   ⟹   NP_446418
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81367,924,872 - 68,051,986 (-)NCBI
mRatBN7.21365,374,372 - 65,501,492 (-)NCBI
Rnor_6.01370,656,727 - 70,783,515 (-)NCBI
Rnor_5.01375,617,972 - 75,749,359 (-)NCBI
RGSC_v3.41368,241,453 - 68,369,419 (-)RGD
Celera1365,279,355 - 65,406,336 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_446418 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA64244 (Get FASTA)   NCBI Sequence Viewer  
  EDM09549 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000003605
  ENSRNOP00000003605.5
RefSeq Acc Id: NP_446418   ⟸   NM_053966
- Peptide Label: precursor
- UniProtKB: F1MAA7 (UniProtKB/TrEMBL),   A6ICU8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075899   ⟸   ENSRNOT00000092521
Ensembl Acc Id: ENSRNOP00000003605   ⟸   ENSRNOT00000003605
Protein Domains
Laminin EGF-like   Laminin IV type A   Laminin N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1MAA7-F1-model_v2 AlphaFold F1MAA7 1-1607 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698895
Promoter ID:EPDNEW_R9420
Type:initiation region
Name:Lamc1_1
Description:laminin subunit gamma 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01370,783,475 - 70,783,535EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621052 AgrOrtholog
BioCyc Gene G2FUF-17889 BioCyc
Ensembl Genes ENSRNOG00000002680 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003605 ENTREZGENE
  ENSRNOT00000003605.9 UniProtKB/TrEMBL
Gene3D-CATH Galactose-binding domain-like UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro EGF-like_dom UniProtKB/TrEMBL
  EGF_laminin UniProtKB/TrEMBL
  Laminin/Netrin_ECM UniProtKB/TrEMBL
  Laminin_B_type_IV UniProtKB/TrEMBL
  Laminin_N UniProtKB/TrEMBL
  LMN_ATRN_NET-like_EGF UniProtKB/TrEMBL
KEGG Report rno:117036 UniProtKB/TrEMBL
NCBI Gene 117036 ENTREZGENE
PANTHER LAMININ SUBUNIT GAMMA-1 UniProtKB/TrEMBL
  NETRIN/LAMININ-RELATED UniProtKB/TrEMBL
Pfam EGF_LMN_ATRN UniProtKB/TrEMBL
  Laminin_B UniProtKB/TrEMBL
  Laminin_EGF UniProtKB/TrEMBL
  Laminin_N UniProtKB/TrEMBL
PhenoGen Lamc1 PhenoGen
PRINTS EGFLAMININ UniProtKB/TrEMBL
PROSITE EGF_LAM_1 UniProtKB/TrEMBL
  EGF_LAM_2 UniProtKB/TrEMBL
  LAMININ_IVA UniProtKB/TrEMBL
  LAMININ_NTER UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002680 RatGTEx
SMART EGF UniProtKB/TrEMBL
  EGF_Lam UniProtKB/TrEMBL
  LamB UniProtKB/TrEMBL
  LamNT UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
UniProt A6ICU8 ENTREZGENE, UniProtKB/TrEMBL
  F1MAA7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-26 Lamc1  laminin subunit gamma 1  Lamc1  laminin, gamma 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Lamc1  laminin, gamma 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Lamc1        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in meninges of the brain, auditory and peripheral nerve fibers, gastrointestinal system, and developing lung airway epithelium 633159
gene_transcript two transcripts of 7.5 and 5.5 kb are most likely due to use of two different polyadenylation signals