Tk1 (thymidine kinase 1) - Rat Genome Database

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Gene: Tk1 (thymidine kinase 1) Rattus norvegicus
Analyze
Symbol: Tk1
Name: thymidine kinase 1
RGD ID: 621014
Description: Enables identical protein binding activity. Involved in several processes, including fetal process involved in parturition; response to cortisol; and thymidine metabolic process. Predicted to be located in cytoplasm and nucleus. Orthologous to human TK1 (thymidine kinase 1); PARTICIPATES IN beta-ureidopropionase deficiency pathway; dihydropyrimidinase deficiency pathway; mitochondrial neurogastrointestinal encephalopathy syndrome pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Thymidine kinase 1 soluble; thymidine kinase 1, soluble; thymidine kinase, cytosolic; Tk
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   SD-Tg(Gfap-Tk1)Jog  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810103,533,449 - 103,544,818 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl10103,533,449 - 103,556,228 (-)EnsemblGRCr8
mRatBN7.210103,034,755 - 103,046,125 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10103,031,521 - 103,046,920 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx10108,135,849 - 108,147,124 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010107,598,960 - 107,610,235 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010102,955,543 - 102,966,869 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010106,817,556 - 106,828,888 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10106,817,601 - 106,828,884 (-)Ensemblrn6Rnor6.0
Rnor_5.010106,456,781 - 106,468,109 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera10101,594,738 - 101,606,057 (-)NCBICelera
Cytogenetic Map10q32.2NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-schisandrin B  (EXP)
1,1-dichloroethene  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-butoxyethanol  (ISO)
2-methylcholine  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitroquinoline N-oxide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (EXP)
alfacalcidol  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
Azoxymethane  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-D-glucosamine  (EXP)
beta-lapachone  (ISO)
bicalutamide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium acetate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
corticosterone  (EXP)
coumestrol  (ISO)
Cuprizon  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
D-glucitol  (ISO)
DDE  (ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
diclofenac  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enniatin  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenvalerate  (EXP)
flavonoids  (ISO)
floxuridine  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
GW 7647  (ISO)
hydrogen peroxide  (ISO)
imidacloprid  (ISO)
indometacin  (EXP)
isoprenaline  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP)
lidocaine  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
methotrexate  (EXP)
methyl methanesulfonate  (ISO)
mitomycin C  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
naphthalene  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
niclosamide  (ISO)
nitric oxide  (ISO)
obeticholic acid  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl caffeate  (EXP)
phenformin  (EXP)
phenobarbital  (ISO)
phenylhydrazine  (EXP)
PhIP  (ISO)
phytoestrogen  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium bromate  (ISO)
potassium dichromate  (ISO)
procarbazine  (ISO)
progesterone  (EXP,ISO)
resveratrol  (ISO)
rotenone  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulindac sulfide  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
trabectedin  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
zalcitabine  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
nucleus  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The rat thymidine kinase gene 5' region: evolution of a promoter. Arcot SS, etal., DNA Seq 1991;2(2):129-31.
2. Intestinal development in the suckling rat: effects of weaning, diet composition, and glucocorticoids on thymidine kinase activity and DNA synthesis. Buts JP and De Meyer R, Pediatr Res. 1984 Feb;18(2):145-50.
3. Clinical value of thymidine kinase in patients with cervical carcinoma. Fujiwaki R, etal., Oncology. 2001;61(1):47-54.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. The clinical significance of thymidine kinase 1 measurement in serum of breast cancer patients using anti-TK1 antibody. He Q, etal., Int J Biol Markers. 2000 Apr-Jun;15(2):139-46.
7. Glutamate dehydrogenase, alanine aminotransferase, thymidine kinase, and arginase in fetal and adult human and rat liver. Herzfeld A, etal., Pediatr Res. 1976 Dec;10(12):960-4.
8. The ontogeny of thymidine kinase in tissues of man and rat. Herzfeld A, etal., Pediatr Res. 1980 Dec;14(12):1304-10.
9. Serum thymidine kinase 1 is a prognostic and monitoring factor in patients with non-small cell lung cancer. Li HX, etal., Oncol Rep. 2005 Jan;13(1):145-9.
10. Differences in cytosolic and mitochondrial 5'-nucleotidase and deoxynucleoside kinase activities in Sprague-Dawley rat and CD-1 mouse tissues: implication for the toxicity of nucleoside analogs in animal models. Mirzaee S, etal., Toxicology. 2010 Jan 12;267(1-3):159-64. Epub 2009 Nov 12.
11. Cloning vectors for expression of cDNA libraries in mammalian cells. Murphy AJ and Efstratiadis A, Proc Natl Acad Sci U S A 1987 Dec;84(23):8277-81.
12. Thymidine kinase 1 regulatory fine-tuning through tetramer formation. Mutahir Z, etal., FEBS J. 2013 Mar;280(6):1531-41. doi: 10.1111/febs.12154. Epub 2013 Feb 25.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
16. GOA pipeline RGD automated data pipeline
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Comprehensive gene review and curation RGD comprehensive gene curation
19. Activity profiles of deoxynucleoside kinases and 5'-nucleotidases in cultured adipocytes and myoblastic cells: insights into mitochondrial toxicity of nucleoside analogs. Rylova SN, etal., Biochem Pharmacol. 2005 Mar 15;69(6):951-60.
20. Effect of copper and cadmium pretreatments on DNA synthesis and thymidine kinase activity in the liver of dimethylnitrosamine-treated and partially hepatectomized rats. Sakai K, etal., Gann. 1983 Oct;74(5):663-70.
21. Yin Yang-1 inhibits vascular smooth muscle cell growth and intimal thickening by repressing p21WAF1/Cip1 transcription and p21WAF1/Cip1-Cdk4-cyclin D1 assembly. Santiago FS, etal., Circ Res. 2007 Jul 20;101(2):146-55. Epub 2007 Jun 7.
Additional References at PubMed
PMID:204065   PMID:8889548   PMID:15733844   PMID:17407781   PMID:18981415   PMID:19063959   PMID:20544526   PMID:21900206   PMID:22385435  


Genomics

Comparative Map Data
Tk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810103,533,449 - 103,544,818 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl10103,533,449 - 103,556,228 (-)EnsemblGRCr8
mRatBN7.210103,034,755 - 103,046,125 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10103,031,521 - 103,046,920 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx10108,135,849 - 108,147,124 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010107,598,960 - 107,610,235 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010102,955,543 - 102,966,869 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010106,817,556 - 106,828,888 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10106,817,601 - 106,828,884 (-)Ensemblrn6Rnor6.0
Rnor_5.010106,456,781 - 106,468,109 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera10101,594,738 - 101,606,057 (-)NCBICelera
Cytogenetic Map10q32.2NCBI
TK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381778,174,079 - 78,187,204 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1778,172,780 - 78,187,233 (-)Ensemblhg38GRCh38
GRCh371776,170,160 - 76,183,285 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361773,681,755 - 73,694,880 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341773,681,775 - 73,694,726NCBI
Celera1772,766,591 - 72,779,726 (-)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1771,594,292 - 71,607,377 (-)NCBIHuRef
CHM1_11776,234,697 - 76,247,823 (-)NCBICHM1_1
T2T-CHM13v2.01779,068,173 - 79,081,298 (-)NCBIT2T-CHM13v2.0
Tk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911117,706,345 - 117,716,913 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11117,706,352 - 117,716,918 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3811117,815,519 - 117,826,087 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11117,815,526 - 117,826,092 (-)Ensemblmm10GRCm38
MGSCv3711117,676,833 - 117,687,328 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611117,631,616 - 117,642,043 (-)NCBIMGSCv36mm8
Celera11129,560,644 - 129,571,039 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1182.96NCBI
Tk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555064,379,830 - 4,394,713 (+)Ensembl
ChiLan1.0NW_0049555064,379,830 - 4,390,729 (+)NCBIChiLan1.0ChiLan1.0
TK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21994,224,936 - 94,238,043 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11799,053,616 - 99,067,499 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01772,251,416 - 72,265,308 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11777,803,938 - 77,816,747 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1777,803,749 - 77,816,747 (-)EnsemblpanPan2panpan1.1
TK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.192,959,450 - 2,970,908 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl92,959,488 - 2,971,064 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha93,642,982 - 3,654,416 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.093,637,295 - 3,648,793 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl93,637,262 - 3,648,777 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.193,660,373 - 3,671,812 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.093,784,580 - 3,796,015 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.093,866,010 - 3,877,445 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056023,599,359 - 3,627,016 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365942,784,226 - 2,794,830 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365942,784,891 - 2,794,693 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl123,786,031 - 3,795,917 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1123,785,997 - 3,794,824 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11670,186,103 - 70,200,689 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1670,186,767 - 70,200,610 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607741,294,951 - 41,309,587 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248017,685,017 - 7,692,872 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248017,685,003 - 7,692,949 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Tk1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1966,240,041 - 66,251,233 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tk1
55 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:46
Interacting mature miRNAs:51
Transcripts:ENSRNOT00000071420
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093723381107556066Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1089039175107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
1576313Pia25Pristane induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1097202388107556066Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1576307Cia28Collagen induced arthritis QTL 28joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087807758107713808Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1091127270107556066Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091727883107713808Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1097202388107556066Rat

Markers in Region
PMC86057P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23109,191,235 - 109,191,478 (+)MAPPERmRatBN7.2
mRatBN7.210103,036,286 - 103,036,632 (+)MAPPERmRatBN7.2
Rnor_6.010106,819,088 - 106,819,433NCBIRnor6.0
Rnor_6.03114,182,471 - 114,182,713NCBIRnor6.0
Rnor_5.03120,723,143 - 120,723,385UniSTSRnor5.0
Rnor_5.010106,458,313 - 106,458,658UniSTSRnor5.0
RGSC_v3.43109,022,992 - 109,023,234UniSTSRGSC3.4
Celera10101,596,270 - 101,596,615UniSTS
Celera3108,089,043 - 108,089,285UniSTS
Cytogenetic Map3q35UniSTS


Related Rat Strains
The following Strains have been annotated to Tk1
SD-Tg(Gfap-Tk1)Jog    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_052800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AJ006455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW919734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF547747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP495650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK471539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CV072953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EV770793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M22642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X54173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y17296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000071420   ⟹   ENSRNOP00000067459
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10103,533,449 - 103,544,715 (-)Ensembl
mRatBN7.2 Ensembl10103,034,754 - 103,046,095 (-)Ensembl
Rnor_6.0 Ensembl10106,817,601 - 106,828,884 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098570   ⟹   ENSRNOP00000088672
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10103,533,449 - 103,556,228 (-)Ensembl
mRatBN7.2 Ensembl10103,031,521 - 103,046,920 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119820   ⟹   ENSRNOP00000092303
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10103,031,521 - 103,046,920 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000142849   ⟹   ENSRNOP00000112471
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10103,542,363 - 103,544,815 (-)Ensembl
RefSeq Acc Id: NM_052800   ⟹   NP_434687
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810103,533,449 - 103,544,777 (-)NCBI
mRatBN7.210103,034,755 - 103,046,083 (-)NCBI
Rnor_6.010106,817,556 - 106,828,884 (-)NCBI
Rnor_5.010106,456,781 - 106,468,109 (-)NCBI
Celera10101,594,738 - 101,606,057 (-)RGD
Sequence:
RefSeq Acc Id: XM_017597017   ⟹   XP_017452506
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810103,534,758 - 103,544,792 (-)NCBI
mRatBN7.210103,034,764 - 103,046,094 (-)NCBI
Rnor_6.010106,817,565 - 106,828,888 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039085225   ⟹   XP_038941153
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810103,540,216 - 103,544,818 (-)NCBI
mRatBN7.210103,042,388 - 103,046,125 (-)NCBI
RefSeq Acc Id: NP_434687   ⟸   NM_052800
- UniProtKB: M0RCX2 (UniProtKB/TrEMBL),   A6HL31 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452506   ⟸   XM_017597017
- Peptide Label: isoform X1
- UniProtKB: A6HL32 (UniProtKB/TrEMBL),   M0RCX2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000067459   ⟸   ENSRNOT00000071420
RefSeq Acc Id: XP_038941153   ⟸   XM_039085225
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000092303   ⟸   ENSRNOT00000119820
Ensembl Acc Id: ENSRNOP00000088672   ⟸   ENSRNOT00000098570
Ensembl Acc Id: ENSRNOP00000112471   ⟸   ENSRNOT00000142849

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P27158-F1-model_v2 AlphaFold P27158 1-121 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697932
Promoter ID:EPDNEW_R8457
Type:initiation region
Name:Tk1_1
Description:thymidine kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.010106,828,894 - 106,828,954EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621014 AgrOrtholog
BioCyc Gene G2FUF-22538 BioCyc
Ensembl Genes ENSRNOG00000047314 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000071420 ENTREZGENE
  ENSRNOT00000142849 ENTREZGENE
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
InterPro P-loop_NTPase UniProtKB/Swiss-Prot
  Thymidine_kinase UniProtKB/Swiss-Prot
KEGG Report rno:24834 UniProtKB/Swiss-Prot
NCBI Gene 24834 ENTREZGENE
PANTHER PTHR11441 UniProtKB/Swiss-Prot
  THYMIDINE KINASE, CYTOSOLIC UniProtKB/Swiss-Prot
Pfam PF00265 UniProtKB/Swiss-Prot
PharmGKB TK1 RGD
PhenoGen Tk1 PhenoGen
RatGTEx ENSRNOG00000047314 RatGTEx
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A0A8I6A703_RAT UniProtKB/TrEMBL
  A0ABK0M2M4_RAT UniProtKB/TrEMBL
  A6HL31 ENTREZGENE, UniProtKB/TrEMBL
  A6HL32 ENTREZGENE, UniProtKB/TrEMBL
  KITH_RAT UniProtKB/Swiss-Prot
  M0RCX2 ENTREZGENE, UniProtKB/TrEMBL
  P27158 ENTREZGENE
UniProt Secondary Q6LAG4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Tk1  thymidine kinase 1  Tk1  thymidine kinase 1, soluble  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Tk1  thymidine kinase 1, soluble  Tk1  thymidine kinase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Tk1  thymidine kinase 1      Symbol and Name updated 629477 APPROVED
2003-03-07 Tk1  thymidine kinase 1  Tk  Thymidine kinase 1, soluble  Data merged from RGD:3867 628472 PROVISIONAL
2002-08-07 Tk1        Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Tk  Thymidine kinase 1, soluble      Symbol and Name status set to approved 70586 APPROVED