Nell2 (neural EGFL like 2) - Rat Genome Database

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Gene: Nell2 (neural EGFL like 2) Rattus norvegicus
Analyze
Symbol: Nell2
Name: neural EGFL like 2
RGD ID: 620999
Description: Enables heparin binding activity; identical protein binding activity; and protein kinase C binding activity. Involved in several processes, including development of secondary female sexual characteristics; neuron cellular homeostasis; and positive regulation of hormone secretion. Located in dendrite; extracellular space; and perikaryon. Orthologous to human NELL2 (neural EGFL like 2); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC681834; NEL-like 2; NEL-like 2 (chicken); nel-like 2 homolog (chicken); NEL-like protein 2; protein kinase C-binding protein NELL2; rCG50753-like; similar to protein kinase C-binding protein NELL2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87128,222,333 - 128,542,127 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7128,078,103 - 128,651,917 (-)EnsemblGRCr8
mRatBN7.27126,343,089 - 126,662,903 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7126,198,851 - 126,733,503 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7128,140,978 - 128,460,541 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07130,366,500 - 130,686,074 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07130,268,233 - 130,594,773 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd7130,291,676 - 130,611,231 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive7131,242,990 - 131,562,543 (-)NCBILyon_Normotensive
Lyon_Hypertensive7131,369,179 - 131,688,736 (-)NCBILyon_Hypertensive
F344_StmMcwi7129,822,002 - 130,141,549 (-)NCBIF344_StmMcwi
Rnor_6.07136,526,497 - 136,853,820 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7136,526,496 - 136,853,957 (-)Ensemblrn6Rnor6.0
Rnor_5.07136,173,239 - 136,494,641 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47133,758,271 - 134,080,104 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7122,721,504 - 123,171,087 (-)NCBICelera
RGSC_v3.17133,835,295 - 134,156,541 (-)NCBI
Cytogenetic Map7q35NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4,4'-trichlorobiphenyl  (ISO)
2-palmitoylglycerol  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
atrazine  (EXP)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (EXP)
calcitriol  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
cytarabine  (ISO)
dexamethasone  (EXP)
Diallyl sulfide  (ISO)
dichlorine  (EXP)
diethylstilbestrol  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
folic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
methapyrilene  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
Moniliformin  (ISO)
Muraglitazar  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
okadaic acid  (ISO)
ozone  (EXP)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenylmercury acetate  (ISO)
progesterone  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
temozolomide  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (EXP)
valproic acid  (ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
vorinostat  (ISO)
XL147  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IDA,IEA)
dendrite  (IDA)
extracellular region  (IEA,ISO)
extracellular space  (IBA,IDA)
perikaryon  (IDA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. A neuron-specific EGF family protein, NELL2, promotes survival of neurons through mitogen-activated protein kinases. Aihara K, etal., Brain Res Mol Brain Res. 2003 Aug 19;116(1-2):86-93.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. NELL2, a neuron-specific EGF-like protein, is selectively expressed in glutamatergic neurons and contributes to the glutamatergic control of GnRH neurons at puberty. Ha CM, etal., Neuroendocrinology. 2008;88(3):199-211. doi: 10.1159/000139579. Epub 2008 Jun 12.
5. Alternative splicing generates a novel non-secretable cytosolic isoform of NELL2. Hwang EM, etal., Biochem Biophys Res Commun. 2007 Feb 16;353(3):805-11. doi: 10.1016/j.bbrc.2006.12.115. Epub 2006 Dec 22.
6. Ontogeny and the possible function of a novel epidermal growth factor-like repeat domain-containing protein, NELL2, in the rat brain. Kim H, etal., J Neurochem 2002 Dec;83(6):1389-400.
7. NELL2 Function in Axon Development of Hippocampal Neurons. Kim HR, etal., Mol Cells. 2020 Jun 30;43(6):581-589. doi: 10.14348/molcells.2020.0032.
8. Involvement of epidermal growth factor-like domain of NELL proteins in the novel protein-protein interaction with protein kinase C. Kuroda S and Tanizawa K, Biochem Biophys Res Commun 1999 Nov 30;265(3):752-7.
9. Biochemical characterization and expression analysis of neural thrombospondin-1-like proteins NELL1 and NELL2. Kuroda S, etal., Biochem Biophys Res Commun 1999 Nov;265(1):79-86.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. A seven-gene prognostic model related to immune checkpoint PD-1 revealing overall survival in patients with lung adenocarcinoma. Niu W and Jiang L, Math Biosci Eng. 2021 Jul 13;18(5):6136-6154. doi: 10.3934/mbe.2021307.
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9480764   PMID:12477932   PMID:18513367   PMID:18677093   PMID:19931511   PMID:21643849   PMID:22496866   PMID:24352699   PMID:25177948   PMID:28301916   PMID:35950455  


Genomics

Comparative Map Data
Nell2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87128,222,333 - 128,542,127 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7128,078,103 - 128,651,917 (-)EnsemblGRCr8
mRatBN7.27126,343,089 - 126,662,903 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7126,198,851 - 126,733,503 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7128,140,978 - 128,460,541 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07130,366,500 - 130,686,074 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07130,268,233 - 130,594,773 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd7130,291,676 - 130,611,231 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive7131,242,990 - 131,562,543 (-)NCBILyon_Normotensive
Lyon_Hypertensive7131,369,179 - 131,688,736 (-)NCBILyon_Hypertensive
F344_StmMcwi7129,822,002 - 130,141,549 (-)NCBIF344_StmMcwi
Rnor_6.07136,526,497 - 136,853,820 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7136,526,496 - 136,853,957 (-)Ensemblrn6Rnor6.0
Rnor_5.07136,173,239 - 136,494,641 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47133,758,271 - 134,080,104 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7122,721,504 - 123,171,087 (-)NCBICelera
RGSC_v3.17133,835,295 - 134,156,541 (-)NCBI
Cytogenetic Map7q35NCBI
NELL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381244,508,275 - 44,921,848 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1244,508,274 - 44,921,889 (-)Ensemblhg38GRCh38
GRCh371244,902,058 - 45,307,772 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361243,188,332 - 43,556,405 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341243,188,331 - 43,556,405NCBI
Celera1243,705,353 - 44,111,067 (-)NCBICelera
Cytogenetic Map12q12NCBI
HuRef1241,929,510 - 42,335,961 (-)NCBIHuRef
CHM1_11244,867,040 - 45,272,689 (-)NCBICHM1_1
T2T-CHM13v2.01244,466,949 - 44,872,599 (-)NCBIT2T-CHM13v2.0
Nell2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391595,117,321 - 95,426,677 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1594,973,111 - 95,426,440 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381595,219,440 - 95,528,796 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1595,075,230 - 95,528,559 (-)Ensemblmm10GRCm38
MGSCv371595,049,881 - 95,359,137 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361595,048,113 - 95,356,432 (-)NCBIMGSCv36mm8
Celera1597,364,534 - 97,674,925 (-)NCBICelera
Cytogenetic Map15E3NCBI
cM Map1549.39NCBI
Nell2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555003,669,837 - 4,080,443 (-)Ensembl
ChiLan1.0NW_0049555003,669,893 - 4,049,765 (-)NCBIChiLan1.0ChiLan1.0
NELL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21049,258,879 - 49,665,010 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11249,255,637 - 49,661,768 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01243,820,215 - 44,226,249 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11244,680,223 - 45,094,070 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1244,688,209 - 45,094,070 (+)EnsemblpanPan2panpan1.1
NELL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1279,300,001 - 9,680,974 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl279,299,893 - 9,680,363 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2736,632,740 - 37,013,748 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0279,488,781 - 9,870,311 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl279,551,037 - 9,870,309 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1279,358,260 - 9,676,754 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0279,396,929 - 9,716,175 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02736,867,127 - 37,248,415 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nell2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494569,939,345 - 70,302,004 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365122,863,485 - 3,224,941 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365122,862,823 - 3,225,350 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NELL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl575,505,099 - 75,837,442 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1575,505,092 - 75,837,324 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2578,515,865 - 78,687,458 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NELL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11140,701,718 - 41,057,489 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1140,701,723 - 41,057,349 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037205,411,968 - 205,768,291 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nell2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248167,503,067 - 8,007,081 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248167,502,615 - 8,006,241 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Nell2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11268,066,201 - 268,373,208 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nell2
3167 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:46
Count of miRNA genes:41
Interacting mature miRNAs:41
Transcripts:ENSRNOT00000008985
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7121393075137014596Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7119280025135560836Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)793302009131686183Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7115313999136544683Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)7116269196132020414Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat

Markers in Region
D7Got112  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27126,483,674 - 126,483,890 (+)MAPPERmRatBN7.2
Rnor_6.07136,667,635 - 136,667,850NCBIRnor6.0
Rnor_5.07136,313,943 - 136,314,158UniSTSRnor5.0
RGSC_v3.47133,898,569 - 133,898,785RGDRGSC3.4
RGSC_v3.47133,898,570 - 133,898,785UniSTSRGSC3.4
RGSC_v3.47133,897,726 - 133,898,785UniSTSRGSC3.4
Celera7122,993,100 - 122,993,319UniSTS
RGSC_v3.17133,975,007 - 133,975,222RGD
RH 3.4 Map71041.7UniSTS
RH 3.4 Map71041.7RGD
RH 2.0 Map7752.8RGD
Cytogenetic Map7q35UniSTS
BF420438  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27126,464,799 - 126,464,906 (+)MAPPERmRatBN7.2
Rnor_6.07136,648,763 - 136,648,869NCBIRnor6.0
Rnor_5.07136,295,071 - 136,295,177UniSTSRnor5.0
RGSC_v3.47133,878,834 - 133,878,940UniSTSRGSC3.4
Celera7122,974,223 - 122,974,329UniSTS
RH 3.4 Map71040.3UniSTS
Cytogenetic Map7q35UniSTS
RH130208  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27126,343,118 - 126,343,338 (+)MAPPERmRatBN7.2
Rnor_6.07136,526,527 - 136,526,746NCBIRnor6.0
Rnor_5.07136,173,269 - 136,173,488UniSTSRnor5.0
RGSC_v3.47133,758,301 - 133,758,520UniSTSRGSC3.4
Celera7122,721,534 - 122,721,753UniSTS
RH 3.4 Map71036.7UniSTS
Cytogenetic Map7q35UniSTS
RH130209  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27126,343,192 - 126,343,344 (+)MAPPERmRatBN7.2
Rnor_6.07136,526,601 - 136,526,752NCBIRnor6.0
Rnor_5.07136,173,343 - 136,173,494UniSTSRnor5.0
RGSC_v3.47133,758,375 - 133,758,526UniSTSRGSC3.4
Celera7122,721,608 - 122,721,759UniSTS
RH 3.4 Map71037.4UniSTS
Cytogenetic Map7q35UniSTS
BI277674  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27126,559,900 - 126,560,050 (+)MAPPERmRatBN7.2
Rnor_6.07136,743,493 - 136,743,642NCBIRnor6.0
Rnor_5.07136,388,008 - 136,388,157UniSTSRnor5.0
RGSC_v3.47133,975,104 - 133,975,253UniSTSRGSC3.4
Celera7123,069,314 - 123,069,463UniSTS
RH 3.4 Map71038.2UniSTS
Cytogenetic Map7q35UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 11 60 157 80 75 48 27 48 6 230 110 3 138 49 92 27 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000008985   ⟹   ENSRNOP00000008985
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7128,222,333 - 128,542,127 (-)Ensembl
mRatBN7.2 Ensembl7126,343,090 - 126,662,694 (-)Ensembl
Rnor_6.0 Ensembl7136,526,496 - 136,853,957 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000087376   ⟹   ENSRNOP00000073082
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7126,352,591 - 126,595,056 (-)Ensembl
Rnor_6.0 Ensembl7136,527,135 - 136,853,154 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099152   ⟹   ENSRNOP00000088740
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7126,343,090 - 126,662,028 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099586   ⟹   ENSRNOP00000093001
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7128,222,333 - 128,612,777 (-)Ensembl
mRatBN7.2 Ensembl7126,343,090 - 126,733,503 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115194   ⟹   ENSRNOP00000094642
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7126,198,851 - 126,662,694 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000120642   ⟹   ENSRNOP00000098277
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7128,222,333 - 128,612,684 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000120643   ⟹   ENSRNOP00000111848
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7128,222,333 - 128,651,917 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000129090   ⟹   ENSRNOP00000112179
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7128,078,103 - 128,542,127 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000163182   ⟹   ENSRNOP00000100578
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7128,222,333 - 128,542,110 (-)Ensembl
RefSeq Acc Id: NM_031070   ⟹   NP_112332
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87128,222,333 - 128,542,127 (-)NCBI
mRatBN7.27126,343,089 - 126,662,903 (-)NCBI
Dahl_SR_JrHsd7130,291,676 - 130,611,231 (-)NCBI
Lyon_Normotensive7131,242,990 - 131,562,543 (-)NCBI
Lyon_Hypertensive7131,369,179 - 131,688,736 (-)NCBI
F344_StmMcwi7129,822,002 - 130,141,549 (-)NCBI
Rnor_6.07136,526,497 - 136,853,820 (-)NCBI
Rnor_5.07136,173,239 - 136,494,641 (-)NCBI
RGSC_v3.47133,758,271 - 134,080,104 (-)RGD
Celera7122,721,504 - 123,171,087 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008765798   ⟹   XP_008764020
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87128,222,333 - 128,541,810 (-)NCBI
mRatBN7.27126,343,089 - 126,662,586 (-)NCBI
Rnor_6.07136,526,497 - 136,853,712 (-)NCBI
Sequence:
RefSeq Acc Id: NP_112332   ⟸   NM_031070
- Peptide Label: precursor
- UniProtKB: Q62918 (UniProtKB/Swiss-Prot),   C8CB44 (UniProtKB/Swiss-Prot),   A1E5S7 (UniProtKB/Swiss-Prot),   Q561K2 (UniProtKB/TrEMBL),   Q8R417 (UniProtKB/TrEMBL),   A0AAA9YW69 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008764020   ⟸   XM_008765798
- Peptide Label: isoform X1
- UniProtKB: Q62918 (UniProtKB/Swiss-Prot),   C8CB44 (UniProtKB/Swiss-Prot),   A1E5S7 (UniProtKB/Swiss-Prot),   Q561K2 (UniProtKB/TrEMBL),   A0AAA9YW69 (UniProtKB/TrEMBL),   Q8R417 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008985   ⟸   ENSRNOT00000008985
Ensembl Acc Id: ENSRNOP00000073082   ⟸   ENSRNOT00000087376
Ensembl Acc Id: ENSRNOP00000088740   ⟸   ENSRNOT00000099152
Ensembl Acc Id: ENSRNOP00000094642   ⟸   ENSRNOT00000115194
Ensembl Acc Id: ENSRNOP00000093001   ⟸   ENSRNOT00000099586
Ensembl Acc Id: ENSRNOP00000111848   ⟸   ENSRNOT00000120643
Ensembl Acc Id: ENSRNOP00000112179   ⟸   ENSRNOT00000129090
Ensembl Acc Id: ENSRNOP00000098277   ⟸   ENSRNOT00000120642
Ensembl Acc Id: ENSRNOP00000100578   ⟸   ENSRNOT00000163182
Protein Domains
EGF-like   Laminin G-like   VWFC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62918-F1-model_v2 AlphaFold Q62918 1-816 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620999 AgrOrtholog
BioCyc Gene G2FUF-32288 BioCyc
Ensembl Genes ENSRNOG00000006235 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000008985 ENTREZGENE
  ENSRNOT00000008985.8 UniProtKB/Swiss-Prot
  ENSRNOT00000120642 ENTREZGENE
Gene3D-CATH 2.60.120.200 UniProtKB/Swiss-Prot
  6.20.200.20 UniProtKB/Swiss-Prot
  Complement Module, domain 1 UniProtKB/Swiss-Prot
  Laminin UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7312010 IMAGE-MGC_LOAD
InterPro ConA-like_dom_sf UniProtKB/Swiss-Prot
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot
  EGF-like_dom UniProtKB/Swiss-Prot
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot
  EGF_dom UniProtKB/Swiss-Prot
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot
  Laminin_G UniProtKB/Swiss-Prot
  NOTCH1_EGF-like UniProtKB/Swiss-Prot
  PKC-binding_NELL UniProtKB/Swiss-Prot
  TSPN-like_N UniProtKB/Swiss-Prot
  VWF_dom UniProtKB/Swiss-Prot
KEGG Report rno:81734 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105410 IMAGE-MGC_LOAD
NCBI Gene 81734 ENTREZGENE
PANTHER NEL HOMOLOG UniProtKB/Swiss-Prot
  PROTEIN KINASE C-BINDING PROTEIN NELL2 UniProtKB/Swiss-Prot
Pfam EGF_3 UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  Laminin_G_2 UniProtKB/Swiss-Prot
  VWC UniProtKB/Swiss-Prot
PhenoGen Nell2 PhenoGen
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot
  EGF_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  VWFC_1 UniProtKB/Swiss-Prot
  VWFC_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000006235 RatGTEx
SMART EGF UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  LamG UniProtKB/Swiss-Prot
  TSPN UniProtKB/Swiss-Prot
  VWC UniProtKB/Swiss-Prot
  VWC_out UniProtKB/Swiss-Prot
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot
  FnI-like domain UniProtKB/Swiss-Prot
  SSF49899 UniProtKB/Swiss-Prot
  SSF57184 UniProtKB/Swiss-Prot
UniProt A0A8I6AH61_RAT UniProtKB/TrEMBL
  A0AAA9YW69 ENTREZGENE
  A0ABK0LA08_RAT UniProtKB/TrEMBL
  A0ABK0LLI9_RAT UniProtKB/TrEMBL
  A0ABK0M805_RAT UniProtKB/TrEMBL
  A1E5S7 ENTREZGENE
  C8CB44 ENTREZGENE
  NELL2_RAT UniProtKB/Swiss-Prot
  Q561K2 ENTREZGENE
  Q62918 ENTREZGENE
  Q8R417 ENTREZGENE
UniProt Secondary A1E5S7 UniProtKB/Swiss-Prot
  C8CB44 UniProtKB/Swiss-Prot
  Q561K2 UniProtKB/Swiss-Prot
  Q8R417 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-06-26 Nell2  neural EGFL like 2  Nell2  NEL-like 2 (chicken)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-04-17 Nell2  NEL-like 2 (chicken)  LOC681834  similar to protein kinase C-binding protein NELL2  Data merged from RGD:1590527 737654 PROVISIONAL
2008-02-22 Nell2  NEL-like 2 (chicken)  Nell2  nel-like 2 homolog (chicken)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC681834  similar to protein kinase C-binding protein NELL2      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-20 Nell2  nel-like 2 homolog (chicken)      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Nell2  nel-like 2 homolog (chicken)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains an NH2-terminal thrombospondin-1 (TSP-1)-like module, five von Willebrand factor C domains, and six epidermal growth factor-like domains 633407
gene_expression expressed in embryos (from day 10); predominant in CNS in prenatal stages in ventricular zone of psinal cord, medulla and pons; expression decreases after birth; in adults found in tenia tecta, piriform cortex, hippocampus, dentate gyrus, cerebellar corte 628415
gene_process may have a role in neurogeneiss in CNS, maintenance of neural functions; may regulate intracellular machinery involving calcium mediated signaling as well as synaptic transport 628415
gene_process neural tissue-specific epidermal growth factor (EGF)-like repeat domain-containing protein 628415