Nell2 (neural EGFL like 2) - Rat Genome Database

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Gene: Nell2 (neural EGFL like 2) Rattus norvegicus
Analyze
Symbol: Nell2
Name: neural EGFL like 2
RGD ID: 620999
Description: Enables heparin binding activity; identical protein binding activity; and protein kinase C binding activity. Involved in several processes, including development of secondary female sexual characteristics; neuron cellular homeostasis; and positive regulation of hormone secretion. Located in several cellular components, including dendrite; extracellular space; and perikaryon. Orthologous to human NELL2 (neural EGFL like 2); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC681834; NEL-like 2; NEL-like 2 (chicken); nel-like 2 homolog (chicken); NEL-like protein 2; protein kinase C-binding protein NELL2; rCG50753-like; similar to protein kinase C-binding protein NELL2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87128,222,333 - 128,542,127 (-)NCBIGRCr8
mRatBN7.27126,343,089 - 126,662,903 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7126,198,851 - 126,733,503 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7128,140,978 - 128,460,541 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07130,366,500 - 130,686,074 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07130,268,233 - 130,594,773 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07136,526,497 - 136,853,820 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7136,526,496 - 136,853,957 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07136,173,239 - 136,494,641 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47133,758,271 - 134,080,104 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17133,835,295 - 134,156,541 (-)NCBI
Celera7122,721,504 - 123,171,087 (-)NCBICelera
Cytogenetic Map7q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 20 of 99 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Nell2Rat17beta-estradiol multiple interactionsISONELL2 (Homo sapiens)6480464[Estradiol co-treated with Progesterone] results in increased expression of NELL2 mRNACTDPMID:20660070
Nell2Rat17beta-estradiol multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of NELL2 mRNACTDPMID:32741896
Nell2Rat17beta-estradiol 3-benzoate multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of NELL2 mRNACTDPMID:32741896
Nell2Rat2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsISONell2 (Mus musculus)6480464[2 more ...CTDPMID:25510870
Nell2Rat2,2',5,5'-tetrachlorobiphenyl multiple interactionsISONell2 (Mus musculus)6480464[2 more ...CTDPMID:25510870
Nell2Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of NELL2 mRNACTDPMID:32109520
Nell2Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of NELL2 mRNACTDPMID:33387578
Nell2Rat2-palmitoylglycerol increases expressionISONELL2 (Homo sapiens)64804642-palmitoylglycerol results in increased expression of NELL2 mRNACTDPMID:37199045
Nell2Rat4,4'-sulfonyldiphenol decreases expressionISONell2 (Mus musculus)6480464bisphenol S results in decreased expression of NELL2 mRNACTDPMID:30951980
Nell2Rat4,4'-sulfonyldiphenol increases methylationISONELL2 (Homo sapiens)6480464bisphenol S results in increased methylation of NELL2 geneCTDPMID:31601247
Nell2Rat5-aza-2'-deoxycytidine affects expressionISONELL2 (Homo sapiens)6480464Decitabine affects the expression of NELL2 mRNACTDPMID:23300844
Nell2Rat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of NELL2 mRNACTDPMID:30047161
Nell2Ratacrylamide decreases expressionEXP 6480464Acrylamide results in decreased expression of NELL2 mRNACTDPMID:28959563
Nell2Ratacrylamide decreases expressionISONell2 (Mus musculus)6480464Acrylamide results in decreased expression of NELL2 mRNACTDPMID:30807115
Nell2Rataflatoxin B1 affects methylationISONELL2 (Homo sapiens)6480464Aflatoxin B1 affects the methylation of NELL2 intronCTDPMID:30157460
Nell2Ratall-trans-retinoic acid decreases expressionISONELL2 (Homo sapiens)6480464Tretinoin results in decreased expression of NELL2 mRNACTDPMID:21934132
Nell2Ratall-trans-retinoic acid increases expressionISONELL2 (Homo sapiens)6480464Tretinoin results in increased expression of NELL2 mRNACTDPMID:23724009
Nell2Ratantirheumatic drug decreases expressionISONELL2 (Homo sapiens)6480464Antirheumatic Agents results in decreased expression of NELL2 mRNACTDPMID:24449571
Nell2Ratatrazine affects methylationEXP 6480464Atrazine affects the methylation of NELL2 geneCTDPMID:28931070 and PMID:35440735
Nell2Ratbelinostat decreases expressionISONELL2 (Homo sapiens)6480464belinostat results in decreased expression of NELL2 mRNACTDPMID:26272509

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Biological Process
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1 to 10 of 10 rows

Cellular Component
1 to 12 of 12 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Nell2Ratcytoplasm located_inIDA 401827138PMID:17196548UniProt 
Nell2Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Nell2Ratcytoplasm is_active_inIBAPANTHER:PTN001170561 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Nell2Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Nell2Ratdendrite  IDA 633407 RGD 
Nell2Ratextracellular region located_inISONell2 (Mus musculus)1624291 PMID:32499443RGDPMID:32499443
Nell2Ratextracellular region located_inIEAUniProtKB-KW:KW-09641600115GO_REF:0000043UniProtGO_REF:0000043
Nell2Ratextracellular region located_inIEAUniProtKB-SubCell:SL-02431600115GO_REF:0000044UniProtGO_REF:0000044
Nell2Ratextracellular space  IDA 633407 RGD 
Nell2Ratextracellular space is_active_inIBAPANTHER:PTN001170558 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Nell2Ratextracellular space located_inIDA 10047268PMID:18547942UniProt 
Nell2Ratperikaryon  IDA 633407 RGD 
1 to 12 of 12 rows

Molecular Function
1 to 15 of 15 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Nell2Ratcalcium ion binding enablesISSUniProtKB:Q994351600115GO_REF:0000024UniProtGO_REF:0000024
Nell2Ratcalcium ion binding enablesIEAInterPro:IPR001881 and InterPro:IPR0180971600115GO_REF:0000002InterProGO_REF:0000002
Nell2Ratcalcium ion binding enablesISONELL2 (Homo sapiens)1624291 PMID:32198364RGDPMID:32198364
Nell2Ratheparin binding  IDA 633407 RGD 
Nell2Ratheparin binding enablesIBAPANTHER:PTN001170558 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Nell2Ratidentical protein binding  IPINell2 (Rattus norvegicus)633407homotrimerizationRGD 
Nell2Ratidentical protein binding enablesISONell2 (Mus musculus)1624291 PMID:32198364RGDPMID:32198364
Nell2Ratidentical protein binding enablesISONELL2 (Homo sapiens)1624291 PMID:32198364RGDPMID:32198364
Nell2Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Nell2Ratprotein binding enablesISONELL2 (Homo sapiens)1624291UniProtKB:P08922 more ...RGDPMID:16713569 more ...
Nell2Ratprotein binding enablesISONell2 (Mus musculus)1624291UniProtKB:Q3UR78 and PMID:37095084RGDPMID:37095084
Nell2Ratprotein binding enablesISONELL2 (Homo sapiens) and UniProtKB:Q99435-11624291UniProtKB:Q96MS0 and PMID:26586761RGDPMID:26586761
Nell2Ratprotein binding enablesISONELL2 (Homo sapiens) and UniProtKB:Q99435-21624291UniProtKB:P37173 more ...RGDPMID:32296183 and PMID:32814053
Nell2Ratprotein kinase C binding  IDA 633406 RGD 
Nell2Ratprotein kinase C binding enablesIBAPANTHER:PTN001170561 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
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1 to 14 of 14 rows
#
Reference Title
Reference Citation
1. A neuron-specific EGF family protein, NELL2, promotes survival of neurons through mitogen-activated protein kinases. Aihara K, etal., Brain Res Mol Brain Res. 2003 Aug 19;116(1-2):86-93.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. NELL2, a neuron-specific EGF-like protein, is selectively expressed in glutamatergic neurons and contributes to the glutamatergic control of GnRH neurons at puberty. Ha CM, etal., Neuroendocrinology. 2008;88(3):199-211. doi: 10.1159/000139579. Epub 2008 Jun 12.
5. Alternative splicing generates a novel non-secretable cytosolic isoform of NELL2. Hwang EM, etal., Biochem Biophys Res Commun. 2007 Feb 16;353(3):805-11. doi: 10.1016/j.bbrc.2006.12.115. Epub 2006 Dec 22.
6. Ontogeny and the possible function of a novel epidermal growth factor-like repeat domain-containing protein, NELL2, in the rat brain. Kim H, etal., J Neurochem 2002 Dec;83(6):1389-400.
7. NELL2 Function in Axon Development of Hippocampal Neurons. Kim HR, etal., Mol Cells. 2020 Jun 30;43(6):581-589. doi: 10.14348/molcells.2020.0032.
8. Involvement of epidermal growth factor-like domain of NELL proteins in the novel protein-protein interaction with protein kinase C. Kuroda S and Tanizawa K, Biochem Biophys Res Commun 1999 Nov 30;265(3):752-7.
9. Biochemical characterization and expression analysis of neural thrombospondin-1-like proteins NELL1 and NELL2. Kuroda S, etal., Biochem Biophys Res Commun 1999 Nov;265(1):79-86.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
1 to 14 of 14 rows
PMID:9480764   PMID:12477932   PMID:18513367   PMID:18677093   PMID:19931511   PMID:21643849   PMID:22496866   PMID:24352699   PMID:25177948   PMID:28301916   PMID:35950455  



Nell2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87128,222,333 - 128,542,127 (-)NCBIGRCr8
mRatBN7.27126,343,089 - 126,662,903 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7126,198,851 - 126,733,503 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7128,140,978 - 128,460,541 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07130,366,500 - 130,686,074 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07130,268,233 - 130,594,773 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07136,526,497 - 136,853,820 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7136,526,496 - 136,853,957 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07136,173,239 - 136,494,641 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47133,758,271 - 134,080,104 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17133,835,295 - 134,156,541 (-)NCBI
Celera7122,721,504 - 123,171,087 (-)NCBICelera
Cytogenetic Map7q35NCBI
NELL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381244,508,275 - 44,921,848 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1244,508,275 - 44,921,848 (-)EnsemblGRCh38hg38GRCh38
GRCh371244,902,058 - 45,307,772 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361243,188,332 - 43,556,405 (-)NCBINCBI36Build 36hg18NCBI36
Build 341243,188,331 - 43,556,405NCBI
Celera1243,705,353 - 44,111,067 (-)NCBICelera
Cytogenetic Map12q12NCBI
HuRef1241,929,510 - 42,335,961 (-)NCBIHuRef
CHM1_11244,867,040 - 45,272,689 (-)NCBICHM1_1
T2T-CHM13v2.01244,466,949 - 44,872,599 (-)NCBIT2T-CHM13v2.0
Nell2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391595,117,321 - 95,426,677 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1594,973,111 - 95,426,440 (-)EnsemblGRCm39 Ensembl
GRCm381595,219,440 - 95,528,796 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1595,075,230 - 95,528,559 (-)EnsemblGRCm38mm10GRCm38
MGSCv371595,049,881 - 95,359,137 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361595,048,113 - 95,356,432 (-)NCBIMGSCv36mm8
Celera1597,364,534 - 97,674,925 (-)NCBICelera
Cytogenetic Map15E3NCBI
cM Map1549.39NCBI
Nell2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555003,669,837 - 4,080,443 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555003,669,893 - 4,049,765 (-)NCBIChiLan1.0ChiLan1.0
NELL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21049,258,879 - 49,665,010 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11249,255,637 - 49,661,768 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01243,820,215 - 44,226,249 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11244,680,223 - 45,094,070 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1244,688,209 - 45,094,070 (+)Ensemblpanpan1.1panPan2
NELL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1279,300,001 - 9,680,974 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl279,299,893 - 9,680,363 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2736,632,740 - 37,013,748 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0279,488,781 - 9,870,311 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl279,551,037 - 9,870,309 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1279,358,260 - 9,676,754 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0279,396,929 - 9,716,175 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02736,867,127 - 37,248,415 (-)NCBIUU_Cfam_GSD_1.0
Nell2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494569,939,345 - 70,302,004 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365122,863,485 - 3,224,941 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365122,862,823 - 3,225,350 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NELL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl575,505,099 - 75,837,442 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1575,505,092 - 75,837,324 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2578,515,865 - 78,687,458 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NELL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11140,701,718 - 41,057,489 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1140,701,723 - 41,057,349 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037205,411,968 - 205,768,291 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nell2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248167,503,067 - 8,007,081 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248167,502,615 - 8,006,241 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Nell2
2090 total Variants


Assembly: Rnor_5.0
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
7 136182947 136182948 C T snv DOB/Oda (KyushuU) View more Information

Predicted Target Of
Summary Value
Count of predictions:46
Count of miRNA genes:41
Interacting mature miRNAs:41
Transcripts:ENSRNOT00000008985
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 23 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)7116677189127103496Rat

1 to 10 of 23 rows
D7Got112  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27126,483,674 - 126,483,890 (+)MAPPERmRatBN7.2
Rnor_6.07136,667,635 - 136,667,850NCBIRnor6.0
Rnor_5.07136,313,943 - 136,314,158UniSTSRnor5.0
RGSC_v3.47133,898,569 - 133,898,785RGDRGSC3.4
RGSC_v3.47133,898,570 - 133,898,785UniSTSRGSC3.4
RGSC_v3.47133,897,726 - 133,898,785UniSTSRGSC3.4
RGSC_v3.17133,975,007 - 133,975,222RGD
Celera7122,993,100 - 122,993,319UniSTS
RH 3.4 Map71041.7UniSTS
RH 3.4 Map71041.7RGD
RH 2.0 Map7752.8RGD
Cytogenetic Map7q35UniSTS
BF420438  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27126,464,799 - 126,464,906 (+)MAPPERmRatBN7.2
Rnor_6.07136,648,763 - 136,648,869NCBIRnor6.0
Rnor_5.07136,295,071 - 136,295,177UniSTSRnor5.0
RGSC_v3.47133,878,834 - 133,878,940UniSTSRGSC3.4
Celera7122,974,223 - 122,974,329UniSTS
RH 3.4 Map71040.3UniSTS
Cytogenetic Map7q35UniSTS
RH130208  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27126,343,118 - 126,343,338 (+)MAPPERmRatBN7.2
Rnor_6.07136,526,527 - 136,526,746NCBIRnor6.0
Rnor_5.07136,173,269 - 136,173,488UniSTSRnor5.0
RGSC_v3.47133,758,301 - 133,758,520UniSTSRGSC3.4
Celera7122,721,534 - 122,721,753UniSTS
RH 3.4 Map71036.7UniSTS
Cytogenetic Map7q35UniSTS
RH130209  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27126,343,192 - 126,343,344 (+)MAPPERmRatBN7.2
Rnor_6.07136,526,601 - 136,526,752NCBIRnor6.0
Rnor_5.07136,173,343 - 136,173,494UniSTSRnor5.0
RGSC_v3.47133,758,375 - 133,758,526UniSTSRGSC3.4
Celera7122,721,608 - 122,721,759UniSTS
RH 3.4 Map71037.4UniSTS
Cytogenetic Map7q35UniSTS
BI277674  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27126,559,900 - 126,560,050 (+)MAPPERmRatBN7.2
Rnor_6.07136,743,493 - 136,743,642NCBIRnor6.0
Rnor_5.07136,388,008 - 136,388,157UniSTSRnor5.0
RGSC_v3.47133,975,104 - 133,975,253UniSTSRGSC3.4
Celera7123,069,314 - 123,069,463UniSTS
RH 3.4 Map71038.2UniSTS
Cytogenetic Map7q35UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 44 113 80 75 48 19 48 6 188 84 93 39 60 27



Ensembl Acc Id: ENSRNOT00000008985   ⟹   ENSRNOP00000008985
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7126,343,090 - 126,662,694 (-)Ensembl
Rnor_6.0 Ensembl7136,526,496 - 136,853,957 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000087376   ⟹   ENSRNOP00000073082
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7126,352,591 - 126,595,056 (-)Ensembl
Rnor_6.0 Ensembl7136,527,135 - 136,853,154 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099152   ⟹   ENSRNOP00000088740
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7126,343,090 - 126,662,028 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099586   ⟹   ENSRNOP00000093001
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7126,343,090 - 126,733,503 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115194   ⟹   ENSRNOP00000094642
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7126,198,851 - 126,662,694 (-)Ensembl
RefSeq Acc Id: NM_031070   ⟹   NP_112332
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87128,222,333 - 128,542,127 (-)NCBI
mRatBN7.27126,343,089 - 126,662,903 (-)NCBI
Rnor_6.07136,526,497 - 136,853,820 (-)NCBI
Rnor_5.07136,173,239 - 136,494,641 (-)NCBI
RGSC_v3.47133,758,271 - 134,080,104 (-)RGD
Celera7122,721,504 - 123,171,087 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008765798   ⟹   XP_008764020
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87128,222,333 - 128,541,810 (-)NCBI
mRatBN7.27126,343,089 - 126,662,586 (-)NCBI
Rnor_6.07136,526,497 - 136,853,712 (-)NCBI
Sequence:
1 to 11 of 11 rows
Protein RefSeqs NP_112332 (Get FASTA)   NCBI Sequence Viewer  
  XP_008764020 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC72245 (Get FASTA)   NCBI Sequence Viewer  
  AAH93617 (Get FASTA)   NCBI Sequence Viewer  
  AAL89577 (Get FASTA)   NCBI Sequence Viewer  
  ABL61253 (Get FASTA)   NCBI Sequence Viewer  
  ACU68930 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000008985
  ENSRNOP00000008985.5
  ENSRNOP00000098277
GenBank Protein Q62918 (Get FASTA)   NCBI Sequence Viewer  
1 to 11 of 11 rows
RefSeq Acc Id: NP_112332   ⟸   NM_031070
- Peptide Label: precursor
- UniProtKB: Q62918 (UniProtKB/Swiss-Prot),   C8CB44 (UniProtKB/Swiss-Prot),   A1E5S7 (UniProtKB/Swiss-Prot),   Q561K2 (UniProtKB/TrEMBL),   Q8R417 (UniProtKB/TrEMBL),   A0AAA9YW69 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008764020   ⟸   XM_008765798
- Peptide Label: isoform X1
- UniProtKB: Q62918 (UniProtKB/Swiss-Prot),   C8CB44 (UniProtKB/Swiss-Prot),   A1E5S7 (UniProtKB/Swiss-Prot),   Q561K2 (UniProtKB/TrEMBL),   A0AAA9YW69 (UniProtKB/TrEMBL),   Q8R417 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008985   ⟸   ENSRNOT00000008985
Ensembl Acc Id: ENSRNOP00000073082   ⟸   ENSRNOT00000087376
Ensembl Acc Id: ENSRNOP00000088740   ⟸   ENSRNOT00000099152
EGF-like   Laminin G-like   VWFC

Name Modeler Protein Id AA Range Protein Structure
AF-Q62918-F1-model_v2 AlphaFold Q62918 1-816 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 40 of 64 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-32288 BioCyc
Ensembl Genes ENSRNOG00000006235 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000008985 ENTREZGENE
  ENSRNOT00000008985.8 UniProtKB/Swiss-Prot
  ENSRNOT00000120642 ENTREZGENE
Gene3D-CATH 2.60.120.200 UniProtKB/Swiss-Prot
  6.20.200.20 UniProtKB/Swiss-Prot
  Complement Module, domain 1 UniProtKB/Swiss-Prot
  Laminin UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7312010 IMAGE-MGC_LOAD
InterPro ConA-like_dom_sf UniProtKB/Swiss-Prot
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot
  EGF-like_dom UniProtKB/Swiss-Prot
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot
  EGF_dom UniProtKB/Swiss-Prot
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot
  Laminin_G UniProtKB/Swiss-Prot
  NOTCH1_EGF-like UniProtKB/Swiss-Prot
  PKC-binding_NELL UniProtKB/Swiss-Prot
  TSPN-like_N UniProtKB/Swiss-Prot
  VWF_dom UniProtKB/Swiss-Prot
KEGG Report rno:81734 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105410 IMAGE-MGC_LOAD
NCBI Gene 81734 ENTREZGENE
PANTHER NEL HOMOLOG UniProtKB/Swiss-Prot
  PROTEIN KINASE C-BINDING PROTEIN NELL2 UniProtKB/Swiss-Prot
Pfam EGF_3 UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  Laminin_G_2 UniProtKB/Swiss-Prot
  VWC UniProtKB/Swiss-Prot
PhenoGen Nell2 PhenoGen
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot
  EGF_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  VWFC_1 UniProtKB/Swiss-Prot
  VWFC_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000006235 RatGTEx
1 to 40 of 64 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-06-26 Nell2  neural EGFL like 2  Nell2  NEL-like 2 (chicken)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-04-17 Nell2  NEL-like 2 (chicken)  LOC681834  similar to protein kinase C-binding protein NELL2  Data merged from RGD:1590527 737654 PROVISIONAL
2008-02-22 Nell2  NEL-like 2 (chicken)  Nell2  nel-like 2 homolog (chicken)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC681834  similar to protein kinase C-binding protein NELL2      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-20 Nell2  nel-like 2 homolog (chicken)      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Nell2  nel-like 2 homolog (chicken)      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_domains contains an NH2-terminal thrombospondin-1 (TSP-1)-like module, five von Willebrand factor C domains, and six epidermal growth factor-like domains 633407
gene_expression expressed in embryos (from day 10); predominant in CNS in prenatal stages in ventricular zone of psinal cord, medulla and pons; expression decreases after birth; in adults found in tenia tecta, piriform cortex, hippocampus, dentate gyrus, cerebellar corte 628415
gene_process may have a role in neurogeneiss in CNS, maintenance of neural functions; may regulate intracellular machinery involving calcium mediated signaling as well as synaptic transport 628415
gene_process neural tissue-specific epidermal growth factor (EGF)-like repeat domain-containing protein 628415