Mllt3 (MLLT3, super elongation complex subunit) - Rat Genome Database

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Gene: Mllt3 (MLLT3, super elongation complex subunit) Rattus norvegicus
Analyze
Symbol: Mllt3
Name: MLLT3, super elongation complex subunit
RGD ID: 620940
Description: Predicted to enable several functions, including chromatin binding activity; histone H3 reader activity; and histone binding activity. Predicted to be involved in several processes, including hematopoietic stem cell differentiation; positive regulation of DNA-templated transcription; and regulation of stem cell division. Predicted to act upstream of or within several processes, including regionalization; regulation of Wnt signaling pathway; and sodium ion transport. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of transcription elongation factor complex. Orthologous to human MLLT3 (MLLT3 super elongation complex subunit); PARTICIPATES IN RNA polymerase II transcription elongation pathway; INTERACTS WITH 1,3-dinitrobenzene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Af-9; Af9; myeloid/lymphoid or mixed lineage-leukemia translocation to 3 homolog; myeloid/lymphoid or mixed lineage-leukemia translocation to 3 homolog (Drosophila); myeloid/lymphoid or mixed-lineage leukemia; myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila) homolog); myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3; myeloid/lymphoid or mixed-lineage leukemia, translocated to, 3; myeloid/lymphoid or mixed-lineage leukemia, translocated to, 3 (trithorax homolog, Drosophila); myeloid/lymphoid or mixed-lineage leukemia,translocated to, 3 (trithorax homolog, Drosophila); translocated to, 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85107,305,008 - 107,561,352 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5107,284,766 - 107,561,352 (-)EnsemblGRCr8
mRatBN7.25102,259,075 - 102,515,447 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5102,260,011 - 102,515,361 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5104,613,871 - 104,868,371 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05106,404,352 - 106,658,847 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05106,458,881 - 106,715,826 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd5107,263,238 - 107,517,502 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive5109,040,399 - 109,297,327 (-)NCBILyon_Normotensive
Lyon_Hypertensive5108,215,572 - 108,472,621 (-)NCBILyon_Hypertensive
F344_StmMcwi5101,985,768 - 102,240,033 (-)NCBIF344_StmMcwi
Rnor_6.05106,103,498 - 106,202,559 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5106,103,407 - 106,207,126 (-)Ensemblrn6Rnor6.0
Rnor_5.05110,089,246 - 110,183,694 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45107,070,371 - 107,088,371 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5100,747,987 - 100,840,556 (+)NCBICelera
RGSC_v3.15107,075,575 - 107,093,597 (-)NCBI
Cytogenetic Map5q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methoxyethanol  (EXP)
2-palmitoylglycerol  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
clotrimazole  (EXP)
cyclosporin A  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
GSK-J4  (ISO)
inulin  (ISO)
ketamine  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
melphalan  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-nitrosodiethylamine  (ISO)
nickel sulfate  (ISO)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
propiconazole  (EXP)
quercetin  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
testosterone  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
zinc protoporphyrin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mouse Af9 is a controller of embryo patterning, like Mll, whose human homologue fuses with Af9 after chromosomal translocation in leukemia. Collins EC, etal., Mol Cell Biol 2002 Oct;22(20):7313-24.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. The super elongation complex (SEC) family in transcriptional control. Luo Z, etal., Nat Rev Mol Cell Biol. 2012 Sep;13(9):543-7. doi: 10.1038/nrm3417. Epub 2012 Aug 16.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. Information Derived from GenBank Report RGD, Sept. 2003
11. Spironolactone rescues Dot1a-Af9-mediated repression of endothelin-1 and improves kidney injury in streptozotocin-induced diabetic rats. Zhou Q, etal., PLoS One. 2012;7(10):e47360. doi: 10.1371/journal.pone.0047360. Epub 2012 Oct 15.
Additional References at PubMed
PMID:12477932   PMID:19056867   PMID:19591803   PMID:22195968   PMID:25417107   PMID:27105114   PMID:27545619   PMID:31776511  


Genomics

Comparative Map Data
Mllt3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85107,305,008 - 107,561,352 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5107,284,766 - 107,561,352 (-)EnsemblGRCr8
mRatBN7.25102,259,075 - 102,515,447 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5102,260,011 - 102,515,361 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5104,613,871 - 104,868,371 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05106,404,352 - 106,658,847 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05106,458,881 - 106,715,826 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd5107,263,238 - 107,517,502 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive5109,040,399 - 109,297,327 (-)NCBILyon_Normotensive
Lyon_Hypertensive5108,215,572 - 108,472,621 (-)NCBILyon_Hypertensive
F344_StmMcwi5101,985,768 - 102,240,033 (-)NCBIF344_StmMcwi
Rnor_6.05106,103,498 - 106,202,559 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5106,103,407 - 106,207,126 (-)Ensemblrn6Rnor6.0
Rnor_5.05110,089,246 - 110,183,694 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45107,070,371 - 107,088,371 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5100,747,987 - 100,840,556 (+)NCBICelera
RGSC_v3.15107,075,575 - 107,093,597 (-)NCBI
Cytogenetic Map5q32NCBI
MLLT3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38920,341,669 - 20,622,499 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl920,341,669 - 20,622,499 (-)Ensemblhg38GRCh38
GRCh37920,341,667 - 20,622,498 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36920,334,968 - 20,612,514 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34920,334,967 - 20,612,450NCBI
Celera920,283,496 - 20,561,027 (-)NCBICelera
Cytogenetic Map9p21.3NCBI
HuRef920,307,852 - 20,585,160 (-)NCBIHuRef
CHM1_1920,344,745 - 20,622,226 (-)NCBICHM1_1
T2T-CHM13v2.0920,355,454 - 20,636,229 (-)NCBIT2T-CHM13v2.0
Mllt3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39487,688,162 - 87,951,652 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl487,688,162 - 87,951,601 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38487,769,925 - 88,033,407 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl487,769,925 - 88,033,364 (-)Ensemblmm10GRCm38
MGSCv37487,415,829 - 87,679,311 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36487,243,893 - 87,504,502 (-)NCBIMGSCv36mm8
Celera486,294,560 - 86,557,875 (-)NCBICelera
Cytogenetic Map4C4NCBI
cM Map441.06NCBI
Mllt3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543422,594,681 - 22,873,826 (-)Ensembl
ChiLan1.0NW_00495543422,594,681 - 22,873,826 (-)NCBIChiLan1.0ChiLan1.0
MLLT3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v211103,938,759 - 104,216,048 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan19103,944,705 - 104,222,437 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0920,140,160 - 20,417,327 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1920,799,010 - 21,073,150 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl920,800,393 - 21,073,046 (-)EnsemblpanPan2panpan1.1
MLLT3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11139,923,165 - 40,203,574 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1139,927,517 - 40,203,281 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1138,587,790 - 38,867,401 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01140,865,722 - 41,146,444 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1140,869,752 - 41,146,462 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11139,557,396 - 39,837,144 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01139,340,486 - 39,620,675 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01139,981,473 - 40,261,006 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mllt3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947154,371,177 - 154,639,572 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366522,044,874 - 2,308,832 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366522,040,685 - 2,309,059 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MLLT3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1202,318,929 - 202,607,058 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11202,317,458 - 202,604,308 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21225,899,052 - 226,359,932 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MLLT3
(Chlorocebus sabaeus - green monkey)		 No map positions available.
Mllt3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473624,298,750 - 24,586,185 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Mllt3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1166,061,261 - 66,316,355 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mllt3
2095 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:13
Count of miRNA genes:12
Interacting mature miRNAs:13
Transcripts:ENSRNOT00000015094
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5102105698152749382Rat
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)573779642118779642Rat
2303586Gluco52Glucose level QTL 522blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)5100826632145826632Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)584630798129630798Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)573779642118779642Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)573779642118779642Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)584630798129630798Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1582212Livw2Liver weight QTL 23.50.0004liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)5104018576124314782Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)592583776137583776Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)598972960143972960Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
2303618Vencon1Ventilatory control QTL 13.8respiration trait (VT:0001943)oxygen consumption (CMO:0002169)5100826632145826632Rat
7394708Emca11Estrogen-induced mammary cancer QTL 11mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)573176602118176602Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)584630798129630798Rat
7394710Emca12Estrogen-induced mammary cancer QTL 12mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)594034903139034903Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)569474415114474415Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)595062526133270832Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
1600362Mcs19Mammary carcinoma susceptibility QTL 192.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)582032155127032155Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)564589016109589016Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)589369373134369373Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)569835120114835120Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)570969494136328156Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)597492524133270832Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)573779642118779642Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)595062526133270832Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)592881678137881678Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat

Markers in Region
RH144610  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25102,284,069 - 102,284,275 (+)MAPPERmRatBN7.2
Rnor_6.05106,124,534 - 106,124,739NCBIRnor6.0
Rnor_5.05110,110,282 - 110,110,487UniSTSRnor5.0
RGSC_v3.45107,091,792 - 107,091,997UniSTSRGSC3.4
Celera5100,819,408 - 100,819,613UniSTS
RH 3.4 Map5744.4UniSTS
Cytogenetic Map5q32UniSTS
BE111905  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25102,326,902 - 102,327,110 (+)MAPPERmRatBN7.2
Rnor_6.05106,171,234 - 106,171,441NCBIRnor6.0
Rnor_5.05110,153,225 - 110,153,432UniSTSRnor5.0
Celera5100,778,349 - 100,778,556UniSTS
RH 3.4 Map5741.8UniSTS
Cytogenetic Map5q32UniSTS
RH139198  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25102,262,097 - 102,262,257 (+)MAPPERmRatBN7.2
Rnor_6.05106,102,450 - 106,102,609NCBIRnor6.0
Rnor_5.05110,088,198 - 110,088,357UniSTSRnor5.0
RGSC_v3.45107,069,323 - 107,069,482UniSTSRGSC3.4
Celera5100,841,445 - 100,841,604UniSTS
RH 3.4 Map5742.5UniSTS
Cytogenetic Map5q32UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 16 12 150 249 91 90 65 139 59 22 485 331 11 228 81 91 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000015094   ⟹   ENSRNOP00000015094
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5107,309,187 - 107,561,352 (-)Ensembl
mRatBN7.2 Ensembl5102,263,117 - 102,515,361 (-)Ensembl
Rnor_6.0 Ensembl5106,103,407 - 106,207,126 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094349   ⟹   ENSRNOP00000087456
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5107,305,008 - 107,561,026 (-)Ensembl
mRatBN7.2 Ensembl5102,260,011 - 102,515,125 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114354   ⟹   ENSRNOP00000080897
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5107,305,008 - 107,561,352 (-)Ensembl
mRatBN7.2 Ensembl5102,260,011 - 102,515,361 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000146249   ⟹   ENSRNOP00000106261
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5107,284,766 - 107,561,352 (-)Ensembl
RefSeq Acc Id: NM_053718   ⟹   NP_446170
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85107,305,008 - 107,561,352 (-)NCBI
mRatBN7.25102,259,075 - 102,515,447 (-)NCBI
Dahl_SR_JrHsd5107,263,238 - 107,517,502 (-)NCBI
Lyon_Normotensive5109,040,399 - 109,297,327 (-)NCBI
Lyon_Hypertensive5108,215,572 - 108,472,621 (-)NCBI
F344_StmMcwi5101,985,768 - 102,240,033 (-)NCBI
Rnor_6.05106,103,498 - 106,202,559 (-)NCBI
Rnor_5.05110,089,246 - 110,183,694 (-)NCBI
RGSC_v3.45107,070,371 - 107,088,371 (-)RGD
Celera5100,747,987 - 100,840,556 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039109122   ⟹   XP_038965050
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85107,305,083 - 107,560,878 (-)NCBI
mRatBN7.25102,259,150 - 102,514,895 (-)NCBI
RefSeq Acc Id: XM_039109123   ⟹   XP_038965051
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85107,305,307 - 107,340,702 (-)NCBI
mRatBN7.25102,259,150 - 102,293,611 (-)NCBI
RefSeq Acc Id: XM_039109124   ⟹   XP_038965052
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85107,305,307 - 107,340,705 (-)NCBI
mRatBN7.25102,259,150 - 102,293,613 (-)NCBI
RefSeq Acc Id: NP_446170   ⟸   NM_053718
- UniProtKB: A0A8I5ZRB6 (UniProtKB/TrEMBL),   A0A0G2QC34 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015094   ⟸   ENSRNOT00000015094
RefSeq Acc Id: XP_038965050   ⟸   XM_039109122
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A8N3 (UniProtKB/TrEMBL),   A0A0G2QC34 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965052   ⟸   XM_039109124
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038965051   ⟸   XM_039109123
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000080897   ⟸   ENSRNOT00000114354
Ensembl Acc Id: ENSRNOP00000087456   ⟸   ENSRNOT00000094349
Ensembl Acc Id: ENSRNOP00000106261   ⟸   ENSRNOT00000146249
Protein Domains
AF-9 ANC1 homology   YEATS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2QC34-F1-model_v2 AlphaFold A0A0G2QC34 1-500 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620940 AgrOrtholog
BioCyc Gene G2FUF-40828 BioCyc
Ensembl Genes ENSRNOG00000011280 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015094.8 UniProtKB/TrEMBL
  ENSRNOT00000094349 ENTREZGENE
  ENSRNOT00000094349.2 UniProtKB/TrEMBL
  ENSRNOT00000114354 ENTREZGENE
  ENSRNOT00000114354.2 UniProtKB/TrEMBL
  ENSRNOT00000146249.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.290 UniProtKB/TrEMBL
  2.60.40.1970 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7129264 IMAGE-MGC_LOAD
InterPro AF-9_AHD UniProtKB/TrEMBL
  YEAST_sf UniProtKB/TrEMBL
  YEATS_dom UniProtKB/TrEMBL
  YEATS_domain UniProtKB/TrEMBL
KEGG Report rno:114510 UniProtKB/TrEMBL
MGC_CLONE MGC:156615 IMAGE-MGC_LOAD
NCBI Gene 114510 ENTREZGENE
PANTHER AHD DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  PROTEIN AF-9 UniProtKB/TrEMBL
Pfam AHD UniProtKB/TrEMBL
  YEATS UniProtKB/TrEMBL
PhenoGen Mllt3 PhenoGen
PROSITE YEATS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011280 RatGTEx
UniProt A0A0G2QC34 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZRB6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A8N3 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LRC5_RAT UniProtKB/TrEMBL
  A2VD08_RAT UniProtKB/TrEMBL
  O88760_RAT UniProtKB/TrEMBL
UniProt Secondary F1LP14 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-22 Mllt3  MLLT3, super elongation complex subunit  Mllt3  myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-07-01 Mllt3  myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3  Mllt3  myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-19 Mllt3  myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3  Mllt3  myeloid/lymphoid or mixed lineage-leukemia translocation to 3 homolog (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Mllt3  myeloid/lymphoid or mixed lineage-leukemia translocation to 3 homolog (Drosophila)  Mllt3  myeloid/lymphoid or mixed-lineage leukemia,translocated to, 3 (trithorax homolog, Drosophila);  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Mllt3  myeloid/lymphoid or mixed-lineage leukemia,translocated to, 3 (trithorax homolog, Drosophila);      Name updated 1299863 APPROVED
2002-08-07 Mllt3  myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila) homolog); translocated to, 3      Symbol and Name status set to provisional 70820 PROVISIONAL