Mapk6 (mitogen-activated protein kinase 6) - Rat Genome Database

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Gene: Mapk6 (mitogen-activated protein kinase 6) Rattus norvegicus
Analyze
Symbol: Mapk6
Name: mitogen-activated protein kinase 6
RGD ID: 62087
Description: Predicted to enable MAP kinase activity; protein heterodimerization activity; and protein kinase binding activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within positive regulation of dendritic spine development. Predicted to be located in cytosol and septin cytoskeleton. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human MAPK6 (mitogen-activated protein kinase 6); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrobenzenesulfonic acid; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ERK-3; ERK3; extracellular signal-regulated kinase 3; MAP kinase 6; MAPK 6; MGC124957; p55-MAPK
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8885,027,141 - 85,050,236 (-)NCBIGRCr8
mRatBN7.2876,146,650 - 76,169,767 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl876,146,690 - 76,169,720 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx881,654,326 - 81,677,362 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0879,919,074 - 79,942,242 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0877,753,658 - 77,776,692 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0882,328,013 - 82,351,108 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl882,328,020 - 82,351,108 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0881,931,183 - 81,954,196 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4880,212,726 - 80,236,362 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1880,231,926 - 80,243,701 (-)NCBI
Celera875,936,355 - 75,959,409 (-)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-nitropyrene  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,6-dinitrotoluene  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-nitroquinoline N-oxide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexachlorocyclohexane  (EXP)
ammonium chloride  (EXP)
aripiprazole  (EXP)
atrazine  (EXP)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
carbon nanotube  (ISO)
carboplatin  (EXP)
cisplatin  (EXP)
clozapine  (EXP)
cobalt dichloride  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
dehydroepiandrosterone  (EXP)
dicrotophos  (ISO)
diuron  (EXP)
epoxiconazole  (ISO)
flutamide  (EXP)
FR900359  (ISO)
gefitinib  (ISO)
gentamycin  (EXP)
haloperidol  (EXP)
hydrogen peroxide  (ISO)
hypochlorous acid  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
limonene  (EXP)
metacetamol  (ISO)
methapyrilene  (EXP)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
mifepristone  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
oxybenzone  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phorone  (EXP)
pirinixic acid  (ISO)
propiconazole  (ISO)
prostaglandin F2alpha  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
Tetrachlorobisphenol A  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trimellitic anhydride  (ISO)
valproic acid  (ISO)
wortmannin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,ISO,ISS)
cytosol  (IEA,ISO)
nucleus  (IBA,ISO,ISS)
protein-containing complex  (ISO)
septin cytoskeleton  (ISO)

References

References - curated
# Reference Title Reference Citation
1. ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Boulton TG, etal., Cell 1991 May 17;65(4):663-75.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:8889548   PMID:12477932   PMID:12808096   PMID:15269285   PMID:15489334   PMID:15538386   PMID:15577943   PMID:16597486   PMID:16973613   PMID:22508986   PMID:24411019   PMID:25187167  
PMID:28429763   PMID:30118880   PMID:33404840  


Genomics

Comparative Map Data
Mapk6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8885,027,141 - 85,050,236 (-)NCBIGRCr8
mRatBN7.2876,146,650 - 76,169,767 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl876,146,690 - 76,169,720 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx881,654,326 - 81,677,362 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0879,919,074 - 79,942,242 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0877,753,658 - 77,776,692 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0882,328,013 - 82,351,108 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl882,328,020 - 82,351,108 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0881,931,183 - 81,954,196 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4880,212,726 - 80,236,362 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1880,231,926 - 80,243,701 (-)NCBI
Celera875,936,355 - 75,959,409 (-)NCBICelera
Cytogenetic Map8q24NCBI
MAPK6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381551,971,825 - 52,067,375 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1551,952,106 - 52,067,375 (+)EnsemblGRCh38hg38GRCh38
GRCh371552,311,416 - 52,359,572 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361550,098,739 - 50,145,754 (+)NCBINCBI36Build 36hg18NCBI36
Build 341550,098,738 - 50,145,753NCBI
Celera1529,205,905 - 29,252,893 (+)NCBICelera
Cytogenetic Map15q21.2NCBI
HuRef1529,169,104 - 29,189,428 (+)NCBIHuRef
CHM1_11552,429,454 - 52,476,450 (+)NCBICHM1_1
T2T-CHM13v2.01549,779,463 - 49,875,996 (+)NCBIT2T-CHM13v2.0
Mapk6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39975,294,064 - 75,317,303 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl975,276,344 - 75,317,287 (-)EnsemblGRCm39 Ensembl
GRCm38975,386,782 - 75,410,016 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl975,369,062 - 75,410,005 (-)EnsemblGRCm38mm10GRCm38
MGSCv37975,234,708 - 75,257,821 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36975,172,810 - 75,195,923 (-)NCBIMGSCv36mm8
Celera972,546,303 - 72,569,234 (-)NCBICelera
Cytogenetic Map9DNCBI
cM Map942.3NCBI
Mapk6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554092,663,569 - 2,676,544 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554092,664,017 - 2,676,538 (-)NCBIChiLan1.0ChiLan1.0
MAPK6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21641,208,567 - 41,303,169 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11545,389,046 - 45,483,641 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01530,946,218 - 31,007,987 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11549,273,095 - 49,335,754 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1549,273,095 - 49,335,754 (+)Ensemblpanpan1.1panPan2
MAPK6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13017,701,154 - 17,737,334 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3017,701,742 - 17,736,298 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3017,629,919 - 17,666,142 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03017,849,086 - 17,885,310 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3017,849,097 - 17,884,048 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13017,768,544 - 17,804,773 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03017,886,556 - 17,922,799 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03017,992,501 - 18,028,970 (+)NCBIUU_Cfam_GSD_1.0
Mapk6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864096,001,083 - 96,031,523 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493647113,849,169 - 13,879,595 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPK6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1119,725,029 - 119,771,312 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11119,725,026 - 119,770,988 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21132,815,469 - 132,850,071 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAPK6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12631,320,025 - 31,365,599 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2631,321,281 - 31,339,672 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048109,846,674 - 109,908,016 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mapk6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247318,413,430 - 8,434,897 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247318,413,430 - 8,438,779 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mapk6
104 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:197
Count of miRNA genes:144
Interacting mature miRNAs:168
Transcripts:ENSRNOT00000013053
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)84980583194805831Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85009524982460899Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85009524982460899Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)85404374498968765Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)85423764485365202Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)85423764485365202Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)85423764499103503Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)854259986100382532Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)87531177784531599Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)87531193882925521Rat

Markers in Region
AW555821  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2876,146,680 - 76,146,795 (+)MAPPERmRatBN7.2
Rnor_6.0882,328,044 - 82,328,158NCBIRnor6.0
Rnor_5.0881,931,214 - 81,931,328UniSTSRnor5.0
RGSC_v3.4880,212,757 - 80,212,871UniSTSRGSC3.4
Celera875,936,386 - 75,936,500UniSTS
Cytogenetic Map8q24UniSTS
AW521769  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2876,150,756 - 76,150,898 (+)MAPPERmRatBN7.2
Rnor_6.0882,332,121 - 82,332,262NCBIRnor6.0
Rnor_5.0881,935,291 - 81,935,432UniSTSRnor5.0
RGSC_v3.4880,216,834 - 80,216,975UniSTSRGSC3.4
Celera875,940,463 - 75,940,604UniSTS
RH 3.4 Map8898.69UniSTS
Cytogenetic Map8q24UniSTS
MAPK6_180.2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2876,147,441 - 76,148,286 (+)MAPPERmRatBN7.2
Rnor_6.0882,328,805 - 82,329,649NCBIRnor6.0
Rnor_5.0881,931,975 - 81,932,819UniSTSRnor5.0
RGSC_v3.4880,213,518 - 80,214,362UniSTSRGSC3.4
Celera875,937,147 - 75,937,991UniSTS
Cytogenetic Map8q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000013053   ⟹   ENSRNOP00000013053
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl876,146,690 - 76,169,720 (-)Ensembl
Rnor_6.0 Ensembl882,328,020 - 82,351,108 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000080797   ⟹   ENSRNOP00000073896
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl882,328,160 - 82,339,937 (-)Ensembl
RefSeq Acc Id: NM_031622   ⟹   NP_113810
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8885,027,141 - 85,050,236 (-)NCBI
mRatBN7.2876,146,650 - 76,169,744 (-)NCBI
Rnor_6.0882,328,013 - 82,351,108 (-)NCBI
Rnor_5.0881,931,183 - 81,954,196 (-)NCBI
RGSC_v3.4880,212,726 - 80,236,362 (-)RGD
Celera875,936,355 - 75,959,409 (-)RGD
Sequence:
RefSeq Acc Id: XM_006243409   ⟹   XP_006243471
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8885,027,170 - 85,049,912 (-)NCBI
mRatBN7.2876,146,650 - 76,169,382 (-)NCBI
Rnor_6.0882,328,013 - 82,350,764 (-)NCBI
Rnor_5.0881,931,183 - 81,954,196 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_113810   ⟸   NM_031622
- UniProtKB: Q32LY4 (UniProtKB/Swiss-Prot),   P27704 (UniProtKB/Swiss-Prot),   A6I1C7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243471   ⟸   XM_006243409
- Peptide Label: isoform X1
- UniProtKB: Q32LY4 (UniProtKB/Swiss-Prot),   P27704 (UniProtKB/Swiss-Prot),   A6I1C7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073896   ⟸   ENSRNOT00000080797
RefSeq Acc Id: ENSRNOP00000013053   ⟸   ENSRNOT00000013053
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P27704-F1-model_v2 AlphaFold P27704 1-720 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696128
Promoter ID:EPDNEW_R6653
Type:initiation region
Name:Mapk6_1
Description:mitogen-activated protein kinase 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0882,351,111 - 82,351,171EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62087 AgrOrtholog
BioCyc Gene G2FUF-29820 BioCyc
Ensembl Genes ENSRNOG00000009381 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055007320 UniProtKB/Swiss-Prot
  ENSRNOG00060017014 UniProtKB/Swiss-Prot
  ENSRNOG00065016898 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000013053 ENTREZGENE
  ENSRNOT00000013053.7 UniProtKB/Swiss-Prot
  ENSRNOT00055012198 UniProtKB/Swiss-Prot
  ENSRNOT00060029098 UniProtKB/Swiss-Prot
  ENSRNOT00065028204 UniProtKB/Swiss-Prot
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7446401 IMAGE-MGC_LOAD
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAPK_ERK3/4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:58840 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:124957 IMAGE-MGC_LOAD
NCBI Gene 58840 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MITOGEN-ACTIVATED PROTEIN KINASE 6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mapk6 PhenoGen
PRINTS ERK3ERK4MAPK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009381 RatGTEx
  ENSRNOG00055007320 RatGTEx
  ENSRNOG00060017014 RatGTEx
  ENSRNOG00065016898 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Protein kinase-like (PK-like) UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
TIGR TC205609
UniProt A6I1C7 ENTREZGENE, UniProtKB/TrEMBL
  MK06_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q32LY4 ENTREZGENE
UniProt Secondary Q32LY4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Mapk6  mitogen-activated protein kinase 6       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation tyrosine phosphorylated following insulin and Ngf treatment 61659