Ccnl1 (cyclin L1) - Rat Genome Database

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Gene: Ccnl1 (cyclin L1) Rattus norvegicus
Analyze
Symbol: Ccnl1
Name: cyclin L1
RGD ID: 620864
Description: Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in regulation of RNA splicing and regulation of transcription by RNA polymerase II. Located in nuclear speck. Orthologous to human CCNL1 (cyclin L1); INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ania-6a; Ccnl; cyclin Ania-6a; cyclin L; cyclin-L; cyclin-L1; cyclin-L1-like; LOC100909712; MGC93069
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82152,495,169 - 152,508,855 (-)NCBIGRCr8
mRatBN7.22150,184,865 - 150,199,524 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2150,184,798 - 150,197,368 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2157,294,697 - 157,307,010 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02155,345,203 - 155,357,516 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02149,977,917 - 149,990,230 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02157,747,295 - 157,759,838 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2157,747,542 - 157,759,838 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02177,110,678 - 177,122,977 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42155,757,335 - 155,769,633 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12155,707,300 - 155,719,596 (-)NCBI
Celera2144,599,445 - 144,611,743 (-)NCBICelera
Cytogenetic Map2q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetaldehyde  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
azoxystrobin  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (EXP)
caffeine  (ISO)
capsaicin  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
chrysene  (ISO)
clozapine  (EXP)
cocaine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dibutyl phthalate  (EXP)
doxorubicin  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glyphosate  (EXP)
haloperidol  (EXP)
imidacloprid  (EXP)
leflunomide  (ISO)
lipopolysaccharide  (EXP)
methamphetamine  (EXP)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mono(2-ethyl-5-oxohexyl) phthalate  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nefazodone  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (EXP)
rac-lactic acid  (ISO)
ranitidine  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin E  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. A complex program of striatal gene expression induced by dopaminergic stimulation. Berke JD, etal., J Neurosci 1998 Jul 15;18(14):5301-10.
2. Dopamine and glutamate induce distinct striatal splice forms of Ania-6, an RNA polymerase II-associated cyclin. Berke JD, etal., Neuron 2001 Oct 25;32(2):277-87.
3. Identification and characterization of the CDK12/cyclin L1 complex involved in alternative splicing regulation. Chen HH, etal., Mol Cell Biol. 2006 Apr;26(7):2736-45.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Regulation of ania-6 splice variants by distinct signaling pathways in striatal neurons. Sgambato V, etal., J Neurochem 2003 Jul;86(1):153-64.
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:17494991  


Genomics

Comparative Map Data
Ccnl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82152,495,169 - 152,508,855 (-)NCBIGRCr8
mRatBN7.22150,184,865 - 150,199,524 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2150,184,798 - 150,197,368 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2157,294,697 - 157,307,010 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02155,345,203 - 155,357,516 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02149,977,917 - 149,990,230 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02157,747,295 - 157,759,838 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2157,747,542 - 157,759,838 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02177,110,678 - 177,122,977 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42155,757,335 - 155,769,633 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12155,707,300 - 155,719,596 (-)NCBI
Celera2144,599,445 - 144,611,743 (-)NCBICelera
Cytogenetic Map2q31NCBI
CCNL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383157,143,121 - 157,160,147 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3157,146,508 - 157,160,760 (-)EnsemblGRCh38hg38GRCh38
GRCh373156,860,910 - 156,877,936 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363158,348,279 - 158,361,176 (-)NCBINCBI36Build 36hg18NCBI36
Build 343158,348,286 - 158,361,184NCBI
Celera3155,289,188 - 155,302,097 (-)NCBICelera
Cytogenetic Map3q25.31NCBI
HuRef3154,261,958 - 154,274,873 (-)NCBIHuRef
CHM1_13156,828,587 - 156,841,484 (-)NCBICHM1_1
T2T-CHM13v2.03159,917,663 - 159,934,689 (-)NCBIT2T-CHM13v2.0
Ccnl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39365,853,333 - 65,869,451 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl365,853,572 - 65,865,670 (-)EnsemblGRCm39 Ensembl
GRCm38365,945,908 - 65,962,029 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl365,946,151 - 65,958,249 (-)EnsemblGRCm38mm10GRCm38
MGSCv37365,750,073 - 65,762,147 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36366,034,080 - 66,046,148 (-)NCBIMGSCv36mm8
Celera366,084,322 - 66,096,395 (-)NCBICelera
Cytogenetic Map3E1NCBI
cM Map330.25NCBI
Ccnl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554488,113,216 - 8,124,628 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554488,112,774 - 8,125,912 (-)NCBIChiLan1.0ChiLan1.0
CCNL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22155,055,162 - 155,075,647 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13155,062,940 - 155,080,377 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03154,192,971 - 154,210,468 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13162,250,825 - 162,264,645 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3162,251,326 - 162,263,174 (-)Ensemblpanpan1.1panPan2
CCNL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12350,639,851 - 50,643,777 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2350,512,891 - 50,525,567 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02351,273,830 - 51,286,528 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2351,273,791 - 51,287,522 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12350,857,079 - 50,869,721 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02350,909,267 - 50,921,953 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02351,194,168 - 51,206,919 (-)NCBIUU_Cfam_GSD_1.0
Ccnl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560285,676,959 - 85,689,190 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365194,044,708 - 4,056,993 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365194,044,762 - 4,056,987 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCNL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1396,986,266 - 97,002,467 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11396,984,542 - 97,004,401 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213105,143,782 - 105,161,937 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CCNL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11533,592,391 - 33,608,124 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1533,593,500 - 33,609,195 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660416,181,869 - 6,195,601 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ccnl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473034,754,581 - 34,768,879 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473034,712,248 - 34,768,236 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ccnl1
40 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:233
Count of miRNA genes:159
Interacting mature miRNAs:186
Transcripts:ENSRNOT00000016016
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1354594Despr10Despair related QTL 100.00000249locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2114654253159654253Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2118111229157142209Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2118189491163189491Rat
1358360Sradr2Stress Responsive Adrenal Weight QTL 210.24adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)2129164097152195315Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2129540907174540907Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
1549828Bp258Blood pressure QTL 2580.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2142323368150650069Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2143657411190602963Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
631520Bp73Blood pressure QTL 730.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147686913168355276Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat

Markers in Region
T03514  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22150,185,151 - 150,185,341 (+)MAPPERmRatBN7.2
Rnor_6.02157,747,582 - 157,747,771NCBIRnor6.0
Rnor_5.02177,110,721 - 177,110,910UniSTSRnor5.0
RGSC_v3.42155,757,378 - 155,757,567UniSTSRGSC3.4
Celera2144,599,488 - 144,599,677UniSTS
Cytogenetic Map2q31UniSTS
RH130191  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22150,184,898 - 150,185,092 (+)MAPPERmRatBN7.2
Rnor_6.02157,747,329 - 157,747,522NCBIRnor6.0
Rnor_5.02177,110,468 - 177,110,661UniSTSRnor5.0
RGSC_v3.42155,757,125 - 155,757,318UniSTSRGSC3.4
Celera2144,599,235 - 144,599,428UniSTS
RH 3.4 Map2974.8UniSTS
Cytogenetic Map2q31UniSTS
RH143534  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22150,190,597 - 150,190,789 (+)MAPPERmRatBN7.2
Rnor_6.02157,753,028 - 157,753,219NCBIRnor6.0
Rnor_5.02177,116,167 - 177,116,358UniSTSRnor5.0
RGSC_v3.42155,762,824 - 155,763,015UniSTSRGSC3.4
Celera2144,604,933 - 144,605,124UniSTS
RH 3.4 Map2970.7UniSTS
Cytogenetic Map2q31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 42 57 41 19 41 7 7 74 35 41 11 7
Low 1 1 4 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010063577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF030091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC085686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC128699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC161817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB608234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000015763   ⟹   ENSRNOP00000015763
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2150,185,109 - 150,197,348 (-)Ensembl
Rnor_6.0 Ensembl2157,747,542 - 157,759,819 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000016016   ⟹   ENSRNOP00000016016
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2150,184,798 - 150,197,368 (-)Ensembl
Rnor_6.0 Ensembl2157,747,542 - 157,759,838 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109005   ⟹   ENSRNOP00000085346
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2150,184,798 - 150,197,368 (-)Ensembl
RefSeq Acc Id: NM_053662   ⟹   NP_446114
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82152,495,169 - 152,507,468 (-)NCBI
mRatBN7.22150,185,109 - 150,197,408 (-)NCBI
Rnor_6.02157,747,539 - 157,759,838 (-)NCBI
Rnor_5.02177,110,678 - 177,122,977 (-)NCBI
RGSC_v3.42155,757,335 - 155,769,633 (-)RGD
Celera2144,599,445 - 144,611,743 (-)RGD
Sequence:
RefSeq Acc Id: XM_063281136   ⟹   XP_063137206
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82152,495,169 - 152,506,168 (-)NCBI
RefSeq Acc Id: XM_063281137   ⟹   XP_063137207
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82152,495,169 - 152,506,201 (-)NCBI
RefSeq Acc Id: XM_063281138   ⟹   XP_063137208
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82152,498,342 - 152,508,855 (-)NCBI
RefSeq Acc Id: XM_063281139   ⟹   XP_063137209
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82152,500,549 - 152,508,825 (-)NCBI
RefSeq Acc Id: XM_063281140   ⟹   XP_063137210
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82152,500,549 - 152,508,829 (-)NCBI
RefSeq Acc Id: XR_010063577
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82152,500,549 - 152,508,824 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_446114   ⟸   NM_053662
- UniProtKB: Q5U364 (UniProtKB/Swiss-Prot),   Q9R1Q2 (UniProtKB/Swiss-Prot),   B1WBN1 (UniProtKB/TrEMBL),   A0A8I6A3Q0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000015763   ⟸   ENSRNOT00000015763
RefSeq Acc Id: ENSRNOP00000016016   ⟸   ENSRNOT00000016016
RefSeq Acc Id: ENSRNOP00000085346   ⟸   ENSRNOT00000109005
RefSeq Acc Id: XP_063137207   ⟸   XM_063281137
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063137206   ⟸   XM_063281136
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063137208   ⟸   XM_063281138
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063137210   ⟸   XM_063281140
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063137209   ⟸   XM_063281139
- Peptide Label: isoform X4
Protein Domains
Cyclin C-terminal   Cyclin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R1Q2-F1-model_v2 AlphaFold Q9R1Q2 1-527 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620864 AgrOrtholog
BioCyc Gene G2FUF-52881 BioCyc
Ensembl Genes ENSRNOG00000011586 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055004549 UniProtKB/Swiss-Prot
  ENSRNOG00060001293 UniProtKB/Swiss-Prot
  ENSRNOG00065025229 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015763.7 UniProtKB/TrEMBL
  ENSRNOT00000016016 ENTREZGENE
  ENSRNOT00000016016.6 UniProtKB/Swiss-Prot
  ENSRNOT00000109005.1 UniProtKB/TrEMBL
  ENSRNOT00055007204 UniProtKB/Swiss-Prot
  ENSRNOT00060001867 UniProtKB/Swiss-Prot
  ENSRNOT00065043471 UniProtKB/Swiss-Prot
Gene3D-CATH Cyclin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9022416 IMAGE-MGC_LOAD
InterPro Cyclin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin/Ssn8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin_C-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:114121 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:187267 IMAGE-MGC_LOAD
NCBI Gene 114121 ENTREZGENE
PANTHER PTHR10026 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10026:SF64 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cyclin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ccnl1 PhenoGen
PIRSF Cyclin_L UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011586 RatGTEx
  ENSRNOG00055004549 RatGTEx
  ENSRNOG00060001293 RatGTEx
  ENSRNOG00065025229 RatGTEx
SMART CYCLIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47954 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A3Q0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q7J2_RAT UniProtKB/TrEMBL
  B1WBN1 ENTREZGENE, UniProtKB/TrEMBL
  CCNL1_RAT UniProtKB/Swiss-Prot
  Q5U364 ENTREZGENE
  Q9R1Q2 ENTREZGENE
UniProt Secondary Q5U364 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Ccnl1  cyclin L1  LOC100909712  cyclin-L1-like  Data merged from RGD:6501887 737654 PROVISIONAL
2012-07-05 LOC100909712  cyclin-L1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Ccnl1  cyclin L1  Ccnl  cyclin L  Symbol and Name updated 1299863 APPROVED
2002-08-07 Ccnl  cyclin L      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to nuclear speckles 632453
gene_pathway may be induced by dopamine-activated signalling pathway 631964