Advanced Search (OLGA)

Gene: Arpc1a (actin related protein 2/3 complex, subunit 1A) Rattus norvegicus

Analyze

Symbol:

Arpc1a

Name:

actin related protein 2/3 complex, subunit 1A

RGD ID:

620834

Description:

Predicted to enable actin filament binding activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation. Predicted to be located in muscle cell projection membrane; nucleus; and site of double-strand break. Predicted to be part of Arp2/3 protein complex. Predicted to be active in glutamatergic synapse. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human ARPC1A (actin related protein 2/3 complex subunit 1A); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; Rab family mediated signaling pathway; Fc gamma receptor mediated signaling pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

actin-related protein 2/3 complex subunit 1A; LOC100360680; suppressor of profilin/p41 of actin-related complex 2/3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	14,616,245 - 14,639,052 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	14,616,248 - 14,639,052 (-)	Ensembl				GRCr8
mRatBN7.2	12	9,502,496 - 9,525,304 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	9,502,501 - 9,525,330 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	10,307,262 - 10,330,326 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	10,930,465 - 10,953,529 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	9,953,893 - 9,976,958 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	11,272,609 - 11,294,084 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	11,272,609 - 11,294,058 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	13,341,711 - 13,363,473 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Celera	12	11,307,305 - 11,329,866 (-)	NCBI		Celera
RGSC_v3.1	12	9,846,583 - 9,863,837 (-)	NCBI
Cytogenetic Map	12	p11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

pancreatic cancer (ISO)

schizophrenia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane (EXP,ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-tribromophenol (ISO)

4,4'-sulfonyldiphenol (ISO)

actinomycin D (ISO)

all-trans-retinoic acid (ISO)

aristolochic acid A (ISO)

Aroclor 1254 (ISO)

azoxystrobin (EXP)

benzene (ISO)

bisphenol A (EXP,ISO)

cannabidiol (EXP)

CGP 52608 (ISO)

chloropicrin (ISO)

chlorpyrifos (EXP)

cisplatin (ISO)

cocaine (EXP)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

DDE (ISO)

dibutyl phthalate (ISO)

elemental selenium (ISO)

enzyme inhibitor (ISO)

folic acid (ISO)

fulvestrant (ISO)

gentamycin (EXP)

glyphosate (EXP)

imidacloprid (EXP)

ivermectin (ISO)

lead(0) (ISO)

methidathion (ISO)

methoxychlor (EXP)

microcystin-LR (EXP)

nitrates (ISO)

Nutlin-3 (ISO)

ozone (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

SB 431542 (ISO)

selenium atom (ISO)

sodium arsenite (ISO)

tert-butyl hydroperoxide (ISO)

thiabendazole (EXP)

trichloroethene (EXP)

triphenyl phosphate (ISO)

valproic acid (ISO)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

Arp2/3 complex-mediated actin nucleation (IBA,IEA,ISO)

biological_process (ND)

Cellular Component

actin cytoskeleton (IEA)

Arp2/3 protein complex (IBA,IEA,ISS)

cytoskeleton (IEA)

glutamatergic synapse (IEA,ISO)

muscle cell projection membrane (IEA,ISO)

nucleus (IEA,ISS)

site of double-strand break (ISS)

synapse (IEA,ISO)

Molecular Function

actin binding (IEA)

actin filament binding (IBA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

Fc gamma receptor mediated signaling pathway (IEA)

insulin responsive facilitative sugar transporter mediated glucose transport pathway (ISO)

Rab family mediated signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Arp2/3- and cofilin-coordinated actin dynamics is required for insulin-mediated GLUT4 translocation to the surface of muscle cells.	Chiu TT, etal., Mol Biol Cell. 2010 Oct 15;21(20):3529-39. doi: 10.1091/mbc.E10-04-0316. Epub 2010 Aug 25.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Characterization of the 7q21-q22 amplicon identifies ARPC1A, a subunit of the Arp2/3 complex, as a regulator of cell migration and invasion in pancreatic cancer.	Laurila E, etal., Genes Chromosomes Cancer. 2009 Apr;48(4):330-9.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
7.	Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress.	Prabakaran S, etal., Mol Psychiatry. 2004 Jul;9(7):684-97, 643.
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:8889548	PMID:12477932	PMID:17086175	PMID:19056867	PMID:22553210	PMID:22871113	PMID:23376485

Genomics

Comparative Map Data

Arpc1a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	14,616,245 - 14,639,052 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	14,616,248 - 14,639,052 (-)	Ensembl				GRCr8
mRatBN7.2	12	9,502,496 - 9,525,304 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	9,502,501 - 9,525,330 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	10,307,262 - 10,330,326 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	10,930,465 - 10,953,529 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	9,953,893 - 9,976,958 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	11,272,609 - 11,294,084 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	11,272,609 - 11,294,058 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	13,341,711 - 13,363,473 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Celera	12	11,307,305 - 11,329,866 (-)	NCBI		Celera
RGSC_v3.1	12	9,846,583 - 9,863,837 (-)	NCBI
Cytogenetic Map	12	p11	NCBI

ARPC1A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	99,325,898 - 99,366,262 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	99,325,880 - 99,366,267 (+)	Ensembl			hg38	GRCh38
GRCh37	7	98,923,521 - 98,963,885 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	98,761,446 - 98,801,821 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	7	98,568,160 - 98,608,538	NCBI
Celera	7	93,657,670 - 93,698,057 (+)	NCBI		Celera
Cytogenetic Map	7	q22.1	NCBI
HuRef	7	93,559,314 - 93,599,623 (+)	NCBI		HuRef
CHM1_1	7	98,853,571 - 98,893,965 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	100,564,792 - 100,605,160 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	98,283,446 - 98,323,834 (+)	NCBI

Arpc1a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	145,020,679 - 145,045,566 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	145,020,640 - 145,045,571 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	145,083,869 - 145,108,756 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	145,083,830 - 145,108,761 (+)	Ensembl			mm10	GRCm38
MGSCv37	5	145,844,738 - 145,869,625 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	145,337,396 - 145,362,283 (+)	NCBI		MGSCv36	mm8
Celera	5	142,075,658 - 142,100,687 (+)	NCBI		Celera
Cytogenetic Map	5	G2	NCBI
cM Map	5	85.0	NCBI

Arpc1a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955460	15,023,221 - 15,051,115 (+)	Ensembl
ChiLan1.0	NW_004955460	15,022,663 - 15,050,955 (+)	NCBI	ChiLan1.0	ChiLan1.0

ARPC1A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	117,183,767 - 117,223,936 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	165,448,403 - 165,488,570 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	91,299,559 - 91,339,729 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	104,801,399 - 104,841,590 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	104,801,399 - 104,841,590 (+)	Ensembl			panPan2	panpan1.1

ARPC1A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	10,212,203 - 10,245,112 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	10,212,494 - 10,245,073 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	11,838,931 - 11,871,811 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	10,212,409 - 10,245,315 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	10,212,412 - 10,245,312 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	10,082,332 - 10,115,224 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	10,060,836 - 10,093,722 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	10,294,657 - 10,327,563 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Arpc1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	138,300,216 - 138,334,198 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936750	1,611,030 - 1,646,608 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936750	1,611,082 - 1,645,045 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ARPC1A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	6,296,278 - 6,324,524 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	3	6,296,257 - 6,324,526 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	6,434,509 - 6,462,700 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ARPC1A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	28	13,793,196 - 13,833,254 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	28	13,764,945 - 13,825,815 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666070	2,470,717 - 2,509,959 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Arpc1a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624740	32,771,885 - 32,805,516 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624740	32,771,870 - 32,801,047 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Arpc1a
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	16	8,187,462 - 8,209,667 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Arpc1a
112 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	109
Count of miRNA genes:	93
Interacting mature miRNAs:	99
Transcripts:	ENSRNOT00000001319, ENSRNOT00000066198
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2312418	Kidm41	Kidney mass QTL 41	3.7	0.0001	kidney mass (VT:0002707)	single kidney wet weight to body weight ratio (CMO:0000622)	12	5921918	25247790	Rat
70213	Niddm27	Non-insulin dependent diabetes mellitus QTL 27	3.72		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	11200494	52308831	Rat
2306789	Ean6	Experimental allergic neuritis QTL 6	4.9		nervous system integrity trait (VT:0010566)	experimental autoimmune neuritis severity score (CMO:0001528)	12	1	29775522	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
1357337	Gluco3	Glucose level QTL 3		0.0004	adipocyte glucose uptake trait (VT:0004185)	absolute change in adipocyte glucose uptake (CMO:0000873)	12	1	16966671	Rat
5684888	Pia42	Pristane induced arthritis QTL 42			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	3489416	48489416	Rat
1331739	Hrtrt14	Heart rate QTL 14	3.56232		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	12	1	38687564	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200497	52308831	Rat
61331	Eau2	Experimental allergic uveoretinitis QTL 2		0.0005	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	12	1	33700600	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	11743528	52308831	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
1581516	Cm56	Cardiac mass QTL 56	4.2	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	12	11869600	16966542	Rat
61334	Gluco17	Glucose level QTL 17	6.3		adipocyte glucose uptake trait (VT:0004185)	adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)	12	1	16966671	Rat
2293684	Bmd26	Bone mineral density QTL 26	4.4	0.0002	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	12	1	38635130	Rat
6893681	Bw109	Body weight QTL 109	2.3	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	12	1	28133365	Rat
1302792	Scl21	Serum cholesterol level QTL 21	3.8	0.0011	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	12	12233000	30490641	Rat
1300174	Bw15	Body weight QTL 15	2.93		body mass (VT:0001259)	body weight loss (CMO:0001399)	12	1	28606299	Rat
1331787	Rf41	Renal function QTL 41	2.998		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	12	1	33700556	Rat
724526	Uae3	Urinary albumin excretion QTL 3	4.9	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	12	1	15486827	Rat
1331763	Wbc2	White blood cell count QTL 2	3.162		leukocyte quantity (VT:0000217)	total white blood cell count (CMO:0000365)	12	11200494	52308831	Rat
7204484	Bp358	Blood pressure QTL 358		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	1	24849755	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	11200494	52308831	Rat
7387292	Kidm42	Kidney mass QTL 42	3.03	0.0004	kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	12	1	41361854	Rat
1298081	Cia25	Collagen induced arthritis QTL 25	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	2747694	47747694	Rat
2303568	Bw88	Body weight QTL 88	3		body mass (VT:0001259)	body weight (CMO:0000012)	12	1	28606299	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	3087180	48087180	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7243862	Mcs30	Mammary carcinoma susceptibility QTL 30	8.62		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	12	5633306	50633306	Rat
2293086	Iddm30	Insulin dependent diabetes mellitus QTL 30	3.82		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	7901625	33938215	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat

Markers in Region

D12Got101

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	9,526,882 - 9,527,086 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	11,295,663 - 11,295,866	NCBI	Rnor6.0
Rnor_5.0	12	13,365,052 - 13,365,255	UniSTS	Rnor5.0
RGSC_v3.4	12	9,840,695 - 9,840,898	RGD	RGSC3.4
RGSC_v3.4	12	9,840,696 - 9,840,899	UniSTS	RGSC3.4
Celera	12	11,331,436 - 11,331,639	UniSTS
RGSC_v3.1	12	9,870,623 - 9,870,826	RGD
RH 3.4 Map	12	102.3	UniSTS
RH 3.4 Map	12	102.3	RGD
RH 2.0 Map	12	96.4	RGD
Cytogenetic Map	12	p11	UniSTS

RH128130

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	9,502,533 - 9,502,749 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	11,272,647 - 11,272,862	NCBI	Rnor6.0
Rnor_5.0	12	13,341,749 - 13,341,964	UniSTS	Rnor5.0
Celera	12	11,307,343 - 11,307,558	UniSTS
RH 3.4 Map	12	121.4	UniSTS
Cytogenetic Map	12	p11	UniSTS

RH125677

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	9,502,598 - 9,502,761 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	11,272,712 - 11,272,874	NCBI	Rnor6.0
Rnor_5.0	12	13,341,814 - 13,341,976	UniSTS	Rnor5.0
Celera	12	11,307,408 - 11,307,570	UniSTS
Cytogenetic Map	12	p11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_031146	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF315378	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC059131	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB327105	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CO396710	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CO562802	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DY310102	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ214345	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000001319 ⟹ ENSRNOP00000001319

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	14,618,514 - 14,639,052 (-)	Ensembl
mRatBN7.2 Ensembl	12	9,504,765 - 9,525,309 (-)	Ensembl
Rnor_6.0 Ensembl	12	11,277,338 - 11,294,058 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000076021 ⟹ ENSRNOP00000068218

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	14,616,248 - 14,638,984 (-)	Ensembl
mRatBN7.2 Ensembl	12	9,502,501 - 9,525,308 (-)	Ensembl
Rnor_6.0 Ensembl	12	11,272,609 - 11,272,997 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000106194 ⟹ ENSRNOP00000088601

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	9,502,564 - 9,516,775 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000117369 ⟹ ENSRNOP00000077939

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	14,616,248 - 14,639,052 (-)	Ensembl
mRatBN7.2 Ensembl	12	9,502,502 - 9,525,330 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000119670 ⟹ ENSRNOP00000086469

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	9,511,287 - 9,525,330 (-)	Ensembl

RefSeq Acc Id:

NM_031146 ⟹ NP_112408

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	14,616,245 - 14,639,052 (-)	NCBI
mRatBN7.2	12	9,502,496 - 9,525,304 (-)	NCBI
Rnor_6.0	12	11,272,609 - 11,294,084 (-)	NCBI
Rnor_5.0	12	13,341,711 - 13,363,473 (-)	NCBI
Celera	12	11,307,305 - 11,329,866 (-)	RGD

Sequence:

show sequence

CTGTCAGCCGCTCCCTCTAGGCCTCCCTCCTCCGTCCGCGCCCGCCGGAGCCTGTTCGCGTCGA
CTGACCAGAGTCCGCGAATCGTTCGCTCCGGACCTCCCGACCTCCCCTACCCCAGCTTTCTGAC
CTGTGAAAACACGTAGGAATCATGTCTCTGCATCAGTTTCTGCTAGAGCCAATCACCTGCCATG
CCTGGAACAGGGATCGGACCCAGATCGCACTGAGCCCCAATAATCATGAAGTGCACATCTACAA
GAAGAATGGGAGTCAGTGGACGAAAGCTCACGAGCTGAAGGAACATAACGGACACATCACAGGT
ATTGACTGGGCTCCTAAGAGCGACCGTATTGTCACTTGTGGGGCGGACCGCAACGCCTATGTCT
GGAGTCAGAAAGATGGCATCTGGAAGCCGACCCTGGTGATCCTGAGGATTAACCGTGCAGCCAC
TTTCGTGAAGTGGTCTCCACTCGAGAACAAGTTTGCTGTGGGGAGTGGAGCCCGGCTCATCTCT
GTCTGCTACTTTGAGTCTGAAAATGACTGGTGGGTCAGCAAGCACATTAAGAAGCCGATCCGCT
CCACAGTCCTCAGCCTGGACTGGCATCCCAACAACGTTTTGCTGGCTGCAGGCTCCTGTGACTT
CAAATGCAGAGTATTTTCGGCCTACATCAAAGAGGTGGATGAGAAGCCAGCCAGCACGCCCTGG
GGCAGCAAGATGCCTTTTGGTCAGCTGATGTCTGAGTTTGGTGGCAGTGGCACTGGTGGCTGGG
TGCACGGGGTCAGCTTCTCTGCCAGTGGGAGCCGGCTGGCCTGGGTCAGCCACGACAGCACAGT
GTCTGTCGCTGATGCCTCAAAAAGTGTGCAGGTTTCAACTCTGAGAACGGAGTTCCTGCCGCTG
CTCAGTGTGTCATTTGTCTCAGAGAACAGCGTTGTGGCTGCCGGCCATGACTGCTGCCCGATGC
TCTTTAACTACGATGACCGTGGCTGTTTGACCTTTGTGTCCAAGCTAGACGTCCCAAAACAGAG
CATCCAGCGCAACATGTCTGCTATGGAACGCTTCCGTAACATGGATAAGAGGGCCACTACCGAG
GACCGCAACACAGCCTTGGAAACACTGCACCAGAACAGCATCACTCAAGTGTCTATTTATGAAG
TGGACAAGCAAGATTGTCGCAAATTTTGCACTACTGGCATCGATGGAGCCATGACAATCTGGGA
TTTCAAGACTCTAGAGTCTTCCATCCAGGGTCTCCGGATAATGTGAAGCCGAGTGAGCCTCTGC
CATCCAGCATGAGGAACGGGACTGAGCAGTCTGCCTGCCGTTCACATGGTGGTGAGGATCCTGG
CCCCAGGAAACACTGTCACACTGAAGCCACTAGCGTGTATCCGTGTGGATGTCGTGGGCGAAGC
GTGGGATTTAGAGCAGCAGTGGTTTGTTTTGCTTTTTCTTTCATTTTGTTTTGTTTTGTTTTGA
TTTTGCTATCTCATTCCATTTTTGACCAAAGCTTCTCTTTAAGTAGTTTATTATGGAAGATTGT
CACACTAACTTAAAGGGGAAGGGACGTGTGTACATTGTGTGCTAAAAAAATTAAAGAAAAATCC
CAAGTGTGCAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_112408	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH59131	(Get FASTA)	NCBI Sequence Viewer
	AAK01364	(Get FASTA)	NCBI Sequence Viewer
	EDL89620	(Get FASTA)	NCBI Sequence Viewer
	EDL89621	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000077939
GenBank Protein	Q99PD4	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_112408 ⟸ NM_031146

- UniProtKB:

Q99PD4 (UniProtKB/Swiss-Prot), A6K1G3 (UniProtKB/TrEMBL), A0A8I5Y805 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSLHQFLLEPITCHAWNRDRTQIALSPNNHEVHIYKKNGSQWTKAHELKEHNGHITGIDWAPKS
DRIVTCGADRNAYVWSQKDGIWKPTLVILRINRAATFVKWSPLENKFAVGSGARLISVCYFESE
NDWWVSKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFSAYIKEVDEKPASTPWGSKMPFG
QLMSEFGGSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLRTEFLPLLSVSFVS
ENSVVAAGHDCCPMLFNYDDRGCLTFVSKLDVPKQSIQRNMSAMERFRNMDKRATTEDRNTALE
TLHQNSITQVSIYEVDKQDCRKFCTTGIDGAMTIWDFKTLESSIQGLRIM

hide sequence

Ensembl Acc Id:

ENSRNOP00000001319 ⟸ ENSRNOT00000001319

Ensembl Acc Id:

ENSRNOP00000068218 ⟸ ENSRNOT00000076021

Ensembl Acc Id:

ENSRNOP00000086469 ⟸ ENSRNOT00000119670

Ensembl Acc Id:

ENSRNOP00000077939 ⟸ ENSRNOT00000117369

Ensembl Acc Id:

ENSRNOP00000088601 ⟸ ENSRNOT00000106194

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q99PD4-F1-model_v2	AlphaFold	Q99PD4	1-370	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698420

Promoter ID:

EPDNEW_R8944

Type:

initiation region

Name:

Arpc1a_1

Description:

actin related protein 2/3 complex, subunit 1A

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	12	11,294,058 - 11,294,118	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620834	AgrOrtholog
BioCyc Gene	G2FUF-20054	BioCyc
Ensembl Genes	ENSRNOG00000000996	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000117369	ENTREZGENE
Gene3D-CATH	2.130.10.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:6921520	IMAGE-MGC_LOAD
InterPro	ARPC1	UniProtKB/Swiss-Prot
	WD40/YVTN_repeat-like_dom_sf	UniProtKB/Swiss-Prot
	WD40_repeat	UniProtKB/Swiss-Prot
	WD40_repeat_dom_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:81824	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:72782	IMAGE-MGC_LOAD
NCBI Gene	81824	ENTREZGENE
PANTHER	PTHR10709	UniProtKB/Swiss-Prot
	PTHR10709:SF11	UniProtKB/Swiss-Prot
Pfam	WD40	UniProtKB/Swiss-Prot
PhenoGen	Arpc1a	PhenoGen
PIRSF	ARP2/3_su1	UniProtKB/Swiss-Prot
PROSITE	WD_REPEATS_2	UniProtKB/Swiss-Prot
	WD_REPEATS_REGION	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000000996	RatGTEx
SMART	WD40	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF50978	UniProtKB/Swiss-Prot
UniProt	A0A096MJQ1_RAT	UniProtKB/TrEMBL
	A0A8I5Y805	ENTREZGENE, UniProtKB/TrEMBL
	A6K1G3	ENTREZGENE, UniProtKB/TrEMBL
	ARC1A_RAT	UniProtKB/Swiss-Prot
	D3ZXP7_RAT	UniProtKB/TrEMBL
	Q6PCU9_RAT	UniProtKB/TrEMBL
	Q99PD4	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-04-17	Arpc1a	actin related protein 2/3 complex, subunit 1A	LOC100360680	actin related protein 2/3 complex, subunit 1A	Data merged from RGD:2321677	737654	PROVISIONAL
2010-05-06	LOC100360680	actin related protein 2/3 complex, subunit 1A			Symbol and Name status set to provisional	70820	PROVISIONAL
2005-01-20	Arpc1a	actin related protein 2/3 complex, subunit 1A		suppressor of profilin/p41 of actin-related complex 2/3	Name updated	1299863	APPROVED
2002-08-07	Arpc1a	suppressor of profilin/p41 of actin-related complex 2/3			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Send us a Message

RGD Manual Annotations

Imported Annotations - KEGG (archival)