Kcna6 (potassium voltage-gated channel subfamily A member 6) - Rat Genome Database

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Gene: Kcna6 (potassium voltage-gated channel subfamily A member 6) Rattus norvegicus
Analyze
Symbol: Kcna6
Name: potassium voltage-gated channel subfamily A member 6
RGD ID: 62083
Description: Enables delayed rectifier potassium channel activity. Involved in potassium ion transmembrane transport. Located in plasma membrane. Part of voltage-gated potassium channel complex. Orthologous to human KCNA6 (potassium voltage-gated channel subfamily A member 6); INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 4,4'-sulfonyldiphenol; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Kv1.6; kv2; potassium channel, voltage gated shaker related subfamily A, member 6; potassium channel-Kv2; potassium voltage gated channel shaker related subfamily member 6; potassium voltage gated channel, shaker related subfamily, member 6; RCK2; voltage-gated potassium channel subunit Kv1.6; voltage-gated potassium channel subunit Kv2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84161,229,103 - 161,262,352 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4161,191,961 - 161,263,240 (-)EnsemblGRCr8
mRatBN7.24159,542,941 - 159,576,189 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4159,542,615 - 159,576,189 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4165,772,732 - 165,805,991 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04161,555,642 - 161,588,899 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04160,189,668 - 160,222,923 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04159,253,934 - 159,287,193 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4159,253,934 - 159,287,193 (-)Ensemblrn6Rnor6.0
Rnor_5.04232,324,385 - 232,357,644 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44163,087,398 - 163,125,320 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4148,259,785 - 148,292,606 (-)NCBICelera
RGSC_v3.14163,366,297 - 163,369,040 (-)NCBI
Cytogenetic Map4q42NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Cloning and expression of a human voltage-gated potassium channel. A novel member of the RCK potassium channel family. Grupe A, etal., EMBO J 1990 Jun;9(6):1749-56.
4. Electrophysiological characterization of a new member of the RCK family of rat brain K+ channels. Kirsch GE, etal., FEBS Lett. 1991 Jan 14;278(1):55-60. doi: 10.1016/0014-5793(91)80082-e.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Heteromultimeric Kv1 channels contribute to myogenic control of arterial diameter. Plane F, etal., Circ Res. 2005 Feb 4;96(2):216-24. Epub 2004 Dec 23.
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Association and colocalization of the Kvbeta1 and Kvbeta2 beta-subunits with Kv1 alpha-subunits in mammalian brain K+ channel complexes. Rhodes KJ, etal., J Neurosci. 1997 Nov 1;17(21):8246-58.
12. PDGF upregulates delayed rectifier via Src family kinases and sphingosine kinase in oligodendroglial progenitors. Soliven B, etal., Am J Physiol Cell Physiol 2003 Jan;284(1):C85-93.
Additional References at PubMed
PMID:2361015   PMID:16624997   PMID:21233214   PMID:21352098   PMID:22079321   PMID:22871113   PMID:24924920   PMID:38043654  


Genomics

Comparative Map Data
Kcna6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84161,229,103 - 161,262,352 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4161,191,961 - 161,263,240 (-)EnsemblGRCr8
mRatBN7.24159,542,941 - 159,576,189 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4159,542,615 - 159,576,189 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4165,772,732 - 165,805,991 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04161,555,642 - 161,588,899 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04160,189,668 - 160,222,923 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04159,253,934 - 159,287,193 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4159,253,934 - 159,287,193 (-)Ensemblrn6Rnor6.0
Rnor_5.04232,324,385 - 232,357,644 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44163,087,398 - 163,125,320 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4148,259,785 - 148,292,606 (-)NCBICelera
RGSC_v3.14163,366,297 - 163,369,040 (-)NCBI
Cytogenetic Map4q42NCBI
KCNA6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38124,809,334 - 4,851,112 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl124,809,334 - 4,813,318 (+)Ensemblhg38GRCh38
GRCh37124,918,500 - 4,960,278 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36124,788,603 - 4,792,839 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34124,788,602 - 4,792,839NCBI
Celera126,540,177 - 6,582,117 (+)NCBICelera
Cytogenetic Map12p13.32NCBI
HuRef124,775,114 - 4,817,084 (+)NCBIHuRef
CHM1_1124,917,927 - 4,959,949 (+)NCBICHM1_1
T2T-CHM13v2.0124,816,353 - 4,858,155 (+)NCBIT2T-CHM13v2.0
Kcna6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396126,685,292 - 126,717,610 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6126,685,292 - 126,717,637 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm386126,708,328 - 126,740,834 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6126,708,329 - 126,740,674 (-)Ensemblmm10GRCm38
MGSCv376126,658,347 - 126,690,692 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv366126,702,307 - 126,705,772 (-)NCBIMGSCv36mm8
Celera6128,378,065 - 128,410,554 (-)NCBICelera
Cytogenetic Map6F3NCBI
cM Map661.72NCBI
Kcna6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554132,614,685 - 2,676,292 (+)Ensembl
ChiLan1.0NW_0049554132,614,685 - 2,676,292 (+)NCBIChiLan1.0ChiLan1.0
KCNA6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21010,356,962 - 10,362,502 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11210,351,747 - 10,357,884 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0124,926,069 - 4,968,475 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1124,846,651 - 4,889,190 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl124,847,510 - 4,849,099 (+)EnsemblpanPan2panpan1.1
KCNA6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12740,042,051 - 40,045,812 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2740,044,334 - 40,045,812 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha276,635,593 - 6,639,492 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02740,397,855 - 40,401,770 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2740,400,162 - 40,401,748 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12740,286,847 - 40,290,747 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02740,311,960 - 40,315,859 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0276,046,284 - 6,050,185 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Kcna6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945104,211,782 - 104,214,883 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366064,969,787 - 4,971,446 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366064,969,282 - 4,972,383 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNA6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl565,657,225 - 65,658,835 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1565,625,581 - 65,659,557 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2567,830,814 - 67,865,506 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNA6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1114,853,706 - 4,894,406 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl114,854,570 - 4,856,162 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660633,352,889 - 3,393,600 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcna6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248601,835,685 - 1,867,104 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248601,835,679 - 1,867,606 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Kcna6
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1621,157,788 - 21,191,522 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Kcna6
167 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:360
Count of miRNA genes:193
Interacting mature miRNAs:228
Transcripts:ENSRNOT00000075771
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4146370897184426481Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4134095016179095016Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4149763204169799698Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4146370897184426481Rat
6478757Anxrr44Anxiety related response QTL 440.01087locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
1358364Sradr4Stress Responsive Adrenal Weight QTL 44.92adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)4131384565176384565Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4123870974168870974Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4117559384162559384Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4140059299181024663Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4157292416184426481Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4106848959168870974Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4127263297172263297Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4126334185171334185Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4147299608184426481Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
6478782Anxrr52Anxiety related response QTL 520.02091locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4124700988169700988Rat
6478720Alc23Alcohol consumption QTL 230.00509drinking behavior trait (VT:0001422)ethanol drink intake rate to body weight ratio (CMO:0001616)4155834926184426481Rat
6478785Anxrr53Anxiety related response QTL 530.01397locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1581566Eae21Experimental allergic encephalomyelitis QTL 216.2body mass (VT:0001259)maximum body weight loss to initial body weight ratio (CMO:0001400)4137447185182447185Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4137430611182430611Rat
6478728Anxrr36Anxiety related response QTL 360.01061locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4134199006168870974Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4148121375176967367Rat
6478733Anxrr37Anxiety related response QTL 370.00095locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
6478737Anxrr38Anxiety related response QTL 380.00159locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4160623982184426481Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4148834094168870974Rat

Markers in Region
D4Got133  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24159,549,565 - 159,549,725 (+)MAPPERmRatBN7.2
Rnor_6.04159,260,569 - 159,260,728NCBIRnor6.0
Rnor_5.04232,350,850 - 232,351,009UniSTSRnor5.0
RGSC_v3.44163,094,025 - 163,094,184UniSTSRGSC3.4
RGSC_v3.44163,094,024 - 163,094,184RGDRGSC3.4
RGSC_v3.14163,338,961 - 163,339,120RGD
RH 3.4 Map41003.8UniSTS
RH 3.4 Map41003.8RGD
Cytogenetic Map4q42UniSTS
RH132337  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24159,543,035 - 159,543,240 (+)MAPPERmRatBN7.2
Rnor_6.04159,254,029 - 159,254,233NCBIRnor6.0
Rnor_5.04232,357,345 - 232,357,549UniSTSRnor5.0
RGSC_v3.44163,087,493 - 163,087,697UniSTSRGSC3.4
Celera4148,259,880 - 148,260,084UniSTS
RH 3.4 Map41009.1UniSTS
Cytogenetic Map4q42UniSTS
BE107724  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24159,576,690 - 159,576,854 (+)MAPPERmRatBN7.2
Rnor_6.04159,287,695 - 159,287,858NCBIRnor6.0
Rnor_5.04232,323,720 - 232,323,883UniSTSRnor5.0
RGSC_v3.44163,125,822 - 163,125,985UniSTSRGSC3.4
Celera4148,293,108 - 148,293,271UniSTS
RH 3.4 Map41008.6UniSTS
Cytogenetic Map4q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 6 62 157 54 56 26 21 26 5 196 104 9 140 44 79 30 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000080139   ⟹   ENSRNOP00000071895
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4161,228,563 - 161,263,240 (-)Ensembl
mRatBN7.2 Ensembl4159,542,941 - 159,576,189 (-)Ensembl
Rnor_6.0 Ensembl4159,253,934 - 159,287,193 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097393   ⟹   ENSRNOP00000086088
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4161,229,134 - 161,261,433 (-)Ensembl
mRatBN7.2 Ensembl4159,542,615 - 159,575,340 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104566   ⟹   ENSRNOP00000086058
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4161,211,313 - 161,261,890 (-)Ensembl
mRatBN7.2 Ensembl4159,567,014 - 159,575,340 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000124646   ⟹   ENSRNOP00000106338
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4161,191,961 - 161,261,890 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000168228   ⟹   ENSRNOP00000099542
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4161,210,443 - 161,262,891 (-)Ensembl
RefSeq Acc Id: NM_023954   ⟹   NP_076444
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84161,229,103 - 161,262,352 (-)NCBI
mRatBN7.24159,542,941 - 159,576,189 (-)NCBI
Rnor_6.04159,253,934 - 159,287,193 (-)NCBI
Rnor_5.04232,324,385 - 232,357,644 (+)NCBI
RGSC_v3.44163,087,398 - 163,125,320 (-)RGD
Celera4148,259,785 - 148,292,606 (-)RGD
Sequence:
RefSeq Acc Id: XM_063286664   ⟹   XP_063142734
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84161,229,104 - 161,261,497 (-)NCBI
Protein Sequences
Protein RefSeqs NP_076444 (Get FASTA)   NCBI Sequence Viewer  
  XP_063142734 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41499 (Get FASTA)   NCBI Sequence Viewer  
  CAC03592 (Get FASTA)   NCBI Sequence Viewer  
  EDM01828 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000071895
GenBank Protein P17659 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_076444   ⟸   NM_023954
- UniProtKB: P19025 (UniProtKB/Swiss-Prot),   P17659 (UniProtKB/Swiss-Prot),   G3V8L6 (UniProtKB/TrEMBL),   A6ILW1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071895   ⟸   ENSRNOT00000080139
Ensembl Acc Id: ENSRNOP00000086058   ⟸   ENSRNOT00000104566
Ensembl Acc Id: ENSRNOP00000086088   ⟸   ENSRNOT00000097393
RefSeq Acc Id: XP_063142734   ⟸   XM_063286664
- Peptide Label: isoform X1
- UniProtKB: P19025 (UniProtKB/Swiss-Prot),   P17659 (UniProtKB/Swiss-Prot),   A6ILW1 (UniProtKB/TrEMBL),   G3V8L6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000099542   ⟸   ENSRNOT00000168228
Ensembl Acc Id: ENSRNOP00000106338   ⟸   ENSRNOT00000124646
Protein Domains
BTB   Ion transport

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P17659-F1-model_v2 AlphaFold P17659 1-530 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62083 AgrOrtholog
BioCyc Gene G2FUF-42963 BioCyc
Ensembl Genes ENSRNOG00000052486 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000080139 ENTREZGENE
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot
  1.20.120.350 UniProtKB/Swiss-Prot
  Potassium Channel Kv1.1, Chain A UniProtKB/Swiss-Prot
InterPro BTB/POZ_dom UniProtKB/Swiss-Prot
  Ion_trans_dom UniProtKB/Swiss-Prot
  K_chnl_volt-dep_Kv UniProtKB/Swiss-Prot
  K_chnl_volt-dep_Kv1 UniProtKB/Swiss-Prot
  K_chnl_volt-dep_Kv1.6 UniProtKB/Swiss-Prot
  KCNA6_BTB_POZ UniProtKB/Swiss-Prot
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot
  T1-type_BTB UniProtKB/Swiss-Prot
  VG_K_chnl UniProtKB/Swiss-Prot
  Volt_channel_dom_sf UniProtKB/Swiss-Prot
NCBI Gene 64358 ENTREZGENE
PANTHER PTHR11537 UniProtKB/Swiss-Prot
  PTHR11537:SF104 UniProtKB/Swiss-Prot
Pfam BTB_2 UniProtKB/Swiss-Prot
  Ion_trans UniProtKB/Swiss-Prot
PhenoGen Kcna6 PhenoGen
PRINTS KCHANNEL UniProtKB/Swiss-Prot
  KV16CHANNEL UniProtKB/Swiss-Prot
  KVCHANNEL UniProtKB/Swiss-Prot
  SHAKERCHANEL UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000052486 RatGTEx
SMART BTB UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54695 UniProtKB/Swiss-Prot
  Voltage-gated potassium channels UniProtKB/Swiss-Prot
UniProt A6ILW1 ENTREZGENE, UniProtKB/TrEMBL
  G3V8L6 ENTREZGENE, UniProtKB/TrEMBL
  KCNA6_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  P19025 ENTREZGENE
  Q9ESW1_RAT UniProtKB/TrEMBL
UniProt Secondary P19025 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcna6  potassium voltage-gated channel subfamily A member 6  Kcna6  potassium channel, voltage gated shaker related subfamily A, member 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcna6  potassium channel, voltage gated shaker related subfamily A, member 6  Kcna6  potassium voltage gated channel, shaker related subfamily, member 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Kcna6  potassium voltage gated channel, shaker related subfamily, member 6       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in midbrain areas and brainstem 61641
gene_function voltage-gated potassium channel subunit 628546
gene_process may act on cell cycle progression by affecting membrane potential, cell volume regulation, intracellular calcium levlels or Cdk inhibitor levels 628546
gene_process involved in cell survival, cell cycle progression, membrane excitability and secretory function 628546
gene_regulation expression induced by platelet-derived growth factor (Pdgf) and basic fibroblast growth factor 628546