Cgrrf1 (cell growth regulator with ring finger domain 1)

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Gene: Cgrrf1 (cell growth regulator with ring finger domain 1) Rattus norvegicus

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Symbol:

Cgrrf1

Name:

cell growth regulator with ring finger domain 1

RGD ID:

620803

Description:

Predicted to enable metal ion binding activity. Involved in negative regulation of cell growth. Predicted to be located in endoplasmic reticulum and nucleoplasm. Orthologous to human CGRRF1 (cell growth regulator with ring finger domain 1); INTERACTS WITH 1,2,4-trimethylbenzene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

cell growth regulator with RING finger domain protein 1; cell growth regulatory gene 19 protein; cell growth regulatory with ring finger domain; Cgr19; MGC93274

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	22,560,902 - 22,588,815 (+)	NCBI		GRCr8
mRatBN7.2	15	20,088,564 - 20,109,042 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	20,088,571 - 20,109,037 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	22,869,313 - 22,889,742 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	23,827,307 - 23,847,736 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	22,077,598 - 22,098,042 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	23,619,176 - 23,639,622 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	23,619,123 - 23,639,628 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	27,562,664 - 27,583,110 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	22,683,387 - 22,703,833 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	22,699,086 - 22,719,533 (+)	NCBI
Celera	15	20,486,913 - 20,507,359 (+)	NCBI		Celera
Cytogenetic Map	15	p14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

DOPA-responsive dystonia (ISO)

syndromic microphthalmia 6 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2,4-trimethylbenzene (EXP)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-nitrofluorene (EXP)

3H-1,2-dithiole-3-thione (EXP)

4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one (EXP)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (EXP,ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

amphetamine (EXP)

Aroclor 1254 (ISO)

arsenite(3-) (ISO)

atrazine (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

cobalt dichloride (EXP,ISO)

copper atom (ISO)

copper(0) (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

dieldrin (EXP)

diethylstilbestrol (EXP)

dorsomorphin (ISO)

ethyl methanesulfonate (ISO)

flutamide (EXP)

formaldehyde (ISO)

gefitinib (ISO)

gentamycin (EXP)

gold atom (ISO)

gold(0) (ISO)

methapyrilene (EXP)

methyl methanesulfonate (ISO)

N-nitrosodimethylamine (EXP)

N-nitrosomorpholine (EXP)

nefazodone (EXP)

nimesulide (EXP)

paracetamol (EXP,ISO)

phenobarbital (ISO)

phorone (EXP)

picoxystrobin (ISO)

piperonyl butoxide (EXP)

pirinixic acid (EXP)

SB 431542 (ISO)

sevoflurane (EXP)

sodium arsenite (ISO)

sunitinib (ISO)

T-2 toxin (EXP)

temozolomide (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

tungsten (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of cell growth (IBA,IDA)

regulation of cell cycle (IEA)

Cellular Component

endoplasmic reticulum (IEA,ISO,ISS)

intracellular membrane-bounded organelle (ISO)

membrane (IEA)

nucleoplasm (IEA,ISO)

nucleus (IEA)

Molecular Function

metal ion binding (IEA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Induction of cell growth regulatory genes by p53.	Madden SL, etal., Cancer Res 1996 Dec 1;56(23):5384-90.
3.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
4.	GOA pipeline	RGD automated data pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:27485036

Genomics

Comparative Map Data

Cgrrf1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	22,560,902 - 22,588,815 (+)	NCBI		GRCr8
mRatBN7.2	15	20,088,564 - 20,109,042 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	20,088,571 - 20,109,037 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	22,869,313 - 22,889,742 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	23,827,307 - 23,847,736 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	22,077,598 - 22,098,042 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	23,619,176 - 23,639,622 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	23,619,123 - 23,639,628 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	27,562,664 - 27,583,110 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	22,683,387 - 22,703,833 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	22,699,086 - 22,719,533 (+)	NCBI
Celera	15	20,486,913 - 20,507,359 (+)	NCBI		Celera
Cytogenetic Map	15	p14	NCBI

CGRRF1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	54,509,906 - 54,539,292 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	54,509,812 - 54,539,292 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	54,976,624 - 55,006,010 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	54,046,337 - 54,075,084 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	54,046,336 - 54,075,084	NCBI
Celera	14	35,026,117 - 35,054,859 (+)	NCBI		Celera
Cytogenetic Map	14	q22.2	NCBI
HuRef	14	35,139,231 - 35,168,038 (+)	NCBI		HuRef
CHM1_1	14	54,915,302 - 54,944,048 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	14	48,715,069 - 48,744,462 (+)	NCBI		T2T-CHM13v2.0

Cgrrf1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	47,069,591 - 47,091,655 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	47,069,582 - 47,091,650 (+)	Ensembl		GRCm39 Ensembl
GRCm38	14	46,832,134 - 46,854,198 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	46,832,125 - 46,854,193 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	47,451,919 - 47,473,865 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	45,754,121 - 45,776,067 (+)	NCBI		MGSCv36	mm8
Celera	14	43,006,333 - 43,028,378 (+)	NCBI		Celera
Cytogenetic Map	14	C1	NCBI
cM Map	14	24.34	NCBI

Cgrrf1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955409	8,939,521 - 8,966,351 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955409	8,939,793 - 8,966,351 (-)	NCBI	ChiLan1.0	ChiLan1.0

CGRRF1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	55,628,211 - 55,660,946 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	54,847,901 - 54,877,462 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	35,096,716 - 35,126,072 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	53,374,648 - 53,404,122 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	53,374,648 - 53,404,122 (+)	Ensembl	panpan1.1		panPan2

CGRRF1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	30,419,716 - 30,449,616 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	30,419,772 - 30,448,577 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	30,188,309 - 30,218,202 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	30,676,833 - 30,706,769 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	30,676,881 - 30,706,946 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	30,280,955 - 30,310,909 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	30,357,426 - 30,387,463 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	30,723,002 - 30,753,117 (+)	NCBI		UU_Cfam_GSD_1.0

Cgrrf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	74,797,701 - 74,831,731 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936697	569,148 - 605,945 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936697	573,477 - 605,899 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CGRRF1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	183,876,919 - 183,903,897 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	183,863,459 - 183,903,803 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

CGRRF1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	31,686,757 - 31,715,593 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666053	19,916,271 - 19,944,701 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cgrrf1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624731	14,760,426 - 14,787,582 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624731	14,761,560 - 14,790,277 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Cgrrf1
101 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	36
Count of miRNA genes:	33
Interacting mature miRNAs:	35
Transcripts:	ENSRNOT00000013912
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1641913	Colcr2	Colorectal carcinoma resistance QTL 2	6.57	0.0197	intestine integrity trait (VT:0010554)	poorly differentiated malignant colorectal tumor number (CMO:0002076)	15	2266368	22711984	Rat
631273	Lecl2	Lens clarity QTL 2		0.001	lens clarity trait (VT:0001304)	age of onset/diagnosis of cataract (CMO:0001584)	15	10596089	55596089	Rat
2300167	Bmd63	Bone mineral density QTL 63	5.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	15	11111142	56111142	Rat
1331729	Rf42	Renal function QTL 42	3.071		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	15	17362897	73690657	Rat
1641887	Alcrsp14	Alcohol response QTL 14			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	15	1	42356671	Rat
731170	Pur3	Proteinuria QTL 3	2.3	0.0005	urine protein amount (VT:0005160)	urine protein excretion rate (CMO:0000759)	15	1	41686771	Rat
738017	Hcas7	Hepatocarcinoma susceptibility QTL 7	2.91		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	15	2266368	46921453	Rat
2300173	Bmd62	Bone mineral density QTL 62	12.8	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	15	11111142	56111142	Rat
9589149	Insul29	Insulin level QTL 29	9.06	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	15	1	34723002	Rat
2324620	Coatc3	Coat color QTL 3			coat/hair pigmentation trait (VT:0010463)	pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)	15	19856566	46187442	Rat
61424	Scl1	Serum cholesterol level QTL 1	7.7	0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	15	16725528	80672115	Rat
10401805	Kidm51	Kidney mass QTL 51			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	15	306329	45306329	Rat
1582251	Gluco24	Glucose level QTL 24	3.2	0.0008	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	15	5530756	50530756	Rat
1354657	Despr13	Despair related QTL 13		0.0022	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	15	1	29912054	Rat
2317750	Glom26	Glomerulus QTL 26	4.3		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	15	12496141	65205939	Rat
2298549	Neuinf12	Neuroinflammation QTL 12	3.5		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	15	1	55302115	Rat
631550	Bw7	Body weight QTL 7	3.6		body mass (VT:0001259)	body weight (CMO:0000012)	15	19856566	34924750	Rat
8552920	Pigfal8	Plasma insulin-like growth factor 1 level QTL 8	3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	15	1	34723002	Rat
2293688	Bss29	Bone structure and strength QTL 29	5.31	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	15	11111142	56111142	Rat
5685002	Bss103	Bone structure and strength QTL 103	2.8		tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	15	14481165	28469888	Rat
8694361	Abfw6	Abdominal fat weight QTL 6	10.2	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	15	1	34723002	Rat

Markers in Region

D15Rat3

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	20,086,924 - 20,087,067 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	23,617,510 - 23,617,652	NCBI	Rnor6.0
Rnor_5.0	15	27,560,998 - 27,561,140	UniSTS	Rnor5.0
RGSC_v3.4	15	22,681,593 - 22,682,012	RGD	RGSC3.4
RGSC_v3.4	15	22,681,721 - 22,681,863	UniSTS	RGSC3.4
RGSC_v3.1	15	22,697,421 - 22,697,563	RGD
Celera	15	20,485,247 - 20,485,389	UniSTS
RH 3.4 Map	15	191.8	RGD
RH 3.4 Map	15	191.8	UniSTS
RH 2.0 Map	15	98.1	RGD
SHRSP x BN Map	15	15.3399	RGD
Cytogenetic Map	15	p14	UniSTS

RH132938

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	20,097,237 - 20,097,424 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	23,627,823 - 23,628,009	NCBI	Rnor6.0
Rnor_5.0	15	27,571,311 - 27,571,497	UniSTS	Rnor5.0
RGSC_v3.4	15	22,692,034 - 22,692,220	UniSTS	RGSC3.4
Celera	15	20,495,560 - 20,495,746	UniSTS
RH 3.4 Map	15	188.1	UniSTS
Cytogenetic Map	15	p14	UniSTS

AA893114

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	20,108,802 - 20,109,043 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	23,639,388 - 23,639,628	NCBI	Rnor6.0
Rnor_5.0	15	27,582,876 - 27,583,116	UniSTS	Rnor5.0
RGSC_v3.4	15	22,703,599 - 22,703,839	UniSTS	RGSC3.4
Celera	15	20,507,125 - 20,507,365	UniSTS
Cytogenetic Map	15	p14	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053899	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039092952	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039092953	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039092954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063273912	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC129244	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC078763	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474040	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ214200	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ218613	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U66471	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000013912 ⟹ ENSRNOP00000013912

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	20,088,578 - 20,109,037 (+)	Ensembl
Rnor_6.0 Ensembl	15	23,619,123 - 23,639,628 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000118998 ⟹ ENSRNOP00000080679

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	20,088,571 - 20,102,968 (+)	Ensembl

RefSeq Acc Id:

NM_053899 ⟹ NP_446351

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	22,568,364 - 22,588,810 (+)	NCBI
mRatBN7.2	15	20,088,591 - 20,109,037 (+)	NCBI
Rnor_6.0	15	23,619,176 - 23,639,622 (+)	NCBI
Rnor_5.0	15	27,562,664 - 27,583,110 (+)	NCBI
RGSC_v3.4	15	22,683,387 - 22,703,833 (+)	RGD
Celera	15	20,486,913 - 20,507,359 (+)	RGD

Sequence:

show sequence

CCTGGGCGAGTGAGGACCTACAAAGTTTGTCCGCTCCGGGGCGCCATACCAGCTCGGTTCCCGG
CCGGCCGGCTGGTCCGGGCTTAGCCAGGAGACCCCGATGGCCGCAGTGTTCCTGGTTACGCTCT
ACGAATACTCGCCGCTCTTCTACATCGCGGTGGTCTTCACCTGCTTCATCGCCACCACCGGCCT
GGTATTAGGATGGCTTGGCTGGGACGTTCCAGTAATTCTGAGAAACTCAGAAGAAACCCAGTTC
AGCACAAGAGCTTTCAAGAAACAAATGAGACAAGTGAAGAATCCGTTCGGCTTAGAGATCACTA
ACTCATCCGCAGCTTCCCTAGCAACAGGTGTAACCTTGACGACAGACTGCCTGGAAGACAGTCG
TCTTACGTGCTACTGGGGGTGCAGTGTTCAAAAGCTCTATGAAGCTCTTCAGAAGCACGTTTAC
TGCTTCAGGATAAGCACTCCGCAAGCCTTGGAAGAGGCGCTGTACAGTGACTATCTCCACCGAG
AACAGTATTTTATTAAAAAGCACAGCAAAGAAGAAATATATTGCCAATTACCAAGCAGTACTGG
GGTTGAAGACTTTGGTCCAGTGCCCAGATCTCGCTATCCGTTGGTAGCTCTGTTGACCCTCGCT
GATGAGGATGACAGGGAAATTTATGACATTATTTCCATGGTGTCTGTCATTCATATTCCTGATA
AGACTTACAAACTTCCCTGCAGAATATTGTATCAATATTTAATCCTGGCTCAAGGTCAATTTTA
TGATCTTAAGCAACTTTTCATGTCTGCAAATAATAGTGCTACTCCCTCCAGAGACCAGTCTCCC
GCAGACGGGAGTGTGGAGCACAGCTTGTTGGAGAAGGCGGGGCTGGCTGGGGCTGAAGTGGACC
CGGTGGAGGAGAGCAGCAAAGACTGTGTGGTGTGCCAGAACGGGGGTGTGAACTGGGTGCTCCT
GCCTTGCCGGCACGCCTGCCTGTGCGACAGCTGTGTGTGCTACTTCAAGCAGTGTCCCATGTGC
CGCCAGTTTGTGCAGGAATCCTTTGCACTGTGTGGTCAGAAAGAGGCAGACAAGGACATACTAG
AAACTTCCTGAAGAATCACAGCCGGAGAGTGTACTTTCTACACAAGGGCAGAACCTCGTGTCCT
TAGAGTCAATCCTAACAGAGTCTGCAGTCTTACCTGTCGGAGAGAGCTCTGTGTGCACTTTCAT
ACTTTGTACAGTACATGGATGACGGGAATAAAGTCTTCTGCTCAGTGCG

hide sequence

RefSeq Acc Id:

XM_039092952 ⟹ XP_038948880

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	22,568,337 - 22,588,815 (+)	NCBI
mRatBN7.2	15	20,088,564 - 20,109,042 (+)	NCBI

RefSeq Acc Id:

XM_039092953 ⟹ XP_038948881

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	22,577,249 - 22,588,815 (+)	NCBI
mRatBN7.2	15	20,097,752 - 20,109,042 (+)	NCBI

RefSeq Acc Id:

XM_039092954 ⟹ XP_038948882

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	22,577,227 - 22,588,815 (+)	NCBI
mRatBN7.2	15	20,097,756 - 20,109,042 (+)	NCBI

RefSeq Acc Id:

XM_063273912 ⟹ XP_063129982

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	22,560,902 - 22,588,815 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_446351	(Get FASTA)	NCBI Sequence Viewer
	XP_038948880	(Get FASTA)	NCBI Sequence Viewer
	XP_038948881	(Get FASTA)	NCBI Sequence Viewer
	XP_038948882	(Get FASTA)	NCBI Sequence Viewer
	XP_063129982	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC52951	(Get FASTA)	NCBI Sequence Viewer
	AAH78763	(Get FASTA)	NCBI Sequence Viewer
	EDL88332	(Get FASTA)	NCBI Sequence Viewer
	EDL88333	(Get FASTA)	NCBI Sequence Viewer
	EDL88334	(Get FASTA)	NCBI Sequence Viewer
	EDL88335	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000013912.3
	ENSRNOP00000080679.1
GenBank Protein	P97587	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_446351 ⟸ NM_053899

- UniProtKB:

P97587 (UniProtKB/Swiss-Prot), G3V7C9 (UniProtKB/TrEMBL), A6KE27 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAAVFLVTLYEYSPLFYIAVVFTCFIATTGLVLGWLGWDVPVILRNSEETQFSTRAFKKQMRQV
KNPFGLEITNSSAASLATGVTLTTDCLEDSRLTCYWGCSVQKLYEALQKHVYCFRISTPQALEE
ALYSDYLHREQYFIKKHSKEEIYCQLPSSTGVEDFGPVPRSRYPLVALLTLADEDDREIYDIIS
MVSVIHIPDKTYKLPCRILYQYLILAQGQFYDLKQLFMSANNSATPSRDQSPADGSVEHSLLEK
AGLAGAEVDPVEESSKDCVVCQNGGVNWVLLPCRHACLCDSCVCYFKQCPMCRQFVQESFALCG
QKEADKDILETS

hide sequence

Ensembl Acc Id:

ENSRNOP00000013912 ⟸ ENSRNOT00000013912

RefSeq Acc Id:	XP_038948880 ⟸ XM_039092952
- Peptide Label:	isoform X1
- UniProtKB:	P97587 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_038948881 ⟸ XM_039092953
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038948882 ⟸ XM_039092954
- Peptide Label:	isoform X4
- UniProtKB:	A6KE30 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000080679 ⟸ ENSRNOT00000118998

RefSeq Acc Id:	XP_063129982 ⟸ XM_063273912
- Peptide Label:	isoform X2
- UniProtKB:	A6KE27 (UniProtKB/TrEMBL), G3V7C9 (UniProtKB/TrEMBL)

Protein Domains

RING-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P97587-F1-model_v2	AlphaFold	P97587	1-332	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699606

Promoter ID:

EPDNEW_R10129

Type:

initiation region

Name:

Cgrrf1_1

Description:

cell growth regulator with ring finger domain 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	15	23,619,221 - 23,619,281	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620803	AgrOrtholog
BioCyc Gene	G2FUF-14170	BioCyc
Ensembl Genes	ENSRNOG00000010178	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000013912.7	UniProtKB/TrEMBL
	ENSRNOT00000118998.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.40.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7107668	IMAGE-MGC_LOAD
InterPro	CGRF1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Znf_RING	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Znf_RING/FYVE/PHD	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:116679	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93274	IMAGE-MGC_LOAD
NCBI Gene	116679	ENTREZGENE
PANTHER	CELL GROWTH REGULATOR WITH RING FINGER DOMAIN PROTEIN 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR15379	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	zf-C3HC4_3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Cgrrf1	PhenoGen
PROSITE	ZF_RING_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000010178	RatGTEx
Superfamily-SCOP	RING/U-box	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6G6Y6_RAT	UniProtKB/TrEMBL
	A6KE27	ENTREZGENE, UniProtKB/TrEMBL
	A6KE28_RAT	UniProtKB/TrEMBL
	A6KE29_RAT	UniProtKB/TrEMBL
	A6KE30	ENTREZGENE, UniProtKB/TrEMBL
	CGRF1_RAT	UniProtKB/Swiss-Prot
	G3V7C9	ENTREZGENE, UniProtKB/TrEMBL
	P97587	ENTREZGENE
	Q6AZ36_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-09-10	Cgrrf1	cell growth regulator with ring finger domain 1	Cgr19	cell growth regulatory with ring finger domain	Symbol and Name updated	1299863	APPROVED
2002-08-07	Cgr19	cell growth regulatory with ring finger domain			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_domains	contains a ring finger domain	632480

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar