RGD Reference Report - Induction of cell growth regulatory genes by p53. - Rat Genome Database

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Induction of cell growth regulatory genes by p53.

Authors: Madden, SL  Galella, EA  Riley, D  Bertelsen, AH  Beaudry, GA 
Citation: Madden SL, etal., Cancer Res 1996 Dec 1;56(23):5384-90.
RGD ID: 632480
Pubmed: PMID:8968090   (View Abstract at PubMed)

Transcriptionally regulated growth-response genes play a pivotal role in the determination of the fate of a cell. p53 is known to transcriptionally regulate genes important in regulating cell growth potential. Using differential reverse transcription-PCR analysis of rat embryo fibroblast cells containing a temperature-sensitive p53 allele, we were able to isolate several transcripts up-regulated specifically in cells harboring functional p53 protein. Two of these genes, SM20 and microsomal epoxide hydrolase (mEH), are previously described genes. Two previously uncharacterized cDNAs, cell growth regulatory (CGR) genes CGR11 and CGR19, were isolated. The predicted amino acid sequence of these novel proteins contain known motifs; EF-hand domains (CGR11) and a ring-finger domain (CGR19), suggestive of function. CGR11 and CGR19 appear to be primary response genes expressed to moderate levels in functional p53 cells. Both CGR11 and CGR19 are able to inhibit the growth of several cell lines.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
negative regulation of cell growth  IDA 632480; 632480 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cgref1  (cell growth regulator with EF hand domain 1)
Cgrrf1  (cell growth regulator with ring finger domain 1)

Objects referenced in this article
Gene CGREF1 cell growth regulator with EF-hand domain 1 Homo sapiens
Gene CGRRF1 cell growth regulator with ring finger domain 1 Homo sapiens

Additional Information