Tas2r121 (taste receptor, type 2, member 121) - Rat Genome Database

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Gene: Tas2r121 (taste receptor, type 2, member 121) Rattus norvegicus
Analyze
Symbol: Tas2r121
Name: taste receptor, type 2, member 121
RGD ID: 620738
Description: Predicted to enable bitter taste receptor activity. Predicted to be involved in detection of chemical stimulus involved in sensory perception of bitter taste and positive regulation of cytokinesis. Predicted to be active in membrane. Orthologous to human TAS2R13 (taste 2 receptor member 13); INTERACTS WITH ammonium chloride; bisphenol A; Tesaglitazar.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: T2R13; T2R7; Tas2r13; Tas2r7; taste receptor T2R7; taste receptor type 2 member 13; taste receptor type 2 member 7; taste receptor, type 2, member 7
RGD Orthologs
Human
Mouse
Bonobo
Squirrel
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84167,718,831 - 167,719,748 (-)NCBIGRCr8
mRatBN7.24165,987,429 - 165,988,346 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx4172,283,766 - 172,284,683 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04168,066,790 - 168,067,707 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04166,700,841 - 166,701,758 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04166,868,482 - 166,869,399 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4166,868,482 - 166,869,399 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04229,397,091 - 229,398,008 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44170,015,848 - 170,016,765 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14170,260,783 - 170,261,701 (-)NCBI
Celera4154,583,540 - 154,584,457 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. A novel family of mammalian taste receptors. Adler E, etal., Cell 2000 Mar 17;100(6):693-702.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10761935   PMID:11696554   PMID:11854532   PMID:12139982   PMID:12581520   PMID:20022913   PMID:22888021  


Genomics

Comparative Map Data
Tas2r121
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84167,718,831 - 167,719,748 (-)NCBIGRCr8
mRatBN7.24165,987,429 - 165,988,346 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx4172,283,766 - 172,284,683 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04168,066,790 - 168,067,707 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04166,700,841 - 166,701,758 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04166,868,482 - 166,869,399 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4166,868,482 - 166,869,399 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04229,397,091 - 229,398,008 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44170,015,848 - 170,016,765 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14170,260,783 - 170,261,701 (-)NCBI
Celera4154,583,540 - 154,584,457 (-)NCBICelera
Cytogenetic Map4q42NCBI
TAS2R13
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381210,907,926 - 10,909,562 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1210,907,926 - 10,909,562 (-)EnsemblGRCh38hg38GRCh38
GRCh371211,060,525 - 11,062,161 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361210,951,792 - 10,953,428 (-)NCBINCBI36Build 36hg18NCBI36
Build 341210,952,252 - 10,953,164NCBI
Celera1216,208,804 - 16,210,440 (-)NCBICelera
Cytogenetic Map12p13.2NCBI
HuRef1210,789,153 - 10,790,789 (-)NCBIHuRef
CHM1_11211,029,834 - 11,031,470 (-)NCBICHM1_1
T2T-CHM13v2.01210,780,964 - 10,782,600 (-)NCBIT2T-CHM13v2.0
Tas2r121
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396132,677,053 - 132,677,970 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6132,677,053 - 132,677,970 (-)EnsemblGRCm39 Ensembl
GRCm386132,700,090 - 132,701,007 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6132,700,090 - 132,701,007 (-)EnsemblGRCm38mm10GRCm38
MGSCv376132,650,108 - 132,651,025 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366132,665,783 - 132,666,700 (-)NCBIMGSCv36mm8
Celera6133,184,668 - 133,185,585 (+)NCBICelera
Cytogenetic Map6G1NCBI
cM Map664.03NCBI
TAS2R13
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21016,381,306 - 16,382,449 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11216,377,975 - 16,379,527 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01210,938,100 - 10,939,939 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11211,204,623 - 11,205,534 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1211,204,623 - 11,205,534 (-)Ensemblpanpan1.1panPan2
Tas2r13
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494596,229,579 - 96,230,418 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365875,957,214 - 5,958,053 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TAS2R13
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11110,754,191 - 10,756,565 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1110,754,845 - 10,755,753 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660892,836,860 - 2,838,482 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:19
Count of miRNA genes:17
Interacting mature miRNAs:18
Transcripts:ENSRNOT00000007521
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4157710145182687754Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system hemolymphoid system nervous system
High
Medium
Low 8
Below cutoff 12 1 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000007521   ⟹   ENSRNOP00000007521
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl4166,868,482 - 166,869,399 (-)Ensembl
RefSeq Acc Id: NM_023997   ⟹   NP_076487
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84167,718,831 - 167,719,748 (-)NCBI
mRatBN7.24165,987,429 - 165,988,346 (-)NCBI
Rnor_6.04166,868,482 - 166,869,399 (-)NCBI
Rnor_5.04229,397,091 - 229,398,008 (-)NCBI
RGSC_v3.44170,015,848 - 170,016,765 (-)RGD
Celera4154,583,540 - 154,584,457 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_076487 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF43917 (Get FASTA)   NCBI Sequence Viewer  
  EDM01678 (Get FASTA)   NCBI Sequence Viewer  
  Q9JKT7 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_076487   ⟸   NM_023997
- UniProtKB: Q9JKT7 (UniProtKB/Swiss-Prot),   A6IMB1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000007521   ⟸   ENSRNOT00000007521

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JKT7-F1-model_v2 AlphaFold Q9JKT7 1-305 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620738 AgrOrtholog
BioCyc Gene G2FUF-42701 BioCyc
Ensembl Genes ENSRNOG00000005717 Ensembl
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro T2R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:78983 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 78983 ENTREZGENE
PANTHER TASTE RECEPTOR TYPE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TASTE RECEPTOR TYPE 2 MEMBER 13 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TAS2R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tas2r121 PhenoGen
RatGTEx ENSRNOG00000005717 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6IMB1 ENTREZGENE, UniProtKB/TrEMBL
  Q9JKT7 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-25 Tas2r121  taste receptor, type 2, member 121  Tas2r7  taste receptor, type 2, member 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Tas2r7  taste receptor, type 2, member 7  T2R7  taste receptor T2R7  Symbol and Name updated 1299863 APPROVED
2002-08-07 T2R7  taste receptor T2R7      Symbol and Name status set to provisional 70820 PROVISIONAL