Fasn (fatty acid synthase) - Rat Genome Database

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Gene: Fasn (fatty acid synthase) Rattus norvegicus
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Symbol: Fasn
Name: fatty acid synthase
RGD ID: 620665
Description: Enables [acyl-carrier-protein] S-malonyltransferase activity; fatty acid synthase activity; and identical protein binding activity. Involved in acetyl-CoA metabolic process; fatty acid biosynthetic process; and response to nutrient. Located in cytoplasm. Biomarker of metabolic dysfunction-associated steatotic liver disease. Orthologous to human FASN (fatty acid synthase); PARTICIPATES IN fatty acid biosynthetic pathway; insulin signaling pathway; INTERACTS WITH (+)-catechin; (-)-epigallocatechin 3-gallate; (R)-carnitine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: type I FAS
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810106,570,415 - 106,588,581 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl10106,570,413 - 106,588,583 (-)EnsemblGRCr8
mRatBN7.210106,072,093 - 106,090,259 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10106,072,091 - 106,090,261 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx10111,176,141 - 111,194,306 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010110,639,183 - 110,657,348 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010105,992,540 - 106,010,706 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010109,987,735 - 110,005,901 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10109,987,735 - 110,005,901 (-)Ensemblrn6Rnor6.0
Rnor_5.010109,579,051 - 109,597,217 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera10104,615,873 - 104,634,039 (-)NCBICelera
Cytogenetic Map10q32.3NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-beta-thujone  (ISO)
(+)-catechin  (EXP,ISO)
(+)-pinoresinol  (ISO)
(+/-)-Aegeline  (ISO)
(-)-acanthoic acid  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(R)-camphor  (ISO)
(R)-carnitine  (EXP)
(R)-linalyl acetate  (ISO)
(RS)-coclaurine  (ISO)
(RS)-norcoclaurine  (ISO)
(S)-coclaurine  (ISO)
(S)-nicotine  (EXP,ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dichloropropan-2-ol  (ISO)
1,8-cineole  (ISO)
1-(3-(trifluoromethyl)phenyl)piperazine  (EXP)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-\{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl\}-1H-imidazole  (ISO)
1-benzylpiperazine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,5-hexanedione  (EXP)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP,ISO)
4'-Methoxychalcone  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-nonylphenol  (EXP)
4-phenylbutyric acid  (ISO)
4-tert-Octylphenol  (EXP)
5-(2-chloroethyl)-4-methylthiazole  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
7,12-dimethyltetraphene  (EXP)
8'-apo-beta,psi-caroten-8'-al  (ISO)
9-cis-retinoic acid  (ISO)
acadesine  (ISO)
acarbose  (EXP)
acetamide  (EXP)
acetamiprid  (EXP)
Acetyl tributyl citrate  (ISO)
acrolein  (ISO)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
alcohol  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
Alisol B  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
alliin  (ISO)
allopurinol  (EXP,ISO)
alpha-linolenic acid  (EXP)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
amiodarone  (EXP,ISO)
amitrole  (EXP)
amlexanox  (ISO)
Ammothamnine  (EXP)
amphotericin B  (ISO)
ampicillin  (ISO)
andrographolide  (ISO)
antimony(0)  (ISO)
antimycin A  (ISO)
apigenin  (ISO)
arachidonic acid  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (EXP,ISO)
ATP  (ISO)
atrazine  (EXP,ISO)
avobenzone  (ISO)
azoxystrobin  (ISO)
baicalein  (ISO)
Bardoxolone methyl  (ISO)
bathocuproine disulfonic acid  (ISO)
benzene  (EXP,ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
Benzyl parahydroxybenzoate  (ISO)
benzylpenicillin  (ISO)
beta-D-glucosamine  (ISO)
beta-hexachlorocyclohexane  (ISO)
beta-naphthoflavone  (ISO)
betulin  (ISO)
bexarotene  (EXP,ISO)
bezafibrate  (EXP,ISO)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
boric acid  (ISO)
brexpiprazole  (ISO)
bromobenzene  (EXP)
buspirone  (EXP)
buta-1,3-diene  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
Butylparaben  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP,ISO)
calcitriol  (ISO)
camphor  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
carvedilol  (EXP)
celecoxib  (ISO)
cerulenin  (ISO)
chenodeoxycholic acid  (ISO)
chitosan  (EXP)
chloroethene  (ISO)
chlorogenic acid  (ISO)
chloropicrin  (ISO)
chlorothalonil  (ISO)
chlorotoluron  (ISO)
chlorpyrifos  (EXP,ISO)
cholic acid  (EXP)
choline  (EXP,ISO)
ciguatoxin CTX1B  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP,ISO)
citalopram  (ISO)
CL316243  (EXP)
clobetasol  (ISO)
clofibrate  (EXP,ISO)
clozapine  (ISO)
cobalt dichloride  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
corn oil  (EXP)
corticosterone  (EXP)
cortisol  (ISO)
coumarin  (EXP)
crizotinib  (ISO)
curcumin  (EXP,ISO)
cyanocob(III)alamin  (EXP)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (EXP,ISO)
cylindrospermopsin  (ISO)
cyproconazole  (EXP,ISO)
D-glucose  (EXP,ISO)
dapagliflozin  (EXP)
DDE  (ISO)
DDT  (EXP)
decabromodiphenyl ether  (EXP,ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
deoxypodophyllotoxin  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
Di-n-hexyl phthalate  (ISO)
Di-n-octyl phthalate  (ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (EXP,ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
diclofenac  (EXP)
dicrotophos  (ISO)
diethyl maleate  (EXP)
diethyl phthalate  (EXP,ISO)
dihydroartemisinin  (ISO)
dihydroxyacetone  (EXP)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (EXP,ISO)
Diosbulbin B  (ISO)
diosgenin  (EXP,ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (ISO)
duvoglustat  (ISO)
elemental selenium  (EXP,ISO)
Elemicin  (ISO)
endosulfan  (EXP)
endrin  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (EXP,ISO)
erastin  (ISO)
erythromycin A  (ISO)
erythromycin estolate  (EXP)
esculetin  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
eugenol  (ISO)
farnesol  (ISO)
fenofibrate  (EXP,ISO)
ferrostatin-1  (ISO)
ferulic acid  (ISO)
fipronil  (ISO)
folic acid  (EXP,ISO)
folpet  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fructooligosaccharide  (ISO)
fructose  (EXP,ISO)
fulvestrant  (ISO)
furan  (EXP)
furfural  (ISO)
gadolinium trichloride  (EXP,ISO)
gamma-hexachlorocyclohexane  (EXP)
Ganoderic acid A  (ISO)
Gastrodin  (ISO)
genistein  (ISO)
gentamycin  (EXP)
Geraniin  (ISO)
geraniol  (EXP)
gingerol  (ISO)
glafenine  (EXP)
glucagon  (ISO)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
glycine betaine  (EXP)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
graphene oxide  (ISO)
guggulsterone  (ISO)
GW 3965  (ISO)
GW 4064  (ISO)
GW 6471  (ISO)
GW 7647  (ISO)
haloperidol  (ISO)
herbacetin  (ISO)
hesperidin  (ISO)
hexadecanoic acid  (EXP,ISO)
hydrazines  (ISO)
ibuprofen  (ISO)
indinavir  (ISO)
indometacin  (EXP,ISO)
isoflavones  (EXP)
isoniazide  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
kahweol  (ISO)
L-methionine  (EXP,ISO)
lamivudine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
linalool  (ISO)
linalyl acetate  (ISO)
linoleic acid  (EXP)
linsidomine  (EXP)
lipopolysaccharide  (ISO)
Lipstatin  (ISO)
liraglutide  (ISO)
lithocholic acid  (ISO)
loliolide  (ISO)
losartan  (EXP)
lovastatin  (ISO)
luteolin  (ISO)
LY294002  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
melatonin  (ISO)
metformin  (EXP,ISO)
methapyrilene  (EXP)
methimazole  (EXP,ISO)
methotrexate  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
metronidazole  (ISO)
mevalonic acid  (EXP)
miconazole  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
Mitotane  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
monocrotophos  (EXP)
monosodium L-glutamate  (EXP,ISO)
morin  (ISO)
motexafin gadolinium  (ISO)
myriocin  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
N-Phenylmaleimide  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
naloxone  (EXP)
naringin  (ISO)
nefazodone  (EXP)
nelfinavir  (ISO)
neohesperidin  (ISO)
neomycin  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (ISO)
nicotine  (EXP,ISO)
nicotinic acid  (ISO)
nimesulide  (EXP)
nitrates  (ISO)
nitrofen  (EXP)
Nivalenol  (ISO)
NMN zwitterion  (ISO)
NMS-873  (ISO)
nordihydroguaiaretic acid  (EXP)
norethisterone  (ISO)
Norethynodrel  (ISO)
Nutlin-3  (ISO)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
Octicizer  (ISO)
okadaic acid  (ISO)
olanzapine  (ISO)
olaparib  (ISO)
oleic acid  (EXP,ISO)
oleuropein  (EXP)
Olmesartan medoxomil  (EXP)
organophosphorus compound  (EXP)
orlistat  (ISO)
orotic acid  (EXP)
oroxylin A  (ISO)
ozone  (EXP,ISO)
p-tert-Amylphenol  (EXP)
paclitaxel  (ISO)
pantoprazole  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paxilline  (ISO)
PD 0325901  (ISO)
penconazole  (ISO)
pendimethalin  (EXP)
perfluorobutanesulfonic acid  (ISO)
perfluorobutyric acid  (EXP,ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (EXP,ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanesulfonamide  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (ISO)
permethrin  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phosphatidylcholine  (ISO)
phosphocholine  (ISO)
phosphorylcholine chloride  (ISO)
pimecrolimus  (ISO)
pirinixic acid  (EXP,ISO)
platycodin D  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
procymidone  (ISO)
propamocarb  (ISO)
propiconazole  (ISO)
Propiverine  (EXP)
propylparaben  (ISO)
prostaglandin E2  (ISO)
protein kinase inhibitor  (ISO)
pterostilbene  (EXP)
puerarin  (ISO)
PX-866  (ISO)
pyriproxyfen  (ISO)
pyrroloquinoline quinone  (EXP)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
raffinose  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rimonabant  (ISO)
ritonavir  (EXP)
rosmarinic acid  (ISO)
rotenone  (EXP,ISO)
S-allylcysteine  (ISO)
sabinene  (ISO)
Salvianolic acid A  (ISO)
SB 431542  (ISO)
scopoletin  (EXP)
selenium atom  (EXP,ISO)
sertraline  (ISO)
sildenafil citrate  (ISO)
silibinin  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (EXP,ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (EXP)
Sodium oleate  (ISO)
spathulenol  (ISO)
stavudine  (ISO)
steviol  (ISO)
streptozocin  (EXP,ISO)
sucrose  (EXP,ISO)
sulconazole  (ISO)
sulfluramid  (ISO)
sulforaphane  (EXP,ISO)
sulindac  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP,ISO)
taurine  (ISO)
tebuconazole  (ISO)
tectorigenin  (ISO)
temozolomide  (ISO)
teriflunomide  (ISO)
Tetrachlorobisphenol A  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thapsigargin  (EXP)
thiazolidinediones  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trametinib  (ISO)
trans-caffeic acid  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
triclocarban  (EXP)
triclosan  (EXP,ISO)
triolein  (ISO)
triphenyl phosphate  (EXP,ISO)
Triptolide  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (EXP,ISO)
tungsten  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP,ISO)
valdecoxib  (EXP)
Valilactone  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vanillic acid  (ISO)
vemurafenib  (ISO)
vitamin D  (ISO)
voriconazole  (EXP)
vorinostat  (ISO)
withaferin A  (ISO)
yohimbine  (ISO)
zearalenone  (ISO)
zidovudine  (ISO)
zinc acetate  (ISO)
zinc atom  (EXP)
zinc dichloride  (ISO)
zinc(0)  (EXP)
zingerone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IDA,IEA,ISO)
cytosol  (IEA,ISO,TAS)
fatty acid synthase complex  (IEA,ISO)
glycogen granule  (IEA,ISO)
melanosome  (IEA)
plasma membrane  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Fermented rice bran supplementation mitigates metabolic syndrome in stroke-prone spontaneously hypertensive rats. Alauddin M, etal., BMC Complement Altern Med. 2016 Nov 8;16(1):442. doi: 10.1186/s12906-016-1427-z.
2. Changes in white adipose tissue metabolism induced by resveratrol in rats. Alberdi G, etal., Nutr Metab (Lond). 2011 May 10;8(1):29. doi: 10.1186/1743-7075-8-29.
3. Molecular cloning and sequencing of cDNAs encoding the entire rat fatty acid synthase. Amy CM, etal., Proc Natl Acad Sci U S A 1989 May;86(9):3114-8.
4. Structure and molecular organization of mammalian fatty acid synthase. Asturias FJ, etal., Nat Struct Mol Biol. 2005 Mar;12(3):225-32. Epub 2005 Feb 13.
5. The fatty acid synthase (FAS) gene and its promoter in Rattus norvegicus. Beck KF, etal., DNA Seq 1992;2(6):359-86.
6. Conformational flexibility of metazoan fatty acid synthase enables catalysis. Brignole EJ, etal., Nat Struct Mol Biol. 2009 Feb;16(2):190-7. Epub 2009 Jan 18.
7. Human fatty acid synthase: role of interdomain in the formation of catalytically active synthase dimer. Chirala SS, etal., Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3104-8.
8. In-depth identification of pathways related to cisplatin-induced hepatotoxicity through an integrative method based on an informatics-assisted label-free protein quantitation and microarray gene expression approach. Cho YE, etal., Mol Cell Proteomics. 2012 Jan;11(1):M111.010884. doi: 10.1074/mcp.M111.010884. Epub 2011 Oct 24.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. The cytoskeleton in 'couch potato-ism': Insights from a murine model of impaired actin dynamics. Gertz K, etal., Exp Neurol. 2018 Aug;306:34-44. doi: 10.1016/j.expneurol.2018.04.004. Epub 2018 Apr 21.
11. Pre-germinated brown rice extract ameliorates high-fat diet-induced metabolic syndrome. Hao CL, etal., J Food Biochem. 2019 Mar;43(3):e12769. doi: 10.1111/jfbc.12769. Epub 2019 Jan 13.
12. Dietary lipoic acid-dependent changes in the activity and mRNA levels of hepatic lipogenic enzymes in rats. Huong DT and Ide T, Br J Nutr. 2008 Jul;100(1):79-87. Epub 2007 Dec 7.
13. Fasting for 3 days during the suckling-weaning transient period in male rats induces metabolic abnormalities in the liver and is associated with impaired glucose tolerance in adulthood. Ikeda M, etal., Eur J Nutr. 2016 Apr;55(3):1059-67. doi: 10.1007/s00394-015-0919-9. Epub 2015 May 6.
14. Mapping of functional interactions between domains of the animal fatty acid synthase by mutant complementation in vitro. Joshi AK, etal., Biochemistry. 1997 Feb 25;36(8):2316-22.
15. Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Menendez JA and Lupu R, Nat Rev Cancer. 2007 Oct;7(10):763-77.
16. Fatty acid synthase: association with insulin resistance, type 2 diabetes, and cancer. Menendez JA, etal., Clin Chem. 2009 Mar;55(3):425-38. Epub 2009 Jan 30.
17. Suppression of fatty acid synthase promoter by polyunsaturated fatty acids. Moon YS, etal., J Lipid Res 2002 May;43(5):691-8.
18. Molecular cloning and sequencing of a cDNA encoding the thioesterase domain of the rat fatty acid synthetase. Naggert J, etal., J Biol Chem 1988 Jan 25;263(3):1146-50.
19. Insulin acutely decreases hepatic fatty acid synthase activity. Najjar SM, etal., Cell Metab. 2005 Jul;2(1):43-53.
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
22. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
23. Expression in Escherichia coli and refolding of the malonyl-/acetyltransferase domain of the multifunctional animal fatty acid synthase. Rangan VS and Smith S, J Biol Chem. 1996 Dec 6;271(49):31749-55. doi: 10.1074/jbc.271.49.31749.
24. Characterization of the inactivation of rat fatty acid synthase by C75: inhibition of partial reactions and protection by substrates. Rendina AR and Cheng D, Biochem J. 2005 Jun 15;388(Pt 3):895-903.
25. GOA pipeline RGD automated data pipeline
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Comprehensive gene review and curation RGD comprehensive gene curation
28. Rat mammary gland fatty acid synthase: localization of the constituent domains and two functional polyadenylation/termination signals in the cDNA. Schweizer M, etal., Nucleic Acids Res 1989 Jan 25;17(2):567-86.
29. Cold acclimation reduces hepatic protein Kinase B and AMP-activated protein kinase phosphorylation and increases gluconeogenesis in Rats. Sepa-Kishi DM, etal., Physiol Rep. 2018 Mar;6(5). doi: 10.14814/phy2.13592.
30. ErbB receptors and fatty acid synthase expression in aggressive head and neck squamous cell carcinomas. Silva SD, etal., Oral Dis. 2010 Nov;16(8):774-80. doi: 10.1111/j.1601-0825.2010.01687.x.
31. Dibromopropanone cross-linking of the phosphopantetheine and active-site cysteine thiols of the animal fatty acid synthase can occur both inter- and intrasubunit. Reevaluation of the side-by-side, antiparallel subunit model. Witkowski A, etal., J Biol Chem. 1999 Apr 23;274(17):11557-63.
32. Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes. Wu M, etal., Proc Natl Acad Sci U S A. 2011 Mar 29;108(13):5378-83. doi: 10.1073/pnas.1002588108. Epub 2011 Mar 9.
33. AZGP1 suppresses the process of colorectal cancer after upregulating FASN expression via mTOR signal pathway. Yu W, etal., Gen Physiol Biophys. 2020 May;39(3):239-248. doi: 10.4149/gpb_2019061.
34. Effect of Creosote Bush-Derived NDGA on Expression of Genes Involved in Lipid Metabolism in Liver of High-Fructose Fed Rats: Relevance to NDGA Amelioration of Hypertriglyceridemia and Hepatic Steatosis. Zhang H, etal., PLoS One. 2015 Sep 22;10(9):e0138203. doi: 10.1371/journal.pone.0138203. eCollection 2015.
Additional References at PubMed
PMID:1736293   PMID:2313386   PMID:3109907   PMID:9798653   PMID:12440974   PMID:12634446   PMID:12759350   PMID:12926246   PMID:15169678   PMID:15610851   PMID:15887043   PMID:15983196  
PMID:16210410   PMID:16800817   PMID:16834571   PMID:17313375   PMID:17709201   PMID:17823126   PMID:18079124   PMID:18096506   PMID:18239060   PMID:18280001   PMID:18380011   PMID:18614015  
PMID:19056867   PMID:19182904   PMID:19946888   PMID:20458337   PMID:20729114   PMID:22331133   PMID:22658674   PMID:22681889   PMID:22871113   PMID:23357280   PMID:23533145   PMID:24668799  
PMID:25046614   PMID:25468996   PMID:25565205   PMID:26246323   PMID:26287659   PMID:27923787   PMID:28027934   PMID:28810876   PMID:29097254   PMID:29476059   PMID:31465767   PMID:32357304  
PMID:33450132   PMID:35210136   PMID:37914358   PMID:38824236  


Genomics

Comparative Map Data
Fasn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810106,570,415 - 106,588,581 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl10106,570,413 - 106,588,583 (-)EnsemblGRCr8
mRatBN7.210106,072,093 - 106,090,259 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10106,072,091 - 106,090,261 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx10111,176,141 - 111,194,306 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010110,639,183 - 110,657,348 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010105,992,540 - 106,010,706 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010109,987,735 - 110,005,901 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10109,987,735 - 110,005,901 (-)Ensemblrn6Rnor6.0
Rnor_5.010109,579,051 - 109,597,217 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera10104,615,873 - 104,634,039 (-)NCBICelera
Cytogenetic Map10q32.3NCBI
FASN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381782,078,338 - 82,098,236 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1782,078,338 - 82,098,294 (-)Ensemblhg38GRCh38
GRCh371780,036,214 - 80,056,112 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361777,629,503 - 77,649,395 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341777,629,503 - 77,649,395NCBI
Celera1776,630,560 - 76,648,850 (-)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1775,436,168 - 75,456,057 (-)NCBIHuRef
CHM1_11780,122,440 - 80,142,272 (-)NCBICHM1_1
T2T-CHM13v2.01782,945,493 - 82,965,389 (-)NCBIT2T-CHM13v2.0
Fasn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911120,696,784 - 120,715,992 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11120,696,672 - 120,715,373 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3811120,805,958 - 120,825,166 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11120,805,846 - 120,824,547 (-)Ensemblmm10GRCm38
MGSCv3711120,667,272 - 120,685,861 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611120,623,167 - 120,640,332 (-)NCBIMGSCv36mm8
Celera11132,542,449 - 132,561,038 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1184.56NCBI
Fasn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555061,063,002 - 1,079,939 (+)Ensembl
ChiLan1.0NW_0049555061,063,002 - 1,079,939 (+)NCBIChiLan1.0ChiLan1.0
FASN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21998,613,649 - 98,633,697 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan117103,514,379 - 103,534,420 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01776,483,108 - 76,503,148 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11782,187,516 - 82,205,647 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1782,187,516 - 82,205,647 (-)EnsemblpanPan2panpan1.1
FASN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.19233,105 - 249,573 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl9232,963 - 249,092 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha9835,096 - 852,365 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.09826,552 - 843,813 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl9825,448 - 843,670 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.19851,506 - 868,761 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.09978,401 - 995,678 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.091,056,702 - 1,073,992 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fasn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602802,978 - 820,174 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365945,592,609 - 5,608,972 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365945,591,785 - 5,609,886 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FASN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl12920,509 - 937,561 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.112922,405 - 937,560 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2121,023,512 - 1,032,662 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FASN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11673,988,410 - 74,008,374 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1673,982,899 - 74,006,551 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607745,523,735 - 45,543,679 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fasn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480110,909,647 - 10,927,547 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462480110,910,022 - 10,926,505 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Fasn
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1963,208,861 - 63,226,963 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fasn
70 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:601
Count of miRNA genes:277
Interacting mature miRNAs:330
Transcripts:ENSRNOT00000073321
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093723381107556066Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1089039175107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
1576313Pia25Pristane induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1097202388107556066Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1576307Cia28Collagen induced arthritis QTL 28joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087807758107713808Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1091127270107556066Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091727883107713808Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1097202388107556066Rat

Markers in Region
RH129091  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210106,072,888 - 106,073,047 (+)MAPPERmRatBN7.2
Rnor_6.010109,988,531 - 109,988,689NCBIRnor6.0
Rnor_5.010109,579,847 - 109,580,005UniSTSRnor5.0
Celera10104,616,669 - 104,616,827UniSTS
RH141092  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210106,072,153 - 106,072,361 (+)MAPPERmRatBN7.2
Rnor_6.010109,987,796 - 109,988,003NCBIRnor6.0
Rnor_5.010109,579,112 - 109,579,319UniSTSRnor5.0
Celera10104,615,934 - 104,616,141UniSTS
PMC156147P10  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210106,075,242 - 106,075,353 (+)MAPPERmRatBN7.2
Rnor_6.010109,990,885 - 109,990,995NCBIRnor6.0
Rnor_5.010109,582,201 - 109,582,311UniSTSRnor5.0
Celera10104,619,023 - 104,619,133UniSTS
PMC207565P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210106,084,121 - 106,084,204 (+)MAPPERmRatBN7.2
Rnor_6.010109,999,764 - 109,999,846NCBIRnor6.0
Rnor_5.010109,591,080 - 109,591,162UniSTSRnor5.0
Celera10104,627,902 - 104,627,984UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000073321   ⟹   ENSRNOP00000064445
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10106,570,413 - 106,588,583 (-)Ensembl
mRatBN7.2 Ensembl10106,072,091 - 106,090,261 (-)Ensembl
Rnor_6.0 Ensembl10109,987,735 - 110,005,901 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100099   ⟹   ENSRNOP00000087318
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10106,072,091 - 106,089,994 (-)Ensembl
RefSeq Acc Id: NM_017332   ⟹   NP_059028
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810106,570,415 - 106,588,581 (-)NCBI
mRatBN7.210106,072,093 - 106,090,259 (-)NCBI
Rnor_6.010109,987,735 - 110,005,901 (-)NCBI
Rnor_5.010109,579,051 - 109,597,217 (-)NCBI
Celera10104,615,873 - 104,634,039 (-)RGD
Sequence:
RefSeq Acc Id: NP_059028   ⟸   NM_017332
- UniProtKB: Q63577 (UniProtKB/Swiss-Prot),   P12785 (UniProtKB/Swiss-Prot),   O09190 (UniProtKB/Swiss-Prot),   O09187 (UniProtKB/Swiss-Prot),   Q64717 (UniProtKB/Swiss-Prot),   A6HLK3 (UniProtKB/TrEMBL),   A0A8I6A2Z2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000064445   ⟸   ENSRNOT00000073321
Ensembl Acc Id: ENSRNOP00000087318   ⟸   ENSRNOT00000100099
Protein Domains
Carrier   Ketosynthase family 3 (KS3)   PKS/mFAS DH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P12785-F1-model_v2 AlphaFold P12785 1-2505 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697980
Promoter ID:EPDNEW_R8505
Type:single initiation site
Name:Fasn_1
Description:fatty acid synthase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.010110,005,903 - 110,005,963EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620665 AgrOrtholog
BioCyc Gene G2FUF-22380 BioCyc
Ensembl Genes ENSRNOG00000045636 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000073321 ENTREZGENE
  ENSRNOT00000073321.3 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.1200.10 UniProtKB/Swiss-Prot
  3.10.129.110 UniProtKB/Swiss-Prot
  3.30.70.3290 UniProtKB/Swiss-Prot
  3.40.366.10 UniProtKB/Swiss-Prot
  3.40.47.10 UniProtKB/Swiss-Prot
  3.40.50.150 UniProtKB/Swiss-Prot
  3.40.50.1820 UniProtKB/Swiss-Prot
  Medium-chain alcohol dehydrogenases, catalytic domain UniProtKB/Swiss-Prot
  NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot
InterPro AB_hydrolase UniProtKB/Swiss-Prot
  Ac_transferase_dom_sf UniProtKB/Swiss-Prot
  ACP-like_sf UniProtKB/Swiss-Prot
  Acyl_transferase UniProtKB/Swiss-Prot
  Acyl_Trfase/lysoPLipase UniProtKB/Swiss-Prot
  FAS_pseudo-KR UniProtKB/Swiss-Prot
  GroES-like_sf UniProtKB/Swiss-Prot
  KAsynt_C_assoc UniProtKB/Swiss-Prot
  Ketoacyl_synth_AS UniProtKB/Swiss-Prot
  Ketoacyl_synth_C UniProtKB/Swiss-Prot
  Ketoacyl_synth_N UniProtKB/Swiss-Prot
  Malonyl_transacylase_ACP-bd UniProtKB/Swiss-Prot
  Methyltransf_12 UniProtKB/Swiss-Prot
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot
  PKS_Beta-ketoAc_synthase_dom UniProtKB/Swiss-Prot
  PKS_dehydratase UniProtKB/Swiss-Prot
  PKS_dehydratase_sf UniProtKB/Swiss-Prot
  PKS_DH_N UniProtKB/Swiss-Prot
  PKS_ER UniProtKB/Swiss-Prot
  PKS_KR UniProtKB/Swiss-Prot
  PKS_mFAS_DH UniProtKB/Swiss-Prot
  PKS_NRPS_Biosynth_Enz UniProtKB/Swiss-Prot
  PKS_PP-bd UniProtKB/Swiss-Prot
  PP-bd_ACP UniProtKB/Swiss-Prot
  Ppantetheine_attach_site UniProtKB/Swiss-Prot
  SAM-dependent_MTases UniProtKB/Swiss-Prot
  Thioesterase UniProtKB/Swiss-Prot
  Thiolase-like UniProtKB/Swiss-Prot
KEGG Report rno:50671 UniProtKB/Swiss-Prot
NCBI Gene 50671 ENTREZGENE
PANTHER FATTY ACID SYNTHASE UniProtKB/Swiss-Prot
  FATTY ACID SYNTHASE UniProtKB/Swiss-Prot
Pfam Acyl_transf_1 UniProtKB/Swiss-Prot
  ADH_zinc_N_2 UniProtKB/Swiss-Prot
  FAS_pseudo-KR UniProtKB/Swiss-Prot
  KAsynt_C_assoc UniProtKB/Swiss-Prot
  ketoacyl-synt UniProtKB/Swiss-Prot
  Ketoacyl-synt_C UniProtKB/Swiss-Prot
  Methyltransf_12 UniProtKB/Swiss-Prot
  PF08659 UniProtKB/Swiss-Prot
  PKS_DH_N UniProtKB/Swiss-Prot
  PP-binding UniProtKB/Swiss-Prot
  Thioesterase UniProtKB/Swiss-Prot
PhenoGen Fasn PhenoGen
PROSITE B_KETOACYL_SYNTHASE UniProtKB/Swiss-Prot
  CARRIER UniProtKB/Swiss-Prot
  KS3_2 UniProtKB/Swiss-Prot
  PHOSPHOPANTETHEINE UniProtKB/Swiss-Prot
  PKS_MFAS_DH UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000045636 RatGTEx
SMART PKS_AT UniProtKB/Swiss-Prot
  PKS_DH UniProtKB/Swiss-Prot
  PKS_ER UniProtKB/Swiss-Prot
  PKS_KR UniProtKB/Swiss-Prot
  PKS_KS UniProtKB/Swiss-Prot
  PKS_PP UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47336 UniProtKB/Swiss-Prot
  SSF50129 UniProtKB/Swiss-Prot
  SSF51735 UniProtKB/Swiss-Prot
  SSF52151 UniProtKB/Swiss-Prot
  SSF53335 UniProtKB/Swiss-Prot
  SSF53474 UniProtKB/Swiss-Prot
  SSF53901 UniProtKB/Swiss-Prot
  SSF55048 UniProtKB/Swiss-Prot
UniProt A0A8I6A2Z2 ENTREZGENE
  A6HLK3 ENTREZGENE, UniProtKB/TrEMBL
  A6HLK4_RAT UniProtKB/TrEMBL
  FAS_RAT UniProtKB/Swiss-Prot
  O09187 ENTREZGENE
  O09190 ENTREZGENE
  P12785 ENTREZGENE
  Q63577 ENTREZGENE
  Q64717 ENTREZGENE
UniProt Secondary O09187 UniProtKB/Swiss-Prot
  O09190 UniProtKB/Swiss-Prot
  Q63577 UniProtKB/Swiss-Prot
  Q64717 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Fasn  fatty acid synthase      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Fasn        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation transcription is inhibited by polyunsaturated fats via the sterol regulatory element-binding protein 728468