Hrh4 (histamine receptor H4) - Rat Genome Database

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Gene: Hrh4 (histamine receptor H4) Rattus norvegicus
Analyze
Symbol: Hrh4
Name: histamine receptor H4
RGD ID: 620631
Description: Enables histamine receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway; and chemical synaptic transmission. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in dendrite and synapse. Orthologous to human HRH4 (histamine receptor H4); INTERACTS WITH 2,4,6-trinitrobenzenesulfonic acid; amitrole; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: H4R; HH4R; histamine H4 receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8184,440,977 - 4,457,132 (+)NCBIGRCr8
mRatBN7.2184,166,270 - 4,182,426 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl184,166,270 - 4,246,345 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx184,389,940 - 4,406,096 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0185,177,508 - 5,193,664 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0184,436,938 - 4,453,080 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0184,365,429 - 4,382,599 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl184,365,429 - 4,382,599 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0184,353,104 - 4,368,967 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4184,275,671 - 4,292,259 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1184,275,670 - 4,292,259 (+)NCBI
Celera184,215,815 - 4,231,769 (+)NCBICelera
Cytogenetic Map18p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
dendrite  (IBA,IEA)
membrane  (ISO)
plasma membrane  (IBA,IEA)
synapse  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Comparison of human, mouse, rat, and guinea pig histamine H4 receptors reveals substantial pharmacological species variation. Liu C, etal., J Pharmacol Exp Ther 2001 Oct;299(1):121-30.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties. Thurmond RL, etal., J Pharmacol Exp Ther 2004 Apr;309(1):404-13. Epub 2004 Jan 13.
Additional References at PubMed
PMID:18345490   PMID:19046950   PMID:19053770   PMID:19271139   PMID:19413571   PMID:21055325   PMID:21839070   PMID:22153663   PMID:22569158   PMID:22624822   PMID:23262779   PMID:23413254  
PMID:23488566   PMID:25253872   PMID:25666529   PMID:30528857  


Genomics

Comparative Map Data
Hrh4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8184,440,977 - 4,457,132 (+)NCBIGRCr8
mRatBN7.2184,166,270 - 4,182,426 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl184,166,270 - 4,246,345 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx184,389,940 - 4,406,096 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0185,177,508 - 5,193,664 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0184,436,938 - 4,453,080 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0184,365,429 - 4,382,599 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl184,365,429 - 4,382,599 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0184,353,104 - 4,368,967 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4184,275,671 - 4,292,259 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1184,275,670 - 4,292,259 (+)NCBI
Celera184,215,815 - 4,231,769 (+)NCBICelera
Cytogenetic Map18p13NCBI
HRH4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381824,460,637 - 24,479,974 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1824,460,637 - 24,479,961 (+)EnsemblGRCh38hg38GRCh38
GRCh371822,040,601 - 22,059,938 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361820,294,591 - 20,313,919 (+)NCBINCBI36Build 36hg18NCBI36
Build 341820,294,590 - 20,313,918NCBI
Celera1818,855,629 - 18,874,954 (+)NCBICelera
Cytogenetic Map18q11.2NCBI
HuRef1818,896,649 - 18,915,969 (+)NCBIHuRef
CHM1_11821,967,599 - 21,986,980 (+)NCBICHM1_1
T2T-CHM13v2.01824,654,947 - 24,674,284 (+)NCBIT2T-CHM13v2.0
Hrh4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391813,140,039 - 13,156,758 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1813,140,047 - 13,155,939 (+)EnsemblGRCm39 Ensembl
GRCm381813,006,982 - 13,023,701 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1813,006,990 - 13,022,882 (+)EnsemblGRCm38mm10GRCm38
MGSCv371813,165,499 - 13,181,391 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361813,150,159 - 13,166,051 (+)NCBIMGSCv36mm8
Celera1813,240,031 - 13,255,921 (+)NCBICelera
Cytogenetic Map18A1NCBI
cM Map186.88NCBI
Hrh4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540212,809,146 - 12,824,226 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540212,809,164 - 12,826,952 (+)NCBIChiLan1.0ChiLan1.0
HRH4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21741,891,026 - 41,911,124 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11827,583,621 - 27,600,463 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01817,711,852 - 17,731,500 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11821,332,651 - 21,351,930 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1821,332,651 - 21,351,930 (+)Ensemblpanpan1.1panPan2
HRH4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1763,918,408 - 63,932,258 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl763,918,232 - 63,932,569 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha763,365,578 - 63,381,202 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0763,977,108 - 63,991,060 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl763,976,989 - 63,991,087 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1763,647,725 - 63,661,244 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0763,661,653 - 63,675,492 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0763,966,352 - 63,980,292 (-)NCBIUU_Cfam_GSD_1.0
LOC101965352
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494459,983,688 - 59,992,066 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365503,815,372 - 3,831,419 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365503,815,372 - 3,831,481 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HRH4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6109,303,820 - 109,319,479 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16109,302,264 - 109,318,607 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26102,070,555 - 102,076,049 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HRH4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11856,056,522 - 56,095,194 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1856,057,605 - 56,068,482 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605030,801,609 - 30,821,594 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hrh4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247707,792,321 - 7,795,303 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hrh4
165 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:261
Count of miRNA genes:159
Interacting mature miRNAs:173
Transcripts:ENSRNOT00000022744
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552968Pigfal19Plasma insulin-like growth factor 1 level QTL 1911.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)18125758124Rat
9590248Scort10Serum corticosterone level QTL 1019.710.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)18125758124Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18130558703Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134291613Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134291613Rat
61388Bp2Blood pressure QTL 23.23arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)18135374722Rat
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18142547119Rat
1641910Colcr3Colorectal carcinoma resistance QTL 35.020.000007intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor surface area measurement (CMO:0002078)18224947722066430Rat
1641910Colcr3Colorectal carcinoma resistance QTL 35.020.000007intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)18224947722066430Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 2 2 2 3 1
Below cutoff 2 4 17 11 10 11 1 2 4 2 8 5 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000022744   ⟹   ENSRNOP00000022744
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl184,166,270 - 4,246,345 (+)Ensembl
Rnor_6.0 Ensembl184,365,429 - 4,382,599 (+)Ensembl
RefSeq Acc Id: NM_131909   ⟹   NP_571984
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8184,440,977 - 4,457,132 (+)NCBI
mRatBN7.2184,166,270 - 4,182,426 (+)NCBI
Rnor_6.0184,365,429 - 4,382,599 (+)NCBI
Rnor_5.0184,353,104 - 4,368,967 (+)NCBI
RGSC_v3.4184,275,671 - 4,292,259 (+)RGD
Celera184,215,815 - 4,231,769 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_571984 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAK97381 (Get FASTA)   NCBI Sequence Viewer  
  EDL75027 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000022744
  ENSRNOP00000022744.2
  ENSRNOP00055011571
  ENSRNOP00060012704
  ENSRNOP00065007503
GenBank Protein Q91ZY1 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_571984   ⟸   NM_131909
- UniProtKB: Q91ZY1 (UniProtKB/Swiss-Prot),   G3V868 (UniProtKB/TrEMBL),   A6KLT2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000022744   ⟸   ENSRNOT00000022744
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q91ZY1-F1-model_v2 AlphaFold Q91ZY1 1-391 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620631 AgrOrtholog
BioCyc Gene G2FUF-8338 BioCyc
Ensembl Genes ENSRNOG00000016887 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00055008573 UniProtKB/Swiss-Prot
  ENSRNOG00060009647 UniProtKB/Swiss-Prot
  ENSRNOG00065006645 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000022744 ENTREZGENE
  ENSRNOT00000022744.5 UniProtKB/TrEMBL
  ENSRNOT00055014473 UniProtKB/Swiss-Prot
  ENSRNOT00060016272 UniProtKB/Swiss-Prot
  ENSRNOT00065010270 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Histamine_H4_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:170704 UniProtKB/Swiss-Prot
NCBI Gene 170704 ENTREZGENE
PANTHER 5-HYDROXYTRYPTAMINE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HISTAMINE H4 RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hrh4 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HISTAMINEH4R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016887 RatGTEx
  ENSRNOG00055008573 RatGTEx
  ENSRNOG00060009647 RatGTEx
  ENSRNOG00065006645 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6KLT2 ENTREZGENE, UniProtKB/TrEMBL
  G3V868 ENTREZGENE, UniProtKB/TrEMBL
  HRH4_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-19 Hrh4  histamine receptor H4  Hrh4  histamine H4 receptor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Hrh4  histamine H4 receptor      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Hrh4  histamine H4 receptor      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in bone marrow and spleen 708595