Hmga2 (high mobility group AT-hook 2) - Rat Genome Database

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Gene: Hmga2 (high mobility group AT-hook 2) Rattus norvegicus
Analyze
Symbol: Hmga2
Name: high mobility group AT-hook 2
RGD ID: 620617
Description: Enables enzyme binding activity. Involved in negative regulation of intracellular steroid hormone receptor signaling pathway; negative regulation of receptor signaling pathway via JAK-STAT; and negative regulation of transcription by RNA polymerase II. Predicted to be located in male germ cell nucleus; nuclear chromosome; and senescence-associated heterochromatin focus. Predicted to be part of SMAD protein complex and protein-DNA complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Silver-Russell syndrome; leiomyoma; lipoma; and ovarian cancer. Orthologous to human HMGA2 (high mobility group AT-hook 2); PARTICIPATES IN Ras mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-methoxyethanol; atrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: high mobility group protein HMGI-C; Hmgic; non-histone chromosomal architectural protein HMGI-C
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8757,762,710 - 57,884,555 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl757,765,675 - 57,880,341 (-)EnsemblGRCr8
mRatBN7.2755,877,145 - 55,998,813 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl755,880,112 - 55,994,784 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx757,786,495 - 57,901,148 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0759,989,707 - 60,104,351 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0759,767,092 - 59,881,753 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0765,159,944 - 65,275,408 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl765,159,944 - 65,275,408 (-)Ensemblrn6Rnor6.0
Rnor_5.0765,375,936 - 65,490,635 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4759,638,555 - 59,753,791 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera752,634,133 - 52,748,501 (-)NCBICelera
RGSC_v3.1759,659,284 - 59,774,521 (-)NCBI
Cytogenetic Map7q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
1-nitropyrene  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2,6-dimethoxyphenol  (ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-deoxy-D-glucose  (ISO)
2-methoxyethanol  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nitrophenol  (ISO)
4-phenylbutyric acid  (ISO)
5-azacytidine  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
brequinar  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
celastrol  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (EXP)
deguelin  (ISO)
dexamethasone  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
doxycycline  (ISO)
endosulfan  (EXP)
erastin  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
furfural  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
glucose  (ISO)
hypochlorous acid  (ISO)
indometacin  (ISO)
itraconazole  (ISO)
ivermectin  (ISO)
ketoconazole  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
maneb  (ISO)
melphalan  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
okadaic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
permethrin  (ISO)
phenanthrene  (ISO)
phenobarbital  (EXP)
pirinixic acid  (EXP)
piroxicam  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
quercitrin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tebufenpyrad  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adipose tissue development  (ISO)
adrenal gland development  (ISO)
base-excision repair  (IEA,ISO,ISS)
cell proliferation in forebrain  (ISO)
chondrocyte differentiation  (IEA,ISO,ISS)
chondrocyte proliferation  (IEA,ISO,ISS)
DNA-templated transcription  (IEA)
endodermal cell differentiation  (IEA,ISO,ISS)
epithelial to mesenchymal transition  (IEA,ISO,ISS)
epithelial tube branching involved in lung morphogenesis  (ISO)
fat cell differentiation  (IEA,ISO,ISS)
fat pad development  (ISO)
heterochromatin formation  (IEA,ISO,ISS)
host-mediated suppression of viral transcription  (IEA,ISO,ISS)
intracellular signal transduction  (IBA,IEA,ISO,ISS)
lung epithelium development  (ISO)
male gonad development  (ISO)
mesenchymal cell differentiation  (IEA,ISO,ISS)
mesodermal cell differentiation  (IEA,ISO,ISS)
mesodermal-endodermal cell signaling  (IEA,ISO,ISS)
multicellular organism growth  (ISO)
negative regulation of apoptotic process  (IEA,ISO,ISS)
negative regulation of astrocyte differentiation  (ISO)
negative regulation of cellular senescence  (IEA,ISO)
negative regulation of DNA-templated transcription  (IEA,ISO,ISS)
negative regulation of double-strand break repair via nonhomologous end joining  (IEA,ISO,ISS)
negative regulation of intracellular steroid hormone receptor signaling pathway  (IDA)
negative regulation of receptor signaling pathway via JAK-STAT  (IDA)
negative regulation of single stranded viral RNA replication via double stranded DNA intermediate  (IEA,ISO,ISS)
negative regulation of transcription by RNA polymerase II  (IDA,IEA,ISO,ISS)
negative regulation of Wnt signaling pathway  (ISO)
obsolete positive regulation of DNA-binding transcription factor activity  (IMP)
oncogene-induced cell senescence  (IEA,ISO,ISS)
pituitary gland development  (ISO)
positive regulation of angiogenesis  (IEA,ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cell proliferation in bone marrow  (IEA,ISO)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of epithelial cell proliferation involved in lung morphogenesis  (ISO)
positive regulation of gene expression  (IEA,ISO,ISS)
positive regulation of macromolecule biosynthetic process  (IEA)
positive regulation of multicellular organism growth  (ISO)
positive regulation of protein serine/threonine kinase activity  (ISO,ISS)
positive regulation of stem cell proliferation  (IEA,ISO,ISS)
positive regulation of transcription by RNA polymerase II  (IEA,ISO,ISS)
regulation of cell cycle process  (IEA,ISO,ISS)
regulation of DNA-templated transcription  (IBA,IEA,ISO,ISS)
regulation of gene expression  (IEA)
regulation of growth hormone secretion  (ISO)
regulation of peptide hormone secretion  (ISO)
regulation of stem cell population maintenance  (IEA,ISO,ISS)
response to virus  (IEA,ISO)
somatic stem cell population maintenance  (ISO)
spermatogenesis  (ISO)
stem cell differentiation  (IEA,ISO)

Cellular Component
chromatin  (IEA)
nuclear chromosome  (IEA,ISO,ISS)
nucleolus  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO,ISS)
protein-DNA complex  (IEA,ISO,ISS)
senescence-associated heterochromatin focus  (IEA,ISO,ISS)
SMAD protein complex  (IEA,ISO,ISS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. In vivo modulation of Hmgic reduces obesity. Anand A and Chada K, Nat Genet. 2000 Apr;24(4):377-80.
2. Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains. Ashar HR, etal., Cell. 1995 Jul 14;82(1):57-65.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Fusion transcripts between the HMGIC gene and RTVL-H-related sequences in mesenchymal tumors without cytogenetic aberrations. Kazmierczak B, etal., Genomics. 1996 Dec 1;38(2):223-6.
5. Oncogenic raf-1 induces the expression of non-histone chromosomal architectural protein HMGI-C via a p44/p42 mitogen-activated protein kinase-dependent pathway in salivary epithelial cells. Li D, etal., J Biol Chem 1997 Oct 3;272(40):25062-70.
6. HMGA2 gene is a promising target for ovarian cancer silencing therapy. Malek A, etal., Int J Cancer. 2008 Jul 15;123(2):348-56.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Neoplastic transformation of rat thyroid cells requires the junB and fra-1 gene induction which is dependent on the HMGI-C gene product. Vallone D, etal., EMBO J. 1997 Sep 1;16(17):5310-21.
13. Requirement for high mobility group protein HMGI-C interaction with STAT3 inhibitor PIAS3 in repression of alpha-subunit of epithelial Na+ channel (alpha-ENaC) transcription by Ras activation in salivary epithelial cells. Zentner MD, etal., J Biol Chem. 2001 Aug 10;276(32):29805-14. Epub 2001 Jun 4.
Additional References at PubMed
PMID:504232   PMID:5051369   PMID:7651535   PMID:7958830   PMID:11555636   PMID:12032866   PMID:14627817   PMID:14645522   PMID:14668482   PMID:14794889   PMID:15225648   PMID:15645138  
PMID:15755872   PMID:16061642   PMID:16109425   PMID:16791210   PMID:16901784   PMID:17005673   PMID:17078040   PMID:17305714   PMID:17324944   PMID:17426251   PMID:17624332   PMID:17854662  
PMID:18640244   PMID:18832382   PMID:18957199   PMID:19465398   PMID:19549901   PMID:20108983   PMID:21484705   PMID:21533145   PMID:23072816   PMID:24661562   PMID:25557289   PMID:25623534  
PMID:26698218   PMID:27693697   PMID:30934671   PMID:32068957   PMID:32370714   PMID:33749722   PMID:35966335  


Genomics

Comparative Map Data
Hmga2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8757,762,710 - 57,884,555 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl757,765,675 - 57,880,341 (-)EnsemblGRCr8
mRatBN7.2755,877,145 - 55,998,813 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl755,880,112 - 55,994,784 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx757,786,495 - 57,901,148 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0759,989,707 - 60,104,351 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0759,767,092 - 59,881,753 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0765,159,944 - 65,275,408 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl765,159,944 - 65,275,408 (-)Ensemblrn6Rnor6.0
Rnor_5.0765,375,936 - 65,490,635 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4759,638,555 - 59,753,791 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera752,634,133 - 52,748,501 (-)NCBICelera
RGSC_v3.1759,659,284 - 59,774,521 (-)NCBI
Cytogenetic Map7q22NCBI
HMGA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381265,824,460 - 65,966,291 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1265,824,460 - 65,966,291 (+)Ensemblhg38GRCh38
GRCh371266,218,240 - 66,360,071 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361264,504,507 - 64,646,338 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341264,504,457 - 64,646,266NCBI
Celera1265,883,845 - 66,025,902 (+)NCBICelera
Cytogenetic Map12q14.3NCBI
HuRef1263,271,242 - 63,413,086 (+)NCBIHuRef
CHM1_11266,185,507 - 66,327,350 (+)NCBICHM1_1
T2T-CHM13v2.01265,803,963 - 65,945,820 (+)NCBIT2T-CHM13v2.0
Hmga2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910120,197,173 - 120,312,374 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10120,197,180 - 120,312,374 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3810120,361,268 - 120,476,469 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10120,361,275 - 120,476,469 (-)Ensemblmm10GRCm38
MGSCv3710119,798,331 - 119,913,991 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3610119,764,721 - 119,880,028 (-)NCBIMGSCv36mm8
Celera10122,723,179 - 122,838,757 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1067.94NCBI
Hmga2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545812,493,790 - 12,624,805 (+)NCBIChiLan1.0ChiLan1.0
HMGA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21028,400,118 - 28,548,065 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11228,396,888 - 28,538,621 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01222,954,946 - 23,096,623 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
HMGA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1108,348,101 - 8,491,435 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha108,278,957 - 8,424,016 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0108,459,176 - 8,604,625 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl108,459,180 - 8,601,880 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1108,335,596 - 8,480,987 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0108,581,865 - 8,727,080 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0108,703,471 - 8,848,741 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Hmga2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494550,151,774 - 50,166,701 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365453,944,419 - 4,064,193 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365453,944,419 - 3,958,289 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HMGA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1530,188,521 - 30,329,635 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2533,375,397 - 33,516,455 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HMGA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11161,509,114 - 61,655,633 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037184,069,350 - 184,211,090 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hmga2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248022,337,464 - 2,467,990 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248022,337,344 - 2,468,757 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Hmga2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11198,345,800 - 198,460,679 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Hmga2
813 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:55
Count of miRNA genes:51
Interacting mature miRNAs:54
Transcripts:ENSRNOT00000065137
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72380760668807606Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74511390390113903Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71051708662346019Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72663805771638057Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72417947886817926Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74913799967614020Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)75170064396700643Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
1298525Cm1Cardiac mass QTL 12.7heart mass (VT:0007028)heart wet weight (CMO:0000069)756625161101625161Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73984590284845902Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73299870277998702Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)74968283263890004Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73617876481178764Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)755498584105834451Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74847504993475049Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73617876481178764Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2303629Vencon3Ventilatory control QTL 37.25respiration trait (VT:0001943)respiration rate (CMO:0000289)74299622658678836Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72862457565788017Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)72154197786817926Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71746044762460447Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
2303582Gluco53Glucose level QTL 533blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)74860308793603087Rat
70207Niddm31Non-insulin dependent diabetes mellitus QTL 313.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)72005723265057232Rat
61439Cia8Collagen induced arthritis QTL 85.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)72718291472182914Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 2 51 126 73 66 45 26 45 6 227 103 11 109 62 92 21 7 7

Sequence


Ensembl Acc Id: ENSRNOT00000065137   ⟹   ENSRNOP00000061041
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl757,765,675 - 57,880,341 (-)Ensembl
mRatBN7.2 Ensembl755,880,112 - 55,994,784 (-)Ensembl
Rnor_6.0 Ensembl765,159,944 - 65,275,408 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103543   ⟹   ENSRNOP00000084064
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl755,980,980 - 55,994,784 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000120053   ⟹   ENSRNOP00000085277
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl755,991,273 - 55,994,784 (-)Ensembl
RefSeq Acc Id: NM_032070   ⟹   NP_114459
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8757,765,675 - 57,880,341 (-)NCBI
mRatBN7.2755,880,112 - 55,994,784 (-)NCBI
Rnor_6.0765,159,944 - 65,275,408 (-)NCBI
Rnor_5.0765,375,936 - 65,490,635 (-)NCBI
RGSC_v3.4759,638,555 - 59,753,791 (-)RGD
Celera752,634,133 - 52,748,501 (-)RGD
Sequence:
RefSeq Acc Id: XM_039079971   ⟹   XP_038935899
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8757,762,710 - 57,884,555 (-)NCBI
mRatBN7.2755,877,145 - 55,998,813 (-)NCBI
Protein Sequences
Protein RefSeqs NP_114459 (Get FASTA)   NCBI Sequence Viewer  
  XP_038935899 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC25950 (Get FASTA)   NCBI Sequence Viewer  
  AAF91385 (Get FASTA)   NCBI Sequence Viewer  
  EDM16566 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000061041
  ENSRNOP00000061041.2
RefSeq Acc Id: NP_114459   ⟸   NM_032070
- UniProtKB: O88791 (UniProtKB/TrEMBL),   F1M940 (UniProtKB/TrEMBL),   A0A9K3Y850 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000061041   ⟸   ENSRNOT00000065137
RefSeq Acc Id: XP_038935899   ⟸   XM_039079971
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000084064   ⟸   ENSRNOT00000103543
Ensembl Acc Id: ENSRNOP00000085277   ⟸   ENSRNOT00000120053

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88791-F1-model_v2 AlphaFold O88791 1-107 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695235
Promoter ID:EPDNEW_R5760
Type:initiation region
Name:Hmga2_1
Description:high mobility group AT-hook 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0765,275,414 - 65,275,474EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620617 AgrOrtholog
BioCyc Gene G2FUF-33911 BioCyc
Ensembl Genes ENSRNOG00000042460 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000065137 ENTREZGENE
  ENSRNOT00000065137.4 UniProtKB/TrEMBL
InterPro AT_hook_DNA-bd_motif UniProtKB/TrEMBL
  HMGI/HMGY UniProtKB/TrEMBL
  HMGI/Y_DNA-bd_CS UniProtKB/TrEMBL
KEGG Report rno:84017 UniProtKB/TrEMBL
NCBI Gene 84017 ENTREZGENE
PANTHER HIGH MOBILITY GROUP PROTEIN HMGI-C UniProtKB/TrEMBL
  HIGH MOBILITY GROUP PROTEINS HMG-A AND C UniProtKB/TrEMBL
Pfam AT_hook UniProtKB/TrEMBL
PhenoGen Hmga2 PhenoGen
PRINTS ATHOOK UniProtKB/TrEMBL
  HIGHMOBLTYIY UniProtKB/TrEMBL
PROSITE HMGI_Y UniProtKB/TrEMBL
RatGTEx ENSRNOG00000042460 RatGTEx
SMART AT_hook UniProtKB/TrEMBL
UniProt A0A9K3Y850 ENTREZGENE, UniProtKB/TrEMBL
  F1M940 ENTREZGENE
  O88791 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1M940 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Hmga2  high mobility group AT-hook 2  Hmgic  non-histone chromosomal architectural protein HMGI-C  Symbol and Name updated 1299863 APPROVED
2002-08-07 Hmgic  non-histone chromosomal architectural protein HMGI-C      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation transcription is activated by oncogenic Raf-1 kinase 632948