Slc16a3 (solute carrier family 16 member 3) - Rat Genome Database

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Gene: Slc16a3 (solute carrier family 16 member 3) Rattus norvegicus
Analyze
Symbol: Slc16a3
Name: solute carrier family 16 member 3
RGD ID: 620603
Description: Enables lactate:proton symporter activity. Involved in plasma membrane lactate transport. Located in plasma membrane. Orthologous to human SLC16A3 (solute carrier family 16 member 3); INTERACTS WITH 17alpha-ethynylestradiol; 2,4-D; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MCT 3; MCT 4; Mct3; MCT4; monocarboxylate transporter; monocarboxylate transporter 3; monocarboxylate transporter 4; solute carrier family 16 (monocarboxylate transporter), member 3; solute carrier family 16 (monocarboxylic acid transporters), member 3; solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810106,712,328 - 106,756,168 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl10106,714,466 - 106,720,903 (+)EnsemblGRCr8
mRatBN7.210106,212,679 - 106,222,564 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10106,212,778 - 106,222,562 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx10111,318,174 - 111,326,740 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010110,781,213 - 110,789,779 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010106,134,447 - 106,143,022 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010110,138,519 - 110,148,360 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10110,138,586 - 110,148,358 (+)Ensemblrn6Rnor6.0
Rnor_5.010109,726,073 - 109,735,892 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.410110,159,679 - 110,163,182 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera10104,753,007 - 104,761,582 (+)NCBICelera
RGSC_v3.110110,174,182 - 110,177,686 (+)NCBI
Cytogenetic Map10q32.3NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-D  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dimethoxyphenol  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
Azoxymethane  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bruceine D  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
celecoxib  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
corilagin  (EXP)
coumarin  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
cytarabine  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
folic acid  (ISO)
folpet  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furfural  (ISO)
genistein  (ISO)
glycidol  (EXP)
GW 4064  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lanthanum trichloride  (EXP)
lead diacetate  (ISO)
lead(0)  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
methylmercury chloride  (ISO)
Monobutylphthalate  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-Nitrosopyrrolidine  (ISO)
naphthalenes  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
nitrofen  (EXP)
okadaic acid  (ISO)
oxaliplatin  (EXP)
oxamic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
Pf-06840003  (ISO)
phenylephrine  (EXP)
potassium chromate  (ISO)
prostaglandin E2  (ISO)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dichromate  (ISO)
Soman  (EXP)
streptozocin  (ISO)
sulfadimethoxine  (EXP)
tamibarotene  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
topotecan  (EXP)
tributylstannane  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
undecane  (EXP)
valproic acid  (ISO)
zidovudine  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
apical plasma membrane  (IEA,ISO)
basolateral plasma membrane  (IBA,IEA,ISO,ISS)
lateral plasma membrane  (IEA,ISO)
membrane  (IEA)
plasma membrane  (IBA,IDA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. A novel postsynaptic density protein: the monocarboxylate transporter MCT2 is co-localized with delta-glutamate receptors in postsynaptic densities of parallel fiber-Purkinje cell synapses. Bergersen L, etal., Exp Brain Res. 2001 Feb;136(4):523-34.
2. The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells. Dimmer KS, etal., Biochem J. 2000 Aug 15;350 Pt 1:219-27.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression. Kirk P, etal., EMBO J. 2000 Aug 1;19(15):3896-904.
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10. Ovens MJ, etal., Biochem J. 2010 Jan 15;425(3):523-30. doi: 10.1042/BJ20091515.
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Lactic acid efflux from white skeletal muscle is catalyzed by the monocarboxylate transporter isoform MCT3. Wilson MC, etal., J Biol Chem 1998 Jun 26;273(26):15920-6.
Additional References at PubMed
PMID:12477932   PMID:15917240   PMID:18523157   PMID:20300744   PMID:21297988   PMID:21376239   PMID:21512297   PMID:21741392   PMID:22658674   PMID:23344966   PMID:23886299   PMID:24464262  
PMID:24610532   PMID:25146899   PMID:25827488   PMID:26831515   PMID:26996590   PMID:29249221   PMID:31578706   PMID:31837519   PMID:33625690  


Genomics

Comparative Map Data
Slc16a3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810106,712,328 - 106,756,168 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl10106,714,466 - 106,720,903 (+)EnsemblGRCr8
mRatBN7.210106,212,679 - 106,222,564 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10106,212,778 - 106,222,562 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx10111,318,174 - 111,326,740 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010110,781,213 - 110,789,779 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010106,134,447 - 106,143,022 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010110,138,519 - 110,148,360 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10110,138,586 - 110,148,358 (+)Ensemblrn6Rnor6.0
Rnor_5.010109,726,073 - 109,735,892 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.410110,159,679 - 110,163,182 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera10104,753,007 - 104,761,582 (+)NCBICelera
RGSC_v3.110110,174,182 - 110,177,686 (+)NCBI
Cytogenetic Map10q32.3NCBI
SLC16A3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381782,217,934 - 82,240,086 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1782,217,878 - 82,261,129 (+)Ensemblhg38GRCh38
GRCh371780,186,311 - 80,197,962 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361777,779,582 - 77,790,658 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341777,780,235 - 77,790,640NCBI
Celera1776,780,516 - 76,791,586 (+)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1775,585,945 - 75,596,959 (+)NCBIHuRef
CHM1_11780,272,024 - 80,283,105 (+)NCBICHM1_1
T2T-CHM13v2.01783,097,177 - 83,108,820 (+)NCBIT2T-CHM13v2.0
Slc16a3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911120,839,310 - 120,849,826 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11120,839,306 - 120,851,694 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3811120,948,484 - 120,959,000 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11120,948,480 - 120,960,868 (+)Ensemblmm10GRCm38
MGSCv3711120,809,798 - 120,820,314 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611120,764,574 - 120,775,090 (+)NCBIMGSCv36mm8
Celera11132,685,655 - 132,696,171 (+)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1184.73NCBI
Slc16a3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955506935,783 - 945,029 (-)Ensembl
ChiLan1.0NW_004955506935,783 - 945,014 (-)NCBIChiLan1.0ChiLan1.0
SLC16A3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21998,768,145 - 98,779,315 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan117103,669,708 - 103,680,875 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01776,638,030 - 76,649,159 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11782,458,711 - 82,462,221 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1782,458,737 - 82,461,721 (+)EnsemblpanPan2panpan1.1
SLC16A3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.19109,557 - 119,179 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl9110,345 - 117,352 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha9712,817 - 724,127 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.09704,211 - 715,519 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl9704,661 - 710,915 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.19729,268 - 740,577 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.09859,232 - 870,540 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.09934,334 - 945,639 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Slc16a3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602690,616 - 698,683 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365945,716,935 - 5,721,343 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365945,715,234 - 5,721,343 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC16A3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl12796,883 - 803,555 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.112796,882 - 807,480 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.212957,853 - 967,564 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC16A3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11674,146,799 - 74,157,626 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1674,150,110 - 74,158,112 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607745,743,496 - 45,754,341 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc16a3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480111,022,034 - 11,031,060 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462480111,022,997 - 11,031,578 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Slc16a3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1963,076,666 - 63,086,608 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Slc16a3
235 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:99
Count of miRNA genes:74
Interacting mature miRNAs:91
Transcripts:ENSRNOT00000054939
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093723381107556066Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1089039175107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
1576313Pia25Pristane induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1097202388107556066Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1576307Cia28Collagen induced arthritis QTL 28joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087807758107713808Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1091127270107556066Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091727883107713808Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1097202388107556066Rat

Markers in Region
UniSTS:461932  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210106,220,184 - 106,220,751 (+)MAPPERmRatBN7.2
Rnor_6.010110,145,981 - 110,146,547NCBIRnor6.0
Rnor_5.010109,733,513 - 109,734,079UniSTSRnor5.0
RGSC_v3.410110,160,805 - 110,161,371UniSTSRGSC3.4
Celera10104,759,205 - 104,759,771UniSTS
Cytogenetic Map10q32.3UniSTS
UniSTS:461931  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210106,220,184 - 106,220,720 (+)MAPPERmRatBN7.2
Rnor_6.010110,145,981 - 110,146,516NCBIRnor6.0
Rnor_5.010109,733,513 - 109,734,048UniSTSRnor5.0
RGSC_v3.410110,160,805 - 110,161,340UniSTSRGSC3.4
Celera10104,759,205 - 104,759,740UniSTS
Cytogenetic Map10q32.3UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 355 192 11 140 80 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000054939   ⟹   ENSRNOP00000051822
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10106,714,466 - 106,720,903 (+)Ensembl
mRatBN7.2 Ensembl10106,213,987 - 106,222,562 (+)Ensembl
Rnor_6.0 Ensembl10110,139,783 - 110,148,358 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000086096   ⟹   ENSRNOP00000069286
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10106,212,778 - 106,222,562 (+)Ensembl
Rnor_6.0 Ensembl10110,138,586 - 110,148,358 (+)Ensembl
RefSeq Acc Id: NM_030834   ⟹   NP_110461
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810106,712,328 - 106,720,903 (+)NCBI
mRatBN7.210106,213,987 - 106,222,562 (+)NCBI
Rnor_6.010110,139,783 - 110,148,358 (+)NCBI
Rnor_5.010109,726,073 - 109,735,892 (+)NCBI
RGSC_v3.410110,159,679 - 110,163,182 (+)RGD
Celera10104,753,007 - 104,761,582 (+)RGD
Sequence:
RefSeq Acc Id: XM_063269934   ⟹   XP_063126004
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810106,717,423 - 106,756,168 (+)NCBI
RefSeq Acc Id: XM_063269935   ⟹   XP_063126005
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810106,717,423 - 106,756,168 (+)NCBI
RefSeq Acc Id: NP_110461   ⟸   NM_030834
- UniProtKB: O35910 (UniProtKB/Swiss-Prot),   B4F761 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000051822   ⟸   ENSRNOT00000054939
Ensembl Acc Id: ENSRNOP00000069286   ⟸   ENSRNOT00000086096
RefSeq Acc Id: XP_063126005   ⟸   XM_063269935
- Peptide Label: isoform X1
- UniProtKB: O35910 (UniProtKB/Swiss-Prot),   B4F761 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126004   ⟸   XM_063269934
- Peptide Label: isoform X1
- UniProtKB: O35910 (UniProtKB/Swiss-Prot),   B4F761 (UniProtKB/TrEMBL)
Protein Domains
Major facilitator superfamily (MFS) profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35910-F1-model_v2 AlphaFold O35910 1-471 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697995
Promoter ID:EPDNEW_R8506
Type:multiple initiation site
Name:Slc16a3_1
Description:solute carrier family 16 member 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.010110,138,570 - 110,138,630EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620603 AgrOrtholog
BioCyc Gene G2FUF-22377 BioCyc
Ensembl Genes ENSRNOG00000036677 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000054939 ENTREZGENE
  ENSRNOT00000054939.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot
InterPro MCT UniProtKB/Swiss-Prot
  MFS UniProtKB/Swiss-Prot
  MFS_dom UniProtKB/Swiss-Prot
  MFS_trans_sf UniProtKB/Swiss-Prot
  Proton-linked_MCT UniProtKB/Swiss-Prot
KEGG Report rno:80878 UniProtKB/Swiss-Prot
NCBI Gene 80878 ENTREZGENE
PANTHER MONOCARBOXYLATE TRANSPORTER UniProtKB/Swiss-Prot
  PTHR11360:SF27 UniProtKB/Swiss-Prot
Pfam MFS_1 UniProtKB/Swiss-Prot
PhenoGen Slc16a3 PhenoGen
PROSITE MFS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000036677 RatGTEx
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot
UniProt B4F761 ENTREZGENE, UniProtKB/TrEMBL
  MOT4_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-09 Slc16a3  solute carrier family 16 member 3  Slc16a3  solute carrier family 16 (monocarboxylate transporter), member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-02 Slc16a3  solute carrier family 16 (monocarboxylate transporter), member 3  Slc16a3  solute carrier family 16, member 3 (monocarboxylic acid transporter 4)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-19 Slc16a3  solute carrier family 16, member 3 (monocarboxylic acid transporter 4)  Slc16a3  solute carrier family 16 (monocarboxylic acid transporters), member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Slc16a3  solute carrier family 16 (monocarboxylic acid transporters), member 3    monocarboxylate transporter  Name updated 1299863 APPROVED
2004-09-10 Slc16a3  monocarboxylate transporter  Mct3    Symbol and Name updated 1299863 APPROVED
2002-08-07 Mct3  monocarboxylate transporter      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in all muscle fibers, and in tissues requiring rapid lactic acid efflux 633258