Ifngr1 (interferon gamma receptor 1) - Rat Genome Database

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Gene: Ifngr1 (interferon gamma receptor 1) Rattus norvegicus
Analyze
Symbol: Ifngr1
Name: interferon gamma receptor 1
RGD ID: 620570
Description: Predicted to enable type II interferon receptor activity. Predicted to be involved in several processes, including glial cell activation; interferon-mediated signaling pathway; and positive regulation of macromolecule metabolic process. Predicted to act upstream of or within cell surface receptor signaling pathway via JAK-STAT and defense response to virus. Located in dendrite and vesicle. Human ortholog(s) of this gene implicated in asthma; hepatitis B; immunodeficiency 27A; immunodeficiency 27B; and tuberculosis. Orthologous to human IFNGR1 (interferon gamma receptor 1); PARTICIPATES IN type II interferon signaling pathway; Chagas disease pathway; cytokine mediated signaling pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ifngr; interferon gamma receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8116,152,811 - 16,171,439 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl116,152,879 - 16,171,437 (+)EnsemblGRCr8
mRatBN7.2114,333,167 - 14,351,799 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl114,333,187 - 14,351,785 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx114,089,865 - 14,108,414 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0120,091,744 - 20,110,287 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0114,313,419 - 14,331,949 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0115,062,380 - 15,080,815 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl115,062,432 - 15,080,907 (+)Ensemblrn6Rnor6.0
Rnor_5.0116,607,955 - 16,626,390 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4114,846,369 - 14,864,804 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera112,776,802 - 12,795,237 (+)NCBICelera
RGSC_v3.1114,846,430 - 14,864,866 (+)NCBI
Cytogenetic Map1p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2'-Methylenebis(4-methyl-6-tert-butylphenol)  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
amphotericin B  (ISO)
antirheumatic drug  (ISO)
aripiprazole  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
belinostat  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzoates  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium selenide  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
clozapine  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
delta-tocotrienol  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dimethyl sulfoxide  (ISO)
diuron  (EXP)
divanadium pentaoxide  (ISO)
doxorubicin  (ISO)
flutamide  (EXP)
formaldehyde  (ISO)
gallic acid  (ISO)
genistein  (EXP)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
GSK-J4  (ISO)
hydrogen peroxide  (ISO)
ketamine  (EXP)
lead diacetate  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
naphthalenes  (EXP)
nickel dichloride  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentamidine  (ISO)
phenobarbital  (ISO)
phenytoin  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
Ro 41-5253  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium stibogluconate  (ISO)
Soman  (EXP)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (ISO)
triphenyl phosphate  (EXP,ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
zinc sulfate  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
dendrite  (IDA)
membrane  (IEA,ISO)
plasma membrane  (IBA,IEA,ISO)
vesicle  (IDA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. A novel single-nucleotide substitution, Leu 467 Pro, in the interferon-gamma receptor 1 gene associated with allergic diseases. Aoki M, etal., Int J Mol Med. 2003 Aug;12(2):185-91.
2. Cytokine, C-Reactive Protein, and Heat Shock Protein mRNA Expression Levels in Patients with Active Behçet's Uveitis. Balkan E, etal., Med Sci Monit. 2018 Mar 13;24:1511-1516. doi: 10.12659/msm.907918.
3. Clinical features of dominant and recessive interferon gamma receptor 1 deficiencies. Dorman SE, etal., Lancet. 2004 Dec 11-17;364(9451):2113-21.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Cloning and expression of the cDNA for the murine interferon gamma receptor. Gray PW, etal., Proc Natl Acad Sci U S A 1989 Nov;86(21):8497-501.
7. Mice deficient in STAT1 but not STAT2 or IRF9 develop a lethal CD4+ T-cell-mediated disease following infection with lymphocytic choriomeningitis virus. Hofer MJ, etal., J Virol. 2012 Jun;86(12):6932-46. doi: 10.1128/JVI.07147-11. Epub 2012 Apr 11.
8. Human atopic dermatitis complicated by eczema herpeticum is associated with abnormalities in IFN-gamma response. Leung DY, etal., J Allergy Clin Immunol. 2011 Apr;127(4):965-73.e1-5.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. A mutation in the interferon-gamma-receptor gene and susceptibility to mycobacterial infection. Newport MJ, etal., N Engl J Med. 1996 Dec 26;335(26):1941-9.
12. Interferon gamma in the etiology of atherosclerosis and periodontitis. Niedzielska I and Cierpka S, Thromb Res. 2010 Oct;126(4):324-7. Epub 2010 Jul 22.
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. Limited systemic sclerosis patients with pulmonary arterial hypertension show biomarkers of inflammation and vascular injury. Pendergrass SA, etal., PLoS One. 2010 Aug 17;5(8):e12106.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. Noncanonical Effects of IRF9 in Intestinal Inflammation: More than Type I and Type III Interferons. Rauch I, etal., Mol Cell Biol. 2015 Jul;35(13):2332-43. doi: 10.1128/MCB.01498-14. Epub 2015 Apr 27.
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Comprehensive gene review and curation RGD comprehensive gene curation
22. Partial recessive IFN-gammaR1 deficiency: genetic, immunological and clinical features of 14 patients from 11 kindreds. Sologuren I, etal., Hum Mol Genet. 2011 Apr 15;20(8):1509-23. Epub 2011 Jan 25.
23. Interferon-gamma potentiates NMDA receptor signaling in spinal dorsal horn neurons via microglia-neuron interaction. Sonekatsu M, etal., Mol Pain. 2016 Apr 18;12. pii: 12/0/1744806916644927. doi: 10.1177/1744806916644927. Print 2016.
24. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
25. NOS2A, TLR4, and IFNGR1 interactions influence pulmonary tuberculosis susceptibility in African-Americans. Velez DR, etal., Hum Genet. 2009 Nov;126(5):643-53. Epub 2009 Jul 3.
26. Interferon-gamma receptors are expressed at synapses in the rat superficial dorsal horn and lateral spinal nucleus. Vikman K, etal., J Neurocytol. 1998 Oct;27(10):749-59.
27. Identification of an IFN-gamma/mast cell axis in a mouse model of chronic asthma. Yu M, etal., J Clin Invest. 2011 Aug;121(8):3133-43.
28. Dynamic immune status analysis of peripheral blood mononuclear cells in patients with Klebsiella pneumoniae bloodstream infection sepsis using single-cell RNA sequencing. Zhang S, etal., Front Immunol. 2024 Jun 5;15:1380211. doi: 10.3389/fimmu.2024.1380211. eCollection 2024.
Additional References at PubMed
PMID:17255335   PMID:19213397   PMID:19380717   PMID:25268627  


Genomics

Comparative Map Data
Ifngr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8116,152,811 - 16,171,439 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl116,152,879 - 16,171,437 (+)EnsemblGRCr8
mRatBN7.2114,333,167 - 14,351,799 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl114,333,187 - 14,351,785 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx114,089,865 - 14,108,414 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0120,091,744 - 20,110,287 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0114,313,419 - 14,331,949 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0115,062,380 - 15,080,815 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl115,062,432 - 15,080,907 (+)Ensemblrn6Rnor6.0
Rnor_5.0116,607,955 - 16,626,390 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4114,846,369 - 14,864,804 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera112,776,802 - 12,795,237 (+)NCBICelera
RGSC_v3.1114,846,430 - 14,864,866 (+)NCBI
Cytogenetic Map1p12NCBI
IFNGR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386137,197,484 - 137,219,385 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6137,197,483 - 137,219,449 (-)Ensemblhg38GRCh38
GRCh376137,518,621 - 137,540,522 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366137,560,315 - 137,582,200 (-)NCBIBuild 36Build 36hg18NCBI36
Build 346137,560,314 - 137,582,200NCBI
Celera6138,258,636 - 138,280,689 (-)NCBICelera
Cytogenetic Map6q23.3NCBI
HuRef6135,080,667 - 135,102,743 (-)NCBIHuRef
CHM1_16137,780,861 - 137,802,819 (-)NCBICHM1_1
T2T-CHM13v2.06138,385,847 - 138,407,878 (-)NCBIT2T-CHM13v2.0
Ifngr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391019,467,697 - 19,485,977 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1019,467,697 - 19,485,977 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381019,591,949 - 19,610,229 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1019,591,949 - 19,610,229 (+)Ensemblmm10GRCm38
MGSCv371019,311,764 - 19,330,031 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361019,281,403 - 19,300,326 (+)NCBIMGSCv36mm8
Celera1019,489,389 - 19,507,558 (+)NCBICelera
Cytogenetic Map10A3NCBI
cM Map108.49NCBI
Ifngr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543622,183,311 - 22,198,291 (+)Ensembl
ChiLan1.0NW_00495543622,183,318 - 22,199,013 (+)NCBIChiLan1.0ChiLan1.0
IFNGR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25157,164,498 - 157,186,793 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16155,063,323 - 155,086,123 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06134,958,270 - 134,980,560 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16139,045,821 - 139,068,053 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6139,045,821 - 139,068,053 (-)EnsemblpanPan2panpan1.1
IFNGR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1129,646,776 - 29,669,669 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl129,647,552 - 29,669,578 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha130,529,308 - 30,552,201 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0129,808,268 - 29,831,164 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl129,806,103 - 29,831,092 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1129,692,670 - 29,715,561 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0129,577,754 - 29,600,649 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0129,877,088 - 29,899,982 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ifngr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946124,740,584 - 124,766,561 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365604,519,474 - 4,545,796 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365604,519,858 - 4,545,763 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IFNGR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl127,037,165 - 27,061,093 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1127,037,151 - 27,061,095 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2130,388,355 - 30,409,360 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IFNGR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11336,203,038 - 36,224,039 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1336,203,004 - 36,222,542 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660408,393,656 - 8,415,178 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ifngr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624886618,289 - 642,928 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624886618,372 - 640,954 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ifngr1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12216,963,207 - 216,981,834 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ifngr1
73 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:264
Count of miRNA genes:164
Interacting mature miRNAs:189
Transcripts:ENSRNOT00000016286
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)1529322934184556Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1774611852746118Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1774612152746121Rat
70179Xhs2X-ray hypersensitivity QTL 23.2intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)1143965634Rat
1354647Despr8Despair related QTL 80.0000341locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1126564886Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)11037949255379492Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1694102251941022Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1529322934184556Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)1690935351909353Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1126564886Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)1690935351909353Rat
5684999Bss102Bone structure and strength QTL 1025.57e-07tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)1690935351909353Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11282049457820494Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)1134184556Rat
1300170Rf6Renal function QTL 63.14renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)1128483164Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)11168446456684464Rat
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1529322934184556Rat

Markers in Region
RH141363  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2114,351,536 - 14,351,721 (+)MAPPERmRatBN7.2
Rnor_6.0115,080,647 - 15,080,831NCBIRnor6.0
Rnor_5.0116,626,222 - 16,626,406UniSTSRnor5.0
RGSC_v3.4114,864,636 - 14,864,820UniSTSRGSC3.4
Celera112,795,069 - 12,795,253UniSTS
RH 3.4 Map1145.51UniSTS
Cytogenetic Map1p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000016286   ⟹   ENSRNOP00000016286
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl116,152,879 - 16,171,437 (+)Ensembl
mRatBN7.2 Ensembl114,333,187 - 14,351,785 (+)Ensembl
Rnor_6.0 Ensembl115,062,432 - 15,080,907 (+)Ensembl
RefSeq Acc Id: NM_053783   ⟹   NP_446235
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8116,152,910 - 16,171,439 (+)NCBI
mRatBN7.2114,333,265 - 14,351,799 (+)NCBI
Rnor_6.0115,062,380 - 15,080,815 (+)NCBI
Rnor_5.0116,607,955 - 16,626,390 (+)NCBI
RGSC_v3.4114,846,369 - 14,864,804 (+)RGD
Celera112,776,802 - 12,795,237 (+)RGD
Sequence:
RefSeq Acc Id: XM_039109109   ⟹   XP_038965037
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8116,157,482 - 16,171,439 (+)NCBI
mRatBN7.2114,333,182 - 14,351,799 (+)NCBI
RefSeq Acc Id: XM_063263679   ⟹   XP_063119749
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8116,152,811 - 16,169,733 (+)NCBI
RefSeq Acc Id: NP_446235   ⟸   NM_053783
- Peptide Label: precursor
- UniProtKB: F7FHZ1 (UniProtKB/TrEMBL),   A6JPB2 (UniProtKB/TrEMBL),   Q6P6T3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016286   ⟸   ENSRNOT00000016286
RefSeq Acc Id: XP_038965037   ⟸   XM_039109109
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063119749   ⟸   XM_063263679
- Peptide Label: isoform X2
Protein Domains
Fibronectin type-III   Interferon gamma receptor D2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6P6T3-F1-model_v2 AlphaFold Q6P6T3 1-464 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689510
Promoter ID:EPDNEW_R35
Type:initiation region
Name:Ifngr1_1
Description:interferon gamma receptor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0115,062,349 - 15,062,409EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620570 AgrOrtholog
BioCyc Gene G2FUF-62227 BioCyc
Ensembl Genes ENSRNOG00000012074 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016286 ENTREZGENE
  ENSRNOT00000016286.8 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5598500 IMAGE-MGC_LOAD
InterPro FN3_sf UniProtKB/TrEMBL
  FN_III UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Interferon_gamma_pox/mammal UniProtKB/TrEMBL
  Interferon_gamma_rcpt_asu UniProtKB/TrEMBL
  Type-II_Cytokine-TF_Rcpt UniProtKB/TrEMBL
KEGG Report rno:116465 UniProtKB/TrEMBL
MGC_CLONE MGC:72347 IMAGE-MGC_LOAD
NCBI Gene 116465 ENTREZGENE
PANTHER INTERFERON/INTERLEUKIN RECEPTOR UniProtKB/TrEMBL
  PTHR20859:SF5 UniProtKB/TrEMBL
Pfam IFNGR1 UniProtKB/TrEMBL
  IFNGR1_transm UniProtKB/TrEMBL
  Tissue_fac UniProtKB/TrEMBL
PhenoGen Ifngr1 PhenoGen
PRINTS INTERFERONGR UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012074 RatGTEx
Superfamily-SCOP FN_III-like UniProtKB/TrEMBL
UniProt A6JPB2 ENTREZGENE, UniProtKB/TrEMBL
  F7FHZ1 ENTREZGENE, UniProtKB/TrEMBL
  Q6P6T3 ENTREZGENE, UniProtKB/TrEMBL
  Q9QZ62_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Ifngr  interferon gamma receptor 1    interferon gamma receptor  Name updated 1299863 APPROVED
2002-08-07 Ifngr  interferon gamma receptor      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in T-cell hybridoma 1302209