Ifngr1 (interferon gamma receptor 1) - Rat Genome Database

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Gene: Ifngr1 (interferon gamma receptor 1) Rattus norvegicus
Analyze
Symbol: Ifngr1
Name: interferon gamma receptor 1
RGD ID: 620570
Description: Predicted to enable type II interferon receptor activity. Predicted to be involved in several processes, including glial cell activation; interferon-mediated signaling pathway; and positive regulation of macromolecule metabolic process. Predicted to act upstream of or within defense response to virus. Located in dendrite and vesicle. Human ortholog(s) of this gene implicated in asthma; hepatitis B; immunodeficiency 27A; immunodeficiency 27B; and tuberculosis. Orthologous to human IFNGR1 (interferon gamma receptor 1); PARTICIPATES IN type II interferon signaling pathway; Chagas disease pathway; cytokine mediated signaling pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ifngr; interferon gamma receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8116,152,811 - 16,171,439 (+)NCBIGRCr8
mRatBN7.2114,333,167 - 14,351,799 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl114,333,187 - 14,351,785 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx114,089,865 - 14,108,414 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0120,091,744 - 20,110,287 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0114,313,419 - 14,331,949 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0115,062,380 - 15,080,815 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl115,062,432 - 15,080,907 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0116,607,955 - 16,626,390 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4114,846,369 - 14,864,804 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1114,846,430 - 14,864,866 (+)NCBI
Celera112,776,802 - 12,795,237 (+)NCBICelera
Cytogenetic Map1p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
amphotericin B  (ISO)
antirheumatic drug  (ISO)
aripiprazole  (ISO)
belinostat  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzoates  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
cadmium dichloride  (EXP)
cadmium selenide  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
clozapine  (ISO)
copper(II) sulfate  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
delta-tocotrienol  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dimethyl sulfoxide  (ISO)
diuron  (EXP)
divanadium pentaoxide  (ISO)
doxorubicin  (ISO)
flutamide  (EXP)
formaldehyde  (ISO)
gallic acid  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hydrogen peroxide  (ISO)
ketamine  (EXP)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
naphthalenes  (EXP)
nickel dichloride  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentamidine  (ISO)
phenobarbital  (ISO)
phenytoin  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
Ro 41-5253  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium stibogluconate  (ISO)
Soman  (EXP)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (ISO)
trichloroethene  (ISO)
triphenyl phosphate  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
zinc sulfate  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
dendrite  (IDA)
membrane  (ISO)
plasma membrane  (IBA,ISO)
vesicle  (IDA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. A novel single-nucleotide substitution, Leu 467 Pro, in the interferon-gamma receptor 1 gene associated with allergic diseases. Aoki M, etal., Int J Mol Med. 2003 Aug;12(2):185-91.
2. Cytokine, C-Reactive Protein, and Heat Shock Protein mRNA Expression Levels in Patients with Active Behçet's Uveitis. Balkan E, etal., Med Sci Monit. 2018 Mar 13;24:1511-1516. doi: 10.12659/msm.907918.
3. Clinical features of dominant and recessive interferon gamma receptor 1 deficiencies. Dorman SE, etal., Lancet. 2004 Dec 11-17;364(9451):2113-21.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Cloning and expression of the cDNA for the murine interferon gamma receptor. Gray PW, etal., Proc Natl Acad Sci U S A 1989 Nov;86(21):8497-501.
7. Mice deficient in STAT1 but not STAT2 or IRF9 develop a lethal CD4+ T-cell-mediated disease following infection with lymphocytic choriomeningitis virus. Hofer MJ, etal., J Virol. 2012 Jun;86(12):6932-46. doi: 10.1128/JVI.07147-11. Epub 2012 Apr 11.
8. Human atopic dermatitis complicated by eczema herpeticum is associated with abnormalities in IFN-gamma response. Leung DY, etal., J Allergy Clin Immunol. 2011 Apr;127(4):965-73.e1-5.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. A mutation in the interferon-gamma-receptor gene and susceptibility to mycobacterial infection. Newport MJ, etal., N Engl J Med. 1996 Dec 26;335(26):1941-9.
12. Interferon gamma in the etiology of atherosclerosis and periodontitis. Niedzielska I and Cierpka S, Thromb Res. 2010 Oct;126(4):324-7. Epub 2010 Jul 22.
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. Limited systemic sclerosis patients with pulmonary arterial hypertension show biomarkers of inflammation and vascular injury. Pendergrass SA, etal., PLoS One. 2010 Aug 17;5(8):e12106.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. Noncanonical Effects of IRF9 in Intestinal Inflammation: More than Type I and Type III Interferons. Rauch I, etal., Mol Cell Biol. 2015 Jul;35(13):2332-43. doi: 10.1128/MCB.01498-14. Epub 2015 Apr 27.
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Comprehensive gene review and curation RGD comprehensive gene curation
22. Partial recessive IFN-gammaR1 deficiency: genetic, immunological and clinical features of 14 patients from 11 kindreds. Sologuren I, etal., Hum Mol Genet. 2011 Apr 15;20(8):1509-23. Epub 2011 Jan 25.
23. Interferon-gamma potentiates NMDA receptor signaling in spinal dorsal horn neurons via microglia-neuron interaction. Sonekatsu M, etal., Mol Pain. 2016 Apr 18;12. pii: 12/0/1744806916644927. doi: 10.1177/1744806916644927. Print 2016.
24. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
25. NOS2A, TLR4, and IFNGR1 interactions influence pulmonary tuberculosis susceptibility in African-Americans. Velez DR, etal., Hum Genet. 2009 Nov;126(5):643-53. Epub 2009 Jul 3.
26. Interferon-gamma receptors are expressed at synapses in the rat superficial dorsal horn and lateral spinal nucleus. Vikman K, etal., J Neurocytol. 1998 Oct;27(10):749-59.
27. Identification of an IFN-gamma/mast cell axis in a mouse model of chronic asthma. Yu M, etal., J Clin Invest. 2011 Aug;121(8):3133-43.
Additional References at PubMed
PMID:17255335   PMID:19213397   PMID:19380717   PMID:25268627  


Genomics

Comparative Map Data
Ifngr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8116,152,811 - 16,171,439 (+)NCBIGRCr8
mRatBN7.2114,333,167 - 14,351,799 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl114,333,187 - 14,351,785 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx114,089,865 - 14,108,414 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0120,091,744 - 20,110,287 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0114,313,419 - 14,331,949 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0115,062,380 - 15,080,815 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl115,062,432 - 15,080,907 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0116,607,955 - 16,626,390 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4114,846,369 - 14,864,804 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1114,846,430 - 14,864,866 (+)NCBI
Celera112,776,802 - 12,795,237 (+)NCBICelera
Cytogenetic Map1p12NCBI
IFNGR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386137,197,484 - 137,219,385 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6137,197,483 - 137,219,449 (-)EnsemblGRCh38hg38GRCh38
GRCh376137,518,621 - 137,540,522 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366137,560,315 - 137,582,200 (-)NCBINCBI36Build 36hg18NCBI36
Build 346137,560,314 - 137,582,200NCBI
Celera6138,258,636 - 138,280,689 (-)NCBICelera
Cytogenetic Map6q23.3NCBI
HuRef6135,080,667 - 135,102,743 (-)NCBIHuRef
CHM1_16137,780,861 - 137,802,819 (-)NCBICHM1_1
T2T-CHM13v2.06138,385,847 - 138,407,878 (-)NCBIT2T-CHM13v2.0
Ifngr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391019,467,697 - 19,485,977 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1019,467,697 - 19,485,977 (+)EnsemblGRCm39 Ensembl
GRCm381019,591,949 - 19,610,229 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1019,591,949 - 19,610,229 (+)EnsemblGRCm38mm10GRCm38
MGSCv371019,311,764 - 19,330,031 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361019,281,403 - 19,300,326 (+)NCBIMGSCv36mm8
Celera1019,489,389 - 19,507,558 (+)NCBICelera
Cytogenetic Map10A3NCBI
cM Map108.49NCBI
Ifngr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495543622,183,318 - 22,199,013 (+)NCBIChiLan1.0ChiLan1.0
IFNGR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25157,164,498 - 157,186,793 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16155,063,323 - 155,086,123 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06134,958,270 - 134,980,560 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16139,045,821 - 139,068,053 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6139,045,821 - 139,068,053 (-)Ensemblpanpan1.1panPan2
IFNGR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1129,646,776 - 29,669,669 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl129,647,552 - 29,669,578 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha130,529,308 - 30,552,201 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0129,808,268 - 29,831,164 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl129,806,103 - 29,831,092 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1129,692,670 - 29,715,561 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0129,577,754 - 29,600,649 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0129,877,088 - 29,899,982 (-)NCBIUU_Cfam_GSD_1.0
Ifngr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946124,740,584 - 124,766,561 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365604,519,474 - 4,545,796 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365604,519,858 - 4,545,763 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IFNGR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl127,037,165 - 27,061,093 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1127,037,151 - 27,061,095 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2130,388,355 - 30,409,360 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IFNGR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11336,203,038 - 36,224,039 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1336,203,004 - 36,222,542 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660408,393,656 - 8,415,178 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ifngr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624886618,289 - 642,928 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624886618,372 - 640,954 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ifngr1
96 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:264
Count of miRNA genes:164
Interacting mature miRNAs:189
Transcripts:ENSRNOT00000016286
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354647Despr8Despair related QTL 80.0000341locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1124744506Rat
2298546Neuinf4Neuroinflammation QTL 45.1nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1128736750Rat
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1132356093Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1132356093Rat
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)1132356093Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)150910843284926Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)150910843284926Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)150910843284926Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1224439043433040Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1592587724697545Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)11148148232355910Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat

Markers in Region
RH141363  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2114,351,536 - 14,351,721 (+)MAPPERmRatBN7.2
Rnor_6.0115,080,647 - 15,080,831NCBIRnor6.0
Rnor_5.0116,626,222 - 16,626,406UniSTSRnor5.0
RGSC_v3.4114,864,636 - 14,864,820UniSTSRGSC3.4
Celera112,795,069 - 12,795,253UniSTS
RH 3.4 Map1145.51UniSTS
Cytogenetic Map1p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 39 11 8
Low 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000016286   ⟹   ENSRNOP00000016286
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl114,333,187 - 14,351,785 (+)Ensembl
Rnor_6.0 Ensembl115,062,432 - 15,080,907 (+)Ensembl
RefSeq Acc Id: NM_053783   ⟹   NP_446235
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8116,152,910 - 16,171,439 (+)NCBI
mRatBN7.2114,333,265 - 14,351,799 (+)NCBI
Rnor_6.0115,062,380 - 15,080,815 (+)NCBI
Rnor_5.0116,607,955 - 16,626,390 (+)NCBI
RGSC_v3.4114,846,369 - 14,864,804 (+)RGD
Celera112,776,802 - 12,795,237 (+)RGD
Sequence:
RefSeq Acc Id: XM_039109109   ⟹   XP_038965037
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8116,157,482 - 16,171,439 (+)NCBI
mRatBN7.2114,333,182 - 14,351,799 (+)NCBI
RefSeq Acc Id: XM_063263679   ⟹   XP_063119749
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8116,152,811 - 16,169,733 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_446235   ⟸   NM_053783
- Peptide Label: precursor
- UniProtKB: F7FHZ1 (UniProtKB/TrEMBL),   A6JPB2 (UniProtKB/TrEMBL),   Q6P6T3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000016286   ⟸   ENSRNOT00000016286
RefSeq Acc Id: XP_038965037   ⟸   XM_039109109
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063119749   ⟸   XM_063263679
- Peptide Label: isoform X2
Protein Domains
Fibronectin type-III   Interferon gamma receptor D2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6P6T3-F1-model_v2 AlphaFold Q6P6T3 1-464 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689510
Promoter ID:EPDNEW_R35
Type:initiation region
Name:Ifngr1_1
Description:interferon gamma receptor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0115,062,349 - 15,062,409EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620570 AgrOrtholog
BioCyc Gene G2FUF-62227 BioCyc
Ensembl Genes ENSRNOG00000012074 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016286 ENTREZGENE
  ENSRNOT00000016286.7 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5598500 IMAGE-MGC_LOAD
InterPro FN3_sf UniProtKB/TrEMBL
  FN_III UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Interferon_gamma_pox/mammal UniProtKB/TrEMBL
  Interferon_gamma_rcpt_asu UniProtKB/TrEMBL
KEGG Report rno:116465 UniProtKB/TrEMBL
MGC_CLONE MGC:72347 IMAGE-MGC_LOAD
NCBI Gene 116465 ENTREZGENE
PANTHER INTERFERON/INTERLEUKIN RECEPTOR UniProtKB/TrEMBL
  PTHR20859:SF5 UniProtKB/TrEMBL
Pfam IFNGR1 UniProtKB/TrEMBL
  IFNGR1_transm UniProtKB/TrEMBL
  Tissue_fac UniProtKB/TrEMBL
PhenoGen Ifngr1 PhenoGen
PRINTS INTERFERONGR UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012074 RatGTEx
Superfamily-SCOP FN_III-like UniProtKB/TrEMBL
UniProt A6JPB2 ENTREZGENE, UniProtKB/TrEMBL
  F7FHZ1 ENTREZGENE, UniProtKB/TrEMBL
  Q6P6T3 ENTREZGENE, UniProtKB/TrEMBL
  Q9QZ62_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Ifngr  interferon gamma receptor 1    interferon gamma receptor  Name updated 1299863 APPROVED
2002-08-07 Ifngr  interferon gamma receptor      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in T-cell hybridoma 1302209