Kit (KIT proto-oncogene receptor tyrosine kinase) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Kit (KIT proto-oncogene receptor tyrosine kinase) Rattus norvegicus
Analyze
Symbol: Kit
Name: KIT proto-oncogene receptor tyrosine kinase
RGD ID: 620568
Description: Enables protein tyrosine kinase activity. Involved in several processes, including positive regulation of Notch signaling pathway; positive regulation of gastro-intestinal system smooth muscle contraction; and positive regulation of long-term neuronal synaptic plasticity. Located in acrosomal vesicle; cytoplasmic side of plasma membrane; and external side of plasma membrane. Used to study aplastic anemia and male infertility. Biomarker of acute pancreatitis; gastroschisis; and ileus. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal stromal tumor; germ cell cancer (multiple); mastocytosis; piebaldism; and renal cell carcinoma. Orthologous to human KIT (KIT proto-oncogene, receptor tyrosine kinase); PARTICIPATES IN acute myeloid leukemia pathway; cytokine mediated signaling pathway; endocytosis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,5-hexanedione; 2-acetamidofluorene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: c-kit receptor tyrosine kinase; Kit oncogene; mast/stem cell growth factor receptor; mast/stem cell growth factor receptor Kit; protein kinase; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: KitWs
Genetic Models: BN-KitWs ; Slc:WSRC-KitWs
Is Marker For: Strains:   F344-TyrCKitH/Kyo ; F344-AsipATyrCKitH/Kyo ; F344-TyrCKitH/Hkv ; F344-TyrCKitH.LEA-(Tel-D17Got10)/Hkv
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81432,901,615 - 32,978,895 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1432,903,033 - 32,978,812 (-)EnsemblGRCr8
mRatBN7.21432,547,459 - 32,624,694 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1432,548,877 - 32,624,652 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1432,908,757 - 32,989,974 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01434,216,558 - 34,297,770 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01432,701,812 - 32,783,026 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01435,072,131 - 35,149,638 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1435,072,108 - 35,149,610 (-)Ensemblrn6Rnor6.0
Rnor_5.01434,901,860 - 34,979,384 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41434,906,043 - 34,984,819 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1431,837,543 - 31,913,518 (-)NCBICelera
RGSC_v3.11434,906,042 - 34,984,819 (-)NCBI
Cytogenetic Map14p11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
Acute Liver Failure  (ISO)
acute myeloid leukemia  (ISO)
acute pancreatitis  (IEP)
acute promyelocytic leukemia  (ISO)
aplastic anemia  (IMP)
Breast Neoplasms  (ISO)
cholangiocarcinoma  (ISO)
Chronic Hepatitis  (IEP)
Constipation  (IEP)
cutaneous mastocytosis  (ISO)
diffuse cutaneous mastocytosis  (ISO)
dysgerminoma  (ISO)
early myoclonic encephalopathy  (ISO)
endometrial stromal sarcoma  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (IEP)
Experimental Mammary Neoplasms  (IAGP)
Gastric Reperfusion Injury  (IEP)
Gastrointestinal Neoplasms  (ISO)
gastrointestinal stromal tumor  (ISO,ISS)
gastroschisis  (IEP)
Germ Cell and Embryonal Neoplasms  (ISO)
granulosa cell tumor  (ISO)
head and neck squamous cell carcinoma  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
Hirschsprung's disease  (ISO)
ileus  (IEP)
interstitial lung disease  (ISO)
invasive ductal carcinoma  (ISO)
Latent Tuberculosis  (ISO)
leiomyosarcoma  (ISO)
lung disease  (ISO)
lung non-small cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
macrocytic anemia  (ISS)
male infertility  (IAGP)
malignant mesothelioma  (ISO)
mastocytosis  (ISO,ISS)
melanoma  (ISO)
Neoplasm Recurrence, Local  (ISO)
nephroblastoma  (ISO)
neurofibroma  (ISO)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
oxyphilic adenoma  (ISO)
Phyllodes Tumor  (ISO)
piebaldism  (ISO,ISS)
primary immunodeficiency disease  (ISO)
Primitive Peripheral Neuroectodermal Tumors  (ISO)
renal cell carcinoma  (ISO)
schizophrenia  (ISO)
seminoma  (ISO)
systemic mastocytosis  (ISO)
testicular cancer  (ISO)
testicular germ cell cancer  (ISO)
Testicular Germ Cell Tumor  (ISO)
Transplant Rejection  (IEP)
urinary bladder cancer  (ISO)
urticaria pigmentosa  (ISO)
uterine carcinosarcoma  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinic acid  (ISO)
(+)-catechin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(20S)-ginsenoside Rg3  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-phenylenediamine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,5-hexanedione  (EXP)
2-acetamidofluorene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
acetic acid  (ISO)
acrolein  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allethrin  (EXP)
alpha-hexachlorocyclohexane  (EXP)
alpha-Zearalanol  (EXP)
alvocidib  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
asperuloside  (ISO)
atropine  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
bromochloroacetic acid  (ISO)
busulfan  (ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clothianidin  (ISO)
compound 48/80  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crizotinib  (ISO)
curcumin  (EXP)
cyclophosphamide  (ISO)
D-glucose  (ISO)
daunorubicin  (EXP)
DDD  (ISO)
DDE  (ISO)
DDT  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dextromethorphan  (ISO)
Diacetoxyscirpenol  (ISO)
diallyl disulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
Didecyldimethylammonium  (ISO)
dieldrin  (ISO)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
endrin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
etoposide  (ISO)
fenvalerate  (EXP)
formaldehyde  (ISO)
fulvestrant  (ISO)
gamma-hexachlorocyclohexane  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
glucose  (ISO)
glyphosate  (ISO)
GSK-J4  (ISO)
ibuprofen  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
malathion  (EXP)
maneb  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
masitinib  (ISO)
mechlorethamine  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
microcystin-LR  (EXP)
midostaurin  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morin  (EXP)
N,O-dimethyltyramine  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
nickel atom  (EXP)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nitrofen  (EXP)
orantinib  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (ISO)
PD 0325901  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
pexidartinib  (ISO)
phosgene  (ISO)
pifithrin-alpha hydrobromide  (ISO)
ponatinib  (ISO)
potassium chromate  (ISO)
potassium dichromate  (EXP)
potassium iodide  (EXP)
rebaudioside A  (ISO)
resveratrol  (EXP)
rosmarinic acid  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
simazine  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sorafenib  (ISO)
steviol  (ISO)
stevioside  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
T-2 toxin  (ISO)
tanespimycin  (EXP,ISO)
tetraphene  (ISO)
thapsigargin  (ISO)
Theaflavin 3,3'-digallate  (ISO)
thiram  (ISO)
thymoquinone  (EXP)
titanium dioxide  (EXP,ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
uranium atom  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vitamin D  (ISO)
vorinostat  (ISO)
VX nerve agent  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (IEA,ISO)
animal organ development  (IEA)
B cell differentiation  (IBA)
cell chemotaxis  (IEA,ISO)
cell migration  (IBA,IEA)
cell surface receptor protein tyrosine kinase signaling pathway  (IEA)
chemotaxis  (IEA)
cytokine-mediated signaling pathway  (IEA,ISO)
detection of mechanical stimulus involved in sensory perception of sound  (IEA,ISO)
developmental pigmentation  (ISO)
digestive tract development  (IEA,ISO)
ectopic germ cell programmed cell death  (ISO)
embryonic hemopoiesis  (IEA,ISO)
epithelial cell proliferation  (IMP)
erythrocyte differentiation  (IEA,ISO)
erythropoietin-mediated signaling pathway  (IEA,ISO)
Fc receptor signaling pathway  (IEA,ISO)
germ cell migration  (IMP)
glycosphingolipid metabolic process  (ISO)
gonad development  (IEA)
hematopoietic progenitor cell differentiation  (IBA)
hematopoietic stem cell migration  (ISO)
hemopoiesis  (IEA,ISO)
immature B cell differentiation  (IEA,ISO)
inflammatory response  (IEA,ISO)
intracellular signal transduction  (ISO)
Kit signaling pathway  (IBA,IEA,ISO)
lamellipodium assembly  (IEA,ISO)
leukocyte activation  (IEA)
lymphoid progenitor cell differentiation  (ISO)
male gonad development  (IEA,ISO)
mast cell chemotaxis  (IEA,ISO)
mast cell degranulation  (IEA,ISO)
mast cell differentiation  (IEA,ISO)
mast cell proliferation  (IEA)
megakaryocyte development  (IEA,ISO)
melanocyte adhesion  (IEA,ISO)
melanocyte differentiation  (IEA,ISO)
melanocyte migration  (IEA,ISO)
myeloid leukocyte differentiation  (ISO)
myeloid progenitor cell differentiation  (ISO)
negative regulation of programmed cell death  (ISO)
organ growth  (IEA)
ovarian follicle development  (IEA,ISO)
peptidyl-tyrosine phosphorylation  (IDA,ISO)
pigmentation  (IEA,ISO)
positive regulation of cell migration  (IBA,IMP)
positive regulation of cell population proliferation  (IBA,IEA,IMP,ISO)
positive regulation of colon smooth muscle contraction  (IMP)
positive regulation of cytokine production involved in immune response  (IEA)
positive regulation of dendritic cell cytokine production  (IEA,ISO)
positive regulation of gene expression  (ISO)
positive regulation of long-term neuronal synaptic plasticity  (IMP)
positive regulation of MAP kinase activity  (ISO)
positive regulation of MAPK cascade  (IEA,ISO)
positive regulation of mast cell cytokine production  (IEA,ISO)
positive regulation of Notch signaling pathway  (IMP)
positive regulation of pseudopodium assembly  (IMP)
positive regulation of pyloric antrum smooth muscle contraction  (IMP)
positive regulation of receptor signaling pathway via JAK-STAT  (IBA,IEA,ISO)
positive regulation of small intestine smooth muscle contraction  (IMP)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
positive regulation of vascular associated smooth muscle cell differentiation  (IEA,ISO)
protein autophosphorylation  (IDA,ISO)
protein phosphorylation  (ISO)
regulation of cell shape  (IEA,ISO)
regulation of developmental process  (IEA)
response to cadmium ion  (IEP)
response to growth factor  (IEA)
response to radiation  (ISO)
response to stress  (IEA)
somatic stem cell population maintenance  (IMP)
spermatid development  (ISO)
spermatogenesis  (IEA,IMP,ISO)
stem cell differentiation  (IEA,ISO)
system development  (IEA)
T cell differentiation  (IEA,ISO)
tongue development  (IEP)
visual learning  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Pacemaker activity and inhibitory neurotransmission in the colon of Ws/Ws mutant rats. Albertí E, etal., Am J Physiol Gastrointest Liver Physiol. 2007 Jun;292(6):G1499-510. Epub 2007 Feb 22.
2. Expression of the stem cell factor receptor c-kit in normal and diseased pediatric liver: identification of a human hepatic progenitor cell? Baumann U, etal., Hepatology. 1999 Jul;30(1):112-7.
3. c-KIT is frequently mutated in bilateral germ cell tumours and down-regulated during progression from intratubular germ cell neoplasia to seminoma. Biermann K, etal., J Pathol. 2007 Nov;213(3):311-8.
4. A novel targeted therapy of Leydig and granulosa cell tumors through the luteinizing hormone receptor using a hecate-chorionic gonadotropin beta conjugate in transgenic mice. Bodek G, etal., Neoplasia. 2005 May;7(5):497-508.
5. Expression, mutational analysis and in vitro response of imatinib mesylate and nilotinib target genes in ovarian granulosa cell tumors. Chu S, etal., Gynecol Oncol. 2008 Jan;108(1):182-90. Epub 2007 Oct 29.
6. Identification of c-Kit receptor as a regulator of adult neural stem cells in the mammalian eye: interactions with Notch signaling. Das AV, etal., Dev Biol. 2004 Sep 1;273(1):87-105.
7. Acupuncture protects the interstitial cells of Cajal by regulating miR-222 in a rat model of post-operative ileus. Deng JJ, etal., Acupunct Med. 2019 Apr;37(2):125-132. doi: 10.1177/0964528419829755. Epub 2019 Mar 11.
8. C-kit expression in high-risk breast cancer subgroup treated with high-dose or conventional dose-dense chemotherapy. Diallo R, etal., Verh Dtsch Ges Pathol. 2006;90:177-85.
9. Expression of c-kit receptor and its autophosphorylation in immature rat type A spermatogonia. Dym M, etal., Biol Reprod. 1995 Jan;52(1):8-19.
10. c-Kit immunophenotyping and metalloproteinase expression profiles of mast cells in interstitial lung diseases. Edwards ST, etal., J Pathol. 2005 Jul;206(3):279-90.
11. C-kit protein expression in uterine and ovarian mesenchymal tumours. Erdogan G, etal., APMIS. 2007 Mar;115(3):204-9.
12. Expression of c-kit proto-oncogene product in breast cancer tissues. Eroglu A and Sari A, Med Oncol. 2007;24(2):169-74.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Mutation of the KIT (mast/stem cell growth factor receptor) protooncogene in human piebaldism. Giebel LB and Spritz RA, Proc Natl Acad Sci U S A. 1991 Oct 1;88(19):8696-9.
15. C-kit protein expression in Wilms' tumour: an immunohistochemical study. Giordano G, etal., Eur J Surg Oncol. 2009 Jun;35(6):629-35. doi: 10.1016/j.ejso.2008.09.014. Epub 2008 Nov 17.
16. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
17. Possible involvement of c-kit receptor and its ligand in increase of mast cells in neurofibroma tissues. Hirota S, etal., Arch Pathol Lab Med. 1993 Oct;117(10):996-9.
18. Stem cell factor and c-kit are expressed by and may affect vascular SMCs through an autocrine pathway. Hollenbeck ST, etal., J Surg Res 2004 Aug;120(2):288-94.
19. Disturbed intestinal movement, bile reflux to the stomach, and deficiency of c-kit-expressing cells in Ws/Ws mutant rats. Isozaki K, etal., Gastroenterology. 1995 Aug;109(2):456-64.
20. Pulsating electromagnetic field induces apoptosis of rat's bowel Cajal's cells. Kaszuba-Zwoinska J, etal., Folia Med Cracov. 2005;46(3-4):87-95.
21. Impairment of spatial learning and hippocampal synaptic potentiation in c-kit mutant rats. Katafuchi T, etal., Learn Mem. 2000 Nov-Dec;7(6):383-92.
22. The meaning of the c-kit proto-oncogene product in malignant transformation in human mammary epithelium. Ko CD, etal., Clin Exp Metastasis. 2003;20(7):593-7.
23. Down-regulation of miR-221 and miR-222 correlates with pronounced Kit expression in gastrointestinal stromal tumors. Koelz M, etal., Int J Oncol. 2011 Feb;38(2):503-11. doi: 10.3892/ijo.2010.857. Epub 2010 Dec 3.
24. Expression of c-kit in common benign and malignant breast lesions. Kondi-Pafiti A, etal., Tumori. 2010 Nov-Dec;96(6):978-84.
25. Stem cell factor/c-kit signaling mediated cardiac stem cell migration via activation of p38 MAPK. Kuang D, etal., Basic Res Cardiol. 2008 May;103(3):265-273. Epub 2007 Dec 17.
26. S100A1 and KIT gene expressions in common subtypes of renal tumours. Li G, etal., Eur J Surg Oncol. 2005 Apr;31(3):299-303.
27. [Changes in mast cells and hepatic expression of c-kit and stem cell factor in the rat model of chronic hepatitis]. Li H, etal., Zhonghua Gan Zang Bing Za Zhi. 2013 Nov;21(11):869-73. doi: 10.3760/cma.j.issn.1007-3418.2013.11.016.
28. A distinct expression pattern and point mutation of c-kit in papillary renal cell carcinomas. Lin ZH, etal., Mod Pathol. 2004 Jun;17(6):611-6.
29. Identification of key genes and pathways associated with cholangiocarcinoma development based on weighted gene correlation network analysis. Liu J, etal., PeerJ. 2019 Oct 31;7:e7968. doi: 10.7717/peerj.7968. eCollection 2019.
30. Lack of c-kit receptor promotes mammary tumors in N-nitrosomethylurea-treated Ws/Ws rats. Maffini MV, etal., Cancer Cell Int. 2008 Apr 29;8:5.
31. Erb and c-Kit receptors have distinctive patterns of expression in adult and developing taste papillae and taste buds. McLaughlin SK J Neurosci. 2000 Aug 1;20(15):5679-88.
32. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
33. Gastroschisis in the rat model is associated with a delayed maturation of intestinal pacemaker cells and smooth muscle cells. Midrio P, etal., J Pediatr Surg. 2004 Oct;39(10):1541-7.
34. Proto-oncogene c-kit expression in malignant melanoma: protein loss with tumor progression. Montone KT, etal., Mod Pathol. 1997 Sep;10(9):939-44.
35. Age-dependent amelioration of hypoplastic anemia in Ws/Ws rats with a small deletion at the kinase domain of c-kit. Morimoto M, etal., Blood. 1993 Dec 1;82(11):3315-20.
36. Elevated expression of the proto-oncogene c-kit in patients with mastocytosis. Nagata H, etal., Leukemia. 1998 Feb;12(2):175-81.
37. Disturbed pyloric motility in Ws/Ws mutant rats due to deficiency of c-kit-expressing interstitial cells of Cajal. Nakama A, etal., Pathol Int. 1998 Nov;48(11):843-9.
38. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
39. Familial gastrointestinal stromal tumours with germline mutation of the KIT gene. Nishida T, etal., Nat Genet. 1998 Aug;19(4):323-4.
40. Anemia and mast cell depletion in mutant rats that are homozygous at "white spotting (Ws)" locus. Niwa Y, etal., Blood. 1991 Oct 15;78(8):1936-41.
41. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
42. Expression of the c-kit gene is critical for migration of neonatal rat gonocytes in vitro. Orth JM, etal., Biol Reprod. 1997 Sep;57(3):676-83.
43. c-kit Expression in small cell carcinoma of the urinary bladder: prognostic and therapeutic implications. Pan CX, etal., Mod Pathol. 2005 Mar;18(3):320-3.
44. A new c-kit mutation in a case of aggressive mast cell disease. Pignon JM, etal., Br J Haematol. 1997 Feb;96(2):374-6.
45. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
46. Expression of proto-oncogene c-kit receptor in rats (Rattus norvegicus) and identification of a mutant mRNA transcript implicated in spermatogenic failure. Prasanth SG and Ali S, DNA Cell Biol. 2003 Jul;22(7):447-56.
47. Expression of protooncogene c-kit receptor in rat testis and uniqueness of extracellular domain across the species with potential in molecular phylogeny. Prasanth SG, etal., DNA Cell Biol. 2004 Jan;23(1):35-43.
48. c-KIT expression and correlation with chemotherapy resistance in ovarian carcinoma: an immunocytochemical study. Raspollini MR, etal., Ann Oncol. 2004 Apr;15(4):594-7.
49. The rs17084733 variant in the KIT 3' UTR disrupts a miR-221/222 binding site in gastrointestinal stromal tumour: a sponge-like mechanism conferring disease susceptibility. Ravegnini G, etal., Epigenetics. 2019 Jun;14(6):545-557. doi: 10.1080/15592294.2019.1595997. Epub 2019 Apr 13.
50. GOA pipeline RGD automated data pipeline
51. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
52. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
53. Cutting edge: c-Kit signaling differentially regulates type 2 innate lymphoid cell accumulation and susceptibility to central nervous system demyelination in male and female SJL mice. Russi AE, etal., J Immunol. 2015 Jun 15;194(12):5609-13. doi: 10.4049/jimmunol.1500068. Epub 2015 May 13.
54. Mutations of c-kit gene in bilateral testicular germ cell tumours in Japan. Sakuma Y, etal., Cancer Lett. 2008 Jan 18;259(1):119-26. Epub 2007 Nov 14.
55. Localization and expression of the c-kit receptor protein in human and rodent testis and sperm. Sandlow JI, etal., Urology. 1997 Mar;49(3):494-500.
56. Role of c-kit receptor tyrosine kinase-mediated signal transduction in proliferation of bile epithelial cells in young rats after ligation of bile duct: a study using Ws/Ws c-kit mutant rats. Satake M, etal., J Hepatol. 2003 Jul;39(1):86-92.
57. Involvement of interstitial cells of Cajal in experimental severe acute pancreatitis in rats. Shi LL, etal., World J Gastroenterol. 2013;19(14):2179-86. doi: 10.3748/wjg.v19.i14.2179.
58. Dominant negative and loss of function mutations of the c-kit (mast/stem cell growth factor receptor) proto-oncogene in human piebaldism. Spritz RA, etal., Am J Hum Genet. 1992 Feb;50(2):261-9.
59. Delayed gastric emptying and disruption of the interstitial cells of Cajal network after gastric ischaemia and reperfusion. Suzuki S, etal., Neurogastroenterol Motil. 2010 May;22(5):585-93, e126. doi: 10.1111/j.1365-2982.2009.01444.x. Epub 2009 Dec 23.
60. Immunoelectron-microscopic study of Kit-expressing cells in the jejunum of wildtype and Ws/Ws rats. Takeda M, etal., Cell Tissue Res. 2001 Apr;304(1):21-30.
61. Activating c-kit gene mutations in human germ cell tumors. Tian Q, etal., Am J Pathol. 1999 Jun;154(6):1643-7.
62. Expression of transcription factors and precursor cell markers during regeneration of beta cells in pancreata of rats treated with streptozotocin. Tiemann K, etal., Virchows Arch. 2007 Mar;450(3):261-6. Epub 2007 Jan 18.
63. Increased c-kit (CD117) expression in malignant mammary phyllodes tumors. Tse GM, etal., Mod Pathol. 2004 Jul;17(7):827-31.
64. Characterization of Ws mutant allele of rats: a 12-base deletion in tyrosine kinase domain of c-kit gene. Tsujimura T, etal., Blood 1991 Oct 15;78(8):1942-6.
65. Substitution of an aspartic acid results in constitutive activation of c-kit receptor tyrosine kinase in a rat tumor mast cell line RBL-2H3. Tsujimura T, etal., Int Arch Allergy Immunol. 1995 Apr;106(4):377-85.
66. A loss of c-kit expression is associated with an advanced stage and poor prognosis in breast cancer. Tsutsui S, etal., Br J Cancer. 2006 Jun 19;94(12):1874-8. Epub 2006 May 23.
67. Interstitial cells of Cajal in human colon and in Hirschsprung's disease. Vanderwinden JM, etal., Gastroenterology. 1996 Oct;111(4):901-10.
68. Viable c-Kit(W/W) mutants reveal pivotal role for c-kit in the maintenance of lymphopoiesis. Waskow C, etal., Immunity. 2002 Sep;17(3):277-88.
69. Continuous cadmium exposure from weaning to maturity induces downregulation of ovarian follicle development-related SCF/c-kit gene expression and the corresponding changes of DNA methylation/microRNA pattern. Weng S, etal., Toxicol Lett. 2014 Mar 21;225(3):367-77. doi: 10.1016/j.toxlet.2014.01.012. Epub 2014 Jan 21.
70. Expression of the c-kit proto-oncogene in rat hepatic allografts during acute rejection. Yamaguchi Y, etal., Hepatology. 1999 Jan;29(1):133-9.
71. Intestinal pacemaker C-KIT+ cells and synapses in allied Hirschsprung's disorders. Yamataka A, etal., J Pediatr Surg. 1997 Jul;32(7):1069-74.
72. miR-222 regulates cell growth, apoptosis, and autophagy of interstitial cells of Cajal isolated from slow transit constipation rats by targeting c-kit. Zheng H, etal., Indian J Gastroenterol. 2021 Apr;40(2):198-208. doi: 10.1007/s12664-020-01143-7. Epub 2021 Apr 1.
Additional References at PubMed
PMID:1721869   PMID:7621074   PMID:9216738   PMID:9324354   PMID:10620616   PMID:10872802   PMID:10943842   PMID:10982396   PMID:11805142   PMID:12135759   PMID:12163398   PMID:12641831  
PMID:12714518   PMID:12714519   PMID:12833143   PMID:12879016   PMID:12900455   PMID:14612394   PMID:14625290   PMID:14660547   PMID:14990792   PMID:15067126   PMID:15322542   PMID:15731517  
PMID:15768389   PMID:15909309   PMID:15947484   PMID:16127161   PMID:16287714   PMID:16455951   PMID:17662946   PMID:17848411   PMID:18087173   PMID:18258601   PMID:18258857   PMID:18308723  
PMID:18448842   PMID:18454155   PMID:18454205   PMID:18538998   PMID:18544282   PMID:18958875   PMID:18971422   PMID:19088079   PMID:19255573   PMID:19375645   PMID:19591228   PMID:19634669  
PMID:19934022   PMID:20100931   PMID:20536544   PMID:20847314   PMID:21135090   PMID:21179204   PMID:21455098   PMID:21559359   PMID:21634019   PMID:21640708   PMID:21708977   PMID:22366471  
PMID:22526758   PMID:22637532   PMID:22871113   PMID:22931954   PMID:23090426   PMID:23284756   PMID:23843227   PMID:24228598   PMID:24825426   PMID:25304966   PMID:25693193   PMID:26240433  
PMID:26393440   PMID:27707610   PMID:28109954   PMID:28801138   PMID:29348441   PMID:29444190   PMID:30283057   PMID:36959556  


Genomics

Comparative Map Data
Kit
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81432,901,615 - 32,978,895 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1432,903,033 - 32,978,812 (-)EnsemblGRCr8
mRatBN7.21432,547,459 - 32,624,694 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1432,548,877 - 32,624,652 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1432,908,757 - 32,989,974 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01434,216,558 - 34,297,770 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01432,701,812 - 32,783,026 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01435,072,131 - 35,149,638 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1435,072,108 - 35,149,610 (-)Ensemblrn6Rnor6.0
Rnor_5.01434,901,860 - 34,979,384 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41434,906,043 - 34,984,819 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1431,837,543 - 31,913,518 (-)NCBICelera
RGSC_v3.11434,906,042 - 34,984,819 (-)NCBI
Cytogenetic Map14p11NCBI
KIT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38454,657,957 - 54,740,715 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl454,657,267 - 54,740,783 (+)Ensemblhg38GRCh38
GRCh37455,524,124 - 55,606,881 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36455,218,852 - 55,301,638 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34455,365,088 - 55,447,783NCBI
Celera453,026,240 - 53,109,027 (+)NCBICelera
Cytogenetic Map4q12NCBI
HuRef451,471,979 - 51,554,769 (+)NCBIHuRef
CHM1_1455,559,642 - 55,642,426 (+)NCBICHM1_1
T2T-CHM13v2.0458,146,698 - 58,229,411 (+)NCBIT2T-CHM13v2.0
Kit
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39575,735,647 - 75,817,382 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl575,735,576 - 75,817,382 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38575,574,987 - 75,656,722 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl575,574,916 - 75,656,722 (+)Ensemblmm10GRCm38
MGSCv37575,971,012 - 76,052,747 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36575,856,721 - 75,938,419 (+)NCBIMGSCv36mm8
Celera572,859,483 - 72,942,690 (+)NCBICelera
Cytogenetic Map5C3.3NCBI
cM Map539.55NCBI
Kit
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544716,148,605 - 16,226,734 (-)Ensembl
ChiLan1.0NW_00495544716,149,014 - 16,226,151 (-)NCBIChiLan1.0ChiLan1.0
KIT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2375,054,170 - 75,136,975 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1475,258,141 - 75,340,942 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0469,199,543 - 69,282,323 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1475,761,946 - 75,844,473 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl475,761,946 - 75,844,473 (-)EnsemblpanPan2panpan1.1
KIT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11347,108,442 - 47,190,935 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1347,108,504 - 47,190,029 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1347,065,096 - 47,146,648 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01347,717,855 - 47,799,689 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1347,717,897 - 47,801,313 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11347,394,247 - 47,475,763 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01346,922,748 - 47,004,082 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01347,870,472 - 47,952,050 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Kit
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528529,059,916 - 29,135,385 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648217,162,950 - 17,238,274 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648217,162,854 - 17,238,319 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KIT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl841,402,043 - 41,493,734 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1841,402,334 - 41,492,306 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2843,550,231 - 43,601,377 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap8p12NCBI
KIT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1713,808,104 - 13,891,003 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl713,808,037 - 13,890,976 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606614,587,172 - 14,670,161 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kit
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476114,733,912 - 14,831,428 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Kit
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11132,332,268 - 32,410,055 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Kit
292 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:127
Count of miRNA genes:95
Interacting mature miRNAs:110
Transcripts:ENSRNOT00000003050
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631528Scl11Serum cholesterol level QTL 114.9blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)141787564536079022Rat
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14140068101Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14140068101Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14939329839411170Rat
1300154Bp189Blood pressure QTL 1893.04arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)143123808072970315Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143067446985041098Rat
2324617Coatc2Coat color QTL 20.001coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)143112133339507682Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14862139853621398Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141891545442433608Rat
7387267Uae42Urinary albumin excretion QTL 420.61urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)142252151767521517Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141889519263895192Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141790672654251504Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141415516Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14862139853621398Rat

Markers in Region
D14Rat13  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21432,583,238 - 32,583,345 (+)MAPPERmRatBN7.2
Rnor_6.01435,107,913 - 35,108,019NCBIRnor6.0
Rnor_5.01434,937,640 - 34,937,746UniSTSRnor5.0
Celera1431,871,910 - 31,872,016UniSTS
RH 3.4 Map14434.28UniSTS
RH 3.4 Map14434.28RGD
RH 2.0 Map14396.3RGD
SHRSP x BN Map1423.82RGD
Cytogenetic Map14p11UniSTS


Related Rat Strains
The following Strains have been annotated to Kit
F344-AsipATyrCKitH/Kyo     F344-TyrCKitH/Hkv     F344-TyrCKitH/Kyo     F344-TyrCKitH.LEA-(Tel-D17Got10)/Hkv    


Genetic Models
This gene Kit is modified in the following models/strains:
BN-KitWs     Slc:WSRC-KitWs    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 85 59 6 349 185 11 143 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001433901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_022264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF228307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF228308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF228309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF228310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF228311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH010214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH010215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS117952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D12524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU247827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU247828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU247829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU247830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU247831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU247832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU247833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000003050   ⟹   ENSRNOP00000003050
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1432,903,033 - 32,978,812 (-)Ensembl
mRatBN7.2 Ensembl1432,548,877 - 32,624,652 (-)Ensembl
Rnor_6.0 Ensembl1435,072,133 - 35,149,608 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000090654   ⟹   ENSRNOP00000068756
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1432,903,033 - 32,947,765 (-)Ensembl
mRatBN7.2 Ensembl1432,548,877 - 32,593,653 (-)Ensembl
Rnor_6.0 Ensembl1435,072,108 - 35,149,610 (-)Ensembl
RefSeq Acc Id: NM_022264   ⟹   NP_071600
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81432,903,033 - 32,978,812 (-)NCBI
mRatBN7.21432,548,877 - 32,624,652 (-)NCBI
Rnor_6.01435,073,551 - 35,149,608 (-)NCBI
Rnor_5.01434,901,860 - 34,979,384 (-)NCBI
RGSC_v3.41434,906,043 - 34,984,819 (-)RGD
Celera1431,837,543 - 31,913,518 (-)RGD
Sequence:
RefSeq Acc Id: XM_006250909   ⟹   XP_006250971
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81432,901,615 - 32,978,895 (-)NCBI
mRatBN7.21432,547,459 - 32,624,694 (-)NCBI
Rnor_6.01435,072,131 - 35,149,638 (-)NCBI
Rnor_5.01434,901,860 - 34,979,384 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001420830 (Get FASTA)   NCBI Sequence Viewer  
  NP_071600 (Get FASTA)   NCBI Sequence Viewer  
  XP_006250971 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF69130 (Get FASTA)   NCBI Sequence Viewer  
  AAF69131 (Get FASTA)   NCBI Sequence Viewer  
  AAF69132 (Get FASTA)   NCBI Sequence Viewer  
  AAF69133 (Get FASTA)   NCBI Sequence Viewer  
  AAF69134 (Get FASTA)   NCBI Sequence Viewer  
  AAG48585 (Get FASTA)   NCBI Sequence Viewer  
  AAG48586 (Get FASTA)   NCBI Sequence Viewer  
  AAG48587 (Get FASTA)   NCBI Sequence Viewer  
  ABX45067 (Get FASTA)   NCBI Sequence Viewer  
  ABX45068 (Get FASTA)   NCBI Sequence Viewer  
  ABX45069 (Get FASTA)   NCBI Sequence Viewer  
  ABX45070 (Get FASTA)   NCBI Sequence Viewer  
  ABX45071 (Get FASTA)   NCBI Sequence Viewer  
  ABX45072 (Get FASTA)   NCBI Sequence Viewer  
  ABX45073 (Get FASTA)   NCBI Sequence Viewer  
  ABX45074 (Get FASTA)   NCBI Sequence Viewer  
  ABX45075 (Get FASTA)   NCBI Sequence Viewer  
  ABX45076 (Get FASTA)   NCBI Sequence Viewer  
  ABX45077 (Get FASTA)   NCBI Sequence Viewer  
  ABX45078 (Get FASTA)   NCBI Sequence Viewer  
  ABX45079 (Get FASTA)   NCBI Sequence Viewer  
  ABX45080 (Get FASTA)   NCBI Sequence Viewer  
  ABX45081 (Get FASTA)   NCBI Sequence Viewer  
  ABX45082 (Get FASTA)   NCBI Sequence Viewer  
  ABX45083 (Get FASTA)   NCBI Sequence Viewer  
  BAA02094 (Get FASTA)   NCBI Sequence Viewer  
  CAJ15132 (Get FASTA)   NCBI Sequence Viewer  
  EDL89921 (Get FASTA)   NCBI Sequence Viewer  
  EDL89922 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000003050
  ENSRNOP00000003050.1
  ENSRNOP00000068756.3
RefSeq Acc Id: NP_071600   ⟸   NM_022264
- Peptide Label: precursor
- UniProtKB: Q63116 (UniProtKB/TrEMBL),   A6JCZ9 (UniProtKB/TrEMBL),   A0A0G2JTL4 (UniProtKB/TrEMBL),   B7SCI8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250971   ⟸   XM_006250909
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000068756   ⟸   ENSRNOT00000090654
Ensembl Acc Id: ENSRNOP00000003050   ⟸   ENSRNOT00000003050
Protein Domains
Ig-like   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63116-F1-model_v2 AlphaFold Q63116 1-978 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699292
Promoter ID:EPDNEW_R9805
Type:multiple initiation site
Name:Kit_1
Description:KIT proto-oncogene receptor tyrosine kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01435,149,622 - 35,149,682EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620568 AgrOrtholog
BioCyc Gene G2FUF-15930 BioCyc
Ensembl Genes ENSRNOG00000002227 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003050 ENTREZGENE
  ENSRNOT00000003050.5 UniProtKB/TrEMBL
  ENSRNOT00000090654.3 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Ig-like UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  Immunoglobulin UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  PDGFRL UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  RTK UniProtKB/TrEMBL
  SCGF_receptor UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_rcpt_3_CS UniProtKB/TrEMBL
KEGG Report rno:64030 UniProtKB/TrEMBL
NCBI Gene 64030 ENTREZGENE
PANTHER MAST/STEM CELL GROWTH FACTOR RECEPTOR KIT UniProtKB/TrEMBL
  PLATELET-DERIVED GROWTH FACTOR RECEPTOR LIKE UniProtKB/TrEMBL
  PROTEIN KINASE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/TrEMBL
Pfam PF00047 UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
PharmGKB KIT RGD
PhenoGen Kit PhenoGen
PIRSF SCGF_recepter UniProtKB/TrEMBL
  TyrPK_CSF1-R UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_III UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002227 RatGTEx
SMART IGc2 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
  SSF48726 UniProtKB/TrEMBL
UniProt A0A0G2JTL4 ENTREZGENE, UniProtKB/TrEMBL
  A6JCZ9 ENTREZGENE
  A6JD00_RAT UniProtKB/TrEMBL
  B7SCI8 ENTREZGENE, UniProtKB/TrEMBL
  B7SCJ0_RAT UniProtKB/TrEMBL
  B7SCJ1_RAT UniProtKB/TrEMBL
  B7SCJ2_RAT UniProtKB/TrEMBL
  Q63116 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A6JCZ9 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-21 Kit  KIT proto-oncogene receptor tyrosine kinase  Kit  v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Kit  v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog    c-kit receptor tyrosine kinase  Name updated 1299863 APPROVED
2002-08-07 Kit  c-kit receptor tyrosine kinase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease deletion of Val-Lys-Gly-Asn sequence is associated with anemia and deficiency in mast cells and melanocytes 633170