RGD Reference Report - A loss of c-kit expression is associated with an advanced stage and poor prognosis in breast cancer. - Rat Genome Database

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A loss of c-kit expression is associated with an advanced stage and poor prognosis in breast cancer.

Authors: Tsutsui, S  Yasuda, K  Suzuki, K  Takeuchi, H  Nishizaki, T  Higashi, H  Era, S 
Citation: Tsutsui S, etal., Br J Cancer. 2006 Jun 19;94(12):1874-8. Epub 2006 May 23.
RGD ID: 2292426
Pubmed: PMID:16721362   (View Abstract at PubMed)
PMCID: PMC2361342   (View Article at PubMed Central)
DOI: DOI:10.1038/sj.bjc.6603183   (Journal Full-text)

To evaluate the c-kit expression in breast cancer, 217 invasive ductal carcinomas of the breast were immunohistochemically stained for c-kit protein. The c-kit expression was positive in 59 (27%) of 217 tumours, while the c-kit expression was negative in 158 (73%) of 217 tumours. There was a significant correlation between a negative expression of the c-kit protein and lymph node metastasis (P < 0.0001), and the incidence of a negative expression of the c-kit protein increased as the number of the metastatic lymph nodes increased (P = 0.0003). The c-kit expression did not significantly correlate with the tumour size, nuclear grade, oestrogen receptor status, MIB-1 counts and p53 protein expression. A univariate analysis indicated the patients with the negative c-kit expression to have a worse disease-free survival (DFS) than those with the positive c-kit expression (P = 0.0041), while a multivariate analysis determined lymph node metastases and the MIB-1 counts to be independently significant factors for DFS. In conclusion, a loss of the c-kit expression was found in about three-fourth of invasive ductal carcinoma of the breast and was associated with lymph node metastases. The prognostic implications of the c-kit expression seem to be due to fact that a loss of the c-kit expression is associated with an advanced stage of breast cancer.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
invasive ductal carcinoma severityIEP 2292426protein:decreased expression:tumor:loss of expression associated with lymph node metastasis (p<0.0001) and reduced disease-free survival (p=0.0041)RGD 
invasive ductal carcinoma severityISOKIT (Homo sapiens)2292426; 2292426 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Kit  (KIT proto-oncogene receptor tyrosine kinase)

Genes (Mus musculus)
Kit  (KIT proto-oncogene receptor tyrosine kinase)

Genes (Homo sapiens)
KIT  (KIT proto-oncogene, receptor tyrosine kinase)


Additional Information