S1pr5 (sphingosine-1-phosphate receptor 5) - Rat Genome Database

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Gene: S1pr5 (sphingosine-1-phosphate receptor 5) Rattus norvegicus
Analyze
Symbol: S1pr5
Name: sphingosine-1-phosphate receptor 5
RGD ID: 620566
Description: Enables G protein-coupled receptor activity. Involved in regulation of neuron differentiation. Predicted to be located in membrane. Predicted to be active in cytoplasm; plasma membrane; and presynapse. Orthologous to human S1PR5 (sphingosine-1-phosphate receptor 5); PARTICIPATES IN sphingosine 1-phosphate signaling pathway; INTERACTS WITH 6-propyl-2-thiouracil; acetamide; aldehydo-D-glucose.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Edg-8; Edg8; endothelial differentiation G-protein-coupled receptor 8; endothelial differentiation, sphingolipid G-protein-coupled receptor, 8; nerve growth factor-regulated G-protein-coupled receptor 1; NRG-1; S1P receptor 5; S1P receptor Edg-8; S1P5; sphingosine 1-phosphate receptor; sphingosine 1-phosphate receptor 5; sphingosine 1-phosphate receptor Edg-8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8828,062,841 - 28,068,013 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl828,061,752 - 28,068,389 (-)EnsemblGRCr8
mRatBN7.2819,786,676 - 19,791,862 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl819,786,663 - 19,791,795 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx823,806,109 - 23,811,040 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0822,103,954 - 22,108,885 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0820,016,404 - 20,021,375 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0822,268,635 - 22,273,708 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,268,657 - 22,270,647 (-)Ensemblrn6Rnor6.0
Rnor_5.0822,323,891 - 22,328,932 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4820,278,404 - 20,283,375 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera821,180,228 - 21,185,199 (-)NCBICelera
RGSC_v3.1820,278,403 - 20,283,375 (-)NCBI
Cytogenetic Map8q13NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
Cuprizon  (EXP)
D-glucose  (EXP)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
formaldehyde  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucose  (EXP)
glycidol  (EXP)
hydrogen peroxide  (ISO)
inulin  (ISO)
lipopolysaccharide  (ISO)
methylmercury chloride  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
nitrates  (EXP)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sphingosine 1-phosphate  (ISO)
streptozocin  (EXP)
sulforaphane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
membrane  (IEA)
plasma membrane  (IBA,IEA)
presynapse  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The immune modulator FTY720 targets sphingosine 1-phosphate receptors. Brinkmann V, etal., J Biol Chem 2002 Jun 14;277(24):21453-7.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Molecular cloning, tissue-specific expression, and chromosomal localization of a novel nerve growth factor-regulated G-protein- coupled receptor, nrg-1. Glickman M, etal., Mol Cell Neurosci 1999 Aug;14(2):141-52.
4. Characterization of a novel sphingosine 1-phosphate receptor, Edg-8. Im DS, etal., J Biol Chem 2000 May 12;275(19):14281-6.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Comparative analysis of human and rat S1P(5) (edg8): differential expression profiles and sensitivities to antagonists. Niedernberg A, etal., Biochem Pharmacol 2002 Oct 15;64(8):1243-50.
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Edg-8 receptors are preferentially expressed in oligodendrocyte lineage cells of the rat CNS. Terai K, etal., Neuroscience 2003;116(4):1053-62.
Additional References at PubMed
PMID:11069896   PMID:15703400   PMID:15741218   PMID:18294150   PMID:22972346   PMID:24602016  


Genomics

Comparative Map Data
S1pr5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8828,062,841 - 28,068,013 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl828,061,752 - 28,068,389 (-)EnsemblGRCr8
mRatBN7.2819,786,676 - 19,791,862 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl819,786,663 - 19,791,795 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx823,806,109 - 23,811,040 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0822,103,954 - 22,108,885 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0820,016,404 - 20,021,375 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0822,268,635 - 22,273,708 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,268,657 - 22,270,647 (-)Ensemblrn6Rnor6.0
Rnor_5.0822,323,891 - 22,328,932 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4820,278,404 - 20,283,375 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera821,180,228 - 21,185,199 (-)NCBICelera
RGSC_v3.1820,278,403 - 20,283,375 (-)NCBI
Cytogenetic Map8q13NCBI
S1PR5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381910,512,742 - 10,517,965 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1910,512,742 - 10,517,931 (-)Ensemblhg38GRCh38
GRCh371910,623,418 - 10,628,641 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,484,623 - 10,489,112 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341910,484,622 - 10,489,112NCBI
Celera1910,518,131 - 10,523,388 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef1910,201,961 - 10,207,399 (-)NCBIHuRef
CHM1_11910,624,176 - 10,629,433 (-)NCBICHM1_1
T2T-CHM13v2.01910,639,179 - 10,644,407 (-)NCBIT2T-CHM13v2.0
S1pr5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39921,154,213 - 21,159,739 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl921,154,208 - 21,159,739 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38921,242,917 - 21,248,443 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl921,242,912 - 21,248,443 (-)Ensemblmm10GRCm38
MGSCv37921,047,361 - 21,052,887 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36920,993,319 - 20,996,611 (-)NCBIMGSCv36mm8
Celera918,512,032 - 18,517,558 (-)NCBICelera
Cytogenetic Map9A3NCBI
cM Map97.75NCBI
S1pr5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554951,717,549 - 1,722,257 (-)NCBIChiLan1.0ChiLan1.0
S1PR5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22015,430,929 - 15,436,593 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11914,429,534 - 14,435,210 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01910,064,332 - 10,069,999 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11910,726,661 - 10,731,230 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1910,727,527 - 10,728,728 (-)EnsemblpanPan2panpan1.1
S1PR5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12050,641,585 - 50,646,938 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2050,643,619 - 50,644,815 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2050,513,495 - 50,518,968 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02051,164,592 - 51,170,064 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2051,165,296 - 51,168,809 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12050,371,184 - 50,376,633 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02050,799,276 - 50,804,758 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02051,040,334 - 51,045,813 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
S1pr5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118209,551,873 - 209,557,153 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936659798,707 - 799,903 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936659798,259 - 801,563 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
S1PR5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl269,293,546 - 69,298,377 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1269,293,537 - 69,299,408 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2269,646,773 - 69,649,084 (-)NCBISscrofa10.2Sscrofa10.2susScr3
S1PR5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.169,537,083 - 9,542,610 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl69,538,156 - 9,539,352 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607410,456,440 - 10,461,715 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
S1pr5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248282,592,475 - 2,601,943 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248282,590,664 - 2,602,136 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
S1pr5
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1817,509,974 - 17,512,043 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in S1pr5
58 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:85
Count of miRNA genes:71
Interacting mature miRNAs:79
Transcripts:ENSRNOT00000028380
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)81038254055382540Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)81296416557964165Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)81296416557964165Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)81038254055382540Rat
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8132882639Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)81038254055382540Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)81296416557964165Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)81038254055382540Rat

Markers in Region
Edg8  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2819,788,055 - 19,788,607 (+)MAPPERmRatBN7.2
Rnor_6.0822,269,993 - 22,270,544NCBIRnor6.0
Rnor_5.0822,325,249 - 22,325,800UniSTSRnor5.0
RGSC_v3.4820,279,740 - 20,280,291UniSTSRGSC3.4
Celera821,181,564 - 21,182,115UniSTS
Cytogenetic Map8q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 10 67 159 89 88 57 92 57 6 351 191 11 138 81 91 31 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000028380   ⟹   ENSRNOP00000028380
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl828,062,184 - 28,067,834 (-)Ensembl
mRatBN7.2 Ensembl819,786,663 - 19,791,795 (-)Ensembl
Rnor_6.0 Ensembl822,268,657 - 22,270,647 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098087   ⟹   ENSRNOP00000090421
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl828,062,002 - 28,068,389 (-)Ensembl
mRatBN7.2 Ensembl819,786,663 - 19,791,795 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000128409   ⟹   ENSRNOP00000101765
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl828,061,752 - 28,068,389 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000155578   ⟹   ENSRNOP00000101555
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl828,061,752 - 28,068,389 (-)Ensembl
RefSeq Acc Id: NM_021775   ⟹   NP_068543
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,062,898 - 28,067,869 (-)NCBI
mRatBN7.2819,786,720 - 19,791,692 (-)NCBI
Rnor_6.0822,268,657 - 22,273,628 (-)NCBI
Rnor_5.0822,323,891 - 22,328,932 (-)NCBI
RGSC_v3.4820,278,404 - 20,283,375 (-)RGD
Celera821,180,228 - 21,185,199 (-)RGD
Sequence:
RefSeq Acc Id: XM_006242663   ⟹   XP_006242725
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,062,841 - 28,068,013 (-)NCBI
mRatBN7.2819,786,698 - 19,791,862 (-)NCBI
Rnor_6.0822,268,635 - 22,273,708 (-)NCBI
Rnor_5.0822,323,891 - 22,328,932 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006242664   ⟹   XP_006242726
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,062,841 - 28,067,824 (-)NCBI
mRatBN7.2819,786,676 - 19,790,623 (-)NCBI
Rnor_6.0822,268,657 - 22,272,080 (-)NCBI
Rnor_5.0822,323,891 - 22,328,932 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006242665   ⟹   XP_006242727
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,062,841 - 28,067,824 (-)NCBI
mRatBN7.2819,786,676 - 19,790,623 (-)NCBI
Rnor_6.0822,268,657 - 22,272,080 (-)NCBI
Rnor_5.0822,323,891 - 22,328,932 (-)NCBI
Sequence:
RefSeq Acc Id: NP_068543   ⟸   NM_021775
- UniProtKB: Q9JKM5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006242725   ⟸   XM_006242663
- Peptide Label: isoform X1
- UniProtKB: Q9QY79 (UniProtKB/Swiss-Prot),   Q9JKM5 (UniProtKB/Swiss-Prot),   A6JNQ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242727   ⟸   XM_006242665
- Peptide Label: isoform X1
- UniProtKB: Q9QY79 (UniProtKB/Swiss-Prot),   Q9JKM5 (UniProtKB/Swiss-Prot),   A6JNQ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242726   ⟸   XM_006242664
- Peptide Label: isoform X1
- UniProtKB: Q9QY79 (UniProtKB/Swiss-Prot),   Q9JKM5 (UniProtKB/Swiss-Prot),   A6JNQ5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028380   ⟸   ENSRNOT00000028380
Ensembl Acc Id: ENSRNOP00000090421   ⟸   ENSRNOT00000098087
Ensembl Acc Id: ENSRNOP00000101555   ⟸   ENSRNOT00000155578
Ensembl Acc Id: ENSRNOP00000101765   ⟸   ENSRNOT00000128409
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JKM5-F1-model_v2 AlphaFold Q9JKM5 1-400 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620566 AgrOrtholog
BioCyc Gene G2FUF-31431 BioCyc
Ensembl Genes ENSRNOG00000020901 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000028380 ENTREZGENE
  ENSRNOT00000028380.6 UniProtKB/Swiss-Prot
  ENSRNOT00000098087 ENTREZGENE
  ENSRNOT00000098087.1 UniProtKB/Swiss-Prot
  ENSRNOT00000155578 ENTREZGENE
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro EDG8_S1P_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  S1P_rcpt UniProtKB/Swiss-Prot
KEGG Report rno:60399 UniProtKB/Swiss-Prot
NCBI Gene 60399 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen S1pr5 PhenoGen
PRINTS EDG8RECEPTOR UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
  S1PRECEPTOR UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020901 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt A6JNQ5 ENTREZGENE, UniProtKB/TrEMBL
  Q9JKM5 ENTREZGENE
  Q9QY79 ENTREZGENE
  S1PR5_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q9QY79 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-05-20 S1pr5  sphingosine-1-phosphate receptor 5  Edg8  endothelial differentiation, sphingolipid G-protein-coupled receptor, 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Edg8  endothelial differentiation, sphingolipid G-protein-coupled receptor, 8    sphingosine 1-phosphate receptor  Name updated 1299863 APPROVED
2002-08-07 Edg8  sphingosine 1-phosphate receptor      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed only in the CNS, preferentially in oligodendrocyte lineage cells 632645
gene_expression expressed predominantly by oligodendrocytes and fibrous astrocytes 632648
gene_expression expressed in oligodendrocyte progenitor cells and immature/maturating oligodendrocytes 1299278
gene_pathway couples to G(i/o)alpha proteins 632648