Gene:	S1pr5 ( Rattus norvegicus ) sphingosine-1-phosphate receptor 5
Description:	G protein-coupled receptor for the lysolipid phosphoric acid mediator sphingosine 1-phosphate
Synonyms:	sphingosine 1-phosphate receptor; endothelial differentiation, sphingolipid G-protein-coupled receptor, 8; Edg-8; endothelial differentiation, sphingolipid g-protein-coupled receptor, 8; Edg8; edg8;
ArrayIDs:	1368705_at; GE21425; 6058709; GE20808; A_43_P12123; 5719275; 6224272; 5699149;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: S1PR5     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: S1pr5     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus S1pr5 genome assembly 3.1 8 20278403 - 20283375     Rat Celera Assembly 8 21180228 - 21185199     RGSC genome assembly v3.4 8 20278404 - 20283375     Cytogenetic 8 q13 Mus musculus S1pr5 Mouse genome assembly build 36.1 9 21047361 - 21050653     Cytogenetic 9 9 A4 Homo sapiens S1PR5 human genome assembly 19 10484622 - 10489112     Human genome assembly build 36.2 19 10484623 - 10489112     Cytogenetic 19 p13.2   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Gene Ontology receptor activity,  G-protein coupled receptor activity,  lysosphingolipid and lysophosphatidic acid receptor activity (details...)
Biological Process	Gene Ontology G-protein coupled receptor protein signaling pathway,  signal transduction,  regulation of neuron differentiation (details...)
Cellular Component	Gene Ontology integral to membrane,  plasma membrane (details...)
Expression	Note Reference expressed only in the CNS, preferentially in oligodendrocyte lineage cells 632645 expressed predominantly by oligodendrocytes and fibrous astrocytes 632648 expressed in oligodendrocyte progenitor cells and immature/maturating oligodendrocytes 1299278
Pathway	Note Reference couples to G(i/o)alpha proteins 632648
External Links
Databases	DATABASE ID SOURCE PROSITE: G_PROTEIN_RECEP_F1_2 IPI PROSITE: G_PROTEIN_RECEP_F1_1 IPI UNIPARC: UPI00000E68B6 IPI KEGG Report: rno:60399 ENTREZGENE HomoloGene Group ID: 11031 ENTREZGENE Germonline: 620566 Pfam: 7tm_1 IPI KEGG Pathway: 04080 ENTREZGENE InterPro: EDG8_S1P_rcpt. IPI InterPro: GPCR_Rhodpsn_supfam. IPI InterPro: S1P_rcpt. IPI InterPro: 7TM_GPCR_Rhodpsn. IPI IPI: IPI00202800 IPI Ensembl Protein: ENSRNOP00000028380 IPI Entrez Gene: S1pr5 ENTREZGENE UniProt: S1PR5_RAT IPI Ensembl Genes: ENSRNOG00000020901 IPI PANTHER: EDG8_S1P_rcpt IPI PRINTS: S1PRECEPTOR. IPI PRINTS: GPCRRHODOPSN. IPI PRINTS: EDG8RECEPTOR. IPI
Sequences	Nucleotide: CH473993 Get FASTA Search GEO Profiles Nucleotide: AF233649 Get FASTA Search GEO Profiles Nucleotide: NM_021775 Get FASTA Search GEO Profiles Nucleotide: AF115249 Get FASTA Search GEO Profiles (View all 4 Nucleotide Accessions) Protein: NP_068543 Get FASTA Protein: EDL78311 Get FASTA Protein: EDL78312 Get FASTA Protein: AAF15395 Get FASTA Protein: AAF35912 Get FASTA Protein: Q9JKM5 Get FASTA (View all 6 Protein Accessions)
Clusters	UniGene: 45601
References
Curated References	9 references in RGD related to S1pr5
Other References	9 other references at PubMed related to S1pr5
Database Information
RGD ID	620566
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 20-MAY-08: S1pr5 sphingosine-1-phosphate receptor 5 Edg8 endothelial differentiation, sphingolipid G-protein-coupled receptor, 8 APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863 10-SEP-04: Edg8 endothelial differentiation, sphingolipid G-protein-coupled receptor, 8 sphingosine 1-phosphate receptor APPROVED Name updated 1299863 07-AUG-02: Edg8 sphingosine 1-phosphate receptor PROVISIONAL Symbol and Name status set to provisional 70820