Syne1 (spectrin repeat containing nuclear envelope protein 1) - Rat Genome Database

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Gene: Syne1 (spectrin repeat containing nuclear envelope protein 1) Rattus norvegicus
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Symbol: Syne1
Name: spectrin repeat containing nuclear envelope protein 1
RGD ID: 620546
Description: Enables enzyme binding activity and signaling receptor binding activity. Involved in several processes, including negative regulation of mesenchymal cell apoptotic process; negative regulation of mini excitatory postsynaptic potential; and regulation of receptor-mediated endocytosis. Located in several cellular components, including dendritic spine head; midbody; and nuclear membrane. Is active in glutamatergic synapse; postsynaptic actin cytoskeleton; and postsynaptic endocytic zone. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita (multiple); bipolar disorder; cerebellar ataxia (multiple); and muscular dystrophy (multiple). Orthologous to human SYNE1 (spectrin repeat containing nuclear envelope protein 1); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CPG2; LOC102546492; LOC103690962; Myne-1; nesprin 1 long isoform; nesprin 1 short isoform; nesprin-1; nesprin-1-like; spectrin repeat containing, nuclear envelope 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Syne1Tn(sb-T2/Bart3)2.68Mcwi
Genetic Models: F344-Syne1Tn(sb-T2/Bart3)2.68Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8143,917,640 - 44,388,802 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl143,895,994 - 44,388,721 (-)EnsemblGRCr8
mRatBN7.2141,512,146 - 41,983,382 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl141,512,030 - 41,983,322 (-)EnsemblmRatBN7.2
Rnor_6.0141,608,287 - 41,763,591 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0141,844,840 - 42,086,662 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0142,947,742 - 43,158,478 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4135,803,552 - 36,269,628 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera137,192,707 - 37,662,090 (-)NCBICelera
RGSC_v3.1135,805,545 - 35,961,017 (-)NCBI
Cytogenetic Map1q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-Nitrobenzanthrone  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bufotalin  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
cobalt dichloride  (EXP)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diclofenac  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
indometacin  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
mercury dibromide  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
morphine  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
nicotine  (ISO)
nitrofen  (EXP)
nitrogen dioxide  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
Soman  (EXP)
testosterone  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP)
topotecan  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Mutation of SYNE-1, encoding an essential component of the nuclear lamina, is responsible for autosomal recessive arthrogryposis. Attali R, etal., Hum Mol Genet. 2009 Sep 15;18(18):3462-9. doi: 10.1093/hmg/ddp290. Epub 2009 Jun 19.
2. Dynamics and nanoscale organization of the postsynaptic endocytic zone at excitatory synapses. Catsburg LA, etal., Elife. 2022 Jan 24;11:e74387. doi: 10.7554/eLife.74387.
3. CPG2: a brain- and synapse-specific protein that regulates the endocytosis of glutamate receptors. Cottrell JR, etal., Neuron. 2004 Nov 18;44(4):677-90.
4. Clinical and genetic study of autosomal recessive cerebellar ataxia type 1. Dupré N, etal., Ann Neurol. 2007 Jul;62(1):93-8.
5. A role for the spectrin superfamily member Syne-1 and kinesin II in cytokinesis. Fan J and Beck KA, J Cell Sci. 2004 Feb 1;117(Pt 4):619-29. Epub 2004 Jan 6.
6. Dominant muscular dystrophy with a novel SYNE1 gene mutation. Fanin M, etal., Muscle Nerve. 2015 Jan;51(1):145-7. doi: 10.1002/mus.24357. Epub 2014 Nov 24.
7. Identification and characterization of GSRP-56, a novel Golgi-localized spectrin repeat-containing protein. Kobayashi Y, etal., Exp Cell Res. 2006 Oct 1;312(16):3152-64. Epub 2006 Jun 27.
8. Regulation of glutamate receptor internalization by the spine cytoskeleton is mediated by its PKA-dependent association with CPG2. Loebrich S, etal., Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):E4548-56. doi: 10.1073/pnas.1318860110. Epub 2013 Nov 4.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. A set of genes expressed in response to light in the adult cerebral cortex and regulated during development. Nedivi E, etal., Proc Natl Acad Sci U S A 1996 Mar 5;93(5):2048-53.
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. Nesprin-1alpha contributes to the targeting of mAKAP to the cardiac myocyte nuclear envelope. Pare GC, etal., Exp Cell Res. 2005 Feb 15;303(2):388-99.
13. Disruption of nesprin-1 produces an Emery Dreifuss muscular dystrophy-like phenotype in mice. Puckelwartz MJ, etal., Hum Mol Genet. 2009 Feb 15;18(4):607-20. doi: 10.1093/hmg/ddn386. Epub 2008 Nov 13.
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Identification of rare nonsynonymous variants in SYNE1/CPG2 in bipolar affective disorder. Sharp SI, etal., Psychiatr Genet. 2017 Jun;27(3):81-88. doi: 10.1097/YPG.0000000000000166.
18. SYNE1 ataxia is a common recessive ataxia with major non-cerebellar features: a large multi-centre study. Synofzik M, etal., Brain. 2016 May;139(Pt 5):1378-93. doi: 10.1093/brain/aww079. Epub 2016 Apr 17.
19. Nesprin-1 plays an important role in the proliferation and apoptosis of mesenchymal stem cells. Yang W, etal., Int J Mol Med. 2013 Oct;32(4):805-12. doi: 10.3892/ijmm.2013.1445. Epub 2013 Jul 16.
20. Nesprin-1 has key roles in the process of mesenchymal stem cell differentiation into cardiomyocyte-like cells in vivo and in vitro. Yang W, etal., Mol Med Rep. 2015 Jan;11(1):133-42. doi: 10.3892/mmr.2014.2754. Epub 2014 Oct 23.
21. Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues. Zhang Q, etal., J Cell Sci 2001 Dec;114(Pt 24):4485-98.
Additional References at PubMed
PMID:10878022   PMID:11801724   PMID:12163176   PMID:12408964   PMID:12808039   PMID:15276322   PMID:17267447   PMID:18396275   PMID:19596800   PMID:21630459   PMID:22518138   PMID:22658674  
PMID:22681889   PMID:24862572   PMID:26776730   PMID:31428857   PMID:31904090  


Genomics

Comparative Map Data
Syne1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8143,917,640 - 44,388,802 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl143,895,994 - 44,388,721 (-)EnsemblGRCr8
mRatBN7.2141,512,146 - 41,983,382 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl141,512,030 - 41,983,322 (-)EnsemblmRatBN7.2
Rnor_6.0141,608,287 - 41,763,591 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0141,844,840 - 42,086,662 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0142,947,742 - 43,158,478 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4135,803,552 - 36,269,628 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera137,192,707 - 37,662,090 (-)NCBICelera
RGSC_v3.1135,805,545 - 35,961,017 (-)NCBI
Cytogenetic Map1q11NCBI
SYNE1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386152,121,687 - 152,637,362 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6152,121,687 - 152,637,801 (-)Ensemblhg38GRCh38
GRCh376152,442,822 - 152,958,497 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366152,484,515 - 153,000,227 (-)NCBIBuild 36Build 36hg18NCBI36
Build 346152,535,028 - 153,050,648NCBI
Celera6153,176,558 - 153,692,233 (-)NCBICelera
Cytogenetic Map6q25.2NCBI
HuRef6150,004,601 - 150,521,666 (-)NCBIHuRef
CHM1_16152,706,924 - 153,222,498 (-)NCBICHM1_1
T2T-CHM13v2.06153,322,984 - 153,838,674 (-)NCBIT2T-CHM13v2.0
Syne1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39104,970,192 - 5,501,013 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl104,970,917 - 5,501,482 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38105,020,192 - 5,550,692 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl105,020,917 - 5,551,482 (-)Ensemblmm10GRCm38
MGSCv37104,795,849 - 5,326,349 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36104,795,849 - 5,324,786 (+)NCBIMGSCv36mm8
Celera104,962,310 - 5,494,074 (-)NCBICelera
Cytogenetic Map10A1NCBI
cM Map102.01NCBI
Syne1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554399,131,227 - 9,574,112 (+)NCBIChiLan1.0ChiLan1.0
SYNE1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25172,142,779 - 172,662,107 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16170,034,582 - 170,554,004 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06149,936,306 - 150,454,822 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16154,627,898 - 155,144,076 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6154,627,904 - 155,144,076 (-)EnsemblpanPan2panpan1.1
SYNE1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1142,384,136 - 42,831,229 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl142,384,038 - 42,823,388 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha143,221,975 - 43,670,831 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0142,566,919 - 43,016,022 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl142,566,922 - 43,015,508 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1142,431,948 - 42,888,641 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0142,297,074 - 42,745,721 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0142,790,456 - 43,239,688 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Syne1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946137,651,183 - 137,925,972 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364894,902,806 - 4,946,302 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364894,903,176 - 5,177,987 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SYNE1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1113,715,644 - 14,201,711 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2116,016,262 - 16,243,210 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SYNE1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11379,572,233 - 80,104,951 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1379,572,936 - 79,988,893 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604051,905,945 - 52,434,336 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Syne1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247855,647,041 - 6,144,065 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Syne1
2484 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:308
Count of miRNA genes:189
Interacting mature miRNAs:216
Transcripts:ENSRNOT00000047472
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)14345783787558729Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1774611852746118Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12940927974409279Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)14345783787558729Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)14212296887122968Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1694102251941022Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)1690935351909353Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11731537851816258Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)1690935351909353Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
5684999Bss102Bone structure and strength QTL 1025.57e-07tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)1690935351909353Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14345783787558729Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12050832665508326Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)11168446456684464Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13456572679565726Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1774612152746121Rat
70179Xhs2X-ray hypersensitivity QTL 23.2intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)1143965634Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)11037949255379492Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)14212296887122968Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11282049457820494Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)12065642065656420Rat

Markers in Region
D1Got40  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2141,549,272 - 41,549,412 (+)MAPPERmRatBN7.2
Rnor_6.0141,645,414 - 41,645,553NCBIRnor6.0
Rnor_5.0142,984,990 - 42,985,129UniSTSRnor5.0
RGSC_v3.4135,839,843 - 35,839,983RGDRGSC3.4
RGSC_v3.4135,839,844 - 35,839,983UniSTSRGSC3.4
Celera137,229,279 - 37,229,428UniSTS
RGSC_v3.1135,842,788 - 35,842,928RGD
Cytogenetic Map1p11UniSTS
D1Got41  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2141,907,941 - 41,908,122 (+)MAPPERmRatBN7.2
Rnor_6.0142,010,590 - 42,010,770NCBIRnor6.0
Rnor_5.0143,341,278 - 43,341,458UniSTSRnor5.0
RGSC_v3.4136,202,770 - 36,202,948RGDRGSC3.4
RGSC_v3.4136,202,770 - 36,202,950UniSTSRGSC3.4
Celera137,591,338 - 37,591,515UniSTS
RGSC_v3.1136,205,715 - 36,205,893RGD
RH 3.4 Map1456.5UniSTS
RH 3.4 Map1456.5RGD
Cytogenetic Map1p11UniSTS
RH134376  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2141,801,060 - 41,801,240 (+)MAPPERmRatBN7.2
Rnor_6.0141,905,527 - 41,905,706NCBIRnor6.0
Rnor_5.0143,236,732 - 43,236,911UniSTSRnor5.0
RGSC_v3.4136,093,249 - 36,093,428UniSTSRGSC3.4
Celera137,485,388 - 37,485,567UniSTS
Cytogenetic Map1p11UniSTS
RH139857  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2141,587,774 - 41,587,990 (+)MAPPERmRatBN7.2
Rnor_6.0141,683,911 - 41,684,126NCBIRnor6.0
Rnor_5.0143,023,487 - 43,023,702UniSTSRnor5.0
RGSC_v3.4135,878,343 - 35,878,558UniSTSRGSC3.4
Celera137,270,306 - 37,270,521UniSTS
Cytogenetic Map1p11UniSTS


Genetic Models
This gene Syne1 is modified in the following models/strains:
F344-Syne1Tn(sb-T2/Bart3)2.68Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 68 171 91 90 59 121 59 6 404 222 12 150 99 103 31 18 18

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001419849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006227851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006227852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008774326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101494 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF452647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY597251 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MK681777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MK681778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X95466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000025795
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl141,905,436 - 41,938,439 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000047472
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl141,512,030 - 41,557,955 (-)Ensembl
Rnor_6.0 Ensembl141,609,128 - 41,754,652 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000081637
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl143,917,641 - 44,388,669 (-)Ensembl
mRatBN7.2 Ensembl141,512,275 - 41,983,322 (-)Ensembl
Rnor_6.0 Ensembl141,832,830 - 42,077,535 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000084571
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl143,917,641 - 44,388,669 (-)Ensembl
mRatBN7.2 Ensembl141,512,275 - 41,983,322 (-)Ensembl
Rnor_6.0 Ensembl141,608,418 - 41,821,544 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000084712
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl141,905,435 - 41,937,822 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000090638
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl141,635,315 - 41,761,735 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000131307   ⟹   ENSRNOP00000099916
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl143,917,641 - 44,388,669 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000131353   ⟹   ENSRNOP00000099293
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl143,917,640 - 44,388,721 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000137901   ⟹   ENSRNOP00000107023
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl143,917,641 - 44,388,669 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000138697   ⟹   ENSRNOP00000104038
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl143,917,551 - 44,388,721 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000143692   ⟹   ENSRNOP00000101560
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl143,895,994 - 44,388,721 (-)Ensembl
RefSeq Acc Id: NM_001419849   ⟹   NP_001406778
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,917,640 - 44,388,721 (-)NCBI
mRatBN7.2141,512,274 - 41,983,374 (-)NCBI
RefSeq Acc Id: XM_006227851   ⟹   XP_006227913
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,917,640 - 44,072,629 (-)NCBI
mRatBN7.2141,512,146 - 41,667,067 (-)NCBI
Rnor_6.0141,609,125 - 41,763,231 (-)NCBI
Rnor_5.0142,947,742 - 43,158,478 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006227852   ⟹   XP_006227914
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,917,640 - 43,963,421 (-)NCBI
mRatBN7.2141,512,273 - 41,558,038 (-)NCBI
Rnor_6.0141,608,287 - 41,655,449 (-)NCBI
Rnor_5.0142,947,742 - 43,158,478 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017590500   ⟹   XP_017445989
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,917,640 - 44,388,723 (-)NCBI
mRatBN7.2141,513,038 - 41,983,375 (-)NCBI
Rnor_6.0141,844,840 - 42,086,662 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039101492   ⟹   XP_038957420
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,917,640 - 44,388,722 (-)NCBI
mRatBN7.2141,512,981 - 41,983,374 (-)NCBI
RefSeq Acc Id: XM_039101493   ⟹   XP_038957421
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,917,640 - 44,388,722 (-)NCBI
mRatBN7.2141,512,146 - 41,983,374 (-)NCBI
RefSeq Acc Id: XM_039101494   ⟹   XP_038957422
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,917,640 - 44,388,722 (-)NCBI
mRatBN7.2141,512,146 - 41,983,374 (-)NCBI
RefSeq Acc Id: XM_039101495   ⟹   XP_038957423
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,917,640 - 44,388,722 (-)NCBI
mRatBN7.2141,512,146 - 41,983,374 (-)NCBI
RefSeq Acc Id: XM_039101496   ⟹   XP_038957424
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,917,640 - 44,388,722 (-)NCBI
mRatBN7.2141,512,146 - 41,983,374 (-)NCBI
RefSeq Acc Id: XM_039101497   ⟹   XP_038957425
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,917,640 - 44,388,726 (-)NCBI
mRatBN7.2141,512,146 - 41,983,322 (-)NCBI
RefSeq Acc Id: XM_039101498   ⟹   XP_038957426
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,917,640 - 44,323,574 (-)NCBI
mRatBN7.2141,512,981 - 41,918,181 (-)NCBI
RefSeq Acc Id: XM_039101499   ⟹   XP_038957427
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,917,640 - 44,388,726 (-)NCBI
mRatBN7.2141,512,437 - 41,983,322 (-)NCBI
RefSeq Acc Id: XM_039101500   ⟹   XP_038957428
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,917,640 - 44,388,744 (-)NCBI
mRatBN7.2141,512,146 - 41,983,374 (-)NCBI
RefSeq Acc Id: XM_039101502   ⟹   XP_038957430
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,917,640 - 44,388,722 (-)NCBI
mRatBN7.2141,512,146 - 41,983,374 (-)NCBI
RefSeq Acc Id: XM_039101503   ⟹   XP_038957431
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,917,640 - 44,388,726 (-)NCBI
mRatBN7.2141,512,981 - 41,983,322 (-)NCBI
RefSeq Acc Id: XM_039101504   ⟹   XP_038957432
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,917,640 - 44,388,722 (-)NCBI
mRatBN7.2141,512,146 - 41,983,374 (-)NCBI
RefSeq Acc Id: XM_039101505   ⟹   XP_038957433
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,917,640 - 44,388,722 (-)NCBI
mRatBN7.2141,512,146 - 41,983,374 (-)NCBI
RefSeq Acc Id: XM_039101506   ⟹   XP_038957434
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,917,640 - 44,388,722 (-)NCBI
mRatBN7.2141,512,146 - 41,983,374 (-)NCBI
RefSeq Acc Id: XM_039101509   ⟹   XP_038957437
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,917,640 - 44,388,723 (-)NCBI
mRatBN7.2141,513,038 - 41,983,375 (-)NCBI
RefSeq Acc Id: XM_039101510   ⟹   XP_038957438
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,917,640 - 44,388,722 (-)NCBI
mRatBN7.2141,512,146 - 41,983,374 (-)NCBI
RefSeq Acc Id: XM_039101511   ⟹   XP_038957439
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,917,640 - 44,388,726 (-)NCBI
mRatBN7.2141,512,146 - 41,983,374 (-)NCBI
RefSeq Acc Id: XM_063270562   ⟹   XP_063126632
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,917,640 - 44,388,722 (-)NCBI
RefSeq Acc Id: XM_063270568   ⟹   XP_063126638
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,917,640 - 44,323,574 (-)NCBI
RefSeq Acc Id: XM_063270573   ⟹   XP_063126643
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,917,640 - 44,388,802 (-)NCBI
RefSeq Acc Id: XM_063270574   ⟹   XP_063126644
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,917,640 - 44,388,744 (-)NCBI
RefSeq Acc Id: XM_063270581   ⟹   XP_063126651
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,917,640 - 44,388,798 (-)NCBI
RefSeq Acc Id: XM_063270583   ⟹   XP_063126653
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,917,640 - 44,388,800 (-)NCBI
RefSeq Acc Id: XM_063270587   ⟹   XP_063126657
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,917,640 - 44,323,574 (-)NCBI
RefSeq Acc Id: XM_063270589   ⟹   XP_063126659
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,917,640 - 44,323,574 (-)NCBI
RefSeq Acc Id: XM_063270600   ⟹   XP_063126670
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,917,640 - 44,388,722 (-)NCBI
RefSeq Acc Id: XM_063270606   ⟹   XP_063126676
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,917,640 - 44,388,722 (-)NCBI
RefSeq Acc Id: XM_063270618   ⟹   XP_063126688
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,917,640 - 44,388,723 (-)NCBI
RefSeq Acc Id: XM_063270623   ⟹   XP_063126693
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,917,640 - 44,282,714 (-)NCBI
RefSeq Acc Id: XM_063270634   ⟹   XP_063126704
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,917,640 - 43,963,421 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001406778 (Get FASTA)   NCBI Sequence Viewer  
  XP_006227913 (Get FASTA)   NCBI Sequence Viewer  
  XP_006227914 (Get FASTA)   NCBI Sequence Viewer  
  XP_017445989 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957420 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957421 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957422 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957423 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957424 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957425 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957426 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957427 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957428 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957430 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957431 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957432 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957433 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957434 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957437 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957438 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957439 (Get FASTA)   NCBI Sequence Viewer  
  XP_063126632 (Get FASTA)   NCBI Sequence Viewer  
  XP_063126638 (Get FASTA)   NCBI Sequence Viewer  
  XP_063126643 (Get FASTA)   NCBI Sequence Viewer  
  XP_063126644 (Get FASTA)   NCBI Sequence Viewer  
  XP_063126651 (Get FASTA)   NCBI Sequence Viewer  
  XP_063126653 (Get FASTA)   NCBI Sequence Viewer  
  XP_063126657 (Get FASTA)   NCBI Sequence Viewer  
  XP_063126659 (Get FASTA)   NCBI Sequence Viewer  
  XP_063126670 (Get FASTA)   NCBI Sequence Viewer  
  XP_063126676 (Get FASTA)   NCBI Sequence Viewer  
  XP_063126688 (Get FASTA)   NCBI Sequence Viewer  
  XP_063126693 (Get FASTA)   NCBI Sequence Viewer  
  XP_063126704 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAL47053 (Get FASTA)   NCBI Sequence Viewer  
  AAT08489 (Get FASTA)   NCBI Sequence Viewer  
  CAA64740 (Get FASTA)   NCBI Sequence Viewer  
  EDL92843 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000076933
  ENSRNOP00000076933.2
  ENSRNOP00000089915
  ENSRNOP00000089915.2
  ENSRNOP00000099293
  ENSRNOP00000099293.1
  ENSRNOP00000099916.1
  ENSRNOP00000101560
  ENSRNOP00000101560.1
  ENSRNOP00000104038
  ENSRNOP00000104038.1
  ENSRNOP00000107023
  ENSRNOP00000107023.1
GenBank Protein QFP98436 (Get FASTA)   NCBI Sequence Viewer  
  QFP98437 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_006227913   ⟸   XM_006227851
- Peptide Label: isoform X26
- UniProtKB: Q8VHJ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006227914   ⟸   XM_006227852
- Peptide Label: isoform X28
- UniProtKB: A0A8I6B1X1 (UniProtKB/TrEMBL),   A6KIM8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017445989   ⟸   XM_017590500
- Peptide Label: isoform X23
- UniProtKB: A0A5P8DHN0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038957439   ⟸   XM_039101511
- Peptide Label: isoform X29
- UniProtKB: A0A5P8DHK4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957428   ⟸   XM_039101500
- Peptide Label: isoform X9
- UniProtKB: A0A5P8DHN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957434   ⟸   XM_039101506
- Peptide Label: isoform X19
- UniProtKB: A0A5P8DHN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957438   ⟸   XM_039101510
- Peptide Label: isoform X22
- UniProtKB: A0A5P8DHK4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957432   ⟸   XM_039101504
- Peptide Label: isoform X16
- UniProtKB: A0A5P8DHN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957424   ⟸   XM_039101496
- Peptide Label: isoform X4
- UniProtKB: A0A5P8DHN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957423   ⟸   XM_039101495
- Peptide Label: isoform X3
- UniProtKB: A0A5P8DHN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957422   ⟸   XM_039101494
- Peptide Label: isoform X2
- UniProtKB: A0A5P8DHN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957433   ⟸   XM_039101505
- Peptide Label: isoform X17
- UniProtKB: A0A5P8DHN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957430   ⟸   XM_039101502
- Peptide Label: isoform X11
- UniProtKB: A0A5P8DHN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957421   ⟸   XM_039101493
- Peptide Label: isoform X1
- UniProtKB: A0A5P8DHN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957425   ⟸   XM_039101497
- Peptide Label: isoform X5
- UniProtKB: A0A5P8DHN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957427   ⟸   XM_039101499
- Peptide Label: isoform X7
- UniProtKB: A0A5P8DHN0 (UniProtKB/TrEMBL),   A0A8I5ZJB9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957420   ⟸   XM_039101492
- Peptide Label: isoform X1
- UniProtKB: A0A5P8DHN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957431   ⟸   XM_039101503
- Peptide Label: isoform X15
- UniProtKB: A0A5P8DHN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957426   ⟸   XM_039101498
- Peptide Label: isoform X6
- UniProtKB: A0A5P8DHN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957437   ⟸   XM_039101509
- Peptide Label: isoform X21
- UniProtKB: A0A5P8DHN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001406778   ⟸   NM_001419849
- UniProtKB: A0A5P8DHN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126643   ⟸   XM_063270573
- Peptide Label: isoform X9
- UniProtKB: A0A5P8DHN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126653   ⟸   XM_063270583
- Peptide Label: isoform X12
- UniProtKB: A0A5P8DHN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126651   ⟸   XM_063270581
- Peptide Label: isoform X12
- UniProtKB: A0A5P8DHN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126644   ⟸   XM_063270574
- Peptide Label: isoform X10
- UniProtKB: A0A5P8DHN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126688   ⟸   XM_063270618
- Peptide Label: isoform X24
- UniProtKB: A0A5P8DHN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126670   ⟸   XM_063270600
- Peptide Label: isoform X18
- UniProtKB: A0A5P8DHN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126676   ⟸   XM_063270606
- Peptide Label: isoform X20
- UniProtKB: A0A5P8DHN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126632   ⟸   XM_063270562
- Peptide Label: isoform X5
- UniProtKB: A0A5P8DHN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126659   ⟸   XM_063270589
- Peptide Label: isoform X14
- UniProtKB: A0A5P8DHN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126638   ⟸   XM_063270568
- Peptide Label: isoform X8
- UniProtKB: A0A5P8DHN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126657   ⟸   XM_063270587
- Peptide Label: isoform X13
- UniProtKB: A0A5P8DHN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126693   ⟸   XM_063270623
- Peptide Label: isoform X25
- UniProtKB: A0A5P8DHN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126704   ⟸   XM_063270634
- Peptide Label: isoform X27
- UniProtKB: A6KIM8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000099293   ⟸   ENSRNOT00000131353
Ensembl Acc Id: ENSRNOP00000101560   ⟸   ENSRNOT00000143692
Ensembl Acc Id: ENSRNOP00000104038   ⟸   ENSRNOT00000138697
Ensembl Acc Id: ENSRNOP00000107023   ⟸   ENSRNOT00000137901
Ensembl Acc Id: ENSRNOP00000099916   ⟸   ENSRNOT00000131307
Protein Domains
Calponin-homology (CH)   KASH   Nesprin-1 spectrin repeats region

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620546 AgrOrtholog
BioCyc Gene G2FUF-61708 BioCyc
Ensembl Genes ENSRNOG00000018960 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000081637 ENTREZGENE
  ENSRNOT00000081637.3 UniProtKB/TrEMBL
  ENSRNOT00000084571 ENTREZGENE
  ENSRNOT00000084571.3 UniProtKB/TrEMBL
  ENSRNOT00000131307.1 UniProtKB/TrEMBL
  ENSRNOT00000131353 ENTREZGENE
  ENSRNOT00000131353.1 UniProtKB/TrEMBL
  ENSRNOT00000137901 ENTREZGENE
  ENSRNOT00000137901.1 UniProtKB/TrEMBL
  ENSRNOT00000138697 ENTREZGENE
  ENSRNOT00000138697.1 UniProtKB/TrEMBL
  ENSRNOT00000143692 ENTREZGENE
  ENSRNOT00000143692.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.418.10 UniProtKB/TrEMBL
  1.20.58.60 UniProtKB/TrEMBL
InterPro Actinin_actin-bd_CS UniProtKB/TrEMBL
  CH-domain UniProtKB/TrEMBL
  CH_dom_sf UniProtKB/TrEMBL
  CH_SYNE1_rpt1 UniProtKB/TrEMBL
  CH_SYNE1_rpt2 UniProtKB/TrEMBL
  KASH UniProtKB/TrEMBL
  Spectrin/alpha-actinin UniProtKB/TrEMBL
  Spectrin_repeat UniProtKB/TrEMBL
  Spectrin_SYNE1 UniProtKB/TrEMBL
  SYNE1/2_dom UniProtKB/TrEMBL
NCBI Gene Syne1 ENTREZGENE
PANTHER KASH DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  NESPRIN-1 UniProtKB/TrEMBL
  PKA ANCHORING PROTEIN UniProtKB/TrEMBL
Pfam KASH UniProtKB/TrEMBL
  PF00307 UniProtKB/TrEMBL
  Spectrin UniProtKB/TrEMBL
  Spectrin_SYNE1 UniProtKB/TrEMBL
  Spectrin_SYNE1_2 UniProtKB/TrEMBL
  SYNE1 UniProtKB/TrEMBL
PhenoGen Syne1 PhenoGen
PROSITE ACTININ_1 UniProtKB/TrEMBL
  ACTININ_2 UniProtKB/TrEMBL
  KASH UniProtKB/TrEMBL
  PS50021 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018960 RatGTEx
SMART KASH UniProtKB/TrEMBL
  SM00033 UniProtKB/TrEMBL
  SPEC UniProtKB/TrEMBL
Superfamily-SCOP Spectrin repeat UniProtKB/TrEMBL
  SSF47576 UniProtKB/TrEMBL
UniProt A0A5P8DHK4 ENTREZGENE, UniProtKB/TrEMBL
  A0A5P8DHN0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZJB9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ABC0_RAT UniProtKB/TrEMBL
  A0A8I6B1X1 ENTREZGENE
  A0ABK0L9I1_RAT UniProtKB/TrEMBL
  A0ABK0LBQ4_RAT UniProtKB/TrEMBL
  A0ABK0LEN2_RAT UniProtKB/TrEMBL
  A0ABK0LEP2_RAT UniProtKB/TrEMBL
  A0ABK0LRY9_RAT UniProtKB/TrEMBL
  A6KIM8 ENTREZGENE, UniProtKB/TrEMBL
  A6KIN5_RAT UniProtKB/TrEMBL
  Q63128_RAT UniProtKB/TrEMBL
  Q8VHJ9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Syne1  spectrin repeat containing nuclear envelope protein 1  LOC103690962  nesprin-1-like  Data merged from RGD:9167308 737654 PROVISIONAL
2015-07-29 Syne1  spectrin repeat containing, nuclear envelope 1  LOC102546492  nesprin-1-like  Data merged from RGD:7698222 737654 PROVISIONAL
2014-08-25 LOC103690962  nesprin-1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2013-12-18 LOC102546492  nesprin-1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-02-25 Syne1  spectrin repeat containing, nuclear envelope 1  CPG2  CPG2 protein  Data merged from RGD:621597 737654 APPROVED
2005-07-08 Syne1  spectrin repeat containing, nuclear envelope 1    nesprin-1  Name updated 1299863 APPROVED
2002-08-07 CPG2  CPG2 protein      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-08-07 Syne1  nesprin-1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains have multiple, clustered spectrin-repeats 634176
gene_expression colocalizes with LAP1, emerin and lamins at the nuclear envelope 634176
gene_process maintains structural integrity and nuclear organization 634176
gene_regulation induced in adult visual cortical areas in response to light 632616