Gene:	Bcl10 ( Rattus norvegicus ) B-cell CLL/lymphoma 10
Description:	plays a role in regulation of apoptosis
Synonyms:	B-cell leukemia/lymphoma 10;  (details...)
ArrayIDs:	6614836; 1368118_at; 5831461; 6236440; 6330927; 6027164; 6630462; rc_AI104659_at; 5755231; GE13054; 5786778; A_42_P508784; 6421910; A_44_P264102; 5734546; 6024647; 6292441;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: BCL10     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Bcl10     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Bcl10 genome assembly 3.1 2 244103619 - 244113130     Rat Celera Assembly 2 226822923 - 226832566     RGSC genome assembly v3.4 2 244116880 - 244126394     Cytogenetic 2 q44 Mus musculus Bcl10 Mouse genome assembly build 36.1 3 145587342 - 145597247     Cytogenetic 3 3 H3 Homo sapiens BCL10 human genome assembly 1 85443952 - 85455604     Human genome assembly build 36.2 1 85504519 - 85516171     Cytogenetic 1 p22   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Gene Ontology NF-kappaB binding,  ubiquitin protein ligase binding,  transcription coactivator activity ...  (details...)
Biological Process	Gene Ontology response to molecule of bacterial origin,  response to fungus,  negative regulation of mature B cell apoptosis ...  (details...)
Cellular Component	Gene Ontology protein complex,  nucleus,  membrane raft ...  (details...)
Disease	Note Reference gene mutated in MALT lymphoma 631970
Mutation/over- and underexpression	Note Reference overexpression reduces c-Jun N-terminal kinase activation and enhanced nuclear factor kappaB activation downstream of TRAF2 631970
External Links
Databases	DATABASE ID SOURCE PROSITE: CARD IPI UNIPARC: UPI0000126830 IPI KEGG Report: rno:83477 ENTREZGENE HomoloGene Group ID: 2912 ENTREZGENE Germonline: 620544 Pfam: CARD IPI KEGG Pathway: 04660 ENTREZGENE KEGG Pathway: 04662 ENTREZGENE InterPro: CARD. IPI InterPro: DEATH-like. IPI IPI: IPI00214295 IPI Ensembl Protein: ENSRNOP00000019911 IPI Gene3D-CATH: DEATH_like IPI IMAGE_CLONE: IMAGE:5621919 IMAGE-MGC_LOAD Entrez Gene: Bcl10 ENTREZGENE MGC_CLONE: MGC:72408 IMAGE-MGC_LOAD UniProt: BCL10_RAT IPI Ensembl Genes: ENSRNOG00000042389 IPI Superfamily-SCOP: DEATH_like IPI
Sequences	Nucleotide: CH473952 Get FASTA Search GEO Profiles Nucleotide: AB016069 Get FASTA Search GEO Profiles Nucleotide: BC061772 Get FASTA Search GEO Profiles Nucleotide: NM_031328 Get FASTA Search GEO Profiles (View all 4 Nucleotide Accessions) Protein: EDL82410 Get FASTA Protein: EDL82411 Get FASTA Protein: NP_112618 Get FASTA Protein: AAH61772 Get FASTA Protein: Q9QYN5 Get FASTA Protein: BAA88822 Get FASTA (View all 6 Protein Accessions)
Clusters	UniGene: 13007
References
Curated References	8 references in RGD related to Bcl10
Other References	5 other references at PubMed related to Bcl10
Database Information
RGD ID	620544
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 25-SEP-08: Bcl10 B-cell CLL/lymphoma 10 Bcl10 B-cell leukemia/lymphoma 10 APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863 22-FEB-08: Bcl10 B-cell leukemia/lymphoma 10 Bcl10 B-cell CLL/lymphoma 10 APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863 20-JAN-05: Bcl10 B-cell CLL/lymphoma 10 APPROVED Symbol and Name status set to approved 1299863 07-AUG-02: Bcl10 B-cell CLL/lymphoma 10 PROVISIONAL Symbol and Name status set to provisional 70820