Cblb (Cbl proto-oncogene B) - Rat Genome Database

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Gene: Cblb (Cbl proto-oncogene B) Rattus norvegicus
Analyze
Symbol: Cblb
Name: Cbl proto-oncogene B
RGD ID: 620535
Description: Enables protein kinase binding activity. Involved in several processes, including cellular response to hydrogen peroxide; negative regulation of apoptotic process; and response to gravity. Predicted to be located in cytoplasm. Predicted to be active in several cellular components, including glutamatergic synapse; membrane raft; and postsynapse. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; stomach carcinoma; and type 1 diabetes mellitus. Orthologous to human CBLB (Cbl proto-oncogene B); PARTICIPATES IN chronic myeloid leukemia pathway; endocytosis pathway; epidermal growth factor/neuregulin signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cas-Br-M (murine) ecotropic retroviral transforming sequence b; Cas-Br-M (murine) ectropic retroviral transforming sequence b; Casitas B-lineage lymphoma B; casitas B-lineage lymphoma proto-oncogene b; Cbl proto-oncogene B, E3 ubiquitin protein ligase; Cbl proto-oncogene, E3 ubiquitin protein ligase B; E3 ubiquitin-protein ligase CBL-B; RING-type E3 ubiquitin transferase CBL-B; SH3-binding protein CBL-B; signal transduction protein CBL-B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   KDP/Tky ; KDP-Tg(H2Kd-Cblb)2Nyo ; KDP-Tg(H2Kd-Cblb)1Nyo ; KDP-Tg(INS-Cblb)1Nyo ; KDP-Tg(CAG-Cblb)1Nyo ; PVG.KDP-Cblb/Nyo ; TM.KDP-Cblb/Nyo ; TM.KDP-Cblb(D9Rat13-D9Rat4)(D12Rat5-D12Rat45)(D18Mit9-D18Rat44)/Nyo
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81162,058,829 - 62,225,904 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1162,061,653 - 62,225,778 (-)EnsemblGRCr8
mRatBN7.21148,589,878 - 48,756,940 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1148,592,703 - 48,756,839 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1157,366,338 - 57,530,452 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01150,028,005 - 50,192,131 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01149,152,080 - 49,316,208 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01151,037,383 - 51,202,761 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1151,037,393 - 51,202,820 (-)Ensemblrn6Rnor6.0
Rnor_5.01154,218,260 - 54,383,403 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41149,690,402 - 49,856,762 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1148,274,821 - 48,438,836 (-)NCBICelera
RGSC_v3.11149,747,990 - 49,914,351 (-)NCBI
Cytogenetic Map11q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
azoxystrobin  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
D-gluconic acid  (EXP)
DDE  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
dichloromethane  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
Enterolactone  (ISO)
ethylbenzene  (EXP)
fenofibrate  (ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
isoprenaline  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methotrexate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pyrimidifen  (ISO)
rac-lactic acid  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA,ISO)
glutamatergic synapse  (IEA,ISO)
membrane raft  (IBA)
plasma membrane  (IBA,IEA,ISO)
postsynapse  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Intraarticular interferon-beta gene therapy ameliorates adjuvant arthritis in rats. Adriaansen J, etal., Hum Gene Ther. 2006 Oct;17(10):985-96.
2. CBLB variants in type 1 diabetes and their genetic interaction with CTLA4. Bergholdt R, etal., J Leukoc Biol. 2005 Apr;77(4):579-85. Epub 2005 Jan 3.
3. [Expression of c-Cbl, Cbl-b, and epidermal growth factor receptor in gastric carcinoma and their clinical significance]. Dong Q, etal., Chin J Cancer. 2010 Jan;29(1):59-64.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Deficiency of Cbl-b gene enhances infiltration and activation of macrophages in adipose tissue and causes peripheral insulin resistance in mice. Hirasaka K, etal., Diabetes. 2007 Oct;56(10):2511-22. Epub 2007 Jun 29.
7. Increased expression of the Cbl family of E3 ubiquitin ligases decreases Interleukin-2 production in a rat model of peripheral neuropathy. Jeong JS, etal., BMC Anesthesiol. 2018 Jul 18;18(1):87. doi: 10.1186/s12871-018-0555-z.
8. Polymorphic variation in the CBLB gene in human type 1 diabetes. Kosoy R, etal., Genes Immun. 2004 May;5(3):232-5.
9. Negative regulation of Lyn protein-tyrosine kinase by c-Cbl ubiquitin-protein ligase in Fc epsilon RI-mediated mast cell activation. Kyo S, etal., Genes Cells. 2003 Oct;8(10):825-36.
10. Single Nucleotide Polymorphisms in CBLB, a Regulator of T-Cell Response, Predict Radiation Pneumonitis and Outcomes After Definitive Radiotherapy for Non-Small-Cell Lung Cancer. Li P, etal., Clin Lung Cancer. 2016 Jul;17(4):253-262.e5. doi: 10.1016/j.cllc.2015.11.008. Epub 2015 Nov 22.
11. Single nucleotide polymorphisms of casitas B-lineage lymphoma proto-oncogene-b predict outcomes of patients with advanced non-small cell lung cancer after first-line platinum based doublet chemotherapy. Li P, etal., J Thorac Dis. 2018 Mar;10(3):1635-1647. doi: 10.21037/jtd.2018.02.31.
12. Expression and Comparison of Cbl-b in Lung Squamous Cell Carcinoma and Adenocarcinoma. Li P, etal., Med Sci Monit. 2018 Jan 31;24:623-635. doi: 10.12659/msm.908076.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Skeletal muscle gene expression in space-flown rats. Nikawa T, etal., FASEB J. 2004 Mar;18(3):522-4. Epub 2004 Jan 8.
16. Phosphorylation of c-Cbl protooncogene product following ethanol administration in rat cerebellum: possible involvement of Fyn kinase. Nishio H, etal., Brain Res 2002 Sep 20;950(1-2):203-9.
17. Interaction analysis of the CBLB and CTLA4 genes in type 1 diabetes. Payne F, etal., J Leukoc Biol. 2007 Mar;81(3):581-3. Epub 2007 Jan 5.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. Negative regulation of FcepsilonRI-mediated mast cell activation by a ubiquitin-protein ligase Cbl-b. Qu X, etal., Blood. 2004 Mar 1;103(5):1779-86. Epub 2003 Nov 6.
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Cbl negatively regulates JNK activation and cell death. Sproul AA, etal., Cell Res. 2009 Aug;19(8):950-61. doi: 10.1038/cr.2009.74.
24. E3 Ubiquitin Ligase Cbl-b Prevents Tumor Metastasis by Maintaining the Epithelial Phenotype in Multiple Drug-Resistant Gastric and Breast Cancer Cells. Xu L, etal., Neoplasia. 2017 Apr;19(4):374-382. doi: 10.1016/j.neo.2017.01.011. Epub 2017 Mar 20.
25. CD28 activation does not down-regulate Cbl-b expression in aged rat T-lymphocytes. Xu Z, etal., Mech Ageing Dev. 2004 Sep;125(9):595-602.
26. Identification and functional analysis of CBLB mutations in type 1 diabetes. Yokoi N, etal., Biochem Biophys Res Commun. 2008 Mar 28;368(1):37-42. Epub 2008 Jan 15.
27. Cblb is a major susceptibility gene for rat type 1 diabetes mellitus. Yokoi N, etal., Nat Genet 2002 Aug;31(4):391-4.
Additional References at PubMed
PMID:11070165   PMID:12697763   PMID:14525909   PMID:14738763   PMID:14747305   PMID:14973438   PMID:15337528   PMID:16002993   PMID:19546233   PMID:20177738   PMID:29237719   PMID:29513566  
PMID:32606037  


Genomics

Comparative Map Data
Cblb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81162,058,829 - 62,225,904 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1162,061,653 - 62,225,778 (-)EnsemblGRCr8
mRatBN7.21148,589,878 - 48,756,940 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1148,592,703 - 48,756,839 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1157,366,338 - 57,530,452 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01150,028,005 - 50,192,131 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01149,152,080 - 49,316,208 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01151,037,383 - 51,202,761 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1151,037,393 - 51,202,820 (-)Ensemblrn6Rnor6.0
Rnor_5.01154,218,260 - 54,383,403 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41149,690,402 - 49,856,762 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1148,274,821 - 48,438,836 (-)NCBICelera
RGSC_v3.11149,747,990 - 49,914,351 (-)NCBI
Cytogenetic Map11q21NCBI
CBLB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383105,655,461 - 105,869,449 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3105,655,461 - 105,869,552 (-)Ensemblhg38GRCh38
GRCh373105,374,305 - 105,588,245 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363106,859,799 - 107,070,577 (-)NCBIBuild 36Build 36hg18NCBI36
Build 343106,859,798 - 107,070,577NCBI
Celera3103,775,519 - 103,986,437 (-)NCBICelera
Cytogenetic Map3q13.11NCBI
HuRef3102,751,829 - 102,962,841 (-)NCBIHuRef
CHM1_13105,340,227 - 105,551,366 (-)NCBICHM1_1
T2T-CHM13v2.03108,373,636 - 108,587,751 (-)NCBIT2T-CHM13v2.0
Cblb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391651,851,593 - 52,028,410 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1651,851,588 - 52,028,411 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381652,031,230 - 52,208,047 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1652,031,225 - 52,208,048 (+)Ensemblmm10GRCm38
MGSCv371652,031,662 - 52,208,160 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361651,950,573 - 52,127,397 (+)NCBIMGSCv36mm8
Celera1652,360,484 - 52,539,724 (+)NCBICelera
Cytogenetic Map16B5NCBI
cM Map1632.88NCBI
Cblb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554276,604,820 - 6,812,882 (-)Ensembl
ChiLan1.0NW_0049554276,601,651 - 6,812,896 (-)NCBIChiLan1.0ChiLan1.0
CBLB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22103,603,565 - 103,820,636 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13103,609,269 - 103,823,777 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03102,752,406 - 102,966,414 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13109,690,120 - 109,905,306 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3109,690,120 - 109,905,191 (-)EnsemblpanPan2panpan1.1
CBLB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13311,255,453 - 11,665,755 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3311,199,863 - 11,530,810 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3311,363,164 - 11,770,049 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03311,418,045 - 11,825,614 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3311,418,236 - 11,631,415 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13311,285,163 - 11,691,897 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03311,352,619 - 11,761,772 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03311,761,341 - 12,168,419 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cblb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602145,313,740 - 145,509,343 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367011,157,797 - 1,353,388 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367011,157,790 - 1,353,375 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CBLB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13153,395,978 - 153,700,056 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113153,480,525 - 153,700,115 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213162,675,952 - 162,892,734 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CBLB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12274,961,831 - 75,181,307 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2274,961,859 - 75,178,548 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604191,314,990 - 91,530,969 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cblb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473143,803,768 - 44,015,870 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473143,803,743 - 44,018,682 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Cblb
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1436,307,209 - 36,470,454 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cblb
1179 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:208
Count of miRNA genes:145
Interacting mature miRNAs:164
Transcripts:ENSRNOT00000002719
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)112252474682951192Rat
1598841Memor7Memory QTL 7exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)113330600878306008Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)114644316891443168Rat
1598811Bp291Blood pressure QTL 2911.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113330600878306008Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)115892833699753367Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113294306789836615Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)113191546976915469Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)113642841681428416Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)113461876079618760Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)115441539196071021Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)115893182292356038Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)115775483796071021Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)113674945981749459Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)113674945981749459Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)115107102196071021Rat
631510Spl2Serum phospholipid level QTL 24.1blood phospholipid amount (VT:0006084)serum phospholipid level (CMO:0001171)112755668572556685Rat

Markers in Region
RH142540  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21148,592,737 - 48,592,935 (+)MAPPERmRatBN7.2
Rnor_6.01151,040,242 - 51,040,439NCBIRnor6.0
Rnor_5.01154,221,119 - 54,221,316UniSTSRnor5.0
RGSC_v3.41149,690,437 - 49,690,634UniSTSRGSC3.4
Celera1148,274,856 - 48,275,053UniSTS
Cytogenetic Map11q21UniSTS


Related Rat Strains
The following Strains have been annotated to Cblb
KDP-Tg(CAG-Cblb)1Nyo     KDP-Tg(H2Kd-Cblb)1Nyo     KDP-Tg(H2Kd-Cblb)2Nyo     KDP-Tg(INS-Cblb)1Nyo     KDP/Tky     PVG.KDP-Cblb/Nyo     TM.KDP-Cblb(D9Rat13-D9Rat4)(D12Rat5-D12Rat45)(D18Mit9-D18Rat44)/Nyo     TM.KDP-Cblb/Nyo    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000002719   ⟹   ENSRNOP00000002719
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1162,061,653 - 62,225,778 (-)Ensembl
mRatBN7.2 Ensembl1148,592,703 - 48,756,839 (-)Ensembl
Rnor_6.0 Ensembl1151,040,207 - 51,202,703 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000077220   ⟹   ENSRNOP00000074638
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1162,061,653 - 62,225,778 (-)Ensembl
mRatBN7.2 Ensembl1148,592,703 - 48,756,839 (-)Ensembl
Rnor_6.0 Ensembl1151,037,393 - 51,202,820 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000155106   ⟹   ENSRNOP00000103092
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1162,061,653 - 62,225,778 (-)Ensembl
RefSeq Acc Id: NM_133601   ⟹   NP_598285
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81162,061,653 - 62,225,778 (-)NCBI
mRatBN7.21148,592,703 - 48,756,839 (-)NCBI
Rnor_6.01151,040,207 - 51,202,703 (-)NCBI
Rnor_5.01154,218,260 - 54,383,403 (-)NCBI
RGSC_v3.41149,690,402 - 49,856,762 (-)RGD
Celera1148,274,821 - 48,438,836 (-)RGD
Sequence:
RefSeq Acc Id: XM_006248258   ⟹   XP_006248320
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81162,058,829 - 62,225,904 (-)NCBI
mRatBN7.21148,589,878 - 48,756,940 (-)NCBI
Rnor_6.01151,037,383 - 51,202,761 (-)NCBI
Rnor_5.01154,218,260 - 54,383,403 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006248259   ⟹   XP_006248321
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81162,058,829 - 62,225,279 (-)NCBI
mRatBN7.21148,593,215 - 48,756,358 (-)NCBI
Rnor_6.01151,040,719 - 51,202,222 (-)NCBI
Rnor_5.01154,218,260 - 54,383,403 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008768626   ⟹   XP_008766848
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81162,058,829 - 62,225,364 (-)NCBI
mRatBN7.21148,593,215 - 48,756,426 (-)NCBI
Rnor_6.01151,040,719 - 51,202,349 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063270260   ⟹   XP_063126330
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81162,058,829 - 62,225,336 (-)NCBI
RefSeq Acc Id: XM_063270261   ⟹   XP_063126331
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81162,058,829 - 62,225,879 (-)NCBI
RefSeq Acc Id: NP_598285   ⟸   NM_133601
- UniProtKB: Q9QZ69 (UniProtKB/Swiss-Prot),   Q8K4S7 (UniProtKB/Swiss-Prot),   A6IQS7 (UniProtKB/TrEMBL),   G3V689 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248320   ⟸   XM_006248258
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006248321   ⟸   XM_006248259
- Peptide Label: isoform X1
- UniProtKB: Q9QZ69 (UniProtKB/Swiss-Prot),   Q8K4S7 (UniProtKB/Swiss-Prot),   A0A0G2K8K2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008766848   ⟸   XM_008768626
- Peptide Label: isoform X1
- UniProtKB: Q9QZ69 (UniProtKB/Swiss-Prot),   Q8K4S7 (UniProtKB/Swiss-Prot),   A0A0G2K8K2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074638   ⟸   ENSRNOT00000077220
Ensembl Acc Id: ENSRNOP00000002719   ⟸   ENSRNOT00000002719
RefSeq Acc Id: XP_063126331   ⟸   XM_063270261
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063126330   ⟸   XM_063270260
- Peptide Label: isoform X2
- UniProtKB: Q9QZ69 (UniProtKB/Swiss-Prot),   Q8K4S7 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000103092   ⟸   ENSRNOT00000155106
Protein Domains
Cbl-PTB   RING-type   UBA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8K4S7-F1-model_v2 AlphaFold Q8K4S7 1-938 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698119
Promoter ID:EPDNEW_R8644
Type:initiation region
Name:Cblb_1
Description:Cbl proto-oncogene B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01151,202,765 - 51,202,825EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620535 AgrOrtholog
BioCyc Gene G2FUF-21473 BioCyc
Ensembl Genes ENSRNOG00000001982 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000002719 ENTREZGENE
  ENSRNOT00000077220 ENTREZGENE
Gene3D-CATH 1.20.930.20 UniProtKB/Swiss-Prot
  3.30.40.10 UniProtKB/Swiss-Prot
  3.30.505.10 UniProtKB/Swiss-Prot
  DNA helicase RuvA subunit, C-terminal domain UniProtKB/Swiss-Prot
  EF-hand UniProtKB/Swiss-Prot
InterPro Adaptor_Cbl UniProtKB/Swiss-Prot
  Adaptor_Cbl_EF_hand-like UniProtKB/Swiss-Prot
  Adaptor_Cbl_N_dom_sf UniProtKB/Swiss-Prot
  Adaptor_Cbl_N_hlx UniProtKB/Swiss-Prot
  Adaptor_Cbl_SH2-like UniProtKB/Swiss-Prot
  CBL-B_RING-HC UniProtKB/Swiss-Prot
  Cbl_PTB UniProtKB/Swiss-Prot
  EF-hand-dom_pair UniProtKB/Swiss-Prot
  SH2_dom_sf UniProtKB/Swiss-Prot
  UBA UniProtKB/Swiss-Prot
  Znf_C3HC4_RING-type UniProtKB/Swiss-Prot
  Znf_RING UniProtKB/Swiss-Prot
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot
  Znf_RING_CS UniProtKB/Swiss-Prot
KEGG Report rno:171136 UniProtKB/Swiss-Prot
NCBI Gene 171136 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE CBL-B UniProtKB/Swiss-Prot
  PTHR23007 UniProtKB/Swiss-Prot
Pfam Cbl_N UniProtKB/Swiss-Prot
  Cbl_N2 UniProtKB/Swiss-Prot
  Cbl_N3 UniProtKB/Swiss-Prot
  zf-C3HC4 UniProtKB/Swiss-Prot
PhenoGen Cblb PhenoGen
PROSITE CBL_PTB UniProtKB/Swiss-Prot
  UBA UniProtKB/Swiss-Prot
  ZF_RING_1 UniProtKB/Swiss-Prot
  ZF_RING_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001982 RatGTEx
SMART RING UniProtKB/Swiss-Prot
  UBA UniProtKB/Swiss-Prot
Superfamily-SCOP RING/U-box UniProtKB/Swiss-Prot
  SSF47473 UniProtKB/Swiss-Prot
  SSF47668 UniProtKB/Swiss-Prot
  SSF55550 UniProtKB/Swiss-Prot
UniProt A0A0G2K8K2 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LJG0_RAT UniProtKB/TrEMBL
  A6IQS6_RAT UniProtKB/TrEMBL
  A6IQS7 ENTREZGENE, UniProtKB/TrEMBL
  CBLB_RAT UniProtKB/Swiss-Prot
  G3V689 ENTREZGENE, UniProtKB/TrEMBL
  Q8K4S7 ENTREZGENE
  Q9QZ69 ENTREZGENE
UniProt Secondary Q9QZ69 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-05 Cblb  Cbl proto-oncogene B  Cblb  Casitas B-lineage lymphoma B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-05-04 Cblb  Casitas B-lineage lymphoma B  Cblb  Cbl proto-oncogene B, E3 ubiquitin protein ligase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-07-18 Cblb  Cbl proto-oncogene B, E3 ubiquitin protein ligase  Cblb  Cbl proto-oncogene, E3 ubiquitin protein ligase B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-13 Cblb  Cbl proto-oncogene, E3 ubiquitin protein ligase B  Cblb  Cas-Br-M (murine) ecotropic retroviral transforming sequence b  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Cblb  Cas-Br-M (murine) ecotropic retroviral transforming sequence b  Cblb  Casitas B-lineage lymphoma b  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Cblb  Casitas B-lineage lymphoma b    Cas-Br-M (murine) ectropic retroviral transforming sequence b  Name updated 1299863 APPROVED
2002-08-07 Cblb  Cas-Br-M (murine) ectropic retroviral transforming sequence b      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease major susceptibility gene for type 1 diabetes characterized by KDP diabetes-prone rat substrain 625457
gene_mutations_overexpression KDP rat contains a CT homozygous nonsense mutation (Arg455X) that removes 484 amino acids including the proline-rich region and leucine zipper domain 625457
gene_process negative regulator of autoimmunity 625457
gene_product 938 amino acid protein 625457