Cblb Rat Gene (Cas-Br-M (murine) ecotropic retroviral transforming sequence b)

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Keyword

Gene:
Cblb ( Rattus norvegicus )
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
Description: a protein exhibiting protein kinase binding, ligase activity (inferred), signal transducer activity (inferred) and other inferred activities; involved in signal transduction, response to hormone stimulus (interferon-beta), T cell activation (mouse ortholog) and other processes; found in membrane raft, nucleus (inferred), cytoplasm (inferred); associated with Diabetes Mellitus, Insulin-Dependent; Arthritis, Experimental
Synonyms: Cas-Br-M (murine) ectropic retroviral transforming sequence b; Casitas B-lineage lymphoma b;
ArrayIDs: 6338961; 5921368; rc_AI072631_at; 6542606; 6730607; 6616106; 1371027_at; rc_AA955794_at; 5867836; 6225688; 6359623; 6532442; 5895117; 5816556; 5781477; 5942434; A_44_P198539; 6354579; 6282696; 6016575; 5879798; 5981525; 6184545; 6025241; GE13456; 6345260; 5865772; 6316950; 6516839; 5848163; 6262460; 6332933;  (details...)
Gene Type: protein-coding
Strain: KDP-Tg(H2Kd-Cblb)1Nyo  KDP-Tg(H2Kd-Cblb)2Nyo  KDP-Tg(CAG-Cblb)1Nyo  TM.KDP-Cblb/Nyo  KDP-Tg(INS-Cblb)1Nyo

Additional Data

Homologs
Homo sapiens: CBLB     See the Human gene in context in:     UCSC     NCBI MapViewer

Mus musculus: Cblb     See the Mouse gene in context in:     UCSC     NCBI MapViewer

Comparative Map Data
Species Symbol Map Name Chr. Position
Rattus norvegicus Cblb Rat Celera Assembly 11 48274821 - 48438836
RGSC genome assembly v3.4 11 49690402 - 49856762
Cytogenetic 11 q21
genome assembly 3.1 11 49747990 - 49914351
Mus musculus Cblb Mouse genome assembly build 36.1 16 52031662 - 52208160
Cytogenetic 16 16 B5
Homo sapiens CBLB human genome assembly 3 106859798 - 107070577
Human genome assembly build 36.2 3 106859799 - 107070577
Cytogenetic 3 q13.11

View comparative maps:      NCBI MapViewer

Genome
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Annotation
Molecular Function

Gene Ontology

signal transducer activity,  protein binding,  zinc ion binding ... (details...)
Biological Process

Note Reference

negative regulator of autoimmunity 625457

Gene Ontology

response to gravity,  negative regulation of alpha-beta T cell proliferation,  negative regulation of T cell receptor signaling pathway ... (details...)
Cellular Component

Gene Ontology

nucleus,  membrane raft,  cytoplasm (details...)
Disease

Note Reference

major susceptibility gene for type 1 diabetes characterized by KDP diabetes-prone rat substrain 625457

Ontology

Insulin Resistance,  Diabetes Mellitus, Insulin-Dependent,  Arthritis, Experimental (details...)
Product

Note Reference

938 amino acid protein 625457

Mutation/over- and underexpression

Note Reference

KDP rat contains a CT homozygous nonsense mutation (Arg455X) that removes 484 amino acids including the proline-rich region and leucine zipper domain 625457

External Links
Databases
DATABASE ID SOURCE
SMART: UBA IPI
SMART: RING IPI
SMART: SH2 IPI
PROSITE: ZF_RING_2 IPI
PROSITE: UBA IPI
PROSITE: ZF_RING_1 IPI
UNIPARC: UPI0000501146 IPI
UNIPARC: UPI0001B79CF7 IPI
UNIPARC: UPI00000E7314 IPI
KEGG Report: rno:171136 ENTREZGENE
HomoloGene Group ID: 15856 ENTREZGENE
Germonline: 620535
Pfam: Cbl_N IPI
Pfam: UBA IPI
Pfam: zf-C3HC4 IPI
Pfam: Cbl_N2 IPI
Pfam: Cbl_N3 IPI
KEGG Pathway: 04630 ENTREZGENE
KEGG Pathway: 05220 ENTREZGENE
KEGG Pathway: 04144 ENTREZGENE
KEGG Pathway: 04012 ENTREZGENE
KEGG Pathway: 04910 ENTREZGENE
KEGG Pathway: 05200 ENTREZGENE
KEGG Pathway: 04660 ENTREZGENE
KEGG Pathway: 04120 ENTREZGENE
InterPro: Adaptor_Cbl_EF_Hand-like. IPI
InterPro: Adaptor_Cbl_N. IPI
InterPro: Adaptor_Cbl_SH2-like. IPI
InterPro: EF-Hand_type. IPI
InterPro: Znf_RING_CS. IPI
InterPro: Znf_RING/FYVE/PHD. IPI
InterPro: Znf_RING. IPI
InterPro: Znf_C3HC4_RING-type. IPI
InterPro: UBA/transl_elong_EF1B_N_euk. IPI
InterPro: UBA/transl_elong_EF1B_N. IPI
InterPro: SH2. IPI
IPI: IPI00203552 IPI
IPI: IPI00950258 IPI
IPI: IPI00777304 IPI
Ensembl Protein: ENSRNOP00000002719 IPI
Ensembl Protein: ENSRNOP00000039085 IPI
Ensembl Protein: ENSRNOP00000060427 IPI
Gene3D-CATH: EF-Hand_type IPI
Gene3D-CATH: Adaptor_Cbl_N IPI
Gene3D-CATH: Znf_RING/FYVE/PHD IPI
Gene3D-CATH: SH2 IPI
Entrez Gene: Cblb ENTREZGENE
UniProt: CBLB_RAT IPI
Ensembl Genes: ENSRNOG00000001982 IPI
Superfamily-SCOP: Adaptor_Cbl_N IPI
Sequences
Nucleotide: AB071283 Get FASTA Search GEO Profiles
Nucleotide: CH473967 Get FASTA Search GEO Profiles
Nucleotide: AF199504 Get FASTA Search GEO Profiles
Nucleotide: NM_133601 Get FASTA Search GEO Profiles
(View all 4 Nucleotide Accessions)
Protein: EDM11080 Get FASTA
Protein: AAF13271 Get FASTA
Protein: NP_598285 Get FASTA
Protein: Q8K4S7 Get FASTA
Protein: EDM11079 Get FASTA
Protein: BAC05498 Get FASTA
(View all 6 Protein Accessions)
Clusters
UniGene: 21799

References
Curated References
16 references in RGD related to Cblb

Other References
12 other references at PubMed related to Cblb

Database Information
RGD ID 620535
History

Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference

18-SEP-08: Cblb Cas-Br-M (murine) ecotropic retroviral transforming sequence b Cblb Casitas B-lineage lymphoma b APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863

20-JAN-05: Cblb Casitas B-lineage lymphoma b Cas-Br-M (murine) ectropic retroviral transforming sequence b APPROVED Name updated 1299863

07-AUG-02: Cblb Cas-Br-M (murine) ectropic retroviral transforming sequence b PROVISIONAL Symbol and Name status set to provisional 70820