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Gene: Slc17a6 (solute carrier family 17 member 6) Rattus norvegicus

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Symbol:

Slc17a6

Name:

solute carrier family 17 member 6

RGD ID:

620531

Description:

Enables chloride channel activity and secondary active transmembrane transporter activity. Involved in several processes, including hippocampus development; neurotransmitter loading into synaptic vesicle; and sodium-dependent phosphate transport. Located in cytoplasmic vesicle; excitatory synapse; and pericellular basket. Is active in synaptic vesicle membrane. Biomarker of transient cerebral ischemia. Orthologous to human SLC17A6 (solute carrier family 17 member 6); PARTICIPATES IN glutamate signaling pathway; INTERACTS WITH (S)-nicotine; 2,3,7,8-Tetrachlorodibenzofuran; ammonium chloride.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

differentation-associated Na-dependent inorganic phosphate cotransporter; differentiation-associated BNPI; differentiation-associated Na(+)-dependent inorganic phosphate cotransporter; Dnpi; solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6; solute carrier family 17 (vesicular glutamate transporter), member 6; vesicular glutamate transporter 2; VGLUT2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SLC17A6 (solute carrier family 17 member 6)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Slc17a6 (solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Slc17a6 (solute carrier family 17 member 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SLC17A6 (solute carrier family 17 member 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SLC17A6 (solute carrier family 17 member 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Slc17a6 (solute carrier family 17 member 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SLC17A6 (solute carrier family 17 member 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SLC17A6 (solute carrier family 17 member 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Slc17a6 (solute carrier family 17 member 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Slc17a6 (solute carrier family 17 member 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	SLC17A7 (solute carrier family 17 member 7)	HGNC	OrthoDB
Alliance orthologs ³
Homo sapiens (human):	SLC17A6 (solute carrier family 17 member 6)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Slc17a6 (solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	slc17a6a (solute carrier family 17 member 6a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	slc17a6b (solute carrier family 17 member 6b)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	DAL5	Alliance	DIOPT (Ensembl Compara\|Hieranoid)
Saccharomyces cerevisiae (baker's yeast):	SOA1	Alliance	DIOPT (Ensembl Compara\|Hieranoid)
Saccharomyces cerevisiae (baker's yeast):	THI73	Alliance	DIOPT (Ensembl Compara\|Hieranoid)
Saccharomyces cerevisiae (baker's yeast):	FEN2	Alliance	DIOPT (Ensembl Compara\|Hieranoid)
Saccharomyces cerevisiae (baker's yeast):	YCT1	Alliance	DIOPT (Ensembl Compara\|Hieranoid)
Caenorhabditis elegans (roundworm):	eat-4	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	VGlut	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	VGlut	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	TNA1	Alliance	DIOPT (Ensembl Compara\|Hieranoid)
Saccharomyces cerevisiae (baker's yeast):	SEO1	Alliance	DIOPT (Ensembl Compara\|Hieranoid)
Saccharomyces cerevisiae (baker's yeast):	VHT1	Alliance	DIOPT (Ensembl Compara\|Hieranoid)
Caenorhabditis elegans (roundworm):	vglu-2	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	vglu-3	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	slc17a7	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	slc17a6	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	slc17a6	Alliance	DIOPT (Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	110,348,447 - 110,388,499 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	110,348,447 - 110,388,498 (+)	Ensembl				GRCr8
mRatBN7.2	1	101,212,489 - 101,252,543 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	101,212,489 - 101,252,542 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	106,619,563 - 106,659,620 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	115,091,464 - 115,131,521 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	108,395,898 - 108,436,013 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	106,980,463 - 107,038,717 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	106,998,623 - 107,038,704 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	108,040,511 - 108,080,524 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	101,425,975 - 101,466,023 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	95,386,910 - 95,426,949 (+)	NCBI		Celera
RGSC_v3.1	1	101,504,085 - 101,544,133 (+)	NCBI
Cytogenetic Map	1	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

learning disability (ISO)

Memory Disorders (ISO)

transient cerebral ischemia (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-nicotine (EXP,ISO)

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4,4'-trichlorobiphenyl (ISO)

3',5'-cyclic AMP (ISO)

4,4'-sulfonyldiphenol (ISO)

aflatoxin B1 (ISO)

ammonium chloride (EXP)

antimycin A (ISO)

arsenite(3-) (ISO)

atrazine (EXP)

Azoxymethane (ISO)

azoxystrobin (ISO)

benzo[a]pyrene (ISO)

beta-naphthoflavone (EXP)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

C60 fullerene (EXP)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

chlorpyrifos (ISO)

Citreoviridin (ISO)

clozapine (ISO)

cocaine (EXP)

cyclosporin A (ISO)

cytarabine (ISO)

deguelin (ISO)

dexamethasone (ISO)

dextran sulfate (ISO)

Diacetoxyscirpenol (ISO)

diclofenac (ISO)

entinostat (ISO)

ethanol (EXP,ISO)

fenpyroximate (ISO)

folic acid (ISO)

furan (EXP)

genistein (ISO)

gentamycin (EXP)

glycidol (EXP)

glyphosate (EXP)

haloperidol (ISO)

L-ascorbic acid (ISO)

lead diacetate (ISO)

lithium atom (ISO)

lithium hydride (ISO)

maneb (ISO)

methimazole (EXP)

methotrexate (ISO)

methoxychlor (EXP)

methylmercury chloride (ISO)

morphine (ISO)

N-nitrosodiethylamine (EXP)

nicotine (EXP,ISO)

paraquat (ISO)

PCB138 (ISO)

phencyclidine (ISO)

picoxystrobin (ISO)

pirinixic acid (ISO)

pyrimidifen (ISO)

risperidone (ISO)

sevoflurane (EXP)

sodium arsenite (ISO)

sterigmatocystin (EXP)

T-2 toxin (ISO)

tebufenpyrad (ISO)

thifluzamide (ISO)

titanium dioxide (ISO)

toluene (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chloride transmembrane transport (IEA)

chloride transport (IEA)

hippocampus development (IEP)

hyaloid vascular plexus regression (ISO,ISS)

L-glutamate import (IEA,ISO,ISS)

L-glutamate transmembrane transport (IDA,IEA,ISO)

monoatomic ion transmembrane transport (IEA)

monoatomic ion transport (IEA)

neural retina development (IEP)

neurotransmitter loading into synaptic vesicle (IBA,IDA,IMP)

neurotransmitter transport (IEA)

neurotransmitter uptake (ISO)

phosphate ion homeostasis (IEA,ISO,ISS)

phosphate ion transport (IDA,IEA)

potassium ion transmembrane transport (IEA)

proton transmembrane transport (IEA)

regulation of synapse structure or activity (IBA)

sodium ion transmembrane transport (IEA)

sodium ion transport (IEA)

sodium-dependent phosphate transport (IDA,ISO)

synaptic transmission, glutamatergic (IBA)

transmembrane transport (IEA)

Cellular Component

chloride channel complex (IEA)

cytoplasmic vesicle (IEA)

early endosome (IDA)

excitatory synapse (IBA,IDA,IEA)

neuron projection (IDA,IEA)

pericellular basket (IDA)

plasma membrane (IEA)

presynapse (ISO)

synapse (IEA)

synaptic vesicle (IDA,ISO)

synaptic vesicle membrane (IBA,IDA,IEA,IEP,ISO)

Molecular Function

antiporter activity (IEA)

chloride channel activity (IDA,IEA)

L-glutamate transmembrane transporter activity (IBA)

L-glutamate uniporter activity (IDA,IEA,ISO)

neurotransmitter transmembrane transporter activity (IBA)

phosphate ion uniporter activity (ISS)

potassium:proton antiporter activity (IDA,ISO)

sodium:phosphate symporter activity (IDA,ISO)

symporter activity (IEA)

transmembrane transporter activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

glutamate signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Vesicular glutamate and GABA transporters sort to distinct sets of vesicles in a population of presynaptic terminals.	Boulland JL, etal., Cereb Cortex. 2009 Jan;19(1):241-8. doi: 10.1093/cercor/bhn077. Epub 2008 May 22.
2.	Expression of the vesicular glutamate transporters during development indicates the widespread corelease of multiple neurotransmitters.	Boulland JL, etal., J Comp Neurol. 2004 Dec 13;480(3):264-80.
3.	Protons Regulate Vesicular Glutamate Transporters through an Allosteric Mechanism.	Eriksen J, etal., Neuron. 2016 May 18;90(4):768-80. doi: 10.1016/j.neuron.2016.03.026. Epub 2016 Apr 28.
4.	VGLUT1 and VGAT are sorted to the same population of synaptic vesicles in subsets of cortical axon terminals.	Fattorini G, etal., J Neurochem. 2009 Sep;110(5):1538-46. Epub 2009 Jul 15.
5.	The expression of vesicular glutamate transporters defines two classes of excitatory synapse.	Fremeau RT, etal., Neuron. 2001 Aug 2;31(2):247-60.
6.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7.	Differentiation-associated Na+-dependent inorganic phosphate cotransporter (DNPI) is a vesicular glutamate transporter in endocrine glutamatergic systems.	Hayashi M, etal., J Biol Chem 2001 Nov 16;276(46):43400-6.
8.	The existence of a second vesicular glutamate transporter specifies subpopulations of glutamatergic neurons.	Herzog E, etal., J Neurosci. 2001 Nov 15;21(22):RC181.
9.	Differential distribution of vesicular glutamate transporters in the rat cerebellar cortex.	Hioki H, etal., Neuroscience 2003;117(1):1-6.
10.	Hypophysiotropic thyrotropin-releasing hormone and corticotropin-releasing hormone neurons of the rat contain vesicular glutamate transporter-2.	Hrabovszky E, etal., Endocrinology 2005 Jan;146(1):341-7. Epub 2004 Oct 14.
11.	Vesicular glutamate transporter contains two independent transport machineries.	Juge N, etal., J Biol Chem. 2006 Dec 22;281(51):39499-506. doi: 10.1074/jbc.M607670200. Epub 2006 Oct 17.
12.	Ion transport and regulation in a synaptic vesicle glutamate transporter.	Li F, etal., Science. 2020 May 22;368(6493):893-897. doi: 10.1126/science.aba9202.
13.	Vesicular glutamate transporters, VGluT1 and VGluT2, in the trigeminal ganglion neurons of the rat, with special reference to coexpression.	Li JL, etal., J Comp Neurol 2003 Aug 18;463(2):212-20.
14.	Expression of vesicular glutamate transporters, VGluT1 and VGluT2, in axon terminals of nociceptive primary afferent fibers in the superficial layers of the medullary and spinal dorsal horns of the rat.	Li JL, etal., J Comp Neurol 2003 Mar 10;457(3):236-49.
15.	Relationship between two types of vesicular glutamate transporters and neurokinin-1 receptor-immunoreactive neurons in the pre-Botzinger complex of rats: light and electron microscopic studies.	Liu YY, etal., Eur J Neurosci 2003 Jan;17(1):41-8.
16.	Age and meloxicam modify the response of the glutamate vesicular transporters (VGLUTs) after transient global cerebral ischemia in the rat brain.	Llorente IL, etal., Brain Res Bull. 2013 May;94:90-7. doi: 10.1016/j.brainresbull.2013.02.006. Epub 2013 Feb 28.
17.	Vesicular glutamate transporter 3 (VGLUT3) identifies spatially segregated excitatory terminals in the rat substantia nigra.	Martin-Ibanez R, etal., Eur J Neurosci. 2006 Feb;23(4):1063-70.
18.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
19.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
20.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
21.	Dual and Direction-Selective Mechanisms of Phosphate Transport by the Vesicular Glutamate Transporter.	Preobraschenski J, etal., Cell Rep. 2018 Apr 10;23(2):535-545. doi: 10.1016/j.celrep.2018.03.055.
22.	Vesicular glutamate transporters use flexible anion and cation binding sites for efficient accumulation of neurotransmitter.	Preobraschenski J, etal., Neuron. 2014 Dec 17;84(6):1287-301. doi: 10.1016/j.neuron.2014.11.008. Epub 2014 Nov 26.
23.	GOA pipeline	RGD automated data pipeline
24.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
26.	Vesicular glutamate transporter 3-immunoreactive pericellular baskets ensheath a distinct population of neurons in the lateral septum.	Riedel A, etal., J Chem Neuroanat. 2008 Dec;36(3-4):177-90. doi: 10.1016/j.jchemneu.2008.06.003. Epub 2008 Jun 19.
27.	Comparison of the ontogeny of the vesicular glutamate transporter 3 (VGLUT3) with VGLUT1 and VGLUT2 in the rat retina.	Stella SL Jr, etal., Brain Res. 2008 Jun 18;1215:20-9. doi: 10.1016/j.brainres.2008.03.038. Epub 2008 Apr 1.
28.	Identification of differentiation-associated brain-specific phosphate transporter as a second vesicular glutamate transporter (VGLUT2).	Takamori S, etal., J Neurosci. 2001 Nov 15;21(22):RC182.

Additional References at PubMed

PMID:11432869	PMID:14667459	PMID:14677070	PMID:14681932	PMID:15009640	PMID:15028755	PMID:15065123	PMID:15205380	PMID:15224985	PMID:15305861	PMID:15379996	PMID:15382259
PMID:15682395	PMID:15714284	PMID:15845085	PMID:15908131	PMID:15983996	PMID:16079394	PMID:16423326	PMID:16481069	PMID:16786558	PMID:16842872	PMID:17175111	PMID:17299752
PMID:17337147	PMID:17825268	PMID:17826944	PMID:17965879	PMID:18291592	PMID:18358609	PMID:18381590	PMID:18436385	PMID:18973592	PMID:19058187	PMID:19191347	PMID:19264112
PMID:19778580	PMID:19844994	PMID:20217347	PMID:20339872	PMID:20533365	PMID:20593358	PMID:21375596	PMID:21609737	PMID:21957077	PMID:21982845	PMID:22570693	PMID:22871113
PMID:23047588	PMID:23326507	PMID:23380804	PMID:23543101	PMID:23835161	PMID:23897509	PMID:24308494	PMID:24639017	PMID:24906290	PMID:25290694	PMID:26362885	PMID:27210824
PMID:29462701	PMID:29465786	PMID:29476059	PMID:29476240	PMID:29650024	PMID:32562720	PMID:32847971	PMID:33550485	PMID:34321562	PMID:35933616	PMID:36085433	PMID:38194067

Genomics

Comparative Map Data

Slc17a6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	110,348,447 - 110,388,499 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	110,348,447 - 110,388,498 (+)	Ensembl				GRCr8
mRatBN7.2	1	101,212,489 - 101,252,543 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	101,212,489 - 101,252,542 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	106,619,563 - 106,659,620 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	115,091,464 - 115,131,521 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	108,395,898 - 108,436,013 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	106,980,463 - 107,038,717 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	106,998,623 - 107,038,704 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	108,040,511 - 108,080,524 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	101,425,975 - 101,466,023 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	95,386,910 - 95,426,949 (+)	NCBI		Celera
RGSC_v3.1	1	101,504,085 - 101,544,133 (+)	NCBI
Cytogenetic Map	1	q22	NCBI

SLC17A6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	22,338,381 - 22,379,503 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	22,338,381 - 22,379,503 (+)	Ensembl			hg38	GRCh38
GRCh37	11	22,359,927 - 22,401,049 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	22,316,243 - 22,357,619 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	11	22,316,242 - 22,357,619	NCBI
Celera	11	22,492,722 - 22,534,075 (+)	NCBI		Celera
Cytogenetic Map	11	p14.3	NCBI
HuRef	11	22,042,899 - 22,084,263 (+)	NCBI		HuRef
CHM1_1	11	22,359,385 - 22,400,763 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	22,458,971 - 22,500,075 (+)	NCBI		T2T-CHM13v2.0

Slc17a6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	51,271,578 - 51,320,874 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	51,271,754 - 51,320,867 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	7	51,621,830 - 51,671,126 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	51,622,006 - 51,671,119 (+)	Ensembl			mm10	GRCm38
MGSCv37	7	58,877,200 - 58,926,496 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	7	51,490,086 - 51,539,138 (+)	NCBI		MGSCv36	mm8
Celera	7	49,002,489 - 49,051,776 (+)	NCBI		Celera
Cytogenetic Map	7	B4	NCBI
cM Map	7	32.78	NCBI

Slc17a6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955476	2,813,368 - 2,854,514 (+)	Ensembl
ChiLan1.0	NW_004955476	2,813,368 - 2,854,371 (+)	NCBI	ChiLan1.0	ChiLan1.0

SLC17A6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	24,627,830 - 24,669,284 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	24,591,980 - 24,633,414 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	22,350,537 - 22,392,009 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	22,257,983 - 22,299,443 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	22,258,011 - 22,301,944 (+)	Ensembl			panPan2	panpan1.1

SLC17A6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	21	44,015,161 - 44,056,286 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	21	44,016,133 - 44,054,931 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	21	43,491,537 - 43,529,754 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	21	45,131,589 - 45,172,308 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	21	45,132,360 - 45,172,255 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	21	44,132,863 - 44,170,882 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	21	44,305,349 - 44,343,374 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	21	44,698,060 - 44,736,170 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Slc17a6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	40,843,801 - 40,886,442 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936654	3,040,312 - 3,083,669 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936654	3,039,825 - 3,082,788 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC17A6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	37,098,992 - 37,138,475 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	2	37,098,983 - 37,138,935 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	40,309,860 - 40,349,435 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLC17A6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	42,634,754 - 42,677,309 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	42,636,512 - 42,677,165 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666038	139,944,822 - 139,988,881 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slc17a6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624766	13,335,130 - 13,376,712 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624766	13,335,186 - 13,376,634 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Slc17a6
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	2	148,967,958 - 149,007,749 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Slc17a6
138 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	217
Count of miRNA genes:	145
Interacting mature miRNAs:	175
Transcripts:	ENSRNOT00000022383
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1582234	Gluco18	Glucose level QTL 18	3.4	0.0003	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	87889942	132889942	Rat
1358359	Sradr1	Stress Responsive Adrenal Weight QTL 1	4.74		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	39728272	132889942	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	51941022	208479811	Rat
1331793	Bp200	Blood pressure QTL 200	3.71601		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	102780511	182384005	Rat
1578654	Bss10	Bone structure and strength QTL 10	4		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	1	51940904	168768703	Rat
1554320	Bmd1	Bone mineral density QTL 1	12.2	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	101228864	146228864	Rat
1331800	Scl25	Serum cholesterol level QTL 25	3.013		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	1	87785026	142582336	Rat
7421628	Bp361	Blood pressure QTL 361		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	83019780	128019780	Rat
631495	Bp96	Blood pressure QTL 96	4.52		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	66404680	111404680	Rat
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34184556	172281316	Rat
2298545	Neuinf8	Neuroinflammation QTL 8	4.6		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	1	66009857	160501508	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34565911	208798288	Rat
631519	Pia11	Pristane induced arthritis QTL 11	5.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	1	93903998	191260518	Rat
1302788	Scl19	Serum cholesterol QTL 19	4.6	0.001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	66400974	132889942	Rat
61399	Tcat1	Tongue tumor resistance QTL 1	3.3		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)	1	108680016	153680016	Rat
1549903	Bp267	Blood pressure QTL 267			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	84107164	115183752	Rat
2313083	Bmd74	Bone mineral density QTL 74	4	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	1	91302413	136302413	Rat
2313402	Anxrr24	Anxiety related response QTL 24			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	1	51511344	153680016	Rat
724567	Tcas6	Tongue tumor susceptibility QTL 6	6.85		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	1	102359314	153680016	Rat
724521	Uae1	Urinary albumin excretion QTL 1	3.8	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	99645382	182701046	Rat
1358902	Bw47	Body weight QTL 47	1.67		body mass (VT:0001259)	body weight (CMO:0000012)	1	99645382	221502378	Rat
1358192	Ept13	Estrogen-induced pituitary tumorigenesis QTL 13	3.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	1	86622262	131622262	Rat
8655649	Arrd1	Age-related retinal degeneration QTL 1	4.89		retinal layer morphology trait (VT:0003727)	percentage of study population developing retinopathy during a period of time (CMO:0002453)	1	109493780	193400781	Rat
2300164	Bmd44	Bone mineral density QTL 44	5.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	1	66077886	111077886	Rat
731168	Bp154	Blood pressure QTL 154	3.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	103779152	223964440	Rat
631205	Bp196	Blood pressure QTL 196	4	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	98879955	208479939	Rat
738022	Anxrr13	Anxiety related response QTL 13	4.6	0.00039	locomotor behavior trait (VT:0001392)	measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)	1	92683681	137683681	Rat
10054135	Gmadr2	Adrenal mass QTL 2	1.97	0.0129	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	86993904	131993904	Rat
7411712	Strs4	Sensitivity to stroke QTL 4	8.7		cerebrum integrity trait (VT:0010549)	percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)	1	87558587	132558587	Rat
1331749	Hrtrt11	Heart rate QTL 11	2.973		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	92683681	137683681	Rat
737977	Bp160	Blood pressure QTL 160		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	97582336	142582336	Rat
2293142	Bp314	Blood pressure QTL 314			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	101594089	146594089	Rat
61433	Cia2	Collagen induced arthritis QTL 2	5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	1	100345976	145345976	Rat
724529	Cm16	Cardiac mass QTL 16	2.7		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	1	96717367	160111531	Rat

Markers in Region

AI060126

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	101,252,259 - 101,252,445 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	107,038,421 - 107,038,606	NCBI	Rnor6.0
Rnor_5.0	1	108,080,228 - 108,080,413	UniSTS	Rnor5.0
RGSC_v3.4	1	101,465,740 - 101,465,925	UniSTS	RGSC3.4
Celera	1	95,426,666 - 95,426,851	UniSTS
RH 3.4 Map	1	944.1	UniSTS
Cytogenetic Map	1	q22	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
9	4	5	127	25	23	10	9	10	2	46	19	124	4	72	13	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053427	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006229265	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017589793	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017589794	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF271235	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473979	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ211915	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000022383 ⟹ ENSRNOP00000022383

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	110,348,447 - 110,388,498 (+)	Ensembl
mRatBN7.2 Ensembl	1	101,212,489 - 101,252,542 (+)	Ensembl
Rnor_6.0 Ensembl	1	106,998,623 - 107,038,704 (+)	Ensembl

RefSeq Acc Id:

NM_053427 ⟹ NP_445879

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	110,348,447 - 110,388,499 (+)	NCBI
mRatBN7.2	1	101,212,489 - 101,252,543 (+)	NCBI
Rnor_6.0	1	106,998,704 - 107,038,704 (+)	NCBI
Rnor_5.0	1	108,040,511 - 108,080,524 (+)	NCBI
RGSC_v3.4	1	101,425,975 - 101,466,023 (+)	RGD
Celera	1	95,386,910 - 95,426,949 (+)	RGD

Sequence:

show sequence

AGACAGTAAGGTTCTTTTGCTTTTTTCCCTTACACAAGGATTCGATGACGTTTTTGGTCAATCT
GATTAAAAGACAGCGGATTTGGTTGCGTTAAGACTTCAAAACCGGGAATTTACGTTGTTTTTCG
GTGAGGTGACTTCCAGAACGGGGACTCATCAGCACCCGCCCAAATACCACGGCACTGCGCGCGC
CCTCGGCCACCGGATCCTCCCCTTCCAATGAGACTTTGTGACTGTGTGTACCAATTCTCCTATT
AGGAAACCCGTGGGCTGAATGCAGCTATTCCGTTGTACTCTCTTTCTCGCTCTCCCTCCCCTCT
CCAACTCACAGCCTTGCTGAAAAGCTCATCTCTGCTGAGAAGAAAACGTTCTACCTTAACCTAT
TAAGACTATGCGCAGAACTCGCCTTTCATAGCCATCACAATTTAAATCTGGTAAGGCTGGACAC
GAGTCTTTACAAGAATGGAGTCGGTAAAACAAAGGATTTTGGCCCCGGGGAAAGAGGGGATAAA
GAATTTTGCTGGAAAATCCCTCGGACAGATCTACAGGGTGCTGGAGAAGAAGCAGGATAACCGA
GAGACCATCGAGCTGACAGAGGACGGCAAGCCCCTGGAGGTGCCTGAGAAGAAGGCTCCGCTAT
GCGACTGTACGTGCTTCGGCCTGCCGCGCCGCTACATCATAGCCATCATGAGCGGCCTCGGCTT
CTGCATCTCCTTTGGTATCCGCTGTAACCTGGGTGTGGCCATTGTGGACATGGTCAACAACAGC
ACCATCCACCGGGGTGGCAAAGTTATCAAGGAGAAAGCCAAGTTTAACTGGGACCCCGAGACTG
TGGGGATGATTCACGGGTCGTTCTTCTGGGGCTATATCATCACGCAGATTCCGGGCGGATACAT
CGCATCGCGACTGGCTGCTAACCGGGTCTTTGGGGCTGCCATACTGCTTACCTCTACCCTCAAT
ATGCTGATCCCATCTGCAGCCAGAGTGCATTATGGATGCGTCATCTTTGTTAGAATATTGCAAG
GACTTGTGGAGGGCGTCACCTACCCAGCCTGTCACGGGATATGGAGCAAGTGGGCCCCTCCTTT
GGAGAGGAGTAGGTTGGCTACCACCTCCTTCTGTGGTTCCTATGCTGGAGCAGTCATTGCAATG
CCCCTAGCTGGTATCCTGGTGCAGTACACTGGATGGTCTTCAGTATTTTACGTATATGGAAGCT
TTGGTATGGTCTGGTATATGTTCTGGCTTCTGGTGTCTTACGAGAGCCCCGCAAAGCATCCAAC
CATAACAGACGAAGAACGTAGGTACATAGAAGAGAGCATCGGGGAGAGCGCAAATCTGTTAGGA
GCAATGGAGAAATTCAAGACCCCATGGAGGAAGTTTTTCACATCCATGCCCGTCTATGCGATAA
TTGTTGCAAACTTCTGCAGGAGTTGGACTTTTTATTTACTGCTCATCAGTCAACCAGCTTATTT
CGAGGAGGTTTTTGGATTTGAAATCAGCAAGGTTGGCATGTTGTCTGCGGTCCCACACCTGGTC
ATGACAATCATTGTGCCTATCGGGGGGCAAATTGCAGACTTTCTAAGGAGCAAGCAAATTCTTT
CAACAACTACAGTGCGAAAGATCATGAACTGCGGGGGTTTTGGCATGGAAGCCACACTGCTTCT
GGTTGTTGGCTACTCTCATACTAGAGGGGTGGCCATCTCCTTCTTGGTGCTTGCAGTGGGATTC
AGTGGATTTGCTATCTCTGGTTTCAATGTGAACCACTTGGATATTGCCCCGAGATATGCCAGTA
TCTTAATGGGCATTTCAAATGGTGTTGGCACGCTGTCGGGAATGGTCTGCCCGATCATTGTTGG
TGCAATGACGAAGAACAAGTCCCGTGAAGAATGGCAGTATGTCTTCCTCATCGCTGCACTGGTC
CACTATGGTGGAGTCATATTTTATGCACTATTTGCCTCAGGAGAGAAGCAACCTTGGGCAGACC
CTGAGGAAACAAGCGAAGAAAAGTGTGGCTTCATTCATGAAGATGAACTGGATGAAGAAACGGG
GGACATCACTCAGAATTACATAAATTACGGTACCACCAAATCCTACGGCGCCACCTCACAGGAG
AACGGAGGCTGGCCTAACGGCTGGGAGAAAAAGGAAGAATTTGTGCAAGAAAGTGCGCAAGACG
CGTACTCCTATAAGGACCGAGATGATTATTCATAACGAAGCTAGTTGCTGGATTCCTTTGTAGT
GTTTGTGATTAAATTAATTGTGATTGCACAAAATCATTTTAAGAAATGTGGTGTAAACATGTAA
ACACATCAACCAAGCAAGTCTTGCTGTTCAAAAAATAATAATAATATGAATTCAAAACAGACCG
TGAGAGTCCCATCAAGTGCAATCTGTGGCGGCAGTCACGTGACGCCATTTCCATTCAGGCCATT
CGTCCTTTTCGTTTGTGATTTAAAGGTTTCCTGTAGAAATAAGTAGGTATTCGTTGGATCCATC
ACCACGTTAGAGAGTACAACTACAACAGTTGGCACATGTCATCCTACGGAAGTTAGGAAGCCAA
AGCTACTGGATTATGTGAACTGCATTTATTTATTTATTACACTGGACTGCAAAATATCCCAGGG
AAATCCTGTCTAGAGACATAGTAGAACTGGAAAGATGGCTAGATTGGGTACTGACGATAATCAT
TGTGTGTATATCATGGAGTGGCTATATCTTTTAATTGGAGAACTATATTGTATAGCTAGCAAAA
TTGTACTGAATTATTACTAGGAGTGCACAGTGTGTGATATTTTGTGATCTTCCAAAAGCTTATC
TTGCAGTGTTTTGTGAAACGCTTGGGCACAAACACTTATTTTTATGAACAAGAGCTTGTAAAGG
GAGGAGTATGCTCCATGCTCTCCCATTCACTACCTGACAGTATCAAACCTTCACATTTCAATGA
AATCCAACGTCCATGTAACATATCACATGACTTTTTTTGCAAAAAAGAATATAAGAAGAAATAG
ACTTCAATGTATTTTTTATTACAACTTTGTACTGGTTGTAACTTGCATTAGGAAAAATGATTAA
TATATGTATAATCGTAAAGAATCTAATAAAAATTTACTATGAAGATATAGCCCTTAAAATGCAA
TATTAACAACAAAAATATATAGAAAATTTAGATAATCTTCCTTGATAACTAGAGACTATATGGA
ACTCACACCACAAAGCTATATATAATATGAAAAGATAAACAATAGAGATTGTATATGTAGACGA
TTTTATGACCTAATGTCCCATTTAAGAGGTATTTGTCTTGAGTATATAGTACAAAGTATATTAA
AATTATATCTACATCCCTGTATATCTTATACATATCCACTCACACAAACATAACAAATACTTTT
CACACAGAACCAAAAACAAGCATACACCTAATGTTGGGTTTGGGGATTGCAATTTCTACTTTCA
TAGAGTCATAGAATTTTAGATGGGAAAAAAAAAGGCATTTTGCTCGTCATTTCTTAATATAATT
AATTCAACAGGAACTGCAACATTTGTGTACCAAGCAATAAGTGCGAAGCATAAACCTGCTGTGT
GTAAACTATCCCCATACTGCTTGTGGTAGCACTGATTTCTTTCTTTTAAAGAACTTAACATCGG
AGCTCTTTACAATGTTTTGCGCTGATAAGAATGCACATCCCAATTTAACGCAAAGTGTCACCTG
GTGTGTTTACCTGTCTGTTTTGGGTATTTGGTCTGTTTGGTGTCCTGTGCTCTTGACTGGAGGC
CCTGCTACTGCGAATATAAAACGTGAAGTTTGTTTCTAAATGCAAACCACTCCTGACCTTAAGA
AACTAAAGTCCCTCTCTGCTTTGTGTCTCCAAGTACTATCATGTGACCATAACCCTTGCTGTGC
TGAGTAAAAAGATGTGAACTGTCATTTTGTTGCTGCGAAGCAAGTGTTAATAAAATGTTCTATT
TAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_445879	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAF76223	(Get FASTA)	NCBI Sequence Viewer
	EDM07210	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000022383
GenBank Protein	Q9JI12	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_445879 ⟸ NM_053427

- UniProtKB:

Q9JI12 (UniProtKB/Swiss-Prot), A6JBH4 (UniProtKB/TrEMBL), G3V851 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MESVKQRILAPGKEGIKNFAGKSLGQIYRVLEKKQDNRETIELTEDGKPLEVPEKKAPLCDCTC
FGLPRRYIIAIMSGLGFCISFGIRCNLGVAIVDMVNNSTIHRGGKVIKEKAKFNWDPETVGMIH
GSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAARVHYGCVIFVRILQGLVEG
VTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVW
YMFWLLVSYESPAKHPTITDEERRYIEESIGESANLLGAMEKFKTPWRKFFTSMPVYAIIVANF
CRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQILSTTTV
RKIMNCGGFGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGI
SNGVGTLSGMVCPIIVGAMTKNKSREEWQYVFLIAALVHYGGVIFYALFASGEKQPWADPEETS
EEKCGFIHEDELDEETGDITQNYINYGTTKSYGATSQENGGWPNGWEKKEEFVQESAQDAYSYK
DRDDYS

hide sequence

Ensembl Acc Id:

ENSRNOP00000022383 ⟸ ENSRNOT00000022383

Protein Domains

Major facilitator superfamily (MFS) profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9JI12-F1-model_v2	AlphaFold	Q9JI12	1-582	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620531	AgrOrtholog
BioCyc Gene	G2FUF-59542	BioCyc
Ensembl Genes	ENSRNOG00000016147	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000022383	ENTREZGENE
Gene3D-CATH	1.20.1250.20	UniProtKB/Swiss-Prot
InterPro	MFS	UniProtKB/Swiss-Prot
	MFS_dom	UniProtKB/Swiss-Prot
	MFS_Na/Anion_cotransporter	UniProtKB/Swiss-Prot
	MFS_trans_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:84487	UniProtKB/Swiss-Prot
NCBI Gene	84487	ENTREZGENE
PANTHER	SOLUTE CARRIER FAMILY 17	UniProtKB/Swiss-Prot
	VESICULAR GLUTAMATE TRANSPORTER 2	UniProtKB/Swiss-Prot
Pfam	MFS_1	UniProtKB/Swiss-Prot
PhenoGen	Slc17a6	PhenoGen
PROSITE	MFS	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000016147	RatGTEx
Superfamily-SCOP	SSF103473	UniProtKB/Swiss-Prot
UniProt	A6JBH4	ENTREZGENE, UniProtKB/TrEMBL
	G3V851	ENTREZGENE, UniProtKB/TrEMBL
	Q9JI12	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-25	Slc17a6	solute carrier family 17 member 6	Slc17a6	solute carrier family 17 (vesicular glutamate transporter), member 6	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-08-02	Slc17a6	solute carrier family 17 (vesicular glutamate transporter), member 6	Slc17a6	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Slc17a6	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6	Dnpi	differentation-associated Na-dependent inorganic phosphate cotransporter	Symbol and Name updated	1299863	APPROVED
2002-08-07	Dnpi	differentation-associated Na-dependent inorganic phosphate cotransporter			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_cellular_localization	localizes on early endosomes	628484
gene_expression	mRNA expressed in the inferior olivary complex, most brainstem precerebellar nuclei sending mossy fibers, and in axon terminals of nociceptive primary afferent fibers	632573
gene_expression	mRNA expressed in the inferior olivary complex, most brainstem precerebellar nuclei sending mossy fibers, and in axon terminals of nociceptive primary afferent fibers	632574
gene_expression	present in neuronla cells,preferentially expressed in pinealocytes, pancreatic alpha cells, alpha cells of Langerhans islets, pancreatic polypeptide-secreting F cells of Langerhans islets	628484
gene_function	transports L-glutamate involving an electrochemical gradient of protons generated by vacuolar proton pump; vesicular transporter in glutamatergic endocrine cells and neurons	628484
gene_function	vesicular glutamate transporter	628484
gene_process	responsible for vesicular storage of L-glutamate	628484
gene_process	may be involved in a dominant excitatory synaptic pathway	632575

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)