Gene:	Hadhb ( Rattus norvegicus ) hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit
Description:	a subunit of a multienzyme complex that is involved in mitochondrial fatty acid oxidation
Synonyms:	IMAGE:6918791; MGC:72701;
ArrayIDs:	6535687; 6415195; 6292726; 1367694_at; 5859754; 6536590; 6471930; 6743886; D16479_at; A_42_P655644; 6742468; GE19474; 6594170; 6361668; 5660952; 5805027; 5881178; 6486578; 6303771; 6551843; 6414758; 6252818; 5705792; 6192746;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: HADHB     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Hadhb     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Hadhb genome assembly 3.1 6 26142349 - 26169900     Rat Celera Assembly 6 25630451 - 25664474     RGSC genome assembly v3.4 6 26139397 - 26173425     Cytogenetic 6 q14 Mus musculus Hadhb Mouse genome assembly build 36.1 5 30481862 - 30511123     Cytogenetic 5 5 B1 Homo sapiens HADHB human genome assembly 2 26379471 - 26424983     Human genome assembly build 36.2 2 26321325 - 26366837     Cytogenetic 2 p23   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Note Reference has long chain 3-ketoacyl-CoA thiolase activity 632874 Gene Ontology long-chain-3-hydroxyacyl-CoA dehydrogenase activity,  long-chain-enoyl-CoA hydratase activity,  NAD or NADH binding ...  (details...)
Biological Process	Gene Ontology fatty acid metabolic process,  fatty acid beta-oxidation,  metabolic process ...  (details...)
Cellular Component	Gene Ontology mitochondrion,  fatty acid beta-oxidation multienzyme complex,  mitochondrial nucleoid ...  (details...)
Disease	Ontology Kidney Failure, Acute,  Pericardial Effusion,  Rhabdomyolysis ...  (details...)
Pathway	Ontology fatty acid metabolic pathway (details...)
Protein	Note Reference encodes a 51,413-Da precursor and a 47,583-Da mature subunit 632874
External Links
Databases	DATABASE ID SOURCE PROSITE: THIOLASE_1 IPI PROSITE: THIOLASE_3 IPI PROSITE: THIOLASE_2 IPI UNIPARC: UPI0000129B70 IPI KEGG Report: rno:171155 ENTREZGENE Germonline: 620513 Pfam: Thiolase_N IPI Pfam: Thiolase_C IPI KEGG Pathway: 00062 ENTREZGENE KEGG Pathway: 00071 ENTREZGENE KEGG Pathway: 00280 ENTREZGENE KEGG Pathway: 01100 ENTREZGENE InterPro: Thiolase_AS. IPI InterPro: Thiolase_C. IPI InterPro: Thiolase_CS. IPI InterPro: Thiolase_N. IPI InterPro: Thiolase_acyl_enz_int_AS. IPI InterPro: Thiolase. IPI InterPro: Thiolase-like. IPI Ensembl Protein: ENSRNOP00000014637 IPI IPI: IPI00198467 IPI Entrez Gene: Hadhb ENTREZGENE IMAGE_CLONE: IMAGE:6918791 IMAGE-MGC_LOAD MGC_CLONE: MGC:72701 IMAGE-MGC_LOAD UniProt: ECHB_RAT IPI Ensembl Genes: ENSRNOG00000010800 IPI Superfamily-SCOP: Thiolase-like IPI PANTHER: Thiolase IPI TIGRFAMs: AcCoA-C-Actrans IPI
Sequences	Nucleotide: D16479 Get FASTA Search GEO Profiles Nucleotide: CH473947 Get FASTA Search GEO Profiles Nucleotide: BC060545 Get FASTA Search GEO Profiles Nucleotide: NM_133618 Get FASTA Search GEO Profiles (View all 4 Nucleotide Accessions) Protein: NP_598302 Get FASTA Protein: EDM02996 Get FASTA Protein: EDM02997 Get FASTA Protein: EDM02998 Get FASTA Protein: AAH60545 Get FASTA Protein: BAA03940 Get FASTA Protein: Q60587 Get FASTA (View all 7 Protein Accessions)
Clusters	UniGene: 11253
References
Curated References	10 references in RGD related to Hadhb
Other References	5 other references at PubMed related to Hadhb
Database Information
RGD ID	620513
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 10-SEP-04: Hadhb hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit APPROVED Symbol and Name status set to approved 1299863 07-AUG-02: Hadhb hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit PROVISIONAL Symbol and Name status set to provisional 70820