Cand1 (cullin-associated and neddylation-dissociated 1) - Rat Genome Database

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Gene: Cand1 (cullin-associated and neddylation-dissociated 1) Rattus norvegicus
Analyze
Symbol: Cand1
Name: cullin-associated and neddylation-dissociated 1
RGD ID: 620479
Description: Enables TBP-class protein binding activity. Involved in positive regulation of RNA polymerase II transcription preinitiation complex assembly. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be part of cullin-RING ubiquitin ligase complex. Predicted to be active in nucleus. Orthologous to human CAND1 (cullin associated and neddylation dissociated 1); PARTICIPATES IN neddylation pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cullin associated and neddylation disassociated 1; cullin-associated and neddylation-dissociated protein 1; cullin-associated NEDD8-dissociated protein 1; p120 CAND1; TBP-interacting protein 120A; TBP-interacting protein of 120 kDa A; TBP-interacting protein TIP120A; Tip120; Tip120A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8756,566,765 - 56,604,653 (-)NCBIGRCr8
mRatBN7.2754,681,114 - 54,719,002 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl754,680,900 - 54,718,993 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx756,587,617 - 56,625,505 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0758,790,753 - 58,828,639 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0758,568,597 - 58,606,483 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0762,124,362 - 62,162,451 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl762,124,362 - 62,162,453 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0762,113,404 - 62,151,493 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4758,461,205 - 58,499,092 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1758,481,934 - 58,519,822 (-)NCBI
Celera751,445,526 - 51,483,413 (-)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cand1Ratmucopolysaccharidosis type IIID  ISOCAND1 (Homo sapiens)8554872ClinVar Annotator: match by term: Mucopolysaccharidosis and MPS-III-DClinVarPMID:20232353 and PMID:28492532
Cand1Ratprostate cancer  ISOCAND1 (Homo sapiens)8554872ClinVar Annotator: match by term: Malignant tumor of prostateClinVarPMID:23265383

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cand1Rat(-)-epigallocatechin 3-gallate decreases expressionISOCAND1 (Homo sapiens)6480464epigallocatechin gallate results in decreased expression of CAND1 proteinCTDPMID:31195006
Cand1Rat1,2-dimethylhydrazine multiple interactionsISOCand1 (Mus musculus)6480464Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in decreased expression of CAND1 mRNA]CTDPMID:22206623
Cand1Rat1,2-dimethylhydrazine decreases expressionISOCand1 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of CAND1 mRNACTDPMID:22206623
Cand1Rat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of CAND1 mRNACTDPMID:17108234 and PMID:29097150
Cand1Rat17beta-estradiol multiple interactionsEXP 6480464[bisphenol A co-treated with Estradiol] results in decreased expression of CAND1 mRNACTDPMID:26496021
Cand1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of CAND1 mRNACTDPMID:33387578
Cand1Rat2,6-dimethoxyphenol multiple interactionsISOCAND1 (Homo sapiens)6480464[Furaldehyde co-treated with pyrogallol 1 more ...CTDPMID:38598786
Cand1Rat2,6-dinitrotoluene affects expressionEXP 64804642 and 6-dinitrotoluene affects the expression of CAND1 mRNACTDPMID:21346803
Cand1Rat3H-1,2-dithiole-3-thione decreases expressionEXP 64804641 and 2-dithiol-3-thione results in decreased expression of CAND1 mRNACTDPMID:19162173
Cand1Rat4,4'-sulfonyldiphenol increases expressionISOCAND1 (Homo sapiens)6480464bisphenol S results in increased expression of CAND1 proteinCTDPMID:34186270
Cand1Ratactinomycin D multiple interactionsISOCAND1 (Homo sapiens)6480464[Dactinomycin co-treated with nutlin 3] results in increased secretion of CAND1 proteinCTDPMID:38460933
Cand1Ratammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of CAND1 mRNACTDPMID:16483693
Cand1Ratantirheumatic drug increases expressionISOCAND1 (Homo sapiens)6480464Antirheumatic Agents results in increased expression of CAND1 mRNACTDPMID:24449571
Cand1Rataristolochic acid A decreases expressionISOCAND1 (Homo sapiens)6480464aristolochic acid I results in decreased expression of CAND1 mRNACTDPMID:33212167
Cand1Ratbenzo[a]pyrene increases mutagenesisISOCAND1 (Homo sapiens)6480464Benzo(a)pyrene results in increased mutagenesis of CAND1 geneCTDPMID:25435355
Cand1Ratbenzo[a]pyrene decreases expressionISOCand1 (Mus musculus)6480464Benzo(a)pyrene metabolite results in decreased expression of CAND1 mRNACTDPMID:32553695
Cand1Ratbenzo[a]pyrene diol epoxide I decreases expressionISOCAND1 (Homo sapiens)64804647 more ...CTDPMID:19150397
Cand1Ratbis(2-ethylhexyl) phthalate increases expressionISOCand1 (Mus musculus)6480464Diethylhexyl Phthalate results in increased expression of CAND1 mRNACTDPMID:34319233
Cand1Ratbisphenol A multiple interactionsEXP 6480464[bisphenol A co-treated with Estradiol] results in decreased expression of CAND1 mRNACTDPMID:26496021
Cand1Ratbisphenol A increases expressionISOCAND1 (Homo sapiens)6480464bisphenol A results in increased expression of CAND1 proteinCTDPMID:34186270

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Biological Process
1 to 16 of 16 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cand1Ratcell differentiation involved_inISOCAND1 (Homo sapiens)1624291 PMID:10581176RGDPMID:10581176
Cand1Ratcell differentiation involved_inIEAUniProtKB:Q86VP6 and ensembl:ENSP000004423181600115GO_REF:0000107EnsemblGO_REF:0000107
Cand1Ratcell differentiation involved_inISSUniProtKB:Q86VP61600115GO_REF:0000024UniProtGO_REF:0000024
Cand1Ratnegative regulation of catalytic activity involved_inISSUniProtKB:Q86VP61600115GO_REF:0000024UniProtGO_REF:0000024
Cand1Ratnegative regulation of catalytic activity involved_inISOCAND1 (Homo sapiens)1624291 PMID:12609982RGDPMID:12609982
Cand1Ratpositive regulation of DNA-templated transcription involved_inIDA 8553447PMID:10567521UniProt 
Cand1Ratpositive regulation of RNA polymerase II transcription preinitiation complex assembly involved_inIDA 8553447PMID:10567521UniProt 
Cand1Ratprotein ubiquitination involved_inISSUniProtKB:Q86VP61600115GO_REF:0000024UniProtGO_REF:0000024
Cand1Ratprotein ubiquitination involved_inIEAUniProtKB:Q86VP6 and ensembl:ENSP000004423181600115GO_REF:0000107EnsemblGO_REF:0000107
Cand1Ratprotein ubiquitination involved_inIBAPANTHER:PTN000294436 and UniProtKB:Q86VP61600115GO_REF:0000033GO_CentralGO_REF:0000033
Cand1Ratprotein ubiquitination involved_inISOCAND1 (Homo sapiens)1624291 PMID:12609982 more ...RGDPMID:12609982 more ...
Cand1RatSCF complex assembly involved_inISSUniProtKB:Q86VP61600115GO_REF:0000024UniProtGO_REF:0000024
Cand1RatSCF complex assembly involved_inIBAPANTHER:PTN000294436 and UniProtKB:Q86VP61600115GO_REF:0000033GO_CentralGO_REF:0000033
Cand1RatSCF complex assembly involved_inIEAUniProtKB:Q86VP6 and ensembl:ENSP000004423181600115GO_REF:0000107EnsemblGO_REF:0000107
Cand1RatSCF complex assembly involved_inISOCAND1 (Homo sapiens)1624291 PMID:15537541 and PMID:21249194RGDPMID:15537541 and PMID:21249194
Cand1RatSCF complex assembly involved_inIEAInterPro:IPR0398521600115GO_REF:0000002InterProGO_REF:0000002
1 to 16 of 16 rows

Cellular Component
1 to 20 of 23 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cand1Ratcullin-RING ubiquitin ligase complex part_ofISOCAND1 (Homo sapiens)1624291 PMID:15537541 more ...RGDPMID:15537541 more ...
Cand1Ratcullin-RING ubiquitin ligase complex part_ofIEAUniProtKB:Q86VP6 and ensembl:ENSP000004423181600115GO_REF:0000107EnsemblGO_REF:0000107
Cand1Ratcullin-RING ubiquitin ligase complex part_ofISSUniProtKB:Q86VP61600115GO_REF:0000024UniProtGO_REF:0000024
Cand1Ratcytoplasm located_inISOCAND1 (Homo sapiens)1624291 PMID:21249194RGDPMID:21249194
Cand1Ratcytoplasm located_inIEAUniProtKB:Q86VP6 and ensembl:ENSP000004423181600115GO_REF:0000107EnsemblGO_REF:0000107
Cand1Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Cand1Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Cand1Ratcytoplasm located_inISSUniProtKB:Q86VP61600115GO_REF:0000024UniProtGO_REF:0000024
Cand1Ratcytosol located_inISOCAND1 (Homo sapiens) and UniProtKB:Q86VP6-11624291 RGDGO_REF:0000052
Cand1Ratcytosol located_inIEAUniProtKB:Q86VP6 and ensembl:ENSP000004423181600115GO_REF:0000107EnsemblGO_REF:0000107
Cand1RatGolgi apparatus located_inISOCAND1 (Homo sapiens) and UniProtKB:Q86VP6-11624291 RGDGO_REF:0000052
Cand1RatGolgi apparatus located_inIEAUniProtKB:Q86VP6 and ensembl:ENSP000004423181600115GO_REF:0000107EnsemblGO_REF:0000107
Cand1Ratnucleoplasm located_inIEAUniProtKB:Q86VP6 and ensembl:ENSP000004423181600115GO_REF:0000107EnsemblGO_REF:0000107
Cand1Ratnucleoplasm located_inISOCAND1 (Homo sapiens) and UniProtKB:Q86VP6-11624291 RGDGO_REF:0000052
Cand1Ratnucleus located_inISSUniProtKB:Q86VP61600115GO_REF:0000024UniProtGO_REF:0000024
Cand1Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Cand1Ratnucleus located_inIEAUniProtKB:Q86VP6 and ensembl:ENSP000004423181600115GO_REF:0000107EnsemblGO_REF:0000107
Cand1Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Cand1Ratnucleus is_active_inIBAMGI:1914338 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cand1Ratnucleus located_inISOCAND1 (Homo sapiens)1624291 PMID:10581176 and PMID:21249194RGDPMID:10581176 and PMID:21249194
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Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cand1Ratprotein binding enablesISOCAND1 (Homo sapiens)1624291UniProtKB:P46776 more ...RGDPMID:12504025 more ...
Cand1Ratprotein binding enablesISOCand1 (Mus musculus)1624291PR:E9Q9D5 PMID:23055941RGDPMID:23055941
Cand1RatTBP-class protein binding  IDA 634479 RGD 

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cand1Ratneddylation pathway  ISS 1559298 RGD 

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#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. TATA-Binding protein-interacting protein 120, TIP120, stimulates three classes of eukaryotic transcription via a unique mechanism. Makino Y, etal., Mol Cell Biol. 1999 Dec;19(12):7951-60.
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. Regulation of cullin-based ubiquitin ligases by the Nedd8/RUB ubiquitin-like proteins. Parry G and Estelle M, Semin Cell Dev Biol. 2004 Apr;15(2):221-9.
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Molecular cloning of a novel 120-kDa TBP-interacting protein. Yogosawa S, etal., Biochem Biophys Res Commun 1996 Dec 13;229(2):612-7.
9. Induced expression, localization, and chromosome mapping of a gene for the TBP-interacting protein 120A. Yogosawa S, etal., Biochem Biophys Res Commun 1999 Dec 9;266(1):123-8.
1 to 9 of 9 rows
PMID:10441524   PMID:10526239   PMID:12609982   PMID:15537541   PMID:19056867   PMID:19946888   PMID:20458337   PMID:21249194   PMID:21630459   PMID:22405651   PMID:23533145   PMID:26316108  
PMID:29367474   PMID:29476059   PMID:32357304   PMID:34974108   PMID:38095165  



Cand1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8756,566,765 - 56,604,653 (-)NCBIGRCr8
mRatBN7.2754,681,114 - 54,719,002 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl754,680,900 - 54,718,993 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx756,587,617 - 56,625,505 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0758,790,753 - 58,828,639 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0758,568,597 - 58,606,483 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0762,124,362 - 62,162,451 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl762,124,362 - 62,162,453 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0762,113,404 - 62,151,493 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4758,461,205 - 58,499,092 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1758,481,934 - 58,519,822 (-)NCBI
Celera751,445,526 - 51,483,413 (-)NCBICelera
Cytogenetic Map7q22NCBI
CAND1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381267,269,358 - 67,319,953 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1267,269,358 - 67,319,953 (+)EnsemblGRCh38hg38GRCh38
GRCh371267,663,138 - 67,713,733 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361265,949,416 - 65,994,189 (+)NCBINCBI36Build 36hg18NCBI36
Build 341265,949,415 - 65,994,187NCBI
Celera1267,327,070 - 67,372,407 (+)NCBICelera
Cytogenetic Map12q14.3-q15NCBI
HuRef1264,713,845 - 64,759,496 (+)NCBIHuRef
CHM1_11267,630,340 - 67,675,666 (+)NCBICHM1_1
T2T-CHM13v2.01267,248,745 - 67,299,478 (+)NCBIT2T-CHM13v2.0
Cand1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910119,034,717 - 119,075,960 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10119,035,160 - 119,075,960 (-)EnsemblGRCm39 Ensembl
GRCm3810119,198,812 - 119,240,055 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10119,199,255 - 119,240,055 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710118,635,868 - 118,677,111 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610118,601,872 - 118,724,036 (-)NCBIMGSCv36mm8
Celera10121,557,633 - 121,598,810 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1067.08NCBI
Cand1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545813,815,819 - 13,850,007 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545813,815,819 - 13,850,007 (+)NCBIChiLan1.0ChiLan1.0
CAND1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21027,037,080 - 27,084,905 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11227,033,844 - 27,080,879 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01221,592,833 - 21,638,382 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11222,099,962 - 22,145,013 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1222,099,962 - 22,145,013 (-)Ensemblpanpan1.1panPan2
CAND1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1109,652,176 - 9,683,373 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl109,641,732 - 9,680,118 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha109,571,760 - 9,612,014 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0109,755,181 - 9,795,481 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl109,755,061 - 9,794,999 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1109,631,961 - 9,672,240 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0109,877,617 - 9,917,882 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0109,999,578 - 10,039,865 (+)NCBIUU_Cfam_GSD_1.0
Cand1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494548,854,528 - 48,892,090 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365455,218,407 - 5,255,245 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365455,217,947 - 5,255,596 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CAND1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl531,657,501 - 31,700,163 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1531,657,508 - 31,700,163 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2534,955,840 - 34,994,724 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CAND1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11162,923,198 - 62,968,789 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1162,922,885 - 62,966,994 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037182,746,329 - 182,791,692 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cand1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248021,014,515 - 1,049,561 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248021,010,749 - 1,049,253 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Cand1
103 total Variants


Assembly: Rnor_6.0
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
7 62151392 62151393 G T snv F344/NCrl (RGD), LEW/Crl (RGD), SR/JrHsd (RGD), SHR/NHsd (RGD), LEW/NCrlBR (RGD) View more Information

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:38
Interacting mature miRNAs:43
Transcripts:ENSRNOT00000010720
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 37 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74725178365728867Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat

1 to 10 of 37 rows
AI195005  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8756,567,009 - 56,567,131 (+)Marker Load Pipeline
mRatBN7.2754,681,357 - 54,681,480 (+)MAPPERmRatBN7.2
Rnor_6.0762,124,606 - 62,124,728NCBIRnor6.0
Rnor_5.0762,113,648 - 62,113,770UniSTSRnor5.0
RGSC_v3.4758,461,449 - 58,461,571UniSTSRGSC3.4
Celera751,445,770 - 51,445,892UniSTS
Cytogenetic Map7q22UniSTS
RH138241  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2754,719,336 - 54,719,472 (+)MAPPERmRatBN7.2
Rnor_6.0762,162,786 - 62,162,921NCBIRnor6.0
Rnor_5.0762,151,828 - 62,151,963UniSTSRnor5.0
RGSC_v3.4758,499,427 - 58,499,562UniSTSRGSC3.4
Celera751,483,748 - 51,483,883UniSTS
RH 3.4 Map7489.3UniSTS
Cytogenetic Map7q22UniSTS
RH139433  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2754,680,931 - 54,681,056 (+)MAPPERmRatBN7.2
Rnor_6.0762,124,180 - 62,124,304NCBIRnor6.0
Rnor_5.0762,113,222 - 62,113,346UniSTSRnor5.0
RGSC_v3.4758,461,023 - 58,461,147UniSTSRGSC3.4
Celera751,445,344 - 51,445,468UniSTS
RH 3.4 Map7489.3UniSTS
Cytogenetic Map7q22UniSTS
BI275731  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2754,681,369 - 54,681,548 (+)MAPPERmRatBN7.2
Rnor_6.0762,124,618 - 62,124,796NCBIRnor6.0
Rnor_5.0762,113,660 - 62,113,838UniSTSRnor5.0
RGSC_v3.4758,461,461 - 58,461,639UniSTSRGSC3.4
Celera751,445,782 - 51,445,960UniSTS
RH 3.4 Map7488.0UniSTS
Cytogenetic Map7q22UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000010720   ⟹   ENSRNOP00000010720
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl754,680,900 - 54,718,993 (-)Ensembl
Rnor_6.0 Ensembl762,124,362 - 62,162,453 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111987   ⟹   ENSRNOP00000086186
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl754,680,900 - 54,698,264 (-)Ensembl
RefSeq Acc Id: NM_054004   ⟹   NP_446456
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8756,566,765 - 56,604,653 (-)NCBI
mRatBN7.2754,681,114 - 54,719,002 (-)NCBI
Rnor_6.0762,124,362 - 62,162,451 (-)NCBI
Rnor_5.0762,113,404 - 62,151,493 (-)NCBI
RGSC_v3.4758,461,205 - 58,499,092 (-)RGD
Celera751,445,526 - 51,483,413 (-)RGD
Sequence:
Protein RefSeqs NP_446456 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA13432 (Get FASTA)   NCBI Sequence Viewer  
  EDM16585 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000010720
  ENSRNOP00000010720.3
GenBank Protein P97536 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446456   ⟸   NM_054004
- UniProtKB: P97536 (UniProtKB/Swiss-Prot),   A6IGW3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010720   ⟸   ENSRNOT00000010720
Ensembl Acc Id: ENSRNOP00000086186   ⟸   ENSRNOT00000111987
TATA-binding protein interacting (TIP20)

Name Modeler Protein Id AA Range Protein Structure
AF-P97536-F1-model_v2 AlphaFold P97536 1-1230 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13695221
Promoter ID:EPDNEW_R5746
Type:initiation region
Name:Cand1_1
Description:cullin-associated and neddylation-dissociated 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0762,162,447 - 62,162,507EPDNEW


1 to 20 of 20 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-33932 BioCyc
Ensembl Genes ENSRNOG00000007834 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010720 ENTREZGENE
  ENSRNOT00000010720.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.10.10 UniProtKB/Swiss-Prot
InterPro ARM-like UniProtKB/Swiss-Prot
  ARM-type_fold UniProtKB/Swiss-Prot
  CAND1/CAND2 UniProtKB/Swiss-Prot
  TATA-bd_TIP120 UniProtKB/Swiss-Prot
KEGG Report rno:117152 UniProtKB/Swiss-Prot
NCBI Gene 117152 ENTREZGENE
PANTHER PTHR12696 UniProtKB/Swiss-Prot
Pfam HEAT_EZ UniProtKB/Swiss-Prot
  TIP120 UniProtKB/Swiss-Prot
PhenoGen Cand1 PhenoGen
RatGTEx ENSRNOG00000007834 RatGTEx
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot
UniProt A0A8I6A6C9_RAT UniProtKB/TrEMBL
  A6IGW3 ENTREZGENE, UniProtKB/TrEMBL
  CAND1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 20 of 20 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-29 Cand1  cullin-associated and neddylation-dissociated 1  Cand1  cullin associated and neddylation disassociated 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Cand1  cullin associated and neddylation disassociated 1  Tip120A  TBP-interacting protein 120A  Symbol and Name updated 1299863 APPROVED
2005-07-08 Tip120A  TBP-interacting protein 120A      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Tip120A  TBP-interacting protein 120A      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_cellular_localization localized to the nucleus 634479
gene_protein 120-kD protein 634479