Inpp4b (inositol polyphosphate-4-phosphatase type II B) - Rat Genome Database

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Gene: Inpp4b (inositol polyphosphate-4-phosphatase type II B) Rattus norvegicus
Analyze
Symbol: Inpp4b
Name: inositol polyphosphate-4-phosphatase type II B
RGD ID: 620470
Description: Enables phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity. Acts upstream of or within phosphatidylinositol dephosphorylation. Predicted to be active in cytoplasm. Orthologous to human INPP4B (inositol polyphosphate-4-phosphatase type II B); PARTICIPATES IN inositol phosphate metabolic pathway; phosphoinositide metabolic pathway; phosphatidylinositol 3-kinase signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: inositol polyphosphate 4-phosphatase type II; inositol polyphosphate-4-phosphatase type II 105kD; inositol polyphosphate-4-phosphatase, type II; inositol polyphosphate-4-phosphatase, type II, 105kD; type II inositol 3,4-bisphosphate 4-phosphatase; type II inositol-3,4-bisphosphate 4-phosphatase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Inpp4bTn(sb-T2/Bart3)2.143Mcwi ; Inpp4bTn(sb-T2/Bart3)2.232Mcwi
Genetic Models: F344-Inpp4bTn(sb-T2/Bart3)2.143Mcwi ; F344-Inpp4bTn(sb-T2/Bart3)2.232Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81942,824,710 - 43,575,039 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1942,829,871 - 43,185,091 (-)EnsemblGRCr8
mRatBN7.21925,920,189 - 26,670,085 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1925,925,358 - 26,280,634 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1932,773,840 - 33,511,367 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01933,427,933 - 34,165,436 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01935,664,080 - 36,411,093 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01929,592,889 - 30,341,528 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1929,597,905 - 29,968,424 (-)Ensemblrn6Rnor6.0
Rnor_5.01940,508,684 - 41,132,035 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41927,722,430 - 28,363,639 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1925,451,220 - 26,189,580 (-)NCBICelera
RGSC_v3.11927,727,256 - 28,484,803 (-)NCBI
Cytogenetic Map19q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-nitropyrene  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP,ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
daunorubicin  (ISO)
Dibutyl phosphate  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
folpet  (ISO)
formaldehyde  (ISO)
genistein  (ISO)
hydroquinone  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
isotretinoin  (ISO)
maneb  (ISO)
methoxychlor  (EXP)
methylparaben  (ISO)
methylseleninic acid  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
panobinostat  (ISO)
paraquat  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-nitrosoglutathione  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family. Norris FA, etal., J Biol Chem 1997 Sep 19;272(38):23859-64.
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:16631325   PMID:21982707   PMID:23078915  


Genomics

Comparative Map Data
Inpp4b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81942,824,710 - 43,575,039 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1942,829,871 - 43,185,091 (-)EnsemblGRCr8
mRatBN7.21925,920,189 - 26,670,085 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1925,925,358 - 26,280,634 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1932,773,840 - 33,511,367 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01933,427,933 - 34,165,436 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01935,664,080 - 36,411,093 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01929,592,889 - 30,341,528 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1929,597,905 - 29,968,424 (-)Ensemblrn6Rnor6.0
Rnor_5.01940,508,684 - 41,132,035 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41927,722,430 - 28,363,639 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1925,451,220 - 26,189,580 (-)NCBICelera
RGSC_v3.11927,727,256 - 28,484,803 (-)NCBI
Cytogenetic Map19q11NCBI
INPP4B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384142,023,160 - 142,846,535 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4142,023,160 - 142,847,432 (-)Ensemblhg38GRCh38
GRCh374142,944,313 - 143,767,688 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364143,168,631 - 143,987,054 (-)NCBIBuild 36Build 36hg18NCBI36
Build 344143,307,498 - 143,710,137NCBI
Celera4140,279,978 - 141,098,274 (-)NCBICelera
Cytogenetic Map4q31.21NCBI
HuRef4138,678,404 - 139,496,966 (-)NCBIHuRef
CHM1_14142,926,560 - 143,744,866 (-)NCBICHM1_1
T2T-CHM13v2.04145,340,544 - 146,163,746 (-)NCBIT2T-CHM13v2.0
Inpp4b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39882,068,895 - 82,865,553 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl882,069,185 - 82,854,543 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38881,342,266 - 82,134,312 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl881,342,556 - 82,127,914 (+)Ensemblmm10GRCm38
MGSCv37884,239,099 - 84,646,460 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36884,610,947 - 85,018,308 (+)NCBIMGSCv36mm8
Celera886,003,317 - 86,422,617 (+)NCBICelera
Cytogenetic Map8C2NCBI
cM Map839.02NCBI
Inpp4b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955471938,005 - 1,291,695 (+)Ensembl
ChiLan1.0NW_004955471938,005 - 1,291,695 (+)NCBIChiLan1.0ChiLan1.0
INPP4B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23139,915,448 - 140,728,958 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14140,308,554 - 141,448,389 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04134,405,934 - 135,213,851 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14145,707,005 - 146,513,611 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4145,706,307 - 146,141,029 (-)EnsemblpanPan2panpan1.1
INPP4B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.119826,711 - 1,192,340 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl19850,784 - 1,186,498 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha191,074,484 - 1,439,447 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.019847,593 - 1,213,382 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl19872,222 - 1,211,381 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.119829,445 - 1,194,997 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0191,190,522 - 1,556,374 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0191,544,331 - 1,910,402 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Inpp4b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530147,989,723 - 48,731,310 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365355,794,135 - 6,171,072 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365355,427,131 - 6,168,622 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
INPP4B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl885,084,133 - 85,514,516 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1884,812,041 - 85,555,200 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2890,440,950 - 90,810,384 (+)NCBISscrofa10.2Sscrofa10.2susScr3
INPP4B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1788,929,249 - 89,732,375 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl788,979,493 - 89,461,475 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603768,478,295 - 69,289,053 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Inpp4b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248531,355,384 - 1,868,812 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248531,350,577 - 2,147,616 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Inpp4b
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11718,120,336 - 18,459,917 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Inpp4b
5059 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:388
Count of miRNA genes:208
Interacting mature miRNAs:253
Transcripts:ENSRNOT00000024981, ENSRNOT00000025013
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)191922068964220689Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19799775052997750Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
61328Eae8Experimental allergic encephalomyelitis QTL 84nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)194172060949971820Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)193128753251431640Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19799775052997750Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
1554318Bmd5Bone mineral density QTL 512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)192318858668188586Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)194172254674246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)194072709254856850Rat
61407Scl12Serum cholesterol level QTL 120.001blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)193009938347207961Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19799775052997750Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)19574806450748064Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
2303628Vencon9Ventilatory control QTL 90.005respiration trait (VT:0001943)minute ventilation (CMO:0000132)192318858668188586Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19799775052997750Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)192010930665109306Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)194072709254856850Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)194072709254856850Rat

Markers in Region
D15Mit4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25138,497,366 - 138,497,449 (+)MAPPERmRatBN7.2
mRatBN7.25138,493,166 - 138,493,249 (+)MAPPERmRatBN7.2
mRatBN7.21926,052,677 - 26,052,794 (+)MAPPERmRatBN7.2
mRatBN7.25138,501,566 - 138,501,649 (+)MAPPERmRatBN7.2
mRatBN7.25138,505,766 - 138,505,849 (+)MAPPERmRatBN7.2
Rnor_6.01929,725,257 - 29,725,373NCBIRnor6.0
Rnor_6.05144,227,288 - 144,227,370NCBIRnor6.0
Rnor_5.01940,635,255 - 40,635,371UniSTSRnor5.0
Rnor_5.05147,995,326 - 147,995,408UniSTSRnor5.0
RGSC_v3.45145,575,830 - 145,575,912UniSTSRGSC3.4
RGSC_v3.41927,849,593 - 27,849,709UniSTSRGSC3.4
Celera1925,576,861 - 25,576,977UniSTS
Celera5137,003,287 - 137,003,369UniSTS
RGSC_v3.11927,854,418 - 27,854,535RGD
Cytogenetic Map19q11UniSTS
D19Rat41  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81943,200,968 - 43,201,119 (+)Marker Load Pipeline
mRatBN7.21926,296,511 - 26,296,662 (+)MAPPERmRatBN7.2
Rnor_6.01929,966,560 - 29,966,710NCBIRnor6.0
Rnor_5.01940,875,102 - 40,875,252UniSTSRnor5.0
RGSC_v3.41928,102,830 - 28,102,981RGDRGSC3.4
RGSC_v3.41928,102,831 - 28,102,981UniSTSRGSC3.4
Celera1925,818,951 - 25,819,101UniSTS
RGSC_v3.11928,107,656 - 28,107,807RGD
SHRSP x BN Map1920.2599UniSTS
SHRSP x BN Map1920.2599RGD
Cytogenetic Map19q11UniSTS
D19Rat120  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21926,182,615 - 26,182,815 (+)MAPPERmRatBN7.2
Rnor_6.01929,855,156 - 29,855,355NCBIRnor6.0
Rnor_5.01940,765,631 - 40,765,830UniSTSRnor5.0
RGSC_v3.41927,980,182 - 27,980,382RGDRGSC3.4
RGSC_v3.41927,980,183 - 27,980,382UniSTSRGSC3.4
Celera1925,706,606 - 25,706,805UniSTS
RGSC_v3.11927,985,008 - 27,985,208RGD
SHRSP x BN Map1920.2599RGD
SHRSP x BN Map1920.2599UniSTS
Cytogenetic Map19q11UniSTS
D19Got19  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21926,283,898 - 26,284,096 (+)MAPPERmRatBN7.2
Rnor_6.01929,954,758 - 29,954,955NCBIRnor6.0
Rnor_5.01940,863,300 - 40,863,497UniSTSRnor5.0
RGSC_v3.41928,089,765 - 28,089,963RGDRGSC3.4
RGSC_v3.41928,089,766 - 28,089,963UniSTSRGSC3.4
Celera1925,806,321 - 25,806,518UniSTS
RGSC_v3.11928,094,591 - 28,094,789RGD
Cytogenetic Map19q11UniSTS
AU047006  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21926,551,265 - 26,551,402 (+)MAPPERmRatBN7.2
Rnor_6.01930,221,722 - 30,221,858NCBIRnor6.0
Rnor_5.01941,130,850 - 41,130,986UniSTSRnor5.0
RGSC_v3.41928,362,454 - 28,362,590UniSTSRGSC3.4
Celera1926,073,432 - 26,073,568UniSTS
Cytogenetic Map19q11UniSTS
RH138607  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21926,236,741 - 26,236,960 (+)MAPPERmRatBN7.2
Rnor_6.01929,908,062 - 29,908,280NCBIRnor6.0
Rnor_5.01940,816,604 - 40,816,822UniSTSRnor5.0
RGSC_v3.41928,041,670 - 28,041,888UniSTSRGSC3.4
Celera1925,759,562 - 25,759,780UniSTS
Cytogenetic Map19q11UniSTS
RH143194  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21926,236,823 - 26,236,947 (+)MAPPERmRatBN7.2
Rnor_6.01929,908,144 - 29,908,267NCBIRnor6.0
Rnor_5.01940,816,686 - 40,816,809UniSTSRnor5.0
RGSC_v3.41928,041,752 - 28,041,875UniSTSRGSC3.4
Celera1925,759,644 - 25,759,767UniSTS
Cytogenetic Map19q11UniSTS
AU029195  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21926,161,303 - 26,161,447 (+)MAPPERmRatBN7.2
Rnor_6.01929,833,847 - 29,833,990NCBIRnor6.0
Rnor_5.01940,744,189 - 40,744,332UniSTSRnor5.0
RGSC_v3.41927,958,518 - 27,958,661UniSTSRGSC3.4
Celera1925,685,318 - 25,685,461UniSTS
Cytogenetic Map19q11UniSTS


Genetic Models
This gene Inpp4b is modified in the following models/strains:
F344-Inpp4bTn(sb-T2/Bart3)2.143Mcwi     F344-Inpp4bTn(sb-T2/Bart3)2.232Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001431397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_053917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC123471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U96920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U96921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000024981   ⟹   ENSRNOP00000024981
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1942,829,871 - 43,185,091 (-)Ensembl
mRatBN7.2 Ensembl1925,925,358 - 26,280,634 (-)Ensembl
Rnor_6.0 Ensembl1929,597,905 - 29,968,424 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000025013   ⟹   ENSRNOP00000025013
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1942,830,100 - 43,185,091 (-)Ensembl
mRatBN7.2 Ensembl1925,925,588 - 26,280,634 (-)Ensembl
Rnor_6.0 Ensembl1929,598,280 - 29,951,493 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097624   ⟹   ENSRNOP00000085379
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1942,830,100 - 43,185,091 (-)Ensembl
mRatBN7.2 Ensembl1925,925,588 - 26,280,634 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000126787   ⟹   ENSRNOP00000106704
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1942,834,664 - 43,185,091 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000149372   ⟹   ENSRNOP00000106546
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1942,829,871 - 43,185,091 (-)Ensembl
RefSeq Acc Id: NM_053917   ⟹   NP_446369
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81942,830,100 - 43,574,411 (-)NCBI
mRatBN7.21925,925,587 - 26,669,963 (-)NCBI
Rnor_6.01929,598,279 - 30,341,442 (-)NCBI
Rnor_5.01940,508,684 - 41,132,035 (-)NCBI
RGSC_v3.41927,722,430 - 28,363,639 (-)RGD
Celera1925,451,220 - 26,189,580 (-)RGD
Sequence:
RefSeq Acc Id: XM_008772462   ⟹   XP_008770684
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81942,830,100 - 43,242,638 (-)NCBI
mRatBN7.21925,926,776 - 26,346,238 (-)NCBI
Rnor_6.01929,598,279 - 30,008,667 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601163   ⟹   XP_017456652
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81942,830,100 - 43,575,036 (-)NCBI
mRatBN7.21925,925,575 - 26,670,084 (-)NCBI
Rnor_6.01929,598,279 - 30,341,527 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601165   ⟹   XP_017456654
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81942,830,100 - 43,575,039 (-)NCBI
mRatBN7.21925,926,776 - 26,670,085 (-)NCBI
Rnor_6.01929,598,279 - 30,341,528 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039097428   ⟹   XP_038953356
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81942,830,100 - 43,575,036 (-)NCBI
mRatBN7.21925,926,776 - 26,670,084 (-)NCBI
RefSeq Acc Id: XM_039097429   ⟹   XP_038953357
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81942,830,100 - 43,495,120 (-)NCBI
mRatBN7.21925,926,776 - 26,589,522 (-)NCBI
RefSeq Acc Id: XM_039097430   ⟹   XP_038953358
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81942,830,100 - 43,575,037 (-)NCBI
mRatBN7.21925,925,575 - 26,670,085 (-)NCBI
RefSeq Acc Id: XM_039097434   ⟹   XP_038953362
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81942,830,100 - 43,068,527 (-)NCBI
mRatBN7.21925,926,776 - 26,164,030 (-)NCBI
RefSeq Acc Id: XM_039097435   ⟹   XP_038953363
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81942,830,100 - 43,149,920 (-)NCBI
mRatBN7.21925,926,776 - 26,245,459 (-)NCBI
RefSeq Acc Id: XM_063277734   ⟹   XP_063133804
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81942,830,100 - 43,575,036 (-)NCBI
RefSeq Acc Id: XM_063277736   ⟹   XP_063133806
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81942,824,710 - 43,242,638 (-)NCBI
RefSeq Acc Id: XM_063277737   ⟹   XP_063133807
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81942,830,100 - 43,242,638 (-)NCBI
RefSeq Acc Id: XM_063277738   ⟹   XP_063133808
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81942,824,710 - 43,242,638 (-)NCBI
RefSeq Acc Id: XM_063277739   ⟹   XP_063133809
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81942,830,100 - 43,575,032 (-)NCBI
RefSeq Acc Id: NP_446369   ⟸   NM_053917
- UniProtKB: A6IYG6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008770684   ⟸   XM_008772462
- Peptide Label: isoform X1
- UniProtKB: A6IYG6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456654   ⟸   XM_017601165
- Peptide Label: isoform X4
- UniProtKB: A0A8I6A1I3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456652   ⟸   XM_017601163
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000024981   ⟸   ENSRNOT00000024981
Ensembl Acc Id: ENSRNOP00000025013   ⟸   ENSRNOT00000025013
RefSeq Acc Id: XP_038953358   ⟸   XM_039097430
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038953356   ⟸   XM_039097428
- Peptide Label: isoform X1
- UniProtKB: A6IYG6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953357   ⟸   XM_039097429
- Peptide Label: isoform X1
- UniProtKB: A6IYG6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953363   ⟸   XM_039097435
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038953362   ⟸   XM_039097434
- Peptide Label: isoform X7
Ensembl Acc Id: ENSRNOP00000085379   ⟸   ENSRNOT00000097624
RefSeq Acc Id: XP_063133808   ⟸   XM_063277738
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063133806   ⟸   XM_063277736
- Peptide Label: isoform X3
- UniProtKB: Q9QWG5 (UniProtKB/Swiss-Prot),   O35825 (UniProtKB/Swiss-Prot),   A6IYG5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133804   ⟸   XM_063277734
- Peptide Label: isoform X1
- UniProtKB: A6IYG6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133809   ⟸   XM_063277739
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063133807   ⟸   XM_063277737
- Peptide Label: isoform X4
- UniProtKB: A0A8I6A1I3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000106704   ⟸   ENSRNOT00000126787
Ensembl Acc Id: ENSRNOP00000106546   ⟸   ENSRNOT00000149372
Protein Domains
C2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QWG5-F1-model_v2 AlphaFold Q9QWG5 1-928 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620470 AgrOrtholog
BioCyc Gene G2FUF-5984 BioCyc
BioCyc Pathway PWY-6368 [3-phosphoinositide degradation] BioCyc
BioCyc Pathway Image PWY-6368 BioCyc
Ensembl Genes ENSRNOG00000018382 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000024981 ENTREZGENE
  ENSRNOT00000024981.7 UniProtKB/Swiss-Prot
  ENSRNOT00000025013 ENTREZGENE
  ENSRNOT00000025013.5 UniProtKB/Swiss-Prot
  ENSRNOT00000097624 ENTREZGENE
Gene3D-CATH 2.60.40.150 UniProtKB/Swiss-Prot
InterPro C2_dom UniProtKB/Swiss-Prot
  C2_domain_sf UniProtKB/Swiss-Prot
  INPP4 UniProtKB/Swiss-Prot
KEGG Report rno:116699 UniProtKB/Swiss-Prot
NCBI Gene 116699 ENTREZGENE
PANTHER INOSITOL POLYPHOSPHATE 4-PHOSPHATASE TYPE II UniProtKB/Swiss-Prot
  PTHR12187 UniProtKB/Swiss-Prot
PhenoGen Inpp4b PhenoGen
PROSITE PS50004 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018382 RatGTEx
Superfamily-SCOP SSF49562 UniProtKB/Swiss-Prot
UniProt A0A8I6A1I3 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LWJ6_RAT UniProtKB/TrEMBL
  A0ABK0LZV7_RAT UniProtKB/TrEMBL
  A6IYG5 ENTREZGENE, UniProtKB/TrEMBL
  A6IYG6 ENTREZGENE, UniProtKB/TrEMBL
  A6IYG7_RAT UniProtKB/TrEMBL
  INP4B_RAT UniProtKB/Swiss-Prot
  O35825 ENTREZGENE
  Q9QWG5 ENTREZGENE
UniProt Secondary O35825 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-12-14 Inpp4b  inositol polyphosphate-4-phosphatase, type II    inositol polyphosphate-4-phosphatase, type II, 105kD  Name updated 1299863 APPROVED
2002-08-07 Inpp4b  inositol polyphosphate-4-phosphatase, type II, 105kD      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression highly expressed in skeletal muscle and heart with some expression in most tissues 633135
gene_protein a 105,257-Da protein 633135