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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620470
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Inpp4b
Name: inositol polyphosphate-4-phosphatase type II B
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Inpp4bdecreases expressionISOINPP4B (Homo sapiens)6480464CTDProgesterone results in decreased expression of INPP4B mRNAPMID:20864642
Inpp4bmultiple interactionsISOINPP4B (Homo sapiens)6480464CTDProgesterone inhibits the reaction [Estradiol results in increased expression of INPP4B mRNA]PMID:21795739
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