Mcam (melanoma cell adhesion molecule) - Rat Genome Database

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Gene: Mcam (melanoma cell adhesion molecule) Rattus norvegicus
Analyze
Symbol: Mcam
Name: melanoma cell adhesion molecule
RGD ID: 620463
Description: Predicted to enable laminin receptor activity. Involved in positive regulation of cell migration. Located in extracellular space. Biomarker of impotence and malignant mesothelioma. Orthologous to human MCAM (melanoma cell adhesion molecule); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CD146; cell surface glycoprotein MUC18; gicerin; l-gicerin; melanoma-associated antigen MUC18; Muc18
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8853,376,225 - 53,384,407 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl853,376,197 - 53,384,406 (+)EnsemblGRCr8
mRatBN7.2844,479,391 - 44,487,575 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl844,479,376 - 44,487,571 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx849,974,482 - 49,982,684 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0848,253,193 - 48,261,397 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0846,124,029 - 46,132,210 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0848,472,824 - 48,481,005 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl848,472,824 - 48,481,001 (+)Ensemblrn6Rnor6.0
Rnor_5.0847,091,191 - 47,099,630 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4847,105,632 - 47,127,936 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera844,066,232 - 44,074,417 (+)NCBICelera
RGSC_v3.1847,130,370 - 47,135,903 (+)NCBI
Cytogenetic Map8q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
6-propyl-2-thiouracil  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amiodarone  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chrysene  (ISO)
cisplatin  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (EXP,ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
etoposide  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
FR900359  (ISO)
geldanamycin  (ISO)
genistein  (ISO)
glycidol  (EXP)
glyphosate  (ISO)
haloperidol  (ISO)
Heptachlor epoxide  (ISO)
hydrogen cyanide  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
methamphetamine  (EXP)
methimazole  (EXP)
mifepristone  (EXP)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N(4)-hydroxycytidine  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (ISO)
nitrofen  (EXP)
okadaic acid  (ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenanthrene  (ISO)
phenylmercury acetate  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium cyanide  (ISO)
potassium dichromate  (ISO)
profenofos  (EXP)
propanal  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
sevoflurane  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
tacrolimus hydrate  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
triadimefon  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Involvement of gicerin, a cell adhesion molecule, in the portal metastasis of rat colorectal adenocarcinoma cells. Adachi K, etal., Oncol Rep. 2010 Dec;24(6):1427-31.
2. Possible implications of MCAM expression in metastasis and non-metastatic of primary uveal melanoma patients. Beutel J, etal., Curr Eye Res. 2009 Nov;34(11):1004-9. doi: 10.3109/02713680903262205.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Endothelial cell adhesion molecule CD146: implications for its role in the pathogenesis of COPD. Kratzer A, etal., J Pathol. 2013 Aug;230(4):388-98. doi: 10.1002/path.4197.
6. Expression of gicerin, a novel cell adhesion molecule, is upregulated in the astrocytes after hypoglossal nerve injury in rats. Li BS, etal., Neurosci Lett. 1999 Feb 5;260(3):149-52.
7. Correction of diabetic erectile dysfunction with adipose derived stem cells modified with the vascular endothelial growth factor gene in a rodent diabetic model. Liu G, etal., PLoS One. 2013 Aug 30;8(8):e72790. doi: 10.1371/journal.pone.0072790.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. CD146 and insulin-like growth factor 2 mRNA-binding protein 3 predict prognosis of asbestos-induced rat mesothelioma. Okazaki Y, etal., Cancer Sci. 2013 Aug;104(8):989-95. doi: 10.1111/cas.12185. Epub 2013 May 26.
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
14. Gicerin, an Ig-superfamily cell adhesion molecule, promotes the invasive and metastatic activities of a mouse fibroblast cell line. Tsukamoto Y, etal., J Cell Physiol 2003 Oct;197(1):103-9.
Additional References at PubMed
PMID:14706627   PMID:14755543   PMID:15489334   PMID:15880440   PMID:20354148   PMID:21423176   PMID:22871113   PMID:23878390   PMID:27068509   PMID:33515199   PMID:34477225   PMID:34575887  


Genomics

Comparative Map Data
Mcam
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8853,376,225 - 53,384,407 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl853,376,197 - 53,384,406 (+)EnsemblGRCr8
mRatBN7.2844,479,391 - 44,487,575 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl844,479,376 - 44,487,571 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx849,974,482 - 49,982,684 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0848,253,193 - 48,261,397 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0846,124,029 - 46,132,210 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0848,472,824 - 48,481,005 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl848,472,824 - 48,481,001 (+)Ensemblrn6Rnor6.0
Rnor_5.0847,091,191 - 47,099,630 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4847,105,632 - 47,127,936 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera844,066,232 - 44,074,417 (+)NCBICelera
RGSC_v3.1847,130,370 - 47,135,903 (+)NCBI
Cytogenetic Map8q22NCBI
MCAM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811119,308,529 - 119,317,130 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11119,307,972 - 119,321,521 (-)Ensemblhg38GRCh38
GRCh3711119,179,239 - 119,187,840 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611118,684,444 - 118,693,050 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3411118,684,187 - 118,693,050NCBI
Celera11116,339,434 - 116,348,037 (-)NCBICelera
Cytogenetic Map11q23.3NCBI
HuRef11115,119,937 - 115,128,540 (-)NCBIHuRef
CHM1_111119,065,786 - 119,074,389 (-)NCBICHM1_1
T2T-CHM13v2.011119,329,165 - 119,337,763 (-)NCBIT2T-CHM13v2.0
Mcam
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39944,045,958 - 44,054,024 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl944,045,766 - 44,054,024 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38944,134,658 - 44,142,727 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl944,134,469 - 44,142,727 (+)Ensemblmm10GRCm38
MGSCv37943,942,741 - 43,950,809 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36943,885,666 - 43,893,719 (+)NCBIMGSCv36mm8
Celera941,392,205 - 41,400,272 (+)NCBICelera
Cytogenetic Map9A5.1NCBI
cM Map924.68NCBI
Mcam
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541220,397,051 - 20,404,780 (-)Ensembl
ChiLan1.0NW_00495541220,396,056 - 20,404,777 (-)NCBIChiLan1.0ChiLan1.0
MCAM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29120,016,269 - 120,024,928 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111121,119,769 - 121,128,446 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011114,149,583 - 114,158,234 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111118,076,841 - 118,084,748 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11118,078,179 - 118,083,893 (-)EnsemblpanPan2panpan1.1
MCAM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1514,590,252 - 14,598,901 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl514,567,238 - 14,598,149 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha514,643,495 - 14,652,026 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0514,533,623 - 14,542,154 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl514,510,591 - 14,542,153 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1514,672,708 - 14,680,319 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0514,575,921 - 14,584,454 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0514,616,078 - 14,624,610 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mcam
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947101,314,589 - 101,328,572 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365424,237,010 - 4,244,462 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365424,235,914 - 4,244,981 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MCAM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl946,512,784 - 46,522,083 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1946,506,375 - 46,522,091 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2951,546,351 - 51,557,212 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MCAM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11110,682,631 - 110,691,717 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1110,684,458 - 110,691,707 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604315,343,344 - 15,351,927 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mcam
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478414,673,060 - 14,681,423 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462478414,671,524 - 14,681,151 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Mcam
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1838,695,953 - 38,703,467 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mcam
25 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:99
Count of miRNA genes:79
Interacting mature miRNAs:93
Transcripts:ENSRNOT00000010463
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)81296416557964165Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)81296416557964165Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)81038254055382540Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
5684993Bmd84Bone mineral density QTL 844.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)85158969958991895Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)81038254055382540Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)81296416557964165Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)81038254055382540Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)83776085958991895Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)81038254055382540Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)83776085961459705Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)83546407171842899Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84961020468373388Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625867378345Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)85076395167219641Rat
1359021Bp271Blood pressure QTL 2711.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)83412590255607752Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat

Markers in Region
BE118163  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2844,476,273 - 44,476,441 (+)MAPPERmRatBN7.2
Rnor_6.0848,468,837 - 48,469,004NCBIRnor6.0
Rnor_5.0847,083,769 - 47,083,936UniSTSRnor5.0
RGSC_v3.4847,116,102 - 47,116,269UniSTSRGSC3.4
Celera844,063,171 - 44,063,338UniSTS
RH 3.4 Map8435.7UniSTS
Cytogenetic Map8q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000010463   ⟹   ENSRNOP00000010464
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl853,376,197 - 53,384,403 (+)Ensembl
mRatBN7.2 Ensembl844,479,376 - 44,487,566 (+)Ensembl
Rnor_6.0 Ensembl848,472,824 - 48,481,001 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090780   ⟹   ENSRNOP00000069860
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl853,376,208 - 53,384,406 (+)Ensembl
mRatBN7.2 Ensembl844,479,391 - 44,487,571 (+)Ensembl
Rnor_6.0 Ensembl848,472,824 - 48,481,001 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105992   ⟹   ENSRNOP00000091494
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl853,376,197 - 53,384,403 (+)Ensembl
mRatBN7.2 Ensembl844,479,376 - 44,487,566 (+)Ensembl
RefSeq Acc Id: NM_001034009   ⟹   NP_001029181
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8853,376,225 - 53,384,407 (+)NCBI
mRatBN7.2844,479,391 - 44,487,575 (+)NCBI
Rnor_6.0848,472,824 - 48,481,005 (+)NCBI
Rnor_5.0847,091,191 - 47,099,630 (+)NCBI
RGSC_v3.4847,105,632 - 47,127,936 (+)RGD
Celera844,066,232 - 44,074,417 (+)RGD
Sequence:
RefSeq Acc Id: NM_023983   ⟹   NP_076473
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8853,376,225 - 53,384,407 (+)NCBI
mRatBN7.2844,479,391 - 44,487,575 (+)NCBI
Rnor_6.0848,472,824 - 48,481,005 (+)NCBI
Rnor_5.0847,091,191 - 47,099,630 (+)NCBI
RGSC_v3.4847,105,632 - 47,127,936 (+)RGD
Celera844,066,232 - 44,074,417 (+)RGD
Sequence:
RefSeq Acc Id: NP_076473   ⟸   NM_023983
- Peptide Label: isoform 1 precursor
- UniProtKB: Q6IRH8 (UniProtKB/Swiss-Prot),   Q9ESS8 (UniProtKB/Swiss-Prot),   Q9EPF2 (UniProtKB/Swiss-Prot),   A6J3W0 (UniProtKB/TrEMBL),   A0A8I6AFJ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001029181   ⟸   NM_001034009
- Peptide Label: isoform 2 precursor
- UniProtKB: A6J3W1 (UniProtKB/TrEMBL),   A0A8I6AFJ0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069860   ⟸   ENSRNOT00000090780
Ensembl Acc Id: ENSRNOP00000010464   ⟸   ENSRNOT00000010463
Ensembl Acc Id: ENSRNOP00000091494   ⟸   ENSRNOT00000105992
Protein Domains
Ig-like   Ig-like C2-type   Ig-like V-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9EPF2-F1-model_v2 AlphaFold Q9EPF2 1-648 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695884
Promoter ID:EPDNEW_R6408
Type:single initiation site
Name:Mcam_1
Description:melanoma cell adhesion molecule
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0848,472,814 - 48,472,874EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620463 AgrOrtholog
BioCyc Gene G2FUF-30734 BioCyc
Ensembl Genes ENSRNOG00000007726 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010463 ENTREZGENE
  ENSRNOT00000010463.7 UniProtKB/Swiss-Prot
  ENSRNOT00000090780 ENTREZGENE
  ENSRNOT00000090780.2 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7105099 IMAGE-MGC_LOAD
InterPro CD80_C2-set UniProtKB/Swiss-Prot
  Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_sub UniProtKB/Swiss-Prot
  Ig_sub2 UniProtKB/Swiss-Prot
  Ig_V-set UniProtKB/Swiss-Prot
  Immunoglobulin UniProtKB/Swiss-Prot
  Surface_Rcpt/Adhesion_Mol UniProtKB/Swiss-Prot
KEGG Report rno:78967 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91447 IMAGE-MGC_LOAD
NCBI Gene 78967 ENTREZGENE
PANTHER CELL SURFACE GLYCOPROTEIN MUC18 UniProtKB/Swiss-Prot
  CELL SURFACE GLYCOPROTEIN MUC18-RELATED UniProtKB/Swiss-Prot
Pfam C2-set_2 UniProtKB/Swiss-Prot
  Ig_3 UniProtKB/Swiss-Prot
  PF00047 UniProtKB/Swiss-Prot
  V-set UniProtKB/Swiss-Prot
PhenoGen Mcam PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007726 RatGTEx
SMART IGc2 UniProtKB/Swiss-Prot
  SM00409 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
UniProt A0A8I6AFJ0 ENTREZGENE, UniProtKB/TrEMBL
  A6J3W0 ENTREZGENE, UniProtKB/TrEMBL
  A6J3W1 ENTREZGENE, UniProtKB/TrEMBL
  MUC18_RAT UniProtKB/Swiss-Prot
  Q6IRH8 ENTREZGENE
  Q9EPF2 ENTREZGENE
  Q9ESS8 ENTREZGENE
UniProt Secondary Q6IRH8 UniProtKB/Swiss-Prot
  Q9ESS8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Mcam  melanoma cell adhesion molecule    l-gicerin  Name updated 1299863 APPROVED
2002-08-07 Mcam  l-gicerin      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_product member of the Ig superfamily 724438